Egg Overactivation—An Overlooked Phenomenon of Gamete Physiology

In many vertebrates, mature ovulated eggs arrest at metaphase II prior to fertilization. The eggs exit meiotic arrest after fertilization-induced or parthenogenetic activation, followed by embryo development or egg degradation, respectively. Calcium-dependent activation of meiotically-arrested eggs has been thoroughly investigated in various species. In addition, several recent studies have detailed the excessive activation of ovulated frog eggs, so called overactivation. This overview highlights the major events of overactivation observed in mature ovulated eggs of the African clawed frog Xenopus laevis with a focus on similarities and differences between spontaneous, oxidative stress-induced, and mechanical stress-induced overactivation. The paper also underscores the dramatically different cell death scenarios that unfold in activated and overactivated eggs.