Catalytic photoinduced deoxygenation via B(C6F5)3-enabled OAT for aromatic C−H amination of alkylarenes

Catalytic photoinduced deoxygenation via B(C6F5)3-enabled OAT for aromatic C−H amination of alkylarenes | Research Square window.SnipcartSettings = { analytics: { enabled: false } }; (function() { var accessVector = localStorage.getItem('access_vector') || ''; window.dataLayer = window.dataLayer || []; if (accessVector) { window.dataLayer.push({ user: { profile: { profileInfo: { snid: accessVector } } } }); } })(); (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-K279D39R'); Browse Preprints In Review Journals COVID-19 Preprints AJE Video Bytes Research Tools Research Promotion AJE Professional Editing AJE Rubriq About Preprint Platform In Review Editorial Policies Our Team Advisory Board Help Center Sign In Submit a Preprint Cite Share Download PDF Article Catalytic photoinduced deoxygenation via B(C 6 F 5 ) 3 -enabled OAT for aromatic C−H amination of alkylarenes Yongmin Ma This is a preprint; it has not been peer reviewed by a journal. https://doi.org/ 10.21203/rs.3.rs-6311401/v1 This work is licensed under a CC BY 4.0 License Status: Published Journal Publication published 27 Nov, 2025 Read the published version in Nature Communications → Version 1 posted You are reading this latest preprint version Abstract The catalytic deoxygenation of N − OH bonds to generate N-centered radicals remains a significant challenge due to the high bond dissociation energy and reliance on stoichiometric auxiliaries or activators. Herein, we report a B(C 6 F 5 ) 3 -catalyzed photoinduced deoxygenation strategy that enables direct aromatic C(sp²) − H amination of alkylarenes using N -hydroxyphthalimides (NHPIs) as nitrogen sources. Mechanistic studies reveal that the in situ formation of a PhthN − O−B(C 6 F 5 ) 3 anion intermediate facilitates an unusual energy transfer (EnT)-mediated N − O bond homolysis, generating a phthalimidyl radical (PhthN•) while regenerating the borane catalyst. This method overrides the conventional preference for benzylic C − H oxidation, achieving exclusive aromatic C − H amination with broad substrate scope, including electron-rich/poor alkylarenes, heteroarenes, and biomolecules. The catalytic protocol operates under mild conditions, avoids stoichiometric organic auxiliaries/activators, and produces H₂O as the sole byproduct, thus, making it a promising option to supplant existing strategies for arene amination. Applications in late-stage functionalization of pharmaceuticals and the synthesis of a nilotinib precursor highlight its synthetic utility. This study establishes B(C 6 F 5 ) 3 as a versatile catalytic oxygen atom transfer (OAT) reagent in photochemistry, opening avenues for sustainable radical generation. Physical sciences/Chemistry/Photochemistry/Photocatalysis Physical sciences/Chemistry/Organic chemistry/Synthetic chemistry methodology Figures Figure 1 Figure 2 Figure 3 Figure 4 Figure 5 Figure 6 Figure 7 Introduction Over the past decade, photoinduced deoxygenation has been recognized as a powerful and efficient approach for accessing highly reactive radicals, particularly N-centered radicals, owing to its atom economy and the accessibility of starting materials. However, the high bond dissociation energy of N − OH bonds frequently necessitates the pre -functionalization of hydroxyl groups into activating groups (AGs) using stoichiometric auxiliaries such as trifluoroacetyl 1 , dinitrophenylsulfonyloxy 2 , 2,4-dinitrophenoxy 3,4 , and isopropionic acid group 5,6 (Fig. 1 a). These additional steps increase procedural complexity, requiring multiple operations and purification stages. To address these challenges, significant efforts have been directed toward in situ -activation strategy. A key breakthrough in this field was reported by Schmidt, who developed a triethylphosphite-promoted oxygen atom transfer (OAT) strategy for generating amidyl radicals and achieved an intermolecular anti -Markovnikov hydroamination of alkenes 7 . Since this pioneering work, several extensions of the phosphine-mediated deoxygenative methodology have been explored 8–12 . Despite these advancements, current methodologies typically rely on stoichiometric amounts of auxiliaries or activators and inevitably generate organic wastes. Consequently, developing a catalytic photoinduced deoxygenation strategy to circumvent these inherent limitations for N radical generation remains an unresolved challenge. Borane Lewis acids, such as B(C 6 F 5 ) 3 , have emerged as versatile and powerful reagents, exhibiting unusual transition-metal-like behaviors beyond classical Lewis acid reactivity 13–15 . The pioneering studies by the groups of Stephan, Santini, Ogoshi, and Oestreich et al. have revealed the exceptional capability of boranes to mediate thermally induced catalytic atom/group transfer of H 16–19 , F 20,21 , and CN 22–24 via heterolysis pathways under harsh conditions (typically requiring elevated temperatures), generating closed-shell nucleophilic cation intermediates (Fig. 1 b, left). Building on the strong B(C 6 F 5 ) 3 -oxygen coordination 25–27 , we hypothesized that B(C 6 F 5 ) 3 could enable a photoinduced catalytic OAT process, generating open-shell radical intermediates through a homolytic pathway under mild conditions. As illustrated in Fig. 1 b (right), we propose that B(C 6 F 5 ) 3 binds to the oxygen atom of N − OH and abstracts the oxygen via photoinduced energy transfer, thereby generating N radicals that undergo addition to inert π-systems (e.g. arenes). The resulting rare O − B(C 6 F 5 ) 3 radical anion undergoes single-electron reduction and diprotonation to donate oxygen, ultimately releasing H 2 O and regenerating B(C 6 F 5 ) 3 . To test our hypothesis and evaluate the performance of this proposed deoxygenation strategy, we selected commercially available N -hydroxyphthalimide (NHPI) as the N − OH substrate 28–30 . NHPI is known to undergo both favored dehydrogenation 31–33 and disfavored deoxygenation processes 1,7,14,34,35 . Methylarene, which contains dual matched reactive sites—an active benzylic C − H (bond dissociation energy ~ 90 kcal/mol) 36 and an inert aromatic C − H (bond dissociation energy ~ 110 kcal/mol) 36 —was chosen as the ideal radical receptor. Under conventional conditions, the PhthNO − H bond in NHPI preferentially fragments through photocatalytic 37 or electrocatalytic activation 38–40 , generating a phthalimide- N -oxyl (PINO) radical. This radical smoothly reacts with methylarene at the benzylic C − H site, yielding the PINOylation product, as reported by the Stahl group 41 . In contrast, we envisioned that a tailored deoxygenative strategy could shift the selectivity toward fragmentation of the less favored PhthN − OH bond, enabling NHPI to serve as a precursor for nitrogen-centered radical. The resulting PhthN radical could then intercept methylarene, selectively aminating the aromatic C − H site. This "inverted selectivity" approach would deliver valuable arylamines 42,43 , which are traditionally synthesized through nitration/reduction 44 or transition-metal catalysis 45–48 . Our motivation for this work is three-fold: (1) to develop a challenging catalytic photoinduced deoxygenation approach that eliminates the need for stoichiometric auxiliaries/activators while circumventing the generation of organic wastes; (2) to expand the capability of B(C 6 F 5 ) 3 for catalytic OAT in photocatalysis; and (3) to achieve the previously challenging inverted selectivity in the reaction of alkylarenes with NHPIs, enabling access to valuable arylamines. In this study, building on our ongoing interest in photoinduced deoxygenation 49,50 , we disclose an unprecedented catalytic strategy for the photoinduced deoxygenation of NHPIs through B(C 6 F 5 ) 3 -enabled OAT process. This strategy has been applied to achieve aromatic C − H amination of alkylarenes (Fig. 1 c). The developed method exhibits high atom and step economy, inverted selectivity for alkylarenes, broad substrate applicability—including late-stage functionalization—and paves the way for efficient and sustainable access to valuable arylamines. Results Optimization of reaction conditions We began our investigation by exploring the catalytic deoxygenation of commercially available NHPI ( 1 ) with toluene ( 2 ) as the reaction partner. Encouragingly, the proposed process proved feasible. Following systematic optimization of reaction parameters (Table S1 ; see Supporting Information for details), we identified the optimal conditions: a combination of B(C 6 F 5 ) 3 (20 mol%), [Ir(dFCF 3 ppy) 2 dtbbpy]PF 6 (2 mol%), and NaHCO 3 (20 mol%) in CHCl 3 (0.02 M), irradiated with blue LEDs at 15°C under an argon atmosphere, yielded 3 in 68% yield with complete selectivity for C(sp 2 ) − H amination over benzylic C − H PINOylation (Table 1 , entry 1). However, 17% of the byproduct phthalimide ( 3′′ ) was also formed, likely resulting from hydrogen abstraction by the PhthN radical from toluene ( 2 ) or CHCl 3 . The site selectivity of the reaction showed a notable dependence on boron acidity. Replacing B(C 6 F 5 ) 3 with weaker Lewis acids, such as B(3,4,5-F 3 C 6 H 2 ) 3 or BPh 3 , significantly decreased deoxygenation efficiency, favoring the PINOylation product 3′ as the major product (entries 2 and 3). Reaction temperature also influenced the formation of product 3 . Higher reaction temperature led to an increased yield of 3′′ (entry 4), whereas lowering the temperature reduced its formation but also severely limited the conversion of 1 , likely due to the poor solubility of 1 at lower temperatures (entry 5). Similarly, reducing the solvent volume caused decreased reaction efficiency due to solubility issues (entry 6). Attempts to improve yield of 3 by testing different solvents were unsuccessful (entries 7 and 8). Control experiments highlighted the critical role of B(C 6 F 5 ) 3 . In its absence, the deoxygenation of 1 did not occur; instead, background PINOylation of 2 proceeded smoothly, yielding 73% of 3′ as the sole product (entry 9). The use of NaHCO 3 as a base was essential for enhancing conversion, likely by deprotonating 1 ; without it, the conversion was significantly reduced (entry 10). Moreover, no product was detected without the photocatalyst or light, underscoring their necessity for this transformation (entry 11). Mechanistic studies To gain deeper insights into the B(C 6 F 5 ) 3 -enabled deoxygenation process, we conducted a series of mechanistic studies. Treating NHPI ( 1 ) with an equivalent amount of B(C 6 F 5 ) 3 resulted