Effect of gestrinone and mifepristone on the growth of cultured rat and human endometrium

The aim of the present study is to investigate the effect of gestrinone and mifepristone on the growth of rat and human endometrium in vitro. In vitro of rat endometrium was treated with l0-6, 3 × 10-6,1O-5mol / L danazol,3 × 10-8,1O-7,3 × 10-7mol / L gestrinone and l0-6 ,1O-5, 10-4mol / L mifepristone for 96 hours in separate groups. The morphologic features of endometrium were evaluated quantitatively by automatic image analysis system. The results showed that danazol inhibited the growth of endometrium, but no significant inhibition was detected in gestrinone and mifepristone groups. Endometrium of women in culture was treated with 10-9mol / L estradiol, 1O-7mol / L progesterone,3×x 10-6mol/ L danazol,1O-7mol/L gestrinone or l0-5mol / L mifepristone for 96 hours in separate groups.The results showed that estradiol or progesterone stimulated proliferation of endometrium, and these effects can be inhibited by gestrinone or mifepristone.