Exploring the anti-convulsant potential of cordia dichotoma leaf extract to combat seizures in swiss albino mice

Exploring the anti-convulsant potential of cordia dichotoma leaf extract to combat seizures in swiss albino mice | Research Square window.SnipcartSettings = { analytics: { enabled: false } }; (function() { var accessVector = localStorage.getItem('access_vector') || ''; window.dataLayer = window.dataLayer || []; if (accessVector) { window.dataLayer.push({ user: { profile: { profileInfo: { snid: accessVector } } } }); } })(); (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-K279D39R'); Browse Preprints In Review Journals COVID-19 Preprints AJE Video Bytes Research Tools Research Promotion AJE Professional Editing AJE Rubriq About Preprint Platform In Review Editorial Policies Our Team Advisory Board Help Center Sign In Submit a Preprint Cite Share Download PDF Research Article Exploring the anti-convulsant potential of cordia dichotoma leaf extract to combat seizures in swiss albino mice Renu Das, umesh kumar This is a preprint; it has not been peer reviewed by a journal. https://doi.org/ 10.21203/rs.3.rs-8395823/v1 This work is licensed under a CC BY 4.0 License Status: Posted Version 1 posted You are reading this latest preprint version Abstract Many neuropsychiatric and neurodegenerative disorders, such as Alzheimer’s disease, anxiety, cerebrovascular impairment, depression, seizures, and Parkinson’s disease, are increasingly prevalent in the modern era, largely due to stressful lifestyles. Prolonged treatment of these disorders with synthetic drugs often leads to severe side effects. In recent years, scientific research has shifted focus toward phytochemical for the treatment of neurological disorders. Nootropic herbs refer to plants or plant parts that exert medicinal effects through their neuroprotective properties, attributed to active phytochemical such as alkaloids, steroids, terpenoids, saponins, phenolic, and flavonoids. These phytocompounds play a crucial role in maintaining the brain's chemical balance by modulating the function of receptors for major inhibitory neurotransmitters. In the present study, it was clearly demonstrated that Cordia dichotoma possesses antiepileptic activity, fulfilling the first objective of this investigation. It is well-known that herbal medicines generally have fewer side effects and lower risk of resistance. The plants used in this study are no exception, as toxicity studies revealed that Cordia dichotoma is relatively safe (LD50 of 19.7 g/kg, with no animal deaths observed even at a dose of 500 mg/kg). Thus, this study encourages further exploration of Ayurveda’s untapped potential in treating epilepsy, as many plants remain unevaluated and may exhibit antiepileptic properties, which addresses the second objective of the research. Clinical Pharmacology Alzheimer’s disease Cordia dichotoma phytocompounds neurodegenerative disorders Full Text Additional Declarations The authors declare no competing interests. Cite Share Download PDF Status: Posted Version 1 posted You are reading this latest preprint version Research Square lets you share your work early, gain feedback from the community, and start making changes to your manuscript prior to peer review in a journal. As a division of Research Square Company, we’re committed to making research communication faster, fairer, and more useful. We do this by developing innovative software and high quality services for the global research community. Our growing team is made up of researchers and industry professionals working together to solve the most critical problems facing scientific publishing. Also discoverable on Platform About Our Team In Review Editorial Policies Advisory Board Help Center Resources Author Services Accessibility API Access RSS feed Manage Cookie Preferences © Research Square 2026 | ISSN 2693-5015 (online) Privacy Policy Terms of Service Do Not Sell My Personal Information {"props":{"pageProps":{"initialData":{"identity":"rs-8395823","acceptedTermsAndConditions":true,"allowDirectSubmit":true,"archivedVersions":[],"articleType":"Research Article","associatedPublications":[],"authors":[{"id":562407055,"identity":"819685b6-8681-4182-8511-e594fdaaabe6","order_by":0,"name":"Renu 