in the formation of a PhthN − O−B(C 6 F 5 ) 3 adduct ( II ), confirmed by 1 H NMR, 19 F NMR spectroscopies, and HRMS analysis (Figs. 2 a and S2–S4). Upon irradiation of this in situ -generated complex with blue LEDs in the presence of toluene ( 2 ) and photocatalyst, the target product ( 3 ) was obtained in 47% yield. This result suggests that the [N − O−B] adduct ( II ) is likely the key active intermediate for generating the PhthN radical. We hypothesize that the subsequent N − O bond fragmentation occurs via an energy transfer (EnT) process rather than the typical electron transfer mechanism. This hypothesis is supported by evidence from photoquenching experiments, cyclic voltammetry, analysis of alternative energy transfer catalysts, UV light irradiation, and TEMPO-trapping experiments (Figs. 2 b-g; see Supporting Information for details). Stern–Volmer fluorescence quenching experiments demonstrates that only the [N − O−B] adduct ( II ) quenches the excited state of the photocatalyst, as shown in Fig. 2 b. This quenching suggests an interaction between the intermediate and the excited-state photocatalyst, supporting an EnT mechanism where intermediate II is sensitized into its triplet state. Further analysis of the redox potential of II (E ox = + 0.48 V vs . Ag/AgCl, E red = − 0.97 V vs . Ag/AgCl; Fig. 2 c) reveals no correlation between redox potential and reactivity. Instead, the amination reactivity is correlated to the energy of the first triplet excited state of the photocatalyst, as shown in Fig. 2 d for two photocatalysts with lower triplet energy. Upon switching the photocatalyst from [Ir(dFCF 3 ​ppy) 2 ​(dtbbpy)]PF 6 to fac -Ir(ppy) 3 ​, which has a bit lower triplet energy (55.2 kcal/mol) 52 but much lower oxidation potential (E* ox = + 0.31 V vs . SCE) 51 , 47% yield of 3a was obtained. Furthermore, the amination process did not proceed entirely when employing [Ru(bpy) 3 ]Cl 2 with sufficient redox potential (E* ox = + 0.78 V vs . SCE, E* red = – 1.44 V vs . SCE) 51 relative to II but lower triplet energy (46.0 kcal/mol) 52 as the photocatalyst. Density functional theory (DFT) calculations (UB3LYP/6-311 + G(d,p)) show that the first excited triplet state energy of [N − O−B] adduct ( II ) is 56.1 kcal/mol, closely matching the triplet state energy of [Ir(dFCF 3 ​ppy) 2 (dtbbpy)]PF 6 (60.8 kcal/mol), supporting the feasibility of EnT from the excited photocatalyst. Further evidence for this pathway came from direct excitation experiments. Irradiating the reaction mixture with 365 nm LEDs (emission range ~ 350–385 nm) in the absence of the photocatalyst produced the desired product ( 3 ) in 13% yield, confirming an EnT mechanism (Fig. 2 e). UV/Vis spectroscopy reveals that II has absorption overlaps with the emission spectrum of the 365 nm LEDs (e.g. the molar absorptivity (ε) for II at 360 nm is 22.1 M − 1 ·cm − 1 , Fig. 2 f). Lastly, the reaction was suppressed upon the addition of TEMPO. HRMS analysis detected TEMPO-NPhth and TEMPO-OB(C 6 F 5 ) 3 anion adducts (Figs. 2 g, S11 and S12), providing further evidence that the N − O bond undergoes a homolysis process. From the above experiments, a plausible mechanism for the amination of methylarenes enabled by the catalytic deoxygenation strategy is outlined in Fig. 3 a. NHPI undergoes deprotonation in the presence of a base to yield intermediate I , which reacts with B(C 6 F 5 ) 3 to form the PhthN-O-B(C 6 F 5 ) 3 anion II . Simultaneously, the photocatalyst absorbs visible light, transitioning to its triplet excited state, which transfers its triplet energy to anion II via a triplet-to-triplet energy transfer (TTEnT) process. The triplet-excited intermediate II* then undergoes N − O bond homolysis to generate the O − B radical anion III and the PhthN radical IV . The PhthN radical IV rapidly adds to the aromatic carbon atom of methylarene ( 2 ), forming the neutral radical intermediate V . This intermediate is subsequently oxidized by the photoexcited photocatalyst (PC*) via single-electron transfer (SET), producing the cationic Wheland intermediate VI . Deprotonation of VI yields the target arylamine product 3 . In parallel, the O − B radical anion III undergoes single-electron reduction by the reduced photocatalyst (PC •– ), followed by protonation to generate the HO − B(C 6 F 5 ) 3 anion VII . Protonation of VII leads to the formation of the active B(C 6 F 5 ) 3 catalyst and water, thus closing the catalytic OAT cycle. To further validate this mechanistic hypothesis, DFT calculations were performed at the (U)B3LYP-D3-(BJ)/def2-QZVP-SMD//(U)B3LYP-D3-(BJ)/6-31G(d)-SMD level (Fig. 3 b; see Supporting Information for details). The reaction begins with NaHCO 3 -assisted deprotonation of NHPI ( 1 ) to form the PhthN − O anion ( I ), with an energy barrier of 7.8 kcal/mol. The subsequent addition of I to B(C 6 F 5 ) 3 is strongly exoergic (ΔG = − 44.5 kcal/mol), stabilizing the resulting anion PhthN − O−B(C 6 F 5 ) 3 ( II ). Photoinduced TTEnT between the excited photocatalyst and II produces the triplet-excited intermediate II* , which fragments via a transition state ( TS ) with a barrier of 10.8 kcal/mol. This protonated by H 2 CO 3 to yield the HO − B(C 6 F 5 ) 3 anion VII , with a free energy change of − 46.3 kcal/mol. Finally, a strongly exoergic proton transfer (ΔG = − 49.9 kcal/mol) from VI to HO − B(C 6 F 5 ) 3 anion forms the desired product 3 and H 2 O − B(C 6 F 5 ) 3 ( VIII ). The latter releases B(C 6 F 5 ) 3 with a low energy barrier of 8.1 kcal/mol, a thermally feasible process under the reaction conditions (15°C). Substrate scope After establishing the optimal conditions and gaining insight into the mechanism, we explored the scope of alkylarenes in the reaction with NHPIs (Fig. 4 ). Satisfyingly, the site-selectivity of this reaction system was unaffected by the presence of electron-donating or electron-withdrawing groups on the benzene ring. Aromatic C − H amination consistently dominated over benzylic C − H oxidation. Methylarenes with methyl substituents at the ortho - ( 4 and 5 ), meta - ( 6 and 7 ), or para - ( 8 ) position delivered products in comparable yields. Electron-donating methylarenes bearing iso- propyl ( 9 ), tert -butyl ( 10 ), and methoxy ( 11 ) groups were successfully transformed into the corresponding products, while electron-withdrawing methylarenes containing ester ( 12 – 21 ), ketone ( 22 ), trifluoromethyl ( 23 and 24 ), nitrile ( 25 ), and nitro ( 26 ) groups demonstrated broad functional group tolerance, providing ample opportunities for further derivatization. Notably, methylarenes with electron-withdrawing groups at the para -position exclusively yielded ortho -amination products, potentially due to electronic effects. Conversely, methylarenes with methoxycarbonyl and trifluoromethyl groups at the ortho -position preferentially underwent amination at the para -position. Halogenated methylarenes underwent smooth C − N coupling, yielding target products ( 27 – 38 ) in useful yields, irrespective of the presence of additional halides (F, Cl, or Br). Furthermore, this strategy was successfully applied to arenes containing both benzylic C − H and aromatic C − H sites, such as ethylarene ( 39 ), benzylarenes ( 40 ), vinylarenes ( 41 and 42 ), and benzyl alcohols ( 43 – 45 ), and cyclic arenes ( 46 – 49 ) consistently affording C(sp 2 ) − H amination products without PINOylation byproducts. We further extended the applicability of this strategy to arenes to investigate its functional group tolerance (Fig. 5 ). Application of the optimized conditions to benzene yielded the target product ( 50 ) in good yield. A variety of arenes bearing electron-donating functional groups such as ethers ( 51 – 54 ), thioether ( 55 ), and trimethylsilane ( 56 ) coupled with NHPI to generate the desired products in moderate to good yields. Electron-withdrawing arenes with esters ( 57 and 58 ), trifluoromethyl ( 59 ), and sulfone ( 60 ) substituent also underwent the reaction, which further broadened the substrate scope of the strategy. Halogenated arenes were successfully aminated, offering orthogonal reactivity to the well-established Buchwald − Hartwig coupling. Notably, polycyclic arenes ( 67 and 68 ) could be selectively aminated at the α -position. To our delight, heteroarenes such as 2,6-dimethoxypyridine and benzothiazole are well-tolerated to yield desired products ( 69 and 70 ). Having evaluated the scope of arenes, we next examined the scope of NHPIs (Fig. 6 ). Pleasingly, NHPIs containing various functional groups, such as methyl ( 71 and 72 ), methoxy ( 73 ), tert -butyl ( 74 ) and halogens ( 75 – 78 ), were successfully deoxygenated under this catalytic system to yield the corresponding products with 4-methylbenzoate. In addition, N -hydroxy-2,3-naphthalimide and 2,3-pyridinedicarboximide also gave the expected product 79 and 80 , albeit in lower yields. The promising functional group tolerance and synthetic convenience of this photoinduced deoxygenation strategy encouraged us to explore its application in biomolecule modification (Fig. 7 a). Alkylarenes derived from L -menthol ( 81 ), (1 R )-(-)-nopol ( 82 ), borneol ( 83 ), perilla alcohol ( 84 ) HDFDMA, lithography monomer ( 85 ), tetrahydrogeraniol ( 86 ), geraniol ( 87 ), 7-ketocholesterol ( 88 ), 7-keto diosgenin ( 89 ) D -galactopyranose derivative ( 90 ), D–r ibonolactone ( 91 ), and simvastatin ( 92 ) were successfully aminated at the ortho -position, albeit with moderate yields. These results underscore the practicality and robustness of this transformation, suggesting broader applications in drug discovery. To demonstrate the potential utility of this strategy, we applied it to the synthesis of a crucial precursor for nilotinib (Fig. 7 b). Selective ortho -C(sp 2 ) − H amination of 4-methylbenzoate with the inexpensive, commercially available NHPI was performed under optimized conditions. Subsequent in situ hydrazinolysis of the formed N -arylphthalimide yielded methyl 3-amino-4-methylbenzoate ( 93 ), avoiding the harsh reaction conditions typically required by conventional nitration/reduction processes. Discussion In summary, we present a catalytic strategy for photoinduced deoxygenation of NHPIs enabled by B(C 6 F 5 ) 3 , which achieves selective aromatic C(sp²) − H amination of alkylarenes. By leveraging the OAT capability of B(C 6 F 5 ) 3 , this method circumvents the need for stoichiometric auxiliaries/activators, generating only H 2 O as a green byproduct. Mechanistic investigations, supported by experimental and DFT calculations, reveal that the in situ -formed PhthN − O− B(C 6 F 5 ) 3 anion undergoes EnT-mediated N − O bond homolysis to produce a PhthN•, enabling the direct coupling with aromatic C − H bonds. The reaction overrides the traditional preference for benzylic C − H oxidation, delivering exclusive aromatic amination across diverse substrates, including electron-rich and electron-deficient alkylarenes, styrenes, and benzyl alcohols. The utility of this strategy is further demonstrated through late-stage functionalization of biomolecules and the synthesis of a key nilotinib precursor. Importantly, this work expands the catalytic capabilities of boranes, establishing B(C 6 F 5 ) 3 as a versatile OAT reagent in photochemical reactions. This approach offers a sustainable and practical alternative to conventional methods for accessing arylamines, with potential applications in synthetic chemistry and drug discovery. Methods General information The reactions were carried out under an inert atmosphere of argon via standard Schlenk techniquesor in a glovebox. All visible light-induced reactions were conducted in borosilicate glass tubes with Teflon-coated magnetic stirring bars in a circulating cooling device and placed 5 cm from a commercial blue LEDs. The photoreaction instrument was purchased from 3s-technology co., China, model: 021-AM2410-229, 0 ~ 100 W, λ = 460 − 470 nm, URL: https://www.3s-tech.net/products/ilmt.html#am . Reactions were monitored by HPLC, 1 H NMR, and/or by TLC on 254 nm silica gel plates (0.2 mm thickness). Flash column chromatography was performed on silica gel (200–300 mesh). Arenes, N- hydroxyphthalimides, boranes, photocatalyst, bases, and solvents were purchased from Energy Chemical (shanghai, china). NMR spectra data were obtained on Avance (III) HD 400 MHz instruments. 1 H NMR and 13 C NMR spectra were referenced to residual protic solvent peaks or TMS signal (0 ppm). 19 F NMR chemical shifts were externally referenced to CCl 3 F (0 ppm). Data for 1 H NMR are recorded as follows: chemical shift ( δ , ppm), multiplicity (s = singlet, d = doublet, t = triplet, m = multiplet or unresolved, br = broad singlet, coupling constant ( J ) in Hz, integration). Data for 13 C and 19 F NMR are reported in terms of chemical shift ( δ , ppm). Liquid chromatography (LC) analysis was performed on an Agilent 1200 Infinity II LC system. High resolution mass spectrometer analysis (HRMS) was performed on Waters Q-TOF Premier (ESI) mass spectrometers. Melting point (m.p.): melting points were measured on a Beijing Tech Instrument X-4 digital display micro melting point apparatus and are uncorrected. Visible light luminescence intensities were recorded using Shimadzu UV-2600i UV-Vis spectrofluorometer. Cyclic voltammograms were recorded using a CHI 660E potentiostat and a Pt working electrode, a Ag/AgCl reference electrode and a Pt sheet auxiliary electrode. General procedure for amination of arenes To a dry Schlenk tube equipped with a magnetic stir bar was added N- hydroxyphthalimide ( B ) (0.2 mmol, 1 equiv.), B(C 6 F 5 ) 3 (20.4 mg, 0.04 mmol, 20 mol%), [Ir(dF(CF 3 )ppy) 2 dtbbpy]PF 6 (4.4 mg, 0.004 mmol, 2 mol%) and NaHCO 3 (3.4 mg, 0.04 mmol, 20 mol%) and the Schlenk tube was evacuated and backfilled with Ar (three times). After the addition of a solution of CHCl 3 (10 mL, 0.02 M) containing alkylarene ( A ) (1.0 mmol, 5 equiv.) by syringe under Ar, the Schlenk tube was positioned approximately 5 cm away from a 25 W blue LEDs lamp. Then the reaction mixture was stirred at the corresponding temperature for 72 h. After completion, the reaction mixture was concentrated to dryness and the residue was purified by flash column chromatography to afford the products. Synthesis of methyl 3-amino-4-methylbenzoate (93) To a dry Schlenk tube equipped with a magnetic stir bar was added NHPI (32.6 mg, 0.2 mmol, 1 equiv.), B(C 6 F 5 ) 3 (20.4 mg, 0.04 mmol, 20 mol%), [Ir(dF(CF 3 )ppy) 2 dtbbpy]PF 6 (4.4 mg, 0.004 mmol, 2 mol%) and NaHCO 3 (3.4 mg, 0.04 mmol, 20 mol%) and the Schlenk tube was evacuated and backfilled with Ar (three times). After addition of a solution of CHCl 3 (10 mL, 0.02 M) containing 4-methylbenzoate (150.2 mg, 1 mmol, 5 equiv.) by syringe under Ar, the Schlenk tube was positioned approximately 5 cm away from a 25 W blue LEDs lamp. Then the reaction mixture was stirred at the corresponding temperature for 72 h. Subsequently, a solution of ethanol (10 mL) containing hydrazine monohydrate (98%, 0.1 mL, 2 mmol, 10 equiv.) was added to the reaction by syringe. After stirring at room temperature for 6 h, the resulting suspension was filtered through a short pad of silica with diethyl ether. The filtrate was washed with 2 M NaOH aqueous solution, dried over anhydrous magnesium sulfate, filtered and concentrated carefully under reduced pressure to afford the crude mixture which was purified by flash column chromatography (silica gel, hexane/ethyl acetate = 5:1) to furnished methyl 3-amino-4-methylbenzoate ( 93 ) as a white solid (17.5 mg, 53%). Declarations Data availability The authors declare that all data supporting the findings of this study are available in the paper and its Supplementary Information files. Author contributions Z. Pan, Y. Ma & L. Wang conceived and designed the experiments. Z. Pan, H. Qiu & R. Zheng performed the experiments and analyzed the data. Z. Pan & Y. Ma wrote the manuscript. Acknowledgements This research was financially supported by the National Nat-ural Science Foundation of China (22071171), the Natural Science Foundation of Zhejiang Province (LZ22B020003) and the initiation grant from Taizhou University. References Allen LJ, Cabrera PJ, Lee M, Sanford MS (2014) N -Acyloxyphthalimides as nitrogen radical precursors in the visible light photocatalyzed room temperature C – H amination of arenes and heteroarenes. J Am Chem Soc 136:5607–5610 Cecere G, König CM, Alleva JL, MacMillan DW (2013) C. 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Nat Rev Chem 7:653–666 Doraghi F et al (2024) Phthalimides: developments in synthesis and functionalization. RSC Adv 14:22809–22827 Wu Z-X et al (2022) Development of N -hydroxy catalysts for C-H functionalization via hydrogen atom transfer: challenges and opportunities. ACS Catal 12:11716–11733 Gaster E, Kozuch S, Pappo D (2017) Selective aerobic oxidation of methylarenes to benzaldehydes catalyzed by N -hydroxyphthalimide and cobalt(ii) acetate in hexafluoropropan-2-ol. Angew Chem Int Ed 56:5912–5915 Enríquez RG, Dato-Santiago JS, del Río-Rodríguez R, Alemán J, Fernández-Salas JA (2024) Acyl radicals generated from aldehydes with NHPI as electrocatalyst: aldehydes and alcohols as carbon-centered radical precursors. Org Chem Front 11:4842–4848 Parida SK et al (2021) Single electron transfer-induced redox processes involving N -(acyloxy)phthalimides. ACS Catal 11:1640–1683 Tripathi CB et al (2017) Photoredox ketone catalysis for the direct C-H imidation and acyloxylation of arenes. 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Supplementary Files ESI.pdf Electronic Supporting Information Cite Share Download PDF Status: Published Journal Publication published 27 Nov, 2025 Read the published version in Nature Communications → Version 1 posted You are reading this latest preprint version Research Square lets you share your work early, gain feedback from the community, and start making changes to your manuscript prior to peer review in a journal. As a division of Research Square Company, we’re committed to making research communication faster, fairer, and more useful. We do this by developing innovative software and high quality services for the global research community. Our growing team is made up of researchers and industry professionals working together to solve the most critical problems facing scientific publishing. Also discoverable on Platform About Our Team In Review Editorial Policies Advisory Board Help Center Resources Author Services Accessibility API Access RSS feed Manage Cookie Preferences © Research Square 2026 | ISSN 2693-5015 (online) Privacy Policy Terms of Service Do Not Sell My Personal Information {"props":{"pageProps":{"initialData":{"identity":"rs-6311401","acceptedTermsAndConditions":true,"allowDirectSubmit":false,"archivedVersions":[],"articleType":"Article","associatedPublications":[],"authors":[{"id":438306266,"identity":"03289772-dc3b-4dce-ae74-3deb9a02b128","order_by":0,"name":"Yongmin Ma","email":"data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAZAAAAAyAQMAAABI0h/eAAAABlBMVEX///8AAABVwtN+AAAACXBIWXMAAA7EAAAOxAGVKw4bAAAA4UlEQVRIiWNgGAWjYNACAxDBfADCOUC8FrbEBhK0gAGPIXFaDI73Hn51o+AOg277me8Pf9QwyPHdSGD8XIBPy5lzadY5Bs8YzM7kbmyQOMZgLHkjgVl6Bj4tN3LMjHMMDjOYHQBqATotccONBDZmHqK0nH/zsAEYAPXEaDF+DNZyI4ex4WADQ4IBIS2SZ86YMQO18JjdeGY4s+GYhOHMMw+bpfFp4TveY/w5589hObPzyQ8+/qixkec7nnzwMz4tCgcY2CSANEwNiM3YgEcDA4N8AwPzB7wqRsEoGAWjYBQAABf+Ufkc3x8zAAAAAElFTkSuQmCC","orcid":"https://orcid.org/0000-0002-9521-767X","institution":"Taizhou University","correspondingAuthor":true,"prefix":"","firstName":"Yongmin","middleName":"","lastName":"Ma","suffix":""}],"badges":[],"createdAt":"2025-03-26 10:31:33","currentVersionCode":1,"declarations":"","doi":"10.21203/rs.3.rs-6311401/v1","doiUrl":"https://doi.org/10.21203/rs.3.rs-6311401/v1","draftVersion":[],"editorialEvents":[{"content":"https://doi.org/10.1038/s41467-025-66712-w","type":"published","date":"2025-11-27T05:00:00+00:00"}],"editorialNote":"","failedWorkflow":false,"files":[{"id":80020265,"identity":"fc2d15b4-9c5f-43a5-be43-fa3e4829f1cc","added_by":"auto","created_at":"2025-04-07 04:44:52","extension":"png","order_by":1,"title":"Figure 1","display":"","copyAsset":false,"role":"figure","size":171696,"visible":true,"origin":"","legend":"\u003cp\u003e\u003cstrong\u003ePhotoinduced deoxygenative N\u003c/strong\u003e\u003cem\u003e\u003cstrong\u003e \u003c/strong\u003e\u003c/em\u003e\u003cstrong\u003eradical generations and amination of alkylarenes.\u003c/strong\u003e \u003cstrong\u003ea\u003c/strong\u003e Comparison of photoinduced deoxygenation strategies for generating N radicals. \u003cstrong\u003eb\u003c/strong\u003e Catalytic atom/group transfer reactivities of borane. \u003cstrong\u003ec\u003c/strong\u003e This work: Aromatic amination of alkylarenes \u003cem\u003evia\u003c/em\u003e B(C\u003csub\u003e6\u003c/sub\u003eF\u003csub\u003e5\u003c/sub\u003e)\u003csub\u003e3\u003c/sub\u003e catalyzed deoxygenation of NHPI.