Long-term Prognostic Outcomes of Multifocal Bilateral Wilms Tumor: A Chinese Multicenter Cohort Study

Long-term Prognostic Outcomes of Multifocal Bilateral Wilms Tumor: A Chinese Multicenter Cohort Study | Authorea try { document.documentElement.classList.add('js'); } catch (e) { } var _gaq = _gaq || []; _gaq.push(['_setAccount', 'G-8VDV14Y67G']); _gaq.push(['_trackPageview']); (function() { var ga = document.createElement('script'); ga.type = 'text/javascript'; ga.async = true; ga.src = ('https:' == document.location.protocol ? 'https://ssl' : 'http://www') + '.google-analytics.com/ga.js'; var s = document.getElementsByTagName('script')[0]; s.parentNode.insertBefore(ga, s); })(); Skip to main content Preprints Collections Wiley Open Research IET Open Research Ecological Society of Japan All Collections About About Authorea FAQs Contact Us Quick Search anywhere Search for preprint articles, keywords, etc. Search Search ADVANCED SEARCH SCROLL This is a preprint and has not been peer reviewed. Data may be preliminary. 28 July 2025 V1 Latest version Share on Long-term Prognostic Outcomes of Multifocal Bilateral Wilms Tumor: A Chinese Multicenter Cohort Study Authors : Jinghao Yan , Xiaofeng Chang , kuiran dong , Hong Qin , Wei Yang 0000-0002-4709-0555 , Jinhu Wang , Min Xu , … Show All … , Yizhuo Zhang 0000-0002-6128-3476 , Jianguo Zhang , Yeming Wu , Qiang Zhao 0000-0003-4847-7054 , Jing Wang , Yan Su , Ju Gao , Deguang Meng , Jun-Cheng Liu , Hongcheng Song 0000-0001-6686-8505 , and Huanmin Wang 0000-0001-6769-9643 [email protected] Show Fewer Authors Info & Affiliations https://doi.org/10.22541/au.175370407.74961549/v1 191 views 150 downloads Contents Abstract Supplementary Material Information & Authors Metrics & Citations View Options References Figures Tables Media Share Abstract This study aims to follow up on the long-term prognosis of patients with synchronous multifocal bilateral Wilms tumor (mBWT) and to explore the relationship between late complications, especially long-term renal impairment and previous treatments. We conducted a systematic follow-up of children with mBWT from a previous retrospective study. The imaging criteria for diagnosing mBWT is the presence of more than two nodules with a diameter of >1cm in one or both kidneys. During the follow-up period, we paid particular attention to whether the patients developed end-stage renal disease (ESRD). A total of 56 patients with mBWT were included in this study. Ten patients (17.8%) underwent one-step bilateral surgery. Twelve children underwent total nephrectomy plus nephron-sparing surgery (TN + NSS), and 44 children underwent bilateral nephron-sparing surgery (NSS). After a median follow-up of 6 years (range 0-15 years), the 5-year OS and EFS rates were 86.8% and 77.1%, respectively. The patients who underwent TN + NSS and those who underwent bilateral NSS showed no statistically significant differences in EFS and OS. During the follow-up, 17 patients experienced impaired renal function or a progressive deterioration. The multivariate analysis results showed that one-stage bilateral surgery was an important factor for long-term renal impairment. In patients with mBWT, NSS was appropriate after 6 weeks of neoadjuvant chemotherapy (NAC). One-step bilateral NSS was a risk factor for long-term renal function impairment in patients with mBWT. Supplementary Material File (maucriput1.doc) Download 306.32 KB File (table 1.doc) Download 190.12 KB File (table2.docx) Download 15.77 KB Information & Authors Information Version history V1 Version 1 28 July 2025 Copyright This work is licensed under a Non Exclusive No Reuse License. Keywords outcomes research renal tumors wilms tumor Authors Affiliations Jinghao Yan Beijing Children’s Hospital Capital Medical University National Center for Children’s Health View all articles by this author Xiaofeng Chang Beijing Children’s Hospital Capital Medical University National Center for Children’s Health View all articles by this author kuiran dong Children’s Hospital of Fudan University National Center for Children’s Health View all articles by this author Hong Qin Beijing Children’s Hospital Capital Medical University National Center for Children’s Health View all articles by this author Wei Yang 0000-0002-4709-0555 Beijing Children’s Hospital Capital Medical University National Center for Children’s Health View all articles by this author Jinhu Wang Children’s Hospital Zhejiang University School of Medicine View all articles by this author Min Xu Shanghai Children’s Medical Center Shanghai Jiao Tong University School of Medicine National Center for Children’s Health View all articles by this author Yizhuo Zhang 0000-0002-6128-3476 Sun Yat-sen University Cancer Center View all articles by this author Jianguo Zhang Inner Mongolia Maternal and Child Health Care Hospital View all articles by this author Yeming Wu Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Medicine View all articles by this author Qiang Zhao 0000-0003-4847-7054 Tianjin Medical University Cancer Institute and Hospital View all articles by this author Jing Wang Shandong Provincial Hospital View all articles by this author Yan Su Beijing Children’s Hospital Capital Medical University National Center for Children’s Health View all articles by this author Ju Gao West China Second University Hospital Sichuan University View all articles by this author Deguang Meng Baoding Hospital of Beijing Children’s Hospital View all articles by this author Jun-Cheng Liu Affiliated Hospital of Sun Yat-sen University View all articles by this author Hongcheng Song 0000-0001-6686-8505 Beijing Children’s Hospital Capital Medical University National Center for Children’s Health View all articles by this author Huanmin Wang 0000-0001-6769-9643 [email protected] Beijing Children’s Hospital Capital Medical University National Center for Children’s Health View all articles by this author Metrics & Citations Metrics Article Usage 191 views 150 downloads .FvxKWukQNSOunydq8rnd { width: 100px; } Citations Download citation Jinghao Yan, Xiaofeng Chang, kuiran dong, et al. Long-term Prognostic Outcomes of Multifocal Bilateral Wilms Tumor: A Chinese Multicenter Cohort Study. Authorea . 28 July 2025. DOI: https://doi.org/10.22541/au.175370407.74961549/v1 If you have the appropriate software installed, you can download article citation data to the citation manager of your choice. Simply select your manager software from the list below and click Download. For more information or tips please see 'Downloading to a citation manager' in the Help menu . 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