Antiviral effect of 1-calcium phosphonate uracil against porcine reproductive and respiratory syndrome virus in vitro

Abstract Background: Porcine reproductive and respiratory syndrome virus (PRRSV) is an RNA virus. Currently, it is treated in various ways, including vaccination with inactivated vaccine, live attenuated vaccine, or subunit vaccine, but the control of PRRSV infection is still inadequate. Therefore, it is necessary to study new drugs against PRRSV infection. In this study, the antiviral effect of 1-calcium phosphonate uracil on PRRSV in vitro was studied. Results: PRRSV was significantly inhibited in SR pretreated cells. In addition, the results showed that SR inhibited the adhesion, entry and genome synthesis of PRRSV, but did not affect the release of PRRSV. Conclusion: Our results suggest that SR may play an antiviral role in PRRSV infection in vitro, which suggests that SR may be a potential new drug for inhibiting PRRSV infection