\u003c/p\u003e","description":"","filename":"image1.png","url":"https://assets-eu.researchsquare.com/files/rs-6311401/v1/5a459fffea16a9a84c8a8b2a.png"},{"id":80019770,"identity":"4084eb2a-2b27-4c50-805b-db829e7175bb","added_by":"auto","created_at":"2025-04-07 04:36:52","extension":"png","order_by":2,"title":"Figure 2","display":"","copyAsset":false,"role":"figure","size":169507,"visible":true,"origin":"","legend":"\u003cp\u003e\u003cstrong\u003eMechanistic studies.\u003c/strong\u003e \u003cstrong\u003ea\u003c/strong\u003e Two-step experiment. \u003cstrong\u003eb\u003c/strong\u003e Stern-Volmer quenching.\u003cstrong\u003e c\u003c/strong\u003e Cyclic voltammetry studies. \u003cstrong\u003ed\u003c/strong\u003e Comparisons of the redox potentials and triplet-state energies. \u003cstrong\u003ee\u003c/strong\u003e Direct excitation. \u003cstrong\u003ef\u003c/strong\u003e UV-vis absorption spectra. \u003cstrong\u003eg\u003c/strong\u003e TEMPO-trapping experiment.\u003c/p\u003e","description":"","filename":"image2.png","url":"https://assets-eu.researchsquare.com/files/rs-6311401/v1/820e3f7bec442694c8e9fae0.png"},{"id":80021360,"identity":"b40ddf22-1b0d-4f7f-9a6a-982b19e61b65","added_by":"auto","created_at":"2025-04-07 05:00:53","extension":"png","order_by":3,"title":"Figure 3","display":"","copyAsset":false,"role":"figure","size":141627,"visible":true,"origin":"","legend":"\u003cp\u003e\u003cstrong\u003eProposed mechanism and calculations.\u003c/strong\u003e \u003cstrong\u003ea\u003c/strong\u003e Proposed mechanism. \u003cstrong\u003eb\u003c/strong\u003e Gibbs free energy profile for possible pathway.\u003c/p\u003e","description":"","filename":"image3.png","url":"https://assets-eu.researchsquare.com/files/rs-6311401/v1/45c6c362e67d461c7437aced.png"},{"id":80019772,"identity":"0bde50c0-4d96-449d-a08e-31cb756fabc1","added_by":"auto","created_at":"2025-04-07 04:36:52","extension":"png","order_by":4,"title":"Figure 4","display":"","copyAsset":false,"role":"figure","size":323055,"visible":true,"origin":"","legend":"\u003cp\u003e\u003cstrong\u003eSubstrate scope of alkylarenes\u003c/strong\u003e\u003csup\u003e\u003cem\u003e\u003cstrong\u003ea\u003c/strong\u003e\u003c/em\u003e\u003c/sup\u003e\u003cstrong\u003e. \u003c/strong\u003e\u003csup\u003e\u003cem\u003ea\u003c/em\u003e\u003c/sup\u003eReaction conditions: NHPI (0.1 mmol), alkylarenes (0.5 mmol), [Ir(dFCF\u003csub\u003e3\u003c/sub\u003eppy)\u003csub\u003e2\u003c/sub\u003edtbbpy]PF\u003csub\u003e6\u003c/sub\u003e (2 mol%), B(C\u003csub\u003e6\u003c/sub\u003eF\u003csub\u003e5\u003c/sub\u003e)\u003csub\u003e3\u003c/sub\u003e (20 mol%), NaHCO\u003csub\u003e3\u003c/sub\u003e (20 mol%), CHCl\u003csub\u003e3\u003c/sub\u003e (5 mL), irradiation with 25 W blue LEDs, Ar, 15 \u003csup\u003eo\u003c/sup\u003eC, 72 h.\u003c/p\u003e","description":"","filename":"image4.png","url":"https://assets-eu.researchsquare.com/files/rs-6311401/v1/b5af65007ccac29eb3962b1a.png"},{"id":80019777,"identity":"a34ec6b9-87d2-45c1-a7b2-a2d6dda1865d","added_by":"auto","created_at":"2025-04-07 04:36:52","extension":"png","order_by":5,"title":"Figure 5","display":"","copyAsset":false,"role":"figure","size":165934,"visible":true,"origin":"","legend":"\u003cp\u003e\u003cstrong\u003eSubstrate scope of arenes\u003c/strong\u003e\u003csup\u003e\u003cem\u003e\u003cstrong\u003ea\u003c/strong\u003e\u003c/em\u003e\u003c/sup\u003e\u003cstrong\u003e. \u003c/strong\u003e\u003csup\u003e\u003cem\u003ea\u003c/em\u003e\u003c/sup\u003eReaction conditions: NHPI (0.1 mmol), arenes (0.5 mmol), [Ir(dFCF\u003csub\u003e3\u003c/sub\u003eppy)\u003csub\u003e2\u003c/sub\u003edtbbpy]PF\u003csub\u003e6\u003c/sub\u003e (2 mol%), B(C\u003csub\u003e6\u003c/sub\u003eF\u003csub\u003e5\u003c/sub\u003e)\u003csub\u003e3\u003c/sub\u003e (20 mol%), NaHCO\u003csub\u003e3\u003c/sub\u003e (20 mol%), CHCl\u003csub\u003e3\u003c/sub\u003e (5 mL), irradiation with 25 W blue LEDs, Ar, 15 \u003csup\u003eo\u003c/sup\u003eC, 72 h.\u003c/p\u003e","description":"","filename":"image5.png","url":"https://assets-eu.researchsquare.com/files/rs-6311401/v1/c0f7efbaf890bc0fdecc7259.png"},{"id":80020496,"identity":"fd1dd971-c183-46e6-b290-f21ebc3e7406","added_by":"auto","created_at":"2025-04-07 04:52:52","extension":"png","order_by":6,"title":"Figure 6","display":"","copyAsset":false,"role":"figure","size":113135,"visible":true,"origin":"","legend":"\u003cp\u003e\u003cstrong\u003eSubstrate scope of NHPIs\u003c/strong\u003e\u003csup\u003e\u003cem\u003e\u003cstrong\u003ea\u003c/strong\u003e\u003c/em\u003e\u003c/sup\u003e\u003cstrong\u003e. \u003c/strong\u003e\u003csup\u003e\u003cem\u003ea\u003c/em\u003e\u003c/sup\u003eReaction conditions: NHPIs (0.1 mmol), 4-methylbenzoate (0.5 mmol), [Ir(dFCF\u003csub\u003e3\u003c/sub\u003eppy)\u003csub\u003e2\u003c/sub\u003edtbbpy]PF\u003csub\u003e6\u003c/sub\u003e (2 mol%), B(C\u003csub\u003e6\u003c/sub\u003eF\u003csub\u003e5\u003c/sub\u003e)\u003csub\u003e3\u003c/sub\u003e (20 mol%), NaHCO\u003csub\u003e3\u003c/sub\u003e (20 mol%), CHCl\u003csub\u003e3\u003c/sub\u003e (5 mL), irradiation with 25 W blue LEDs, Ar, 15 \u003csup\u003eo\u003c/sup\u003eC, 72 h.\u003c/p\u003e","description":"","filename":"image6.png","url":"https://assets-eu.researchsquare.com/files/rs-6311401/v1/f1042e4284906eb147e27401.png"},{"id":80019796,"identity":"34ba1861-3193-432f-9dd9-f121385a36b3","added_by":"auto","created_at":"2025-04-07 04:36:53","extension":"png","order_by":7,"title":"Figure 7","display":"","copyAsset":false,"role":"figure","size":158185,"visible":true,"origin":"","legend":"\u003cp\u003e\u003cstrong\u003eApplication of the catalytic photoinduced deoxygenation. a\u003c/strong\u003e Modification of biomolecules and drugs. \u003cstrong\u003eb\u003c/strong\u003e Application to the synthesis of the precursor of Nilotinib.\u003c/p\u003e","description":"","filename":"image7.png","url":"https://assets-eu.researchsquare.com/files/rs-6311401/v1/d5afa81457f495e4966d03a4.png"},{"id":99211901,"identity":"03c86212-c9c2-4c86-a7c0-455ab61bbd08","added_by":"auto","created_at":"2025-12-30 08:18:23","extension":"pdf","order_by":0,"title":"","display":"","copyAsset":false,"role":"manuscript-pdf","size":2176769,"visible":true,"origin":"","legend":"","description":"","filename":"manuscript.pdf","url":"https://assets-eu.researchsquare.com/files/rs-6311401/v1/85c768cc-d095-497e-a011-f6a4c19ad9fd.pdf"},{"id":80021357,"identity":"3d7754ff-18f8-40f4-83c3-bfafc0c0bd7e","added_by":"auto","created_at":"2025-04-07 05:00:53","extension":"pdf","order_by":1,"title":"","display":"","copyAsset":false,"role":"supplement","size":13102564,"visible":true,"origin":"","legend":"Electronic Supporting Information","description":"","filename":"ESI.pdf","url":"https://assets-eu.researchsquare.com/files/rs-6311401/v1/f2106fb472f1ddf4d863d9a2.pdf"}],"financialInterests":"There is \u003cb\u003eNO\u003c/b\u003e Competing Interest.","formattedTitle":"\u003cp\u003eCatalytic photoinduced deoxygenation via B(C\u003csub\u003e6\u003c/sub\u003eF\u003csub\u003e5\u003c/sub\u003e)\u003csub\u003e3\u003c/sub\u003e-enabled OAT for aromatic C−H amination of alkylarenes\u003c/p\u003e","fulltext":[{"header":"Introduction","content":"\u003cp\u003eOver the past decade, photoinduced deoxygenation has been recognized as a powerful and efficient approach for accessing highly reactive radicals, particularly N-centered radicals, owing to its atom economy and the accessibility of starting materials. However, the high bond dissociation energy of N\u0026thinsp;\u0026minus;\u0026thinsp;OH bonds frequently necessitates the \u003cem\u003epre\u003c/em\u003e-functionalization of hydroxyl groups into activating groups (AGs) using stoichiometric auxiliaries such as trifluoroacetyl\u003csup\u003e1\u003c/sup\u003e, dinitrophenylsulfonyloxy\u003csup\u003e2\u003c/sup\u003e, 2,4-dinitrophenoxy\u003csup\u003e3,4\u003c/sup\u003e, and isopropionic acid group\u003csup\u003e5,6\u003c/sup\u003e (Fig.\u0026nbsp;\u003cspan refid=\"Fig1\" class=\"InternalRef\"\u003e1\u003c/span\u003ea). These additional steps increase procedural complexity, requiring multiple operations and purification stages. To address these challenges, significant efforts have been directed toward \u003cem\u003ein situ\u003c/em\u003e-activation strategy. A key breakthrough in this field was reported by Schmidt, who developed a triethylphosphite-promoted oxygen atom transfer (OAT) strategy for generating amidyl radicals and achieved an intermolecular \u003cem\u003eanti\u003c/em\u003e-Markovnikov hydroamination of alkenes\u003csup\u003e7\u003c/sup\u003e. Since this pioneering work, several extensions of the phosphine-mediated deoxygenative methodology have been explored\u003csup\u003e8\u0026ndash;12\u003c/sup\u003e. Despite these advancements, current methodologies typically rely on stoichiometric amounts of auxiliaries or activators and inevitably generate organic wastes. Consequently, developing a catalytic photoinduced deoxygenation strategy to circumvent these inherent limitations for N radical generation remains an unresolved challenge.\u003c/p\u003e \u003cp\u003e \u003c/p\u003e \u003cp\u003eBorane Lewis acids, such as B(C\u003csub\u003e6\u003c/sub\u003eF\u003csub\u003e5\u003c/sub\u003e)\u003csub\u003e3\u003c/sub\u003e, have emerged as versatile and powerful reagents, exhibiting unusual transition-metal-like behaviors beyond classical Lewis acid reactivity\u003csup\u003e13\u0026ndash;15\u003c/sup\u003e. The pioneering studies by the groups of Stephan, Santini, Ogoshi, and Oestreich \u003cem\u003eet al.\u003c/em\u003e have revealed the exceptional capability of boranes to mediate thermally induced catalytic atom/group transfer of H\u003csup\u003e16\u0026ndash;19\u003c/sup\u003e, F\u003csup\u003e20,21\u003c/sup\u003e, and CN\u003csup\u003e22\u0026ndash;24\u003c/sup\u003e \u003cem\u003evia\u003c/em\u003e heterolysis pathways under harsh conditions (typically requiring elevated temperatures), generating closed-shell nucleophilic cation intermediates (Fig.\u0026nbsp;\u003cspan refid=\"Fig1\" class=\"InternalRef\"\u003e1\u003c/span\u003eb, left). Building on the strong B(C\u003csub\u003e6\u003c/sub\u003eF\u003csub\u003e5\u003c/sub\u003e)\u003csub\u003e3\u003c/sub\u003e-oxygen coordination\u003csup\u003e25\u0026ndash;27\u003c/sup\u003e, we hypothesized that B(C\u003csub\u003e6\u003c/sub\u003eF\u003csub\u003e5\u003c/sub\u003e)\u003csub\u003e3\u003c/sub\u003e could enable a photoinduced catalytic OAT process, generating open-shell radical intermediates through a homolytic pathway under mild conditions. As illustrated in Fig.