Digital microfluidic system and method based on double half-moon serrated electrodes

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This paper introduces a digital microfluidic system with novel double half-moon serrated electrodes that enhance droplet drive capability and enable omnidirectional motion, achieving average velocities up to 2.57 mm/s.

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This preprint describes the design and fabrication of a PCB-based digital microfluidic platform intended to reduce drive voltage and manufacturing costs while improving droplet actuation, using a proposed double half-moon serrated electrode geometry. The authors created three variants of this electrode with different scaling parameters and experimentally tested droplet motion, reporting that the scaling relation A=1 produced the best performance, including transverse droplet velocities of 1.18 mm/s at 120 V and 2.57 mm/s at 200 V, and longitudinal velocities of 0.98 mm/s at 120 V and 1.88 mm/s at 200 V, outperforming rectangular and sawtooth electrode designs. A key limitation is that the work is presented as an unreviewed preprint without additional caveats beyond its status. The paper does not explicitly discuss endometriosis or adenomyosis; it was included in the corpus via a keyword match in the upstream search index.

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Abstract

Abstract With the advancement and widespread adoption of digital microfluidic technology, this paper designs and fabricates a PCB-based digital microfluidic system to reduce the drive voltage and manufacturing costs of digital microfluidic chips while efficiently enhancing droplet drive capability. This system integrates with other peripherals to establish a digital microfluidic platform. A new electrode shape, a double half-moon serrated electrode, is proposed, which is capable of providing a large droplet driving force, and at the same time has the ability to freely switch the direction of droplet motion in all directions by conveniently combining and arranging them. Three kinds of double half-moon sawtooth electrodes with different scaling parameters were designed and experimentally verified to drive the droplets, and the results showed that the scaling relation A=1 was more effective, and the average velocity of the droplets in the transverse direction at 120 V was 1.18 mm/s, and the average velocity at 200 V was 2.57 mm/s, while in the longitudinal direction, the average velocity at 120 V was 0.98 mm/s and in the longitudinal direction, the average velocity at 200V is 1.88mm/s. The experimental data illustrate that the digital microfluidic electrode designed in this paper can effectively enhance the driving ability of the droplet compared with the electrodes such as rectangular electrode and sawtooth electrode.
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Digital microfluidic system and method based on double half-moon serrated electrodes | Research Square window.SnipcartSettings = { analytics: { enabled: false } }; (function() { var accessVector = localStorage.getItem('access_vector') || ''; window.dataLayer = window.dataLayer || []; if (accessVector) { window.dataLayer.push({ user: { profile: { profileInfo: { snid: accessVector } } } }); } })(); (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-K279D39R'); Browse Preprints In Review Journals COVID-19 Preprints AJE Video Bytes Research Tools Research Promotion AJE Professional Editing AJE Rubriq About Preprint Platform In Review Editorial Policies Our Team Advisory Board Help Center Sign In Submit a Preprint Cite Share Download PDF Research Article Digital microfluidic system and method based on double half-moon serrated electrodes Xijun Huang, Xuxiong Zhong, Huijin Chen, Chuanpei Xu, Binwen Xu, and 1 more This is a preprint; it has not been peer reviewed by a journal. https://doi.org/ 10.21203/rs.3.rs-7599175/v1 This work is licensed under a CC BY 4.0 License Status: Posted Version 1 posted You are reading this latest preprint version Abstract With the advancement and widespread adoption of digital microfluidic technology, this paper designs and fabricates a PCB-based digital microfluidic system to reduce the drive voltage and manufacturing costs of digital microfluidic chips while efficiently enhancing droplet drive capability. This system integrates with other peripherals to establish a digital microfluidic platform. A new electrode shape, a double half-moon serrated electrode, is proposed, which is capable of providing a large droplet driving force, and at the same time has the ability to freely switch the direction of droplet motion in all directions by conveniently combining and arranging them. Three kinds of double half-moon sawtooth electrodes with different scaling parameters were designed and experimentally verified to drive the droplets, and the results showed that the scaling relation A=1 was more effective, and the average velocity of the droplets in the transverse direction at 120 V was 1.18 mm/s, and the average velocity at 200 V was 2.57 mm/s, while in the longitudinal direction, the average velocity at 120 V was 0.98 mm/s and in the longitudinal direction, the average velocity at 200V is 1.88mm/s. The experimental data illustrate that the digital microfluidic electrode designed in this paper can effectively enhance the driving ability of the droplet compared with the electrodes such as rectangular electrode and sawtooth electrode. Full Text Additional Declarations No competing interests reported. Cite Share Download PDF Status: Posted Version 1 posted You are reading this latest preprint version Research Square lets you share your work early, gain feedback from the community, and start making changes to your manuscript prior to peer review in a journal. As a division of Research Square Company, we’re committed to making research communication faster, fairer, and more useful. We do this by developing innovative software and high quality services for the global research community. Our growing team is made up of researchers and industry professionals working together to solve the most critical problems facing scientific publishing. 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