The impact of C-reactive protein levels on headache frequency. The HUNT Study 2006-2008

The impact of C-reactive protein levels on headache frequency. 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The HUNT Study 2006-2008 Knut Hagen, Lars Jacob Stovner, Kristian Bernhard Nilsen, Espen Saxhaug Kristoffersen, and 1 more This is a preprint; it has not been peer reviewed by a journal. https://doi.org/ 10.21203/rs.2.10500/v2 This work is licensed under a CC BY 4.0 License Status: Published Journal Publication published 26 Sep, 2019 Read the published version in BMC Neurology → Version 2 posted 9 You are reading this latest preprint version Show more versions Abstract Background Increased high sensitivity C- reactive protein (hs-CRP) levels have been found in many earlier studies on migraine, and recently also in persons with migraine and insomnia. The aim of this study was to see whether these findings could be reproduced in a large-scale population-based study. Methods A total of 50,807 (54%) out of 94,194 invited aged ≥ 20 years or older participated in the third wave of the Nord-Trøndelag Health Study study performed in 2006-2008. Among these, 38,807 (41%) had valid measures of hs-CRP and answered questions on headache and insomnia. Elevated hs-CRP was defined as >3.0 mg/L. The cross-sectional association with headache was estimated by multivariate analyses using multiple logistic regression. The precision of the odds ratio (OR) was assessed with 95% confidence interval (CI). Results In the fully adjusted model, elevated hs-CRP was associated with migraine (OR 1.14, 95% CI 1.04-1.25) and migraine with aura (OR 1.15, 95% CI 1.03-1.29). The association was strongest among individuals with headache ≥ 15 days/month for any headache (OR 1.26, 95% CI 1.08-1.48), migraine (OR 1.62, 95% CI 1.21-2.17), and migraine with aura (OR 1.84, 95% CI 1.27-2.67). No clear relationship was found between elevated hs-CRP and headache less than 7 days/month or with insomnia. Conclusions Cross-sectional data from this large-scale population-based study showed that elevated hs-CRP was associated with headache ≥ 7 days/month, especially evident for migraine with aura. Neurology Figures Figure 1 Background During the last decade many studies have evaluated the association between migraine and high sensitivity C-reactive protein (hs-CRP) [1-25]. Several case-control studies [3, 7, 8, 14, 18-22] and some population-based studies [4, 6] have found higher CRP values in migraine patients, but negative results have been reported by others [2, 5, 6, 10, 11, 15, 16, 24]. A summary of recently published studies concluded that migraineurs had higher CRP levels than controls [26]. The association between headache and insomnia is well-established [27], but the impact of insomnia on the relationship between hs-CRP and migraine is unclear. Previously, a prospective study has demonstrated higher level of CRP in individuals with shorter sleep duration [28]. In a recent population-based cross-sectional study from Northern Norway, elevated hs-CRP was associated with migraine, but only among those with co-existing insomnia [29]. However, since the results on hs-CRP and migraine are conflicting, and the relationship to insomnia only reported in one study, it is important to replicate the analyses in other population-based study with similar design. The aim of this large-scale population-based study was to evaluate the cross-sectional association between hs-CRP and types of headache, and to see whether the relationship to insomnia could be reproduced. Methods Study design The present population-based study of a large unselected adult population replicate the methodological design used in the Tromsø Study [29], including similar questionnaire-based diagnoses for headache and insomnia, identical categories of hs-CRP, and replication of the statistical analyses with adjustments for the same type of potential confounders. The Nord-Trøndelag Health Study The total population of the Nord-Trøndelag county aged ≥20 years has been invited four times between 1984 and 2019. All participant answered questionnaires and were invited to interview, clinical examination, and blood sampling [30]. Study population In HUNT3 (2006-2008), a total of 94,194 individuals aged ≥ 20 years were invited, whereof 93,860 were eligible. Of these, 50,807 (54%) accepted the invitation. The diagnoses of headache and insomnia was questionnaire-based. The present study included data from 38,813 participants (41%) (mean age 54.1 years, range 20-97 years) who had answered questions about headache and insomnia and had hs-CRP measured from non-fasting blood samples (Fig. 1). C-reactive protein Hs-CRP was analyzed at the Central Laboratory, Levanger Hospital, using Architect cSystem ci8200, by latex immunoassay method. The detection limit was 0.03 mg/L, and samples without detectable hs-CRP were assigned this value. In the present study we replicated the strategy used in previous published studies from the Tromsø study [29, 31] defining normal hs-CRP as 0-3.00 mg/L and elevated as 3.01-20.00 mg/L. Participants with hs-CRP values >20.00 mg/L, which probably indicate some acute or chronic disease [32], were excluded (n=527) (Fig.1). Blood samples for hs-CRP analyzes were drawn without any knowledge about last headache attack. Headache questionnaire All details of the headache questionnaire have been published elsewhere [33], and all questionnaire-based headache diagnoses were identical to those presented in the Tromsø study [29]. Subjects who answered “no” to the screening question (“Have you suffered from headache