\u0026nbsp;\u003cspan refid=\"Fig1\" class=\"InternalRef\"\u003e1\u003c/span\u003eb (right), we propose that B(C\u003csub\u003e6\u003c/sub\u003eF\u003csub\u003e5\u003c/sub\u003e)\u003csub\u003e3\u003c/sub\u003e binds to the oxygen atom of N\u0026thinsp;\u0026minus;\u0026thinsp;OH and abstracts the oxygen \u003cem\u003evia\u003c/em\u003e photoinduced energy transfer, thereby generating N radicals that undergo addition to inert π-systems (e.g. arenes). The resulting rare O\u0026thinsp;\u0026minus;\u0026thinsp;B(C\u003csub\u003e6\u003c/sub\u003eF\u003csub\u003e5\u003c/sub\u003e)\u003csub\u003e3\u003c/sub\u003e radical anion undergoes single-electron reduction and diprotonation to donate oxygen, ultimately releasing H\u003csub\u003e2\u003c/sub\u003eO and regenerating B(C\u003csub\u003e6\u003c/sub\u003eF\u003csub\u003e5\u003c/sub\u003e)\u003csub\u003e3\u003c/sub\u003e.\u003c/p\u003e \u003cp\u003eTo test our hypothesis and evaluate the performance of this proposed deoxygenation strategy, we selected commercially available \u003cem\u003eN\u003c/em\u003e-hydroxyphthalimide (NHPI) as the N\u0026thinsp;\u0026minus;\u0026thinsp;OH substrate\u003csup\u003e28\u0026ndash;30\u003c/sup\u003e. NHPI is known to undergo both favored dehydrogenation\u003csup\u003e31\u0026ndash;33\u003c/sup\u003e and disfavored deoxygenation processes\u003csup\u003e1,7,14,34,35\u003c/sup\u003e. Methylarene, which contains dual matched reactive sites\u0026mdash;an active benzylic C\u0026thinsp;\u0026minus;\u0026thinsp;H (bond dissociation energy\u0026thinsp;~\u0026thinsp;90 kcal/mol)\u003csup\u003e36\u003c/sup\u003e and an inert aromatic C\u0026thinsp;\u0026minus;\u0026thinsp;H (bond dissociation energy\u0026thinsp;~\u0026thinsp;110 kcal/mol)\u003csup\u003e36\u003c/sup\u003e\u0026mdash;was chosen as the ideal radical receptor. Under conventional conditions, the PhthNO\u0026thinsp;\u0026minus;\u0026thinsp;H bond in NHPI preferentially fragments through photocatalytic\u003csup\u003e37\u003c/sup\u003e or electrocatalytic activation\u003csup\u003e38\u0026ndash;40\u003c/sup\u003e, generating a phthalimide-\u003cem\u003eN\u003c/em\u003e-oxyl (PINO) radical. This radical smoothly reacts with methylarene at the benzylic C\u0026thinsp;\u0026minus;\u0026thinsp;H site, yielding the PINOylation product, as reported by the Stahl group\u003csup\u003e41\u003c/sup\u003e. In contrast, we envisioned that a tailored deoxygenative strategy could shift the selectivity toward fragmentation of the less favored PhthN\u0026thinsp;\u0026minus;\u0026thinsp;OH bond, enabling NHPI to serve as a precursor for nitrogen-centered radical. The resulting PhthN radical could then intercept methylarene, selectively aminating the aromatic C\u0026thinsp;\u0026minus;\u0026thinsp;H site. This \"inverted selectivity\" approach would deliver valuable arylamines\u003csup\u003e42,43\u003c/sup\u003e, which are traditionally synthesized through nitration/reduction\u003csup\u003e44\u003c/sup\u003e or transition-metal catalysis\u003csup\u003e45\u0026ndash;48\u003c/sup\u003e.\u003c/p\u003e \u003cp\u003eOur motivation for this work is three-fold: (1) to develop a challenging catalytic photoinduced deoxygenation approach that eliminates the need for stoichiometric auxiliaries/activators while circumventing the generation of organic wastes; (2) to expand the capability of B(C\u003csub\u003e6\u003c/sub\u003eF\u003csub\u003e5\u003c/sub\u003e)\u003csub\u003e3\u003c/sub\u003e for catalytic OAT in photocatalysis; and (3) to achieve the previously challenging inverted selectivity in the reaction of alkylarenes with NHPIs, enabling access to valuable arylamines. In this study, building on our ongoing interest in photoinduced deoxygenation\u003csup\u003e49,50\u003c/sup\u003e, we disclose an unprecedented catalytic strategy for the photoinduced deoxygenation of NHPIs through B(C\u003csub\u003e6\u003c/sub\u003eF\u003csub\u003e5\u003c/sub\u003e)\u003csub\u003e3\u003c/sub\u003e-enabled OAT process. This strategy has been applied to achieve aromatic C\u0026thinsp;\u0026minus;\u0026thinsp;H amination of alkylarenes (Fig.\u0026nbsp;\u003cspan refid=\"Fig1\" class=\"InternalRef\"\u003e1\u003c/span\u003ec). The developed method exhibits high atom and step economy, inverted selectivity for alkylarenes, broad substrate applicability\u0026mdash;including late-stage functionalization\u0026mdash;and paves the way for efficient and sustainable access to valuable arylamines.\u003c/p\u003e"},{"header":"Results","content":"\u003cdiv id=\"Sec3\" class=\"Section2\"\u003e \u003ch2\u003eOptimization of reaction conditions\u003c/h2\u003e \u003cp\u003eWe began our investigation by exploring the catalytic deoxygenation of commercially available NHPI (\u003cb\u003e1\u003c/b\u003e) with toluene (\u003cb\u003e2\u003c/b\u003e) as the reaction partner. Encouragingly, the proposed process proved feasible. Following systematic optimization of reaction parameters (Table \u003cspan refid=\"MOESM1\" class=\"InternalRef\"\u003eS1\u003c/span\u003e; see Supporting Information for details), we identified the optimal conditions: a combination of B(C\u003csub\u003e6\u003c/sub\u003eF\u003csub\u003e5\u003c/sub\u003e)\u003csub\u003e3\u003c/sub\u003e (20 mol%), [Ir(dFCF\u003csub\u003e3\u003c/sub\u003eppy)\u003csub\u003e2\u003c/sub\u003edtbbpy]PF\u003csub\u003e6\u003c/sub\u003e (2 mol%), and NaHCO\u003csub\u003e3\u003c/sub\u003e (20 mol%) in CHCl\u003csub\u003e3\u003c/sub\u003e (0.02 M), irradiated with blue LEDs at 15\u0026deg;C under an argon atmosphere, yielded \u003cb\u003e3\u003c/b\u003e in 68% yield with complete selectivity for C(sp\u003csup\u003e2\u003c/sup\u003e)\u0026thinsp;\u0026minus;\u0026thinsp;H amination over benzylic C\u0026thinsp;\u0026minus;\u0026thinsp;H PINOylation (Table\u0026nbsp;\u003cspan refid=\"Tab1\" class=\"InternalRef\"\u003e1\u003c/span\u003e, entry 1). However, 17% of the byproduct phthalimide (\u003cb\u003e3\u0026prime;\u0026prime;\u003c/b\u003e) was also formed, likely resulting from hydrogen abstraction by the PhthN radical from toluene (\u003cb\u003e2\u003c/b\u003e) or CHCl\u003csub\u003e3\u003c/sub\u003e. The site selectivity of the reaction showed a notable dependence on boron acidity. Replacing B(C\u003csub\u003e6\u003c/sub\u003eF\u003csub\u003e5\u003c/sub\u003e)\u003csub\u003e3\u003c/sub\u003e with weaker Lewis acids, such as B(3,4,5-F\u003csub\u003e3\u003c/sub\u003eC\u003csub\u003e6\u003c/sub\u003eH\u003csub\u003e2\u003c/sub\u003e)\u003csub\u003e3\u003c/sub\u003e or BPh\u003csub\u003e3\u003c/sub\u003e, significantly decreased deoxygenation efficiency, favoring the PINOylation product \u003cb\u003e3\u0026prime;\u003c/b\u003e as the major product (entries 2 and 3). Reaction temperature also influenced the formation of product \u003cb\u003e3\u003c/b\u003e. Higher reaction temperature led to an increased yield of \u003cb\u003e3\u0026prime;\u0026prime;\u003c/b\u003e (entry 4), whereas lowering the temperature reduced its formation but also severely limited the conversion of \u003cb\u003e1\u003c/b\u003e, likely due to the poor solubility of \u003cb\u003e1\u003c/b\u003e at lower temperatures (entry 5). Similarly, reducing the solvent volume caused decreased reaction efficiency due to solubility issues (entry 6). Attempts to improve yield of \u003cb\u003e3\u003c/b\u003e by testing different solvents were unsuccessful (entries 7 and 8). Control experiments highlighted the critical role of B(C\u003csub\u003e6\u003c/sub\u003eF\u003csub\u003e5\u003c/sub\u003e)\u003csub\u003e3\u003c/sub\u003e. In its absence, the deoxygenation of \u003cb\u003e1\u003c/b\u003e did not occur; instead, background PINOylation of \u003cb\u003e2\u003c/b\u003e proceeded smoothly, yielding 73% of \u003cb\u003e3\u0026prime;\u003c/b\u003e as the sole product (entry 9). The use of NaHCO\u003csub\u003e3\u003c/sub\u003e as a base was essential for enhancing conversion, likely by deprotonating \u003cb\u003e1\u003c/b\u003e; without it, the conversion was significantly reduced (entry 10). Moreover, no product was detected without the photocatalyst or light, underscoring their necessity for this transformation (entry 11).\u003c/p\u003e \u003cp\u003e\u003cimg 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\" height=\"558\" width=\"584\"\u003e\u003c/p\u003e\n\u003ch3\u003eMechanistic studies\u003c/h3\u003e\n\u003cp\u003eTo gain deeper insights into the B(C\u003csub\u003e6\u003c/sub\u003eF\u003csub\u003e5\u003c/sub\u003e)\u003csub\u003e3\u003c/sub\u003e-enabled deoxygenation process, we conducted a series of mechanistic studies. Treating NHPI (\u003cb\u003e1\u003c/b\u003e) with an equivalent amount of B(C\u003csub\u003e6\u003c/sub\u003eF\u003csub\u003e5\u003c/sub\u003e)\u003csub\u003e3\u003c/sub\u003e resulted in the formation of a PhthN\u0026thinsp;\u0026minus;\u0026thinsp;O\u0026minus;B(C\u003csub\u003e6\u003c/sub\u003eF\u003csub\u003e5\u003c/sub\u003e)\u003csub\u003e3\u003c/sub\u003e adduct (\u003cb\u003eII\u003c/b\u003e), confirmed by \u003csup\u003e1\u003c/sup\u003eH NMR, \u003csup\u003e19\u003c/sup\u003eF NMR spectroscopies, and HRMS analysis (Figs.\u0026nbsp;\u003cspan refid=\"Fig2\" class=\"InternalRef\"\u003e2\u003c/span\u003ea and S2\u0026ndash;S4). Upon irradiation of this \u003cem\u003ein situ\u003c/em\u003e-generated complex with blue LEDs in the presence of toluene (\u003cb\u003e2\u003c/b\u003e) and photocatalyst, the target product (\u003cb\u003e3\u003c/b\u003e) was obtained in 47% yield. This result suggests that the [N\u0026thinsp;\u0026minus;\u0026thinsp;O\u0026minus;B] adduct (\u003cb\u003eII\u003c/b\u003e) is likely the key active intermediate for generating the PhthN radical. We hypothesize that the subsequent N\u0026thinsp;\u0026minus;\u0026thinsp;O bond fragmentation occurs \u003cem\u003evia\u003c/em\u003e an energy transfer (EnT) process rather than the typical electron transfer mechanism. This hypothesis is supported by evidence from photoquenching experiments, cyclic voltammetry, analysis of alternative energy transfer catalysts, UV light irradiation, and TEMPO-trapping experiments (Figs.\u0026nbsp;\u003cspan refid=\"Fig2\" class=\"InternalRef\"\u003e2\u003c/span\u003eb-g; see Supporting Information for details). Stern\u0026ndash;Volmer fluorescence quenching experiments demonstrates that only the [N\u0026thinsp;\u0026minus;\u0026thinsp;O\u0026minus;B] adduct (\u003cb\u003eII\u003c/b\u003e) quenches the excited state of the photocatalyst, as shown in Fig.\u0026nbsp;\u003cspan refid=\"Fig2\" class=\"InternalRef\"\u003e2\u003c/span\u003eb. This quenching suggests an interaction between the intermediate and the excited-state photocatalyst, supporting an EnT mechanism where intermediate \u003cb\u003eII\u003c/b\u003e is sensitized into its triplet state. Further analysis of the redox potential of \u003cb\u003eII\u003c/b\u003e (E\u003csub\u003eox\u003c/sub\u003e\u0026thinsp;=\u0026thinsp;+\u0026thinsp;0.48 V \u003cem\u003evs\u003c/em\u003e. Ag/AgCl, E\u003csub\u003ered\u003c/sub\u003e\u0026thinsp;=\u0026thinsp;\u0026minus;\u0026thinsp;0.97 V \u003cem\u003evs\u003c/em\u003e. Ag/AgCl; Fig.