Microscopic Uterine Lymphangioleiomyomatosis Perivascular Epithelioid Cell Neoplasm

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Abstract

Lymphangioleiomyomatosis (LAM) is part of a family of lesions collectively known as perivascular epithelioid cell neoplasms (PEComas). Though these lesions are comprised of histologically and immunohistochemically distinctive perivascular epithelioid cells, their diagnosis is controversial and some investigators question their existence entirely. We present a unique case of perhaps the earliest microscopic example of a LAM PEComa in the uterine myometrium, and contrast its features to that of intravascular adenomyosis, intravascular endometrial stromal sarcoma, and intravascular leiomyoma.

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Condition tags

adenomyosis

MeSH descriptors

Lymphangioleiomyomatosis Myometrium Uterine Neoplasms Epithelioid Cells Epithelioid Cells Female Humans Lymphangioleiomyomatosis Middle Aged Myometrium Uterine Neoplasms

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europepmc
last seen: 2026-06-19T06:14:56.452680+00:00
openalex
last seen: 2026-06-04T00:00:01.174412+00:00
pubmed
last seen: 2026-05-13T22:16:54.825375+00:00
License: CC0 · commercial use OK