MAPK signaling pathway and endometriosis: what is the link?
This paper reviews potential links between the MAPK signaling pathway, including its components like p38MAP kinase and Ras/Raf/MAPK, and the pathophysiology of endometriosis.
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This short commentary/editorial discusses the evidence linking mitogen-activated protein kinase (MAPK) signaling to endometriosis, drawing on prior studies of MAPK-related mechanisms such as aberrant activation of Ras/Raf/MAPK and roles for MAPKs in cellular proliferation and survival. It highlights reported associations between MAPK pathway activity and endometriotic biology, while also noting that the field includes mechanistic insights derived largely from referenced experimental work rather than presenting new primary data. A limitation is that the article provides a synthesis of existing literature without detailing original methods or new experimental results. This paper is centrally about endometriosis — it specifically addresses the proposed mechanistic link between MAPK signaling pathway activity and endometriosis.
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- europepmc
- last seen: 2026-06-20T06:14:18.781669+00:00
- pubmed
- last seen: 2026-05-13T22:15:58.344756+00:00
- unpaywall
- last seen: 2026-05-14T19:30:52.867331+00:00
Courtesy of the U.S. National Library of Medicine