MAPK signaling pathway and endometriosis: what is the link?

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This paper reviews potential links between the MAPK signaling pathway, including its components like p38MAP kinase and Ras/Raf/MAPK, and the pathophysiology of endometriosis.

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This short commentary/editorial discusses the evidence linking mitogen-activated protein kinase (MAPK) signaling to endometriosis, drawing on prior studies of MAPK-related mechanisms such as aberrant activation of Ras/Raf/MAPK and roles for MAPKs in cellular proliferation and survival. It highlights reported associations between MAPK pathway activity and endometriotic biology, while also noting that the field includes mechanistic insights derived largely from referenced experimental work rather than presenting new primary data. A limitation is that the article provides a synthesis of existing literature without detailing original methods or new experimental results. This paper is centrally about endometriosis — it specifically addresses the proposed mechanistic link between MAPK signaling pathway activity and endometriosis.

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References Watanabe A, Taniguchi F, Izawa M, Suou K et al (2009) The role of survivin in the resistance of endometriotic stromal cells to drug-induced apoptosis. Hum Reprod 24(12):3172–3179 Hapangama DK, Turner MA, Drury JA, Quenby S, Saretzki G, Martin-Ruiz C et al (2008) Endometriosis is associated with aberrant endometrial expression of telomerase and increased telomere length. Hum Reprod 23:1511–1519 Maida Y, Kyo S, Kanaya T, Wang Z, Yatabe N, Tanaka M et al (2002) Direct activation of telomerase by EGF through Ets-mediated transactivation of TERT via MAP kinase signaling pathway. Oncogene 21:4071–4079 Zhihong AI, Yin L, Zhou X, Zhu Y et al (2006) Inhibition of survivin reduces cell proliferation and induces apoptosis in human endometrial cancer. Cancer 107:746–756 Zhou WD, Chen QH, Chen QX (2010) The action of p38MAP Kinase and its inhibitors on endometriosis. Yao Xue Xue Bao 45:548–554 Yoshino O, Osuga Y, Hirota Y, Koga K et al (2004) Possible pathophysiological roles of miogeno-activated protein kinases (MAPKs) in endometriosis. Am J Reprod Immunol 52:306–311 Yotova IY, Quan P, Leditzing N, Beer U et al (2011) Abnormal activation of Ras/Raf/MAPK and RhoA/ROCKII signaling pathways in eutopic endometrial stromal cells of patients with endometriosis. Hum Reprod 26:885–897 Ji Ru-Rong (2009) Gereau RW, Malcangio M, Strichartz GR. MAP kinase and pain. Brain Res Rev 60:135–148 Conflict of interest The authors declare there is no conflict of interest. Author information Authors and Affiliations Corresponding author Rights and permissions About this article Cite this article Mormile, R., Vittori, G. MAPK signaling pathway and endometriosis: what is the link?. Arch Gynecol Obstet 287, 837–838 (2013). https://doi.org/10.1007/s00404-012-2587-9 Received: Accepted: Published: Issue date: DOI: https://doi.org/10.1007/s00404-012-2587-9

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Condition tags

endometriosis

MeSH descriptors

Apoptosis Endometriosis MAP Kinase Signaling System Endometriosis Female Humans Inhibitor of Apoptosis Proteins Inhibitor of Apoptosis Proteins Survivin Telomerase Telomerase

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europepmc
last seen: 2026-06-20T06:14:18.781669+00:00
pubmed
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