Soluble Intercellular Adhesion Molecule 1 in Serum and Peritoneal Fluid on Patients with Endometriosis

Objective: To investigate the levels of soluble intracellular adhesion molecule-1(sICAM-1) in serum and peritoneal fluid(PF) of patients with or without endometriosis(EMs),and to discuss the clinic significance of serum sICAM-1 in pelvic endometriosis.Methods: Levels of sICAM-1 were detected by an enzyme-linked immunoassay(ELISA),and were compared between EMs and controls in serum and in PF.Results: ① Significantly higher sICAM-1 levels in serum and PF were observed in patients with EMs than those in controls(P(0.05);)② Levels of sICAM-1 in serum and PF were significant differences between different stages of EMs,and in the early stage was higher than in the advanced stage(P0.05);③ there was a correlation between levels of sICAM-1 in serum and PF(r=0.662,P0.05);④ the sensitivity and specificity of serum sICAM-1 in detecting peritoneal endometriosis were 0.6 and 0.867,respectively.Conclusion: The sICAM-1 may participate in the inflammatory process in endometriosis.Serum concentrations of sICAM-1 seem to be the effective indicator for the diagnosis of endometriosis.