Simulation of Polymeric Microstructures for Biosensing Applications using COMSOL Multiphysics

Simulation of Polymeric Microstructures for Biosensing Applications using COMSOL Multiphysics | Research Square window.SnipcartSettings = { analytics: { enabled: false } }; (function() { var accessVector = localStorage.getItem('access_vector') || ''; window.dataLayer = window.dataLayer || []; if (accessVector) { window.dataLayer.push({ user: { profile: { profileInfo: { snid: accessVector } } } }); } })(); (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-K279D39R'); Browse Preprints In Review Journals COVID-19 Preprints AJE Video Bytes Research Tools Research Promotion AJE Professional Editing AJE Rubriq About Preprint Platform In Review Editorial Policies Our Team Advisory Board Help Center Sign In Submit a Preprint Cite Share Download PDF Research Article Simulation of Polymeric Microstructures for Biosensing Applications using COMSOL Multiphysics Atul Parida, Abhyarthana Bisoyi, Aruna Tripathy, Satyabhama Dash This is a preprint; it has not been peer reviewed by a journal. https://doi.org/ 10.21203/rs.3.rs-7715766/v1 This work is licensed under a CC BY 4.0 License Status: Posted Version 1 posted You are reading this latest preprint version Abstract Applications in the field of biomedical engineering have been made possible by the rapid advancement of MEMS (micro-electronic-mechanical) systems. The field of biosensing application has benefited greatly from the quick development of polymeric micro cantilever technology. In this study, polycrystalline silicon, and polydimethylsiloxane (PDMS) is used as substrate elements for the biosensor. The polymer has been proposed for numerous uses, including sensing, due to its intriguing characteristics. When compared to other sensors, PDMS offers highly amazing sensing capabilities. A biosensor is a tool that detects the build-up of biological species, such as biomolecules or even biological compositions. It primarily consists of three categories: a signal-generating component that fundamentally identifies the biological species, a signal transducer, and a reading device. To determine the minimal force needed for a divergence of and to demonstrate the application of polymeric micro-cantilevers for the accurate early detection of diseases like HIV (Human Immunodeficiency Virus) and TB (Tuberculosis). This paper presents simulation results of cantilevers made of polymeric materials and compares them to cantilevers made of standard polysilicon. Polymeric micro cantilever simulations for biosensor applications were carried out using the Multiphysics simulation program COMSOL 5.3. As a final thought, we can presume that affordable, biocompatible, and straightforward-to-produce sensors are absent from the health care system today. It is synthesized on a single-use, cost-effective basis using micro-cantilevers and micro-beams. PDMS is an elastomer that is frequently used to create medical microstructures based on specifications. For the application, having Young's modulus of under 750 kPa is highly desirable and 160 GPa for Polycrystalline Silicon. The paper focuses on creating and simulating PDMS cantilever structures of devices that have already been made in the lab, as well as assessing the specific divergence that will be used to determine the precise mass that should be placed on the edge of these micro-structures. To improve the device's sensitivity, a modification to the microcantilever beam's design is unavoidable. The project contains a study of the sensitivity of the microcantilever biosensor to improve the deflection of the microcantilever beam by considering several parameters including the length of the beam, the thickness of the beam, and some shape modifications of the microcantilever beam. The microcantilever beam's length or thickness can be changed to increase or decrease the deflection. The deflection values for two microcantilever beam forms with identical length, thickness, and materials are noted, and it is inferred that shape alteration will increase the microcantilever beam's deflection. MEMS PDMS Biosensing Applications Microcantilever COMSOL Biomedical Engineering Full Text Additional Declarations No competing interests reported. Cite Share Download PDF Status: Posted Version 1 posted You are reading this latest preprint version Research Square lets you share your work early, gain feedback from the community, and start making changes to your manuscript prior to peer review in a journal. As a division of Research Square Company, we’re committed to making research communication faster, fairer, and more useful. We do this by developing innovative software and high quality services for the global research community. Our growing team is made up of researchers and industry professionals working together to solve the most critical problems facing scientific publishing. Also discoverable on Platform About Our Team In Review Editorial Policies Advisory Board Help Center Resources Author Services Accessibility API Access RSS feed Manage Cookie Preferences © Research Square 2026 | ISSN 2693-5015 (online) Privacy Policy Terms of Service Do Not Sell My Personal Information {"props":{"pageProps":{"initialData":{"identity":"rs-7715766","acceptedTermsAndConditions":true,"allowDirectSubmit":true,"archivedVersions":[],"articleType":"Research Article","associatedPublications":[],"authors":[{"id":531759797,"identity":"06506a5f-b9a5-49b7-8618-74de0d63da42","order_by":0,"name":"Atul Parida","email":"","orcid":"","institution":"Alumni of Odisha University of Technology and Research (OUTR)","correspondingAuthor":false,"prefix":"","firstName":"Atul","middleName":"","lastName":"Parida","suffix":""},{"id":531759798,"identity":"d81e2d7f-c072-4a1d-bf0b-719d3d7f9a0f","order_by":1,"name":"Abhyarthana 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This paper presents simulation results of cantilevers made of polymeric materials and compares them to cantilevers made of standard polysilicon. Polymeric micro cantilever simulations for biosensor applications were carried out using the Multiphysics simulation program COMSOL 5.3. As a final thought, we can presume that affordable, biocompatible, and straightforward-to-produce sensors are absent from the health care system today. It is synthesized on a single-use, cost-effective basis using micro-cantilevers and micro-beams. PDMS is an elastomer that is frequently used to create medical microstructures based on specifications. For the application, having Young's modulus of under 750 kPa is highly desirable and 160 GPa for Polycrystalline Silicon. 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