Mechanism Study on the Treatment of Pelvic Pain in Endometriosis by Qu Yu Jie Du Xiao Zheng Decotion in Combination with Dextroprogesterone

Mengjie Chen, Chen Wang
In: MEDS Basic Medicine · 2023 · vol. 1(2) · doi:10.23977/medbm.2023.010214 · W4390860811
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⚙ AI-generated summary by claude@2026-06, 2026-06-08 ⓘ

The combination of Qu Yu Jie Du Xiao Zheng Decotion and Dydrogesterone significantly relieved pelvic pain in endometriosis patients by regulating serum levels of TNF-α, NGF, and PGE2.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-09 · read from full text ⓘ

This paper studied clinical efficacy and potential mechanisms of Qu Yu Jie Du Xiao Zheng Decotion combined with dydrogesterone for pelvic pain in 60 randomized patients with endometriosis, comparing a Chinese medicine group, a Western medicine group, and a combination group. After treatment, the combination group reported significantly greater pain relief and higher apparent efficacy for menstrual pain, pelvic pressure pain, and palpable nodules than the other groups, alongside significant post-treatment differences in serum TNF-α, NGF, and PGE2 levels across groups. The major limitation stated in the provided text is that outcome measures are summarized without details on blinding, follow-up duration, or adverse events. This paper is centrally about endometriosis — it evaluates and mechanistically links a combined Chinese–Western regimen to changes in inflammatory (TNF-α), neural (NGF), and prostaglandin (PGE2) markers associated with endometriosis-related pelvic pain.

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Abstract

This study aimed to evaluate the clinical efficacy and effect on serum levels of PGE2, NGF and TNF-α of the combination of Qu Yu Jie Du Xiao Zheng Decotion and Dydrogesterone in treating pelvic pain in patients with endometriosis. Sixty patients were randomly divided into three groups: Chinese medicine group, Western medicine group, and combination group. After treatment, the combination group showed significant relief of pain, and the apparent efficacy of menstrual pain, pelvic pressure pain, and palpable nodules was 70%, 83.33%, and 61.54%, respectively, which was significantly higher than that of the other two groups. There were significant differences in serum TNF-α, NGF and PGE2 levels among the three groups after treatment. The conclusion was that the combination of Qu Yu Jie Du Xiao Zheng Decotion and Dydrogesterone could significantly improve the immune function of patients with endometriosis, regulate levels of nerve growth factor, tumor necrosis factor, and prostaglandin E2, thereby relieving pain.
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Keywords

Endometriosis, Qu Yu Jie Du Xiao Zheng Decotion, Deferiprone, Tumor Necrosis Factor, Prostaglandins, Nerve Growth FactorCITE THIS PAPER Chen Wang, Mengjie Chen, Mechanism Study on the Treatment of Pelvic Pain in Endometriosis by Qu Yu Jie Du Xiao Zheng Decotion in Combination with Dextroprogesterone. MEDS Basic Medicine (2023) Vol. 1: 89-96. DOI: http://dx.doi.org/10.23977/medbm.2023.010214.

References

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endometriosis

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