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Analysis of endometrial and peritoneal tissues from 114 women revealed that ectopic lesions exhibit elevated MMP-9, MMP-28, ADAM-10, and ADAM-17 expression alongside reduced TIMP-1, indicating these factors contribute to endometriosis invasion.
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by qwen3.7-flash, 2026-09-17
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This study investigated the expression of invasion-related factors, including MMP-9, MMP-28, TIMP-1, ADAM-10, and ADAM-17, in tissue samples from 114 premenopausal women undergoing laparoscopic surgery for suspected endometriosis. Researchers analyzed mRNA levels in eutopic endometrium, ectopic lesions, and peritoneal tissues using quantitative real-time PCR to compare patients with the condition against controls. The results demonstrated significantly elevated expression of MMP-9, MMP-28, ADAM-10, and ADAM-17 in ectopic endometrial tissue compared to control eutopic endometrium, while TIMP-1 was notably decreased in paired ectopic cases relative to the patient's own eutopic endometrium. These findings indicate that an imbalance in these metalloproteinases and their inhibitors contributes to the invasive nature of the disease and suggests that the eutopic endometrium in affected patients is inherently more prone to peritoneal implantation. This paper is centrally about endometriosis — specifically the molecular mechanisms of lesion invasion and the role of MMP-TIMP imbalances in disease progression.
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Endometriose und die Expression von Invasionsfaktoren im Endometrium und im Peritoneum Hintergrund: Endometriose ist eine östrogen-abhängige Entzündungserkrankung, die bis zu 10% der gebärfähigen Frauen betreffen kann. Verschiedene Invasionsfaktoren einschließlich Matrix Metalloproteinasen (MMPs) und ADAMs (A Disintegrin and Metalloproteinase) führen zu einem frühen Defekt in der physiologischen Aktivität des Endometriums und die darauffolgende Wucherung aus der Gebärmutterhöhle. Sogenannte Gewebeinhibitoren von Metalloproteinasen (TIMPs) sind die funktionellen Inhibitoren von MMPs und dadurch kann ein MMP-TIMP Ungleichgewicht zur Entwicklung ektoper Läsionen beitragen. In dieser Studie wurden insgesamt 114 prämenopausale Frauen mit oder ohne Unfruchtbarkeit, die sich einer laparoskopischen Chirurgie auf Verdacht einer Endometriose unterzogen haben, einbezogen. Methoden: MMP-9, MMP-28, TIMP-1, ADAM-10 und ADAM-17 mRNA Expressionen von 53 Endometriose-freien Patienten und 61 Endometriose Patienten wurden mittels Real-Time quantitative PCR (qRT-PCR) analysiert. Insgesamt wurden 151 frische endometriale Gewebsproben, die 62 ektope beinhalten und 54 peritoneale Gewebsproben untersucht. Ergebnisse: Im Vergleich zum eutopen Endometrium waren die Expressionswerte von MMP-9, MMP-28, ADAM-10 und ADAM-17 im ektopen Endometrium signifikant erhöht. In gepaarten Fällen war die TIMP-1 Expression im ektopen Endometrium signifikant niedriger als im eutopen Endometrium. Schlussfolgerung: Diese Resultate lassen darauf schließen, dass MMP-9, MMP-28, TIMP-1, ADAM-10 und ADAM-17 an der invasiven Erkrankung der Endometriose beteiligt sind. Des Weiteren zeigen die Ergebnisse, dass jenes eutope Endometrium von Endometriose-Patienten anfälliger für peritoneale Implantationen zu sein scheint als das von Kontrollpatienten. Schlüssel Wörter: Endometriose, endometriale Invasionsfaktoren, Peritoneum, MMP-9, MMP-28, TIMP-1, ADAM-10, ADAM-17
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Endometriosis and the Expression of Invasion Factors both in the Endometrium and the Peritoneum Background: Endometriosis is a common oestrogen-dependent inflammatory disease which affects up to 10% of women during their reproductive years. Different invasion factors including Matrix Metalloproteinases (MMPs) and ADAMs (A Disintegrin and Metalloproteinase) lead to an early defect in the physiological activity of the endometrium, which result in its overgrowth outside the uterine cavity. Tissue inhibitors of metalloproteinases (TIMPs) are the functional inhibitors of MMPs and therefore MMP-TIMP imbalance may contribute to the development of ectopic lesions. A total of 114 premenopausal women were recruited in this study who underwent laparoscopic surgery due to the suspicion of endometriosis with or without infertility. Methods: MMP-9, MMP-28, TIMP-1, ADAM-10 and ADAM-17 mRNA expressions were analyzed from 53 controls and 61 patients with endometriosis by quantitative Real-Time PCR (qRT-PCR). Results: Significant higher MMP-9, MMP-28, ADAM-10 and ADAM-17 expressions were observed in the ectopic endometrium compared to the eutopic endometrium of controls and women with endometriosis. In paired cases TIMP-1 expression was significantly decreased in ectopic lesions compared to the eutopic endometrium of patients. Conclusion: These findings suggest that MMP-9, MMP-28, ADAM-10 and ADAM-17 contribute to invasive disease of endometriosis. Furthermore results show that the eutopic endometrium from endometriosis patients appears to be more invasive and prone to peritoneal implantation than that from women without the disease. Key Words: endometriosis, endometriotic invasion factors, peritoneum, MMP-9, MMP-28, TIMP-1, ADAM-10, ADAM-17
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