\u0026nbsp;\u003cspan refid=\"Fig2\" class=\"InternalRef\"\u003e2\u003c/span\u003ec) reveals no correlation between redox potential and reactivity. Instead, the amination reactivity is correlated to the energy of the first triplet excited state of the photocatalyst, as shown in Fig.\u0026nbsp;\u003cspan refid=\"Fig2\" class=\"InternalRef\"\u003e2\u003c/span\u003ed for two photocatalysts with lower triplet energy. Upon switching the photocatalyst from [Ir(dFCF\u003csub\u003e3\u003c/sub\u003e​ppy)\u003csub\u003e2\u003c/sub\u003e​(dtbbpy)]PF\u003csub\u003e6\u003c/sub\u003e to \u003cem\u003efac\u003c/em\u003e-Ir(ppy)\u003csub\u003e3\u003c/sub\u003e​, which has a bit lower triplet energy (55.2 kcal/mol)\u003csup\u003e52\u003c/sup\u003e but much lower oxidation potential (E*\u003csub\u003eox\u003c/sub\u003e\u0026thinsp;=\u0026thinsp;+\u0026thinsp;0.31 V \u003cem\u003evs\u003c/em\u003e. SCE) \u003csup\u003e51\u003c/sup\u003e, 47% yield of \u003cb\u003e3a\u003c/b\u003e was obtained. Furthermore, the amination process did not proceed entirely when employing [Ru(bpy)\u003csub\u003e3\u003c/sub\u003e]Cl\u003csub\u003e2\u003c/sub\u003e with sufficient redox potential (E*\u003csub\u003eox\u003c/sub\u003e\u0026thinsp;=\u0026thinsp;+\u0026thinsp;0.78 V \u003cem\u003evs\u003c/em\u003e. SCE, E*\u003csub\u003ered\u003c/sub\u003e = \u0026ndash; 1.44 V \u003cem\u003evs\u003c/em\u003e. SCE)\u003csup\u003e51\u003c/sup\u003e relative to \u003cb\u003eII\u003c/b\u003e but lower triplet energy (46.0 kcal/mol)\u003csup\u003e52\u003c/sup\u003e as the photocatalyst. Density functional theory (DFT) calculations (UB3LYP/6-311\u0026thinsp;+\u0026thinsp;G(d,p)) show that the first excited triplet state energy of [N\u0026thinsp;\u0026minus;\u0026thinsp;O\u0026minus;B] adduct (\u003cb\u003eII\u003c/b\u003e) is 56.1 kcal/mol, closely matching the triplet state energy of [Ir(dFCF\u003csub\u003e3\u003c/sub\u003e​ppy)\u003csub\u003e2\u003c/sub\u003e(dtbbpy)]PF\u003csub\u003e6\u003c/sub\u003e (60.8 kcal/mol), supporting the feasibility of EnT from the excited photocatalyst. Further evidence for this pathway came from direct excitation experiments. Irradiating the reaction mixture with 365 nm LEDs (emission range\u0026thinsp;~\u0026thinsp;350\u0026ndash;385 nm) in the absence of the photocatalyst produced the desired product (\u003cb\u003e3\u003c/b\u003e) in 13% yield, confirming an EnT mechanism (Fig.\u0026nbsp;\u003cspan refid=\"Fig2\" class=\"InternalRef\"\u003e2\u003c/span\u003ee). UV/Vis spectroscopy reveals that \u003cb\u003eII\u003c/b\u003e has absorption overlaps with the emission spectrum of the 365 nm LEDs (e.g. the molar absorptivity (ε) for \u003cb\u003eII\u003c/b\u003e at 360 nm is 22.1 M\u003csup\u003e\u0026minus;\u0026thinsp;1\u003c/sup\u003e\u0026middot;cm\u003csup\u003e\u0026minus;\u0026thinsp;1\u003c/sup\u003e, Fig.\u0026nbsp;\u003cspan refid=\"Fig2\" class=\"InternalRef\"\u003e2\u003c/span\u003ef). Lastly, the reaction was suppressed upon the addition of TEMPO. HRMS analysis detected TEMPO-NPhth and TEMPO-OB(C\u003csub\u003e6\u003c/sub\u003eF\u003csub\u003e5\u003c/sub\u003e)\u003csub\u003e3\u003c/sub\u003e anion adducts (Figs.\u0026nbsp;\u003cspan refid=\"Fig2\" class=\"InternalRef\"\u003e2\u003c/span\u003eg, S11 and S12), providing further evidence that the N\u0026thinsp;\u0026minus;\u0026thinsp;O bond undergoes a homolysis process.\u003c/p\u003e \u003cp\u003e \u003c/p\u003e \u003cp\u003eFrom the above experiments, a plausible mechanism for the amination of methylarenes enabled by the catalytic deoxygenation strategy is outlined in Fig.\u0026nbsp;\u003cspan refid=\"Fig3\" class=\"InternalRef\"\u003e3\u003c/span\u003ea. NHPI undergoes deprotonation in the presence of a base to yield intermediate \u003cb\u003eI\u003c/b\u003e, which reacts with B(C\u003csub\u003e6\u003c/sub\u003eF\u003csub\u003e5\u003c/sub\u003e)\u003csub\u003e3\u003c/sub\u003e to form the PhthN-O-B(C\u003csub\u003e6\u003c/sub\u003eF\u003csub\u003e5\u003c/sub\u003e)\u003csub\u003e3\u003c/sub\u003e anion \u003cb\u003eII\u003c/b\u003e. Simultaneously, the photocatalyst absorbs visible light, transitioning to its triplet excited state, which transfers its triplet energy to anion \u003cb\u003eII\u003c/b\u003e \u003cem\u003evia\u003c/em\u003e a triplet-to-triplet energy transfer (TTEnT) process. The triplet-excited intermediate \u003cb\u003eII*\u003c/b\u003e then undergoes N\u0026thinsp;\u0026minus;\u0026thinsp;O bond homolysis to generate the O\u0026thinsp;\u0026minus;\u0026thinsp;B radical anion \u003cb\u003eIII\u003c/b\u003e and the PhthN radical \u003cb\u003eIV\u003c/b\u003e. The PhthN radical \u003cb\u003eIV\u003c/b\u003e rapidly adds to the aromatic carbon atom of methylarene (\u003cb\u003e2\u003c/b\u003e), forming the neutral radical intermediate \u003cb\u003eV\u003c/b\u003e. This intermediate is subsequently oxidized by the photoexcited photocatalyst (PC*) \u003cem\u003evia\u003c/em\u003e single-electron transfer (SET), producing the cationic Wheland intermediate \u003cb\u003eVI\u003c/b\u003e. Deprotonation of \u003cb\u003eVI\u003c/b\u003e yields the target arylamine product \u003cb\u003e3\u003c/b\u003e. In parallel, the O\u0026thinsp;\u0026minus;\u0026thinsp;B radical anion \u003cb\u003eIII\u003c/b\u003e undergoes single-electron reduction by the reduced photocatalyst (PC\u003csup\u003e\u0026bull;\u0026ndash;\u003c/sup\u003e), followed by protonation to generate the HO\u0026thinsp;\u0026minus;\u0026thinsp;B(C\u003csub\u003e6\u003c/sub\u003eF\u003csub\u003e5\u003c/sub\u003e)\u003csub\u003e3\u003c/sub\u003e anion \u003cb\u003eVII\u003c/b\u003e. Protonation of \u003cb\u003eVII\u003c/b\u003e leads to the formation of the active B(C\u003csub\u003e6\u003c/sub\u003eF\u003csub\u003e5\u003c/sub\u003e)\u003csub\u003e3\u003c/sub\u003e catalyst and water, thus closing the catalytic OAT cycle.\u003c/p\u003e \u003cp\u003eTo further validate this mechanistic hypothesis, DFT calculations were performed at the (U)B3LYP-D3-(BJ)/def2-QZVP-SMD//(U)B3LYP-D3-(BJ)/6-31G(d)-SMD level (Fig.\u0026nbsp;\u003cspan refid=\"Fig3\" class=\"InternalRef\"\u003e3\u003c/span\u003eb; see Supporting Information for details). The reaction begins with NaHCO\u003csub\u003e3\u003c/sub\u003e-assisted deprotonation of NHPI (\u003cb\u003e1\u003c/b\u003e) to form the PhthN\u0026thinsp;\u0026minus;\u0026thinsp;O anion (\u003cb\u003eI\u003c/b\u003e), with an energy barrier of 7.8 kcal/mol. The subsequent addition of \u003cb\u003eI\u003c/b\u003e to B(C\u003csub\u003e6\u003c/sub\u003eF\u003csub\u003e5\u003c/sub\u003e)\u003csub\u003e3\u003c/sub\u003e is strongly exoergic (ΔG\u0026thinsp;=\u0026thinsp;\u0026minus;\u0026thinsp;44.5 kcal/mol), stabilizing the resulting anion PhthN\u0026thinsp;\u0026minus;\u0026thinsp;O\u0026minus;B(C\u003csub\u003e6\u003c/sub\u003eF\u003csub\u003e5\u003c/sub\u003e)\u003csub\u003e3\u003c/sub\u003e (\u003cb\u003eII\u003c/b\u003e). Photoinduced TTEnT between the excited photocatalyst and \u003cb\u003eII\u003c/b\u003e produces the triplet-excited intermediate \u003cb\u003eII*\u003c/b\u003e, which fragments \u003cem\u003evia\u003c/em\u003e a transition state (\u003cb\u003eTS\u003c/b\u003e) with a barrier of 10.8 kcal/mol. This protonated by H\u003csub\u003e2\u003c/sub\u003eCO\u003csub\u003e3\u003c/sub\u003e to yield the HO\u0026thinsp;\u0026minus;\u0026thinsp;B(C\u003csub\u003e6\u003c/sub\u003eF\u003csub\u003e5\u003c/sub\u003e)\u003csub\u003e3\u003c/sub\u003e anion \u003cb\u003eVII\u003c/b\u003e, with a free energy change of \u0026minus;\u0026thinsp;46.3 kcal/mol. Finally, a strongly exoergic proton transfer (ΔG\u0026thinsp;=\u0026thinsp;\u0026minus;\u0026thinsp;49.9 kcal/mol) from \u003cb\u003eVI\u003c/b\u003e to HO\u0026thinsp;\u0026minus;\u0026thinsp;B(C\u003csub\u003e6\u003c/sub\u003eF\u003csub\u003e5\u003c/sub\u003e)\u003csub\u003e3\u003c/sub\u003e anion forms the desired product \u003cb\u003e3\u003c/b\u003e and H\u003csub\u003e2\u003c/sub\u003eO\u0026thinsp;\u0026minus;\u0026thinsp;B(C\u003csub\u003e6\u003c/sub\u003eF\u003csub\u003e5\u003c/sub\u003e)\u003csub\u003e3\u003c/sub\u003e (\u003cb\u003eVIII\u003c/b\u003e). The latter releases B(C\u003csub\u003e6\u003c/sub\u003eF\u003csub\u003e5\u003c/sub\u003e)\u003csub\u003e3\u003c/sub\u003e with a low energy barrier of 8.1 kcal/mol, a thermally feasible process under the reaction conditions (15\u0026deg;C).\u003c/p\u003e \u003cp\u003e \u003c/p\u003e\n\u003ch3\u003eSubstrate scope\u003c/h3\u003e\n\u003cp\u003eAfter establishing the optimal conditions and gaining insight into the mechanism, we explored the scope of alkylarenes in the reaction with NHPIs (Fig.\u0026nbsp;\u003cspan refid=\"Fig4\" class=\"InternalRef\"\u003e4\u003c/span\u003e). Satisfyingly, the site-selectivity of this reaction system was unaffected by the presence of electron-donating or electron-withdrawing groups on the benzene ring. Aromatic C\u0026thinsp;\u0026minus;\u0026thinsp;H amination consistently dominated over benzylic C\u0026thinsp;\u0026minus;\u0026thinsp;H oxidation. Methylarenes with methyl substituents at the \u003cem\u003eortho\u003c/em\u003e- (\u003cb\u003e4\u003c/b\u003e and \u003cb\u003e5\u003c/b\u003e), \u003cem\u003emeta\u003c/em\u003e- (\u003cb\u003e6\u003c/b\u003e and \u003cb\u003e7\u003c/b\u003e), or \u003cem\u003epara\u003c/em\u003e- (\u003cb\u003e8\u003c/b\u003e) position delivered products in comparable yields. Electron-donating methylarenes bearing \u003cem\u003eiso-\u003c/em\u003epropyl (\u003cb\u003e9\u003c/b\u003e), \u003cem\u003etert\u003c/em\u003e-butyl (\u003cb\u003e10\u003c/b\u003e), and methoxy (\u003cb\u003e11\u003c/b\u003e) groups were successfully transformed into the corresponding products, while electron-withdrawing methylarenes containing ester (\u003cb\u003e12\u003c/b\u003e\u0026ndash;\u003cb\u003e21\u003c/b\u003e), ketone (\u003cb\u003e22\u003c/b\u003e), trifluoromethyl (\u003cb\u003e23\u003c/b\u003e and \u003cb\u003e24\u003c/b\u003e), nitrile (\u003cb\u003e25\u003c/b\u003e), and nitro (\u003cb\u003e26\u003c/b\u003e) groups demonstrated broad functional group tolerance, providing ample opportunities for further derivatization. Notably, methylarenes with electron-withdrawing groups at the \u003cem\u003epara\u003c/em\u003e-position exclusively yielded \u003cem\u003eortho\u003c/em\u003e-amination products, potentially due to electronic effects. Conversely, methylarenes with methoxycarbonyl and trifluoromethyl groups at the \u003cem\u003eortho\u003c/em\u003e-position preferentially underwent amination at the \u003cem\u003epara\u003c/em\u003e-position. Halogenated methylarenes underwent smooth C\u0026thinsp;\u0026minus;\u0026thinsp;N coupling, yielding target products (\u003cb\u003e27\u003c/b\u003e\u0026ndash;\u003cb\u003e38\u003c/b\u003e) in useful yields, irrespective of the presence of additional halides (F, Cl, or Br). Furthermore, this strategy was successfully applied to arenes containing both benzylic C\u0026thinsp;\u0026minus;\u0026thinsp;H and aromatic C\u0026thinsp;\u0026minus;\u0026thinsp;H sites, such as ethylarene (\u003cb\u003e39\u003c/b\u003e), benzylarenes (\u003cb\u003e40\u003c/b\u003e), vinylarenes (\u003cb\u003e41\u003c/b\u003e and \u003cb\u003e42\u003c/b\u003e), and benzyl alcohols (\u003cb\u003e43\u003c/b\u003e\u0026ndash;\u003cb\u003e45\u003c/b\u003e), and cyclic arenes (\u003cb\u003e46\u003c/b\u003e\u0026ndash;\u003cb\u003e49\u003c/b\u003e) consistently affording C(sp\u003csup\u003e2\u003c/sup\u003e)\u0026thinsp;\u0026minus;\u0026thinsp;H amination products without PINOylation byproducts.