К вопросу о патогенезе наружного генитального эндометриоза

External genital endometriosis (EGE) is characterized by good-quality growth of a fabric, on morphological and functional properties similar with the endometrium. It concerns one of extended gynecologic diseases of reproductive age of 7-15 %, at infertility frequency makes it from 25 to 40 %, at chronic pelvic pains of 40-70 %. The special role in development of EGE belongs to the processes occurring in peritoneal fluid which is characterized by the high contents of cytokines and the growth factors, in particular a transforming factor growth beta (TGF-β). TGF-β shows different biological properties and plays a key role in migration, proliferation and differentiation of cells. Melatonin (MT) -is the pineal gland hormone, for the first time it was found in 1958. MT is a component of antioxidant defense system of an organism, due to its free radical scavenging ability and to its capacity to stimulate several antioxidant enzymes, such as superoxide dismutase (SOD), catalase, etc. From literature it is known that the oxidative stress underlies many molecular and genetic violations, including EGE.