PHYSICAL EXERCISE RESTORES NEUROCOGNITIVE HOMEOSTASIS DISRUPTED BY NON-SEVERE MURINE MALARIA

2025 · doi:10.1101/2025.01.08.631885
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Abstract Malaria disrupts neurocognitive homeostasis in humans, including in the non-severe manifestation of the disease - which is the most prevalent form of malaria in the world. This disruption is classically observed in human and experimental models of cerebral malaria. More recently, we demonstrated that this can also be observed in an experimental model of non-severe malaria and that Th2-immune response improves cognition and attenuates anxiety-like behavior associated to malaria. Complementarily, we have been studying the effect of physical exercise in restoring the neurocognitive homeostasis lost after non-severe murine malaria. Competing Interest Statement The authors have declared no competing interest. Footnotes IdOL - ingrid.lavigne{at}ioc.fiocruz.br, MdSO - monica.nogueira{at}ioc.fiocruz.br, CTDR- malaria{at}fiocruz.br

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