\u003c/p\u003e \u003cp\u003e \u003c/p\u003e \u003cp\u003eWe further extended the applicability of this strategy to arenes to investigate its functional group tolerance (Fig.\u0026nbsp;\u003cspan refid=\"Fig5\" class=\"InternalRef\"\u003e5\u003c/span\u003e). Application of the optimized conditions to benzene yielded the target product (\u003cb\u003e50\u003c/b\u003e) in good yield. A variety of arenes bearing electron-donating functional groups such as ethers (\u003cb\u003e51\u003c/b\u003e\u0026ndash;\u003cb\u003e54\u003c/b\u003e), thioether (\u003cb\u003e55\u003c/b\u003e), and trimethylsilane (\u003cb\u003e56\u003c/b\u003e) coupled with NHPI to generate the desired products in moderate to good yields. Electron-withdrawing arenes with esters (\u003cb\u003e57\u003c/b\u003e and \u003cb\u003e58\u003c/b\u003e), trifluoromethyl (\u003cb\u003e59\u003c/b\u003e), and sulfone (\u003cb\u003e60\u003c/b\u003e) substituent also underwent the reaction, which further broadened the substrate scope of the strategy. Halogenated arenes were successfully aminated, offering orthogonal reactivity to the well-established Buchwald\u0026thinsp;\u0026minus;\u0026thinsp;Hartwig coupling. Notably, polycyclic arenes (\u003cb\u003e67\u003c/b\u003e and \u003cb\u003e68\u003c/b\u003e) could be selectively aminated at the \u003cem\u003eα\u003c/em\u003e-position. To our delight, heteroarenes such as 2,6-dimethoxypyridine and benzothiazole are well-tolerated to yield desired products (\u003cb\u003e69\u003c/b\u003e and \u003cb\u003e70\u003c/b\u003e).\u003c/p\u003e \u003cp\u003e \u003c/p\u003e \u003cp\u003eHaving evaluated the scope of arenes, we next examined the scope of NHPIs (Fig.\u0026nbsp;\u003cspan refid=\"Fig6\" class=\"InternalRef\"\u003e6\u003c/span\u003e). Pleasingly, NHPIs containing various functional groups, such as methyl (\u003cb\u003e71\u003c/b\u003e and \u003cb\u003e72\u003c/b\u003e), methoxy (\u003cb\u003e73\u003c/b\u003e), \u003cem\u003etert\u003c/em\u003e-butyl (\u003cb\u003e74\u003c/b\u003e) and halogens (\u003cb\u003e75\u003c/b\u003e\u0026ndash;\u003cb\u003e78\u003c/b\u003e), were successfully deoxygenated under this catalytic system to yield the corresponding products with 4-methylbenzoate. In addition, \u003cem\u003eN\u003c/em\u003e-hydroxy-2,3-naphthalimide and 2,3-pyridinedicarboximide also gave the expected product \u003cb\u003e79\u003c/b\u003e and \u003cb\u003e80\u003c/b\u003e, albeit in lower yields.\u003c/p\u003e \u003cp\u003e \u003c/p\u003e \u003cp\u003eThe promising functional group tolerance and synthetic convenience of this photoinduced deoxygenation strategy encouraged us to explore its application in biomolecule modification (Fig.\u0026nbsp;\u003cspan refid=\"Fig7\" class=\"InternalRef\"\u003e7\u003c/span\u003ea). Alkylarenes derived from \u003cem\u003eL\u003c/em\u003e-menthol (\u003cb\u003e81\u003c/b\u003e), (1\u003cem\u003eR\u003c/em\u003e)-(-)-nopol (\u003cb\u003e82\u003c/b\u003e), borneol (\u003cb\u003e83\u003c/b\u003e), perilla alcohol (\u003cb\u003e84\u003c/b\u003e) HDFDMA, lithography monomer (\u003cb\u003e85\u003c/b\u003e), tetrahydrogeraniol (\u003cb\u003e86\u003c/b\u003e), geraniol (\u003cb\u003e87\u003c/b\u003e), 7-ketocholesterol (\u003cb\u003e88\u003c/b\u003e), 7-keto diosgenin (\u003cb\u003e89\u003c/b\u003e) \u003cem\u003eD\u003c/em\u003e-galactopyranose derivative (\u003cb\u003e90\u003c/b\u003e), \u003cem\u003eD\u0026ndash;r\u003c/em\u003eibonolactone (\u003cb\u003e91\u003c/b\u003e), and simvastatin (\u003cb\u003e92\u003c/b\u003e) were successfully aminated at the \u003cem\u003eortho\u003c/em\u003e-position, albeit with moderate yields. These results underscore the practicality and robustness of this transformation, suggesting broader applications in drug discovery. To demonstrate the potential utility of this strategy, we applied it to the synthesis of a crucial precursor for nilotinib (Fig.\u0026nbsp;\u003cspan refid=\"Fig7\" class=\"InternalRef\"\u003e7\u003c/span\u003eb). Selective \u003cem\u003eortho\u003c/em\u003e-C(sp\u003csup\u003e2\u003c/sup\u003e)\u0026thinsp;\u0026minus;\u0026thinsp;H amination of 4-methylbenzoate with the inexpensive, commercially available NHPI was performed under optimized conditions. Subsequent \u003cem\u003ein situ\u003c/em\u003e hydrazinolysis of the formed \u003cem\u003eN\u003c/em\u003e-arylphthalimide yielded methyl 3-amino-4-methylbenzoate (\u003cb\u003e93\u003c/b\u003e), avoiding the harsh reaction conditions typically required by conventional nitration/reduction processes.\u003c/p\u003e \u003cp\u003e \u003c/p\u003e"},{"header":"Discussion","content":"\u003cp\u003eIn summary, we present a catalytic strategy for photoinduced deoxygenation of NHPIs enabled by B(C\u003csub\u003e6\u003c/sub\u003eF\u003csub\u003e5\u003c/sub\u003e)\u003csub\u003e3\u003c/sub\u003e, which achieves selective aromatic C(sp\u0026sup2;)\u0026thinsp;\u0026minus;\u0026thinsp;H amination of alkylarenes. By leveraging the OAT capability of B(C\u003csub\u003e6\u003c/sub\u003eF\u003csub\u003e5\u003c/sub\u003e)\u003csub\u003e3\u003c/sub\u003e, this method circumvents the need for stoichiometric auxiliaries/activators, generating only H\u003csub\u003e2\u003c/sub\u003eO as a green byproduct. Mechanistic investigations, supported by experimental and DFT calculations, reveal that the \u003cem\u003ein situ\u003c/em\u003e-formed PhthN\u0026thinsp;\u0026minus;\u0026thinsp;O\u0026minus; B(C\u003csub\u003e6\u003c/sub\u003eF\u003csub\u003e5\u003c/sub\u003e)\u003csub\u003e3\u003c/sub\u003e anion undergoes EnT-mediated N\u0026thinsp;\u0026minus;\u0026thinsp;O bond homolysis to produce a PhthN\u0026bull;, enabling the direct coupling with aromatic C\u0026thinsp;\u0026minus;\u0026thinsp;H bonds. The reaction overrides the traditional preference for benzylic C\u0026thinsp;\u0026minus;\u0026thinsp;H oxidation, delivering exclusive aromatic amination across diverse substrates, including electron-rich and electron-deficient alkylarenes, styrenes, and benzyl alcohols. The utility of this strategy is further demonstrated through late-stage functionalization of biomolecules and the synthesis of a key nilotinib precursor. Importantly, this work expands the catalytic capabilities of boranes, establishing B(C\u003csub\u003e6\u003c/sub\u003eF\u003csub\u003e5\u003c/sub\u003e)\u003csub\u003e3\u003c/sub\u003e as a versatile OAT reagent in photochemical reactions. This approach offers a sustainable and practical alternative to conventional methods for accessing arylamines, with potential applications in synthetic chemistry and drug discovery.\u003c/p\u003e"},{"header":"Methods","content":"\u003cdiv id=\"Sec8\" class=\"Section2\"\u003e \u003ch2\u003eGeneral information\u003c/h2\u003e \u003cp\u003eThe reactions were carried out under an inert atmosphere of argon \u003cem\u003evia\u003c/em\u003e standard Schlenk techniquesor in a glovebox. All visible light-induced reactions were conducted in borosilicate glass tubes with Teflon-coated magnetic stirring bars in a circulating cooling device and placed 5 cm from a commercial blue LEDs. The photoreaction instrument was purchased from 3s-technology co., China, model: 021-AM2410-229, 0\u0026thinsp;~\u0026thinsp;100 W, λ\u0026thinsp;=\u0026thinsp;460\u0026thinsp;\u0026minus;\u0026thinsp;470 nm, URL: \u003cspan class=\"ExternalRef\"\u003e\u003cspan class=\"RefSource\"\u003ehttps://www.3s-tech.net/products/ilmt.html#am\u003c/span\u003e\u003cspan address=\"https://www.3s-tech.net/products/ilmt.html#am\" targettype=\"URL\" class=\"RefTarget\"\u003e\u003c/span\u003e\u003c/span\u003e. Reactions were monitored by HPLC, \u003csup\u003e1\u003c/sup\u003eH NMR, and/or by TLC on 254 nm silica gel plates (0.2 mm thickness). Flash column chromatography was performed on silica gel (200\u0026ndash;300 mesh). Arenes, \u003cem\u003eN-\u003c/em\u003ehydroxyphthalimides, boranes, photocatalyst, bases, and solvents were purchased from Energy Chemical (shanghai, china). NMR spectra data were obtained on Avance (III) HD 400 MHz instruments. \u003csup\u003e1\u003c/sup\u003eH NMR and \u003csup\u003e13\u003c/sup\u003eC NMR spectra were referenced to residual protic solvent peaks or TMS signal (0 ppm). \u003csup\u003e19\u003c/sup\u003eF NMR chemical shifts were externally referenced to CCl\u003csub\u003e3\u003c/sub\u003eF (0 ppm). Data for \u003csup\u003e1\u003c/sup\u003eH NMR are recorded as follows: chemical shift (\u003cem\u003eδ\u003c/em\u003e, ppm), multiplicity (s\u0026thinsp;=\u0026thinsp;singlet, d\u0026thinsp;=\u0026thinsp;doublet, t\u0026thinsp;=\u0026thinsp;triplet, m\u0026thinsp;=\u0026thinsp;multiplet or unresolved, br\u0026thinsp;=\u0026thinsp;broad singlet, coupling constant (\u003cem\u003eJ\u003c/em\u003e) in Hz, integration). Data for \u003csup\u003e13\u003c/sup\u003eC and \u003csup\u003e19\u003c/sup\u003eF NMR are reported in terms of chemical shift (\u003cem\u003eδ\u003c/em\u003e, ppm). Liquid chromatography (LC) analysis was performed on an Agilent 1200 Infinity II LC system. High resolution mass spectrometer analysis (HRMS) was performed on Waters Q-TOF Premier (ESI) mass spectrometers. Melting point (m.p.): melting points were measured on a Beijing Tech Instrument X-4 digital display micro melting point apparatus and are uncorrected. Visible light luminescence intensities were recorded using Shimadzu UV-2600i UV-Vis spectrofluorometer. Cyclic voltammograms were recorded using a CHI 660E potentiostat and a Pt working electrode, a Ag/AgCl reference electrode and a Pt sheet auxiliary electrode.