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college,bilaspur,c.g.","isAcceptedByJournal":false,"isAuthorSuppliedPdf":true,"isDeskRejected":"","isHiddenFromSearch":false,"isInQc":false,"isInWorkflow":true,"isPdf":true,"isPdfUpToDate":true,"isWithdrawnOrRetracted":false,"journal":{"display":true,"email":"[email protected]","identity":"researchsquare","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":true,"externalIdentity":"","sideBox":"","snPcode":"","submissionUrl":"/submission","title":"Research Square","twitterHandle":"researchsquare","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"","reportingPortfolio":"","inReviewEnabled":false,"inReviewRevisionsEnabled":true},"keywords":"Alzheimer’s disease, Cordia dichotoma, phytocompounds, neurodegenerative disorders","lastPublishedDoi":"10.21203/rs.3.rs-8395823/v1","lastPublishedDoiUrl":"https://doi.org/10.21203/rs.3.rs-8395823/v1","license":{"name":"CC BY 4.0","url":"https://creativecommons.org/licenses/by/4.0/"},"manuscriptAbstract":"\u003cp\u003eMany neuropsychiatric and neurodegenerative disorders, such as Alzheimer\u0026rsquo;s disease, anxiety, cerebrovascular impairment, depression, seizures, and Parkinson\u0026rsquo;s disease, are increasingly prevalent in the modern era, largely due to stressful lifestyles. Prolonged treatment of these disorders with synthetic drugs often leads to severe side effects. In recent years, scientific research has shifted focus toward phytochemical for the treatment of neurological disorders. Nootropic herbs refer to plants or plant parts that exert medicinal effects through their neuroprotective properties, attributed to active phytochemical such as alkaloids, steroids, terpenoids, saponins, phenolic, and flavonoids. These phytocompounds play a crucial role in maintaining the brain's chemical balance by modulating the function of receptors for major inhibitory neurotransmitters. In the present study, it was clearly demonstrated that Cordia dichotoma possesses antiepileptic activity, fulfilling the first objective of this investigation. It is well-known that herbal medicines generally have fewer side effects and lower risk of resistance. The plants used in this study are no exception, as toxicity studies revealed that Cordia dichotoma is relatively safe (LD50 of 19.7 g/kg, with no animal deaths observed even at a dose of 500 mg/kg). Thus, this study encourages further exploration of Ayurveda\u0026rsquo;s untapped potential in treating epilepsy, as many plants remain unevaluated and may exhibit antiepileptic properties, which addresses the second objective of the research.\u003c/p\u003e","manuscriptTitle":"Exploring the anti-convulsant potential of cordia dichotoma leaf extract to combat seizures in swiss albino mice","msid":"","msnumber":"","nonDraftVersions":[{"code":1,"date":"2025-12-19 13:20:37","doi":"10.21203/rs.3.rs-8395823/v1","editorialEvents":[{"type":"communityComments","content":0}],"status":"published","journal":{"display":true,"email":"[email protected]","identity":"researchsquare","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":true,"externalIdentity":"","sideBox":"","snPcode":"","submissionUrl":"/submission","title":"Research Square","twitterHandle":"researchsquare","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"","reportingPortfolio":"","inReviewEnabled":false,"inReviewRevisionsEnabled":true}}],"origin":"","ownerIdentity":"e6daf34a-02c0-4367-811e-10c93dc416a4","owner":[],"postedDate":"December 19th, 2025","published":true,"recentEditorialEvents":[],"rejectedJournal":[],"revision":"","amendment":"","status":"posted","subjectAreas":[{"id":59956769,"name":"Clinical Pharmacology"}],"tags":[],"updatedAt":"2025-12-19T13:20:37+00:00","versionOfRecord":[],"versionCreatedAt":"2025-12-19 13:20:37","video":"","vorDoi":"","vorDoiUrl":"","workflowStages":[]},"version":"v1","identity":"rs-8395823","journalConfig":"researchsquare"},"__N_SSP":true},"page":"/article/[identity]/[[...version]]","query":{"redirect":"/article/rs-8395823","identity":"rs-8395823","version":["v1"]},"buildId":"8U1c8b4HqxoKbykW_rLl7","isFallback":false,"isExperimentalCompile":false,"dynamicIds":[84888],"gssp":true,"scriptLoader":[]}