jabbrv-ltwa-all.ldf jabbrv-ltwa-en.ldf Multivariate Analysis of Prognostic Factors in Persistent Pulmonary Hypertension of the Newborn (PPHN)

jabbrv-ltwa-all.ldf jabbrv-ltwa-en.ldf Multivariate Analysis of Prognostic Factors in Persistent Pulmonary Hypertension of the Newborn (PPHN) | Authorea try { document.documentElement.classList.add('js'); } catch (e) { } var _gaq = _gaq || []; _gaq.push(['_setAccount', 'G-8VDV14Y67G']); _gaq.push(['_trackPageview']); (function() { var ga = document.createElement('script'); ga.type = 'text/javascript'; ga.async = true; ga.src = ('https:' == document.location.protocol ? 'https://ssl' : 'http://www') + '.google-analytics.com/ga.js'; var s = document.getElementsByTagName('script')[0]; s.parentNode.insertBefore(ga, s); })(); Skip to main content Preprints Collections Wiley Open Research IET Open Research Ecological Society of Japan All Collections About About Authorea FAQs Contact Us Quick Search anywhere Search for preprint articles, keywords, etc. Search Search ADVANCED SEARCH SCROLL This is a preprint and has not been peer reviewed. Data may be preliminary. 17 July 2025 V1 Latest version Share on jabbrv-ltwa-all.ldf jabbrv-ltwa-en.ldf Multivariate Analysis of Prognostic Factors in Persistent Pulmonary Hypertension of the Newborn (PPHN) Authors : Peng-xiang Chen 0009-0004-6886-6246 , Li-yan Song , Gu Qiang [email protected] , Bo Yuan , and Yang Yang Authors Info & Affiliations https://doi.org/10.22541/au.175273953.39111878/v1 150 views 80 downloads Contents Abstract Supplementary Material Information & Authors Metrics & Citations View Options References Figures Tables Media Share Abstract Persistent Pulmonary Hypertension of the Newborn (PPHN) is a life-threatening disorder characterized by pathologically elevated pulmonary vascular resistance and severe hypoxemia, with mortality rates ranging from 5% to 10%. Its pathogenesis involves pulmonary vascular remodeling and abnormal vasoconstriction. This retrospective study analyzed 162 PPHN neonates admitted between July 2017 and October 2024 to identify independent prognostic risk factors. Using LASSO regression for variable selection and multivariate logistic regression modeling, the results demonstrated:Birth asphyxia (OR = 3.73, 95% CI: 1.31–11.45) and invasive mechanical ventilation (OR = 4.41, 95% CI: 1.14–22.54) were independent risk factors for poor prognosis。Right-to-left shunting through a patent ductus arteriosus showed a trend toward poor prognosis (OR = 4.63, 95% CI: 0.53–62.51), but the wide confidence interval necessitates validation with larger cohorts.Low-molecular-weight heparin (LMWH) therapy exhibited a significant negative correlation with adverse outcomes (OR = 0.27, 95% CI: 0.05–1.09), suggesting a protective effect, though limited by small sample size (n = 45).Prolonged hospitalization (OR = 0.19, 95% CI: 0.07–0.43) may reflect treatment complexity and requires adjustment for disease severity.Further analysis highlighted that lung-protective ventilation strategies (low tidal volume, moderate PEEP) improved oxygenation and reduced lung injury risks. This study provides evidence-based insights for early risk stratification and individualized PPHN management. Future multicenter randomized controlled trials are warranted to validate LMWH efficacy and explore biomarker-guided precision therapies. Supplementary Material File (2025-07.docx) Download 170.66 KB Information & Authors Information Version history V1 Version 1 17 July 2025 Copyright This work is licensed under a Non Exclusive No Reuse License. Keywords lasso regression low-molecular-weight heparin lung-protective ventilation persistent pulmonary hypertension of the newborn (pphn) risk factors Authors Affiliations Peng-xiang Chen 0009-0004-6886-6246 First Affiliated Hospital of Shihezi University School of Medicine View all articles by this author Li-yan Song First Affiliated Hospital of Shihezi University School of Medicine View all articles by this author Gu Qiang [email protected] First Affiliated Hospital of Shihezi University School of Medicine View all articles by this author Bo Yuan First Affiliated Hospital of Shihezi University School of Medicine View all articles by this author Yang Yang First Affiliated Hospital of Shihezi University School of Medicine View all articles by this author Metrics & Citations Metrics Article Usage 150 views 80 downloads .FvxKWukQNSOunydq8rnd { width: 100px; } Citations Download citation Peng-xiang Chen, Li-yan Song, Gu Qiang, et al. jabbrv-ltwa-all.ldf jabbrv-ltwa-en.ldf Multivariate Analysis of Prognostic Factors in Persistent Pulmonary Hypertension of the Newborn (PPHN). Authorea . 17 July 2025. DOI: https://doi.org/10.22541/au.175273953.39111878/v1 If you have the appropriate software installed, you can download article citation data to the citation manager of your choice. Simply select your manager software from the list below and click Download. For more information or tips please see 'Downloading to a citation manager' in the Help menu . Format Please select one from the list RIS (ProCite, Reference Manager) EndNote BibTex Medlars RefWorks Direct import Tips for downloading citations document.getElementById('citMgrHelpLink').addEventListener('click', function() { popupHelp(this.href); return false; }); $(".js__slcInclude").on("change", function(e){ if ($(this).val() == 'refworks') $('#direct').prop("checked", false); $('#direct').prop("disabled", ($(this).val() == 'refworks')); }); View Options View options PDF View PDF Figures Tables Media Share Share Share article link Copy Link Copied! Copying failed. 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