Prognostic evaluation based on dual time 18F-FDG PET/CT radiomics features in patients with locally advanced pancreatic cancer treated by Stereotactic Body Radiation Therapy

Abstract Background: 18F-FDG PET/CT is widely used in the prognosis evaluation of tumor patients. The radiomics features can provide additional information for clinical prognostic assessment. Purpose: To explore the prognostic value of radiomics features from dual time 18 F-FDG PET/CT images for locally advanced pancreatic cancer (LAPC) patients treated with stereotactic body radiation therapy (SBRT). Materials and Methods: This retrospective study included 70 LAPC patients who received early and delayed 18 F-FDG PET/CT scans before SBRT treatment. A total of 1188 quantitative imaging features were extracted from dual time PET/CT images. To avoid over-fitting, the univariate analysis and elastic net were used to obtain a sparse set of image features, that were applied to develop a radiomics score (Rad-score). Then the Harrell consistency index (C-index) was used to evaluate the prognosis model. Results: The Rad-score from dual time images contains six features, including intensity histogram, morphological, and texture features. In the validation cohort, the univariate analysis showed that the Rad-score was the independent prognostic factor (p<0.001, hazard ratio [HR]: 3.2). And in the multivariate analysis, the Rad-score was the only prognostic factor (p < 0.01, HR: 4.1) that was significantly associated with the OS of patients. In addition, according to cross-validation, the C-index of the prognosis model based on the Rad-score from dual-time images is better than the early and delay images (0.720 vs 0.683 vs 0.583). Conclusion: The Rad-score based on dual-time 18F-FDG PET/CT images is a promising non-invasive method with better prognostic value.