THE IMPORTANCE OF SERUM DECORIN LEVELS IN EARLY DIAGNOSIS OF PPROM IN SECOND AND THIRD TRIMESTER PREGNANCIES

OBJECTIVE: To investigate whether there is a relationship with serum decorin levels in second and third trimester pregnant women with PPROM. DESIGN: After this study was approved by the Clinical Research Ethics Committee of Sisli Hamidiye Etfal Training and Research Hospital all subjects included in the study signed informed consent forms that they agreed to participate in the study. SETTING: We collected all biochemical and demograpfic characteristics of patients. Decorin levels of plasma samples were measured using the Human Decorin Elisa Kit. POPULATION: 35 patients who were diagnosed with PPROM from the outpatient clinic with the complaint of sudden gush of amniotic fluid and 35 patients without any obstetric problem were included in our study. METHODS: This study is a prospective controlled study. All statistical analyzes were performed using IBM SPSS 26.0 statistical package program and Microsoft Excel V 2019. MAIN OUTCOME MEASURES: The mean plasma decorin level was 14.7 ng/ml in the PPROM group and it was not found to be statistically significantly lower than the control group with the mean plasma decorin level of 17.5 ng/ml (p=0.339). RESULTS: A significant correlation was found between plasma decorin levels and BMI in both groups (p<0.05). In the PPROM group, no significant correlation was found between the latent time from sampling to delivery of the pregnant woman (p=0.153). CONCLUSIONS: We concluded that the approach to diagnose or predict PPROM by determining the serum decorin levels that we aimed in our study is not currently possible.