Mechanism Study on the Treatment of Pelvic Pain in Endometriosis by Qu Yu Jie Du Xiao Zheng Decotion in Combination with Dextroprogesterone

This paper studied clinical efficacy and potential mechanisms of Qu Yu Jie Du Xiao Zheng Decotion combined with dydrogesterone for pelvic pain in 60 randomized patients with endometriosis, comparing a Chinese medicine group, a Western medicine group, and a combination group. After treatment, the combination group reported significantly greater pain relief and higher apparent efficacy for menstrual pain, pelvic pressure pain, and palpable nodules than the other groups, alongside significant post-treatment differences in serum TNF-α, NGF, and PGE2 levels across groups. The major limitation stated in the provided text is that outcome measures are summarized without details on blinding, follow-up duration, or adverse events. This paper is centrally about endometriosis — it evaluates and mechanistically links a combined Chinese–Western regimen to changes in inflammatory (TNF-α), neural (NGF), and prostaglandin (PGE2) markers associated with endometriosis-related pelvic pain.

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