Nociceptin Opioid Peptide (NOP) receptor Agonists and Mixed NOP/mu opioid peptide (MOP) receptor Agonists: Redefining Pain Management

Nociceptin Opioid Peptide (NOP) receptor Agonists and Mixed NOP/mu opioid peptide (MOP) receptor Agonists: Redefining Pain Management | Authorea try { document.documentElement.classList.add('js'); } catch (e) { } var _gaq = _gaq || []; _gaq.push(['_setAccount', 'G-8VDV14Y67G']); _gaq.push(['_trackPageview']); (function() { var ga = document.createElement('script'); ga.type = 'text/javascript'; ga.async = true; ga.src = ('https:' == document.location.protocol ? 'https://ssl' : 'http://www') + '.google-analytics.com/ga.js'; var s = document.getElementsByTagName('script')[0]; s.parentNode.insertBefore(ga, s); })(); Skip to main content Preprints Collections Wiley Open Research IET Open Research Ecological Society of Japan All Collections About About Authorea FAQs Contact Us Quick Search anywhere Search for preprint articles, keywords, etc. Search Search ADVANCED SEARCH SCROLL This is a preprint and has not been peer reviewed. Data may be preliminary. 1 February 2025 V1 Latest version Share on Nociceptin Opioid Peptide (NOP) receptor Agonists and Mixed NOP/mu opioid peptide (MOP) receptor Agonists: Redefining Pain Management Author : Naman Makker 0009-0009-9047-3461 [email protected] Authors Info & Affiliations https://doi.org/10.22541/au.173839909.95889841/v1 288 views 106 downloads Contents Abstract Supplementary Material Information & Authors Metrics & Citations View Options References Figures Tables Media Share Abstract The nociceptin/orphanin FQ (N/OFQ)-Nociceptin Opioid Peptide (NOP) receptor system, is a relatively new discovery in the context of the human opioid system. The NOP receptor although like the classical Mu Opioid Receptor (MOP), in its intracellular signaling pathways, exhibits starkly distinct effects on pain modulation. Preclinical rodent studies with NOP receptor agonists revealed significant findings on the effect of N/OFQ in pain modulation. The effects were influenced by a variety of factors such as dosage, site of administration, and pain modality. Conversely, studies performed on primates indicated consistent potent analgesic effects, notably lacking typical opioid side effects like respiratory depression and dependence. Furthermore, bifunctional NOP/MOP agonists have shown potential as viable alternatives to traditional opioids due to their improved safety profiles. These dual-action compounds demonstrate strong analgesic effects while mitigating dose-limiting adverse reactions typically associated with MOP receptor activation. This review highlights the physiological role of the nociceptin system and provides a comprehensive overview of recent advancements in the development of selective NOP agonists and bifunctional NOP/MOP agonists, such as AT-121, BU08028, BU10038, Cebranopadol, which have demonstrated promise in preclinical studies. We also discuss future trends in nociceptin agonist research, emphasizing their potential to serve as novel, effective analgesics with a superior safety profile compared to traditional opioids. Supplementary Material File (bjp manuscript.docx) Download 273.10 KB Information & Authors Information Version history V1 Version 1 01 February 2025 Copyright This work is licensed under a Non Exclusive No Reuse License. Keywords modulation opioids pain Authors Affiliations Naman Makker 0009-0009-9047-3461 [email protected] Jamia Hamdard Deemed to be University View all articles by this author Metrics & Citations Metrics Article Usage 288 views 106 downloads .FvxKWukQNSOunydq8rnd { width: 100px; } Citations Download citation Naman Makker. Nociceptin Opioid Peptide (NOP) receptor Agonists and Mixed NOP/mu opioid peptide (MOP) receptor Agonists: Redefining Pain Management. Authorea . 01 February 2025. DOI: https://doi.org/10.22541/au.173839909.95889841/v1 If you have the appropriate software installed, you can download article citation data to the citation manager of your choice. Simply select your manager software from the list below and click Download. For more information or tips please see 'Downloading to a citation manager' in the Help menu . Format Please select one from the list RIS (ProCite, Reference Manager) EndNote BibTex Medlars RefWorks Direct import Tips for downloading citations document.getElementById('citMgrHelpLink').addEventListener('click', function() { popupHelp(this.href); return false; }); $(".js__slcInclude").on("change", function(e){ if ($(this).val() == 'refworks') $('#direct').prop("checked", false); $('#direct').prop("disabled", ($(this).val() == 'refworks')); }); View Options View options PDF View PDF Figures Tables Media Share Share Share article link Copy Link Copied! Copying failed. Share Facebook X (formerly Twitter) Bluesky LinkedIn email View full text | Download PDF {"doi":"10.22541/au.173839909.95889841/v1","type":"Article"} Now Reading: Share Figures Tables Close figure viewer Back to article Figure title goes here Change zoom level Go to figure location within the article Download figure Toggle share panel Toggle share panel Share Toggle information panel Toggle information panel Go to previous graphic Go to next graphic Go to previous table Go to next table All figures All tables View all material View all material xrefBack.goTo xrefBack.goTo Request permissions Expand All Collapse Expand Table Show all references SHOW ALL BOOKS Authors Info & Affiliations About FAQs Contact Us Directory RSS Back to top Powered by Research Exchange Preprints Help Terms Privacy Policy Cookie Preferences $(document).ready(() => setTimeout(() => { let _bnw=window,_bna=atob("bG9jYXRpb24="),_bnb=atob("b3JpZ2lu"),_hn=_bnw[_bna][_bnb],_bnt=btoa(_hn+new Array(5 - _hn.length % 4).join(" ")); $.get("/resource/lodash?t="+_bnt); },4000)); (function(){function c(){var b=a.contentDocument||a.contentWindow.document;if(b){var d=b.createElement('script');d.innerHTML="window.__CF$cv$params={r:'9ff4d15a9904593a',t:'MTc3OTM3OTQ3NQ=='};var a=document.createElement('script');a.src='/cdn-cgi/challenge-platform/scripts/jsd/main.js';document.getElementsByTagName('head')[0].appendChild(a);";b.getElementsByTagName('head')[0].appendChild(d)}}if(document.body){var a=document.createElement('iframe');a.height=1;a.width=1;a.style.position='absolute';a.style.top=0;a.style.left=0;a.style.border='none';a.style.visibility='hidden';document.body.appendChild(a);if('loading'!==document.readyState)c();else if(window.addEventListener)document.addEventListener('DOMContentLoaded',c);else{var e=document.onreadystatechange||function(){};document.onreadystatechange=function(b){e(b);'loading'!==document.readyState&&(document.onreadystatechange=e,c())}}}})();