\u003c/p\u003e \u003c/div\u003e\n\u003ch3\u003eGeneral procedure for amination of arenes\u003c/h3\u003e\n\u003cp\u003eTo a dry Schlenk tube equipped with a magnetic stir bar was added \u003cem\u003eN-\u003c/em\u003ehydroxyphthalimide (\u003cb\u003eB\u003c/b\u003e) (0.2 mmol, 1 equiv.), B(C\u003csub\u003e6\u003c/sub\u003eF\u003csub\u003e5\u003c/sub\u003e)\u003csub\u003e3\u003c/sub\u003e (20.4 mg, 0.04 mmol, 20 mol%), [Ir(dF(CF\u003csub\u003e3\u003c/sub\u003e)ppy)\u003csub\u003e2\u003c/sub\u003edtbbpy]PF\u003csub\u003e6\u003c/sub\u003e (4.4 mg, 0.004 mmol, 2 mol%) and NaHCO\u003csub\u003e3\u003c/sub\u003e (3.4 mg, 0.04 mmol, 20 mol%) and the Schlenk tube was evacuated and backfilled with Ar (three times). After the addition of a solution of CHCl\u003csub\u003e3\u003c/sub\u003e (10 mL, 0.02 M) containing alkylarene (\u003cb\u003eA\u003c/b\u003e) (1.0 mmol, 5 equiv.) by syringe under Ar, the Schlenk tube was positioned approximately 5 cm away from a 25 W blue LEDs lamp. Then the reaction mixture was stirred at the corresponding temperature for 72 h. After completion, the reaction mixture was concentrated to dryness and the residue was purified by flash column chromatography to afford the products.\u003c/p\u003e\n\u003ch3\u003eSynthesis of methyl 3-amino-4-methylbenzoate (93)\u003c/h3\u003e\n\u003cp\u003e \u003cdiv class=\"BlockQuote\"\u003e \u003cp\u003eTo a dry Schlenk tube equipped with a magnetic stir bar was added NHPI (32.6 mg, 0.2 mmol, 1 equiv.), B(C\u003csub\u003e6\u003c/sub\u003eF\u003csub\u003e5\u003c/sub\u003e)\u003csub\u003e3\u003c/sub\u003e (20.4 mg, 0.04 mmol, 20 mol%), [Ir(dF(CF\u003csub\u003e3\u003c/sub\u003e)ppy)\u003csub\u003e2\u003c/sub\u003edtbbpy]PF\u003csub\u003e6\u003c/sub\u003e (4.4 mg, 0.004 mmol, 2 mol%) and NaHCO\u003csub\u003e3\u003c/sub\u003e (3.4 mg, 0.04 mmol, 20 mol%) and the Schlenk tube was evacuated and backfilled with Ar (three times). After addition of a solution of CHCl\u003csub\u003e3\u003c/sub\u003e (10 mL, 0.02 M) containing 4-methylbenzoate (150.2 mg, 1 mmol, 5 equiv.) by syringe under Ar, the Schlenk tube was positioned approximately 5 cm away from a 25 W blue LEDs lamp. Then the reaction mixture was stirred at the corresponding temperature for 72 h. Subsequently, a solution of ethanol (10 mL) containing hydrazine monohydrate (98%, 0.1 mL, 2 mmol, 10 equiv.) was added to the reaction by syringe. After stirring at room temperature for 6 h, the resulting suspension was filtered through a short pad of silica with diethyl ether. The filtrate was washed with 2 M NaOH aqueous solution, dried over anhydrous magnesium sulfate, filtered and concentrated carefully under reduced pressure to afford the crude mixture which was purified by flash column chromatography (silica gel, hexane/ethyl acetate\u0026thinsp;=\u0026thinsp;5:1) to furnished methyl 3-amino-4-methylbenzoate (\u003cb\u003e93\u003c/b\u003e) as a white solid (17.5 mg, 53%).\u003c/p\u003e \u003c/div\u003e \u003c/p\u003e "},{"header":"Declarations","content":"\u003cdiv id=\"Sec11\" class=\"Section2\"\u003e \u003ch2\u003eData availability\u003c/h2\u003e \u003cp\u003eThe authors declare that all data supporting the findings of this study are available in the paper and its Supplementary Information files.\u003c/p\u003e \u003c/div\u003e\n\u003ch2\u003eAuthor contributions\u003c/h2\u003e \u003cp\u003eZ. Pan, Y. Ma \u0026amp; L. Wang conceived and designed the experiments. Z. Pan, H. Qiu \u0026amp; R. Zheng performed the experiments and analyzed the data. Z. Pan \u0026amp; Y. Ma wrote the manuscript.\u003c/p\u003e\u003ch2\u003eAcknowledgements\u003c/h2\u003e \u003cp\u003eThis research was financially supported by the National Nat-ural Science Foundation of China (22071171), the Natural Science Foundation of Zhejiang Province (LZ22B020003) and the initiation grant from Taizhou University.\u003c/p\u003e"},{"header":"References","content":"\u003col\u003e\u003cli\u003e\u003cspan\u003eAllen LJ, Cabrera PJ, Lee M, Sanford MS (2014) \u003cem\u003eN\u003c/em\u003e-Acyloxyphthalimides as nitrogen radical precursors in the visible light photocatalyzed room temperature C\u0026thinsp;\u0026ndash;\u0026thinsp;H amination of arenes and heteroarenes. J Am Chem Soc 136:5607\u0026ndash;5610\u003c/span\u003e\u003c/li\u003e \u003cli\u003e\u003cspan\u003eCecere G, K\u0026ouml;nig CM, Alleva JL, MacMillan DW (2013) C. 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Wiley-VCH, Weinheim\u003c/span\u003e\u003c/li\u003e \u003cli\u003e\u003cspan\u003eKahl T et al (2000) Ullmann\u0026rsquo;s encyclopedia of industrial chemistry. Wiley-VCH, New York\u003c/span\u003e\u003c/li\u003e \u003cli\u003e\u003cspan\u003eRuiz-Castillo P, Buchwald SL (2016) Applications of palladium-catalyzed C\u0026ndash;N cross-coupling reactions. Chem Rev 116:12564\u0026ndash;12649\u003c/span\u003e\u003c/li\u003e \u003cli\u003e\u003cspan\u003eWest MJ et al (2019) Mechanistic development and recent applications of the Chan\u0026ndash;Lam amination. Chem Rev 119:12491\u0026ndash;12523\u003c/span\u003e\u003c/li\u003e \u003cli\u003e\u003cspan\u003eCuypers T, Tomkins P, De Vos DE (2018) Direct liquid-phase phenol-to-aniline amination using Pd/C. Catal Sci Technol 8:2519\u0026ndash;2523\u003c/span\u003e\u003c/li\u003e \u003cli\u003e\u003cspan\u003eIchitsuka T et al (2020) Continuous synthesis of aryl amines from phenols utilizing integrated packed-bed flow systems. 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Angew Chem Int Ed 61:e202115334\u003c/span\u003e\u003c/li\u003e\u003c/ol\u003e"}],"fulltextSource":"","fullText":"","funders":[],"hasAdminPriorityOnWorkflow":false,"hasManuscriptDocX":true,"hasOptedInToPreprint":true,"hasPassedJournalQc":"","hasAnyPriority":true,"hideJournal":false,"highlight":"","institution":"","isAcceptedByJournal":true,"isAuthorSuppliedPdf":false,"isDeskRejected":"","isHiddenFromSearch":false,"isInQc":false,"isInWorkflow":false,"isPdf":false,"isPdfUpToDate":true,"isWithdrawnOrRetracted":false,"journal":{"display":true,"email":"[email protected]","identity":"nature-portfolio","isNatureJournal":true,"hasQc":false,"allowDirectSubmit":false,"externalIdentity":"","sideBox":"","snPcode":"","submissionUrl":"","title":"Nature Portfolio","twitterHandle":"","acdcEnabled":false,"dfaEnabled":false,"editorialSystem":"ejp","reportingPortfolio":"","inReviewEnabled":true,"inReviewRevisionsEnabled":false},"keywords":"","lastPublishedDoi":"10.21203/rs.3.rs-6311401/v1","lastPublishedDoiUrl":"https://doi.org/10.21203/rs.3.rs-6311401/v1","license":{"name":"CC BY 4.0","url":"https://creativecommons.org/licenses/by/4.0/"},"manuscriptAbstract":"\u003cp\u003eThe catalytic deoxygenation of N\u0026thinsp;\u0026minus;\u0026thinsp;OH bonds to generate N-centered radicals remains a significant challenge due to the high bond dissociation energy and reliance on stoichiometric auxiliaries or activators. Herein, we report a B(C\u003csub\u003e6\u003c/sub\u003eF\u003csub\u003e5\u003c/sub\u003e)\u003csub\u003e3\u003c/sub\u003e-catalyzed photoinduced deoxygenation strategy that enables direct aromatic C(sp\u0026sup2;)\u0026thinsp;\u0026minus;\u0026thinsp;H amination of alkylarenes using \u003cem\u003eN\u003c/em\u003e-hydroxyphthalimides (NHPIs) as nitrogen sources. Mechanistic studies reveal that the \u003cem\u003ein situ\u003c/em\u003e formation of a PhthN\u0026thinsp;\u0026minus;\u0026thinsp;O\u0026minus;B(C\u003csub\u003e6\u003c/sub\u003eF\u003csub\u003e5\u003c/sub\u003e)\u003csub\u003e3\u003c/sub\u003e anion intermediate facilitates an unusual energy transfer (EnT)-mediated N\u0026thinsp;\u0026minus;\u0026thinsp;O bond homolysis, generating a phthalimidyl radical (PhthN\u0026bull;) while regenerating the borane catalyst. This method overrides the conventional preference for benzylic C\u0026thinsp;\u0026minus;\u0026thinsp;H oxidation, achieving exclusive aromatic C\u0026thinsp;\u0026minus;\u0026thinsp;H amination with broad substrate scope, including electron-rich/poor alkylarenes, heteroarenes, and biomolecules. The catalytic protocol operates under mild conditions, avoids stoichiometric organic auxiliaries/activators, and produces H₂O as the sole byproduct, thus, making it a promising option to supplant existing strategies for arene amination. Applications in late-stage functionalization of pharmaceuticals and the synthesis of a nilotinib precursor highlight its synthetic utility. This study establishes B(C\u003csub\u003e6\u003c/sub\u003eF\u003csub\u003e5\u003c/sub\u003e)\u003csub\u003e3\u003c/sub\u003e as a versatile catalytic oxygen atom transfer (OAT) reagent in photochemistry, opening avenues for sustainable radical generation.\u003c/p\u003e","manuscriptTitle":"Catalytic photoinduced deoxygenation via B(C6F5)3-enabled OAT for aromatic C−H amination of alkylarenes","msid":"","msnumber":"","nonDraftVersions":[{"code":1,"date":"2025-04-07 04:36:47","doi":"10.21203/rs.3.rs-6311401/v1","editorialEvents":[],"status":"published","journal":{"display":true,"email":"[email protected]","identity":"nature-communications","isNatureJournal":true,"hasQc":false,"allowDirectSubmit":false,"externalIdentity":"NCOMMS","sideBox":"Learn more about [Nature Communications](http://www.nature.com/ncomms/)","snPcode":"","submissionUrl":"https://mts-ncomms.nature.com/","title":"Nature Communications","twitterHandle":"","acdcEnabled":true,"dfaEnabled":true,"editorialSystem":"ejp","reportingPortfolio":"Nature Communications","inReviewEnabled":true,"inReviewRevisionsEnabled":false}}],"origin":"","ownerIdentity":"069e4d03-cf67-4d51-abfc-bdf72591ff43","owner":[],"postedDate":"April 7th, 2025","published":true,"recentEditorialEvents":[],"rejectedJournal":[],"revision":"","amendment":"","status":"published-in-journal","subjectAreas":[{"id":46756276,"name":"Physical sciences/Chemistry/Photochemistry/Photocatalysis"},{"id":46756277,"name":"Physical sciences/Chemistry/Organic chemistry/Synthetic chemistry methodology"}],"tags":[],"updatedAt":"2025-12-30T08:18:18+00:00","versionOfRecord":{"articleIdentity":"rs-6311401","link":"https://doi.org/10.1038/s41467-025-66712-w","journal":{"identity":"nature-communications","isVorOnly":false,"title":"Nature Communications"},"publishedOn":"2025-11-27 05:00:00","publishedOnDateReadable":"November 27th, 2025"},"versionCreatedAt":"2025-04-07 04:36:47","video":"","vorDoi":"10.1038/s41467-025-66712-w","vorDoiUrl":"https://doi.org/10.1038/s41467-025-66712-w","workflowStages":[]},"version":"v1","identity":"rs-6311401","journalConfig":"researchsquare"},"__N_SSP":true},"page":"/article/[identity]/[[...version]]","query":{"redirect":"/article/rs-6311401","identity":"rs-6311401","version":["v1"]},"buildId":"8U1c8b4HqxoKbykW_rLl7","isFallback":false,"isExperimentalCompile":false,"dynamicIds":[84888],"gssp":true,"scriptLoader":[]}