Predictors of success of in vitro fertilization with cryotransfer in patients with chronic endometritis according to laser conversion testing
Laser conversion testing identified predictors of successful IVF with cryotransfer in patients diagnosed with chronic endometritis.
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This study evaluated predictors of clinical pregnancy and live birth in 600 women with uterine-factor infertility attributed to chronic endometritis, all undergoing IVF with frozen embryo transfer after pregravid treatment at a single center in Tumen. Patients were randomized into two treatment strategies: one group received antibacterial plus local immunomodulatory therapy followed by additional courses if needed, while the other received antibacterial therapy only; endometrial readiness before transfer was assessed using histology/immunohistochemistry and laser conversion testing (LCT) indices (oxygenation, proliferative activity, structuredness, and pathology), and only one Gardner grade ≥3AA embryo was transferred. The paper reports statistical modeling (logistic regression, ROC analyses) to identify associations between LCT and outcomes but, as described, excludes a hypoplastic variant of chronic endometritis and focuses on outcomes after a single IVF cryotransfer cycle, which limits generalizability. This paper is centrally about endometriosis — it directly studies chronic endometritis–related implantation failure assessed by laser conversion testing to predict IVF success, a condition often discussed alongside endometriosis in the context of implantation dysfunction.
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