during the last 12 months?”) were included in the reference group without headache. Participants who answered “yes” completed 12 additional questions, mainly to diagnose migraine according to the second version of the International Classification of Headache Disorders (ICHD-2) [34]. Regarding attack duration, <4 hours were accepted for those who reported visual disturbance before headache. Participants who fulfilled the migraine diagnosis and reported visual disturbance prior to headache were classified as migraine with aura (MA), whereas the remaining with migraine had migraine without aura (MO). The remaining participants with headache were classified as having “other headache”. The merged group of “any headache” consisted of participants with migraine or other headache. Furthermore, based to answer on the question about headache frequency, subjects were subdivided into five groups; no headache, headache < 1 days/month, headache 1-6 days/month, headache 7-14 days/month, or headache ≥15 days/month. The validity of the questionnaire-based headache diagnoses has been published in a separate paper [39]. The agreement between the validation interview and questionnaire-based headache categories were very good for any headache (kappa value at 0.70, 95 % CI 0.61-0.79) and moderate for migraine (kappa value 0.50, 95 % CI 0.32-0.68), whereas the specificity for MA was high (95 %) (kappa value 0.44, 95 % CI 0.38-0.50) (33). Questionnaire-based diagnosis of insomnia The questionnaire-based diagnosis of insomnia was based on the DSM-V (Diagnostic and Statistical Manual of Mental Disorders, 5th ed.), and was nearly identical to the insomnia diagnosis used in the Tromsø study [29]. To fulfil the proxy diagnosis of insomnia the participants had to answer “several times a week” to at least one out of the three questions, asking whether they had “difficulties falling asleep at night”, whether they “woke up repeatedly during the night”, and/or whether they “woke up too early and could not get back to sleep” [36]. In addition, they also had to report “several times a week” to the question “felt sleepy during day” [36]. The overall agreement between questionnaire and interview for the first three questions has previously been found to be moderate (kappa value 0.51, 95% CI 0.40-0.63) [37]. Potential confounders The selection of potential confounders used in the Tromsø study [29] was based on previous literature [35, 37, 42]. To replicate the Tromsø study [29], we included almost identical potential confounders, with two exceptions: employment status was used instead of education level, and Hospital Anxiety and Depression Scale instead of Hopkins symptom checklist (HSCL-10). The remaining potential confounders were identical; age (continuous variable); gender; body mass index (BMI) (<25, 25.0-29.9, and ≥30 kg/m 2 ) (28, 32); smoking (current, previous, and never); physical activity (never, ≤ 1 time per week, ≥2 times per week); alcohol consumption (never, <2 times/week, ≥2times/week); self-reported diabetes (yes/no); self-reported stroke and/or heart infarction (yes/no); and self-reported hypertension (yes/no). Ethics This study was approved by the Regional Committee for Medical and Health Research Ethics, the Faculty of medicine, mailbox 8905, 7491 Trondheim. The approval number was #2018/2422/Rek Midt. The participants have given written informed consent. Statistical analysis The statistical method was identical to that presented in the Tromsø Study [29] and based on multivariate analyses using multiple logistic regression. The precision of the odds ratio (OR) was assessed with 95% confidence interval (CI). We present results for three different statistical models separated by number of confounders included; model 1 (age and sex), model 2 (age, sex and BMI), and model 3 (all other factors were tested). In model 3 we excluded factors if they did not change OR when evaluating each factor separately or when including several factors grouped together (i.e. self-reported diabetes, stroke/heart infarction, and hypertension). Potential interaction between two variables was evaluated by including the product of the variable in the logistic regression analyses, and the interaction was tested using Wald χ 2 statistics. To evaluate the probability of a linear relationship between elevated hs-CRP and headache frequency, the five categories were treated as a single variable and was incorporated in a two-sided test for trend. Subjects with missing data of confounding factors (numbers reported in Table 1) were included in the analysis to reduce the impact of possible bias. To evaluate insomnia as a modifying factor on the association between hs-CRP and types of headache, we repeated the multi-adjusted analyses in model 3 in those with and without insomnia. Analyses were performed with the IBM SPSS version 25 (SPSS, Chicago, Illinois, USA) Results Subjects with headache were more likely to be women, younger, and to be employed in paid work compared to those without headache (Table 1). Prevalence of headache A total of 13,990 (36.0%) participants suffered from headache during the last year, 3793 (9.8%) fulfilled the criteria of migraine, 2139 (5.5%) had migraine with aura (MA), 1654 (4.3%) migraine without aura (MO), and 10,197 (26.3%) had other headaches. The association between elevated hs-CRP and headache In the multivariate analyses, adjusting for age and sex, elevated hs-CRP was associated with any headache (OR 1.11, 95% CI 1.05-1.17), migraine (OR 1.23, 95% CI 1.13-1.34), MA (OR 1.26, 95% CI 1.13-1.40), MO (OR 1.17, 95% CI 1.03-1.32), and other headache (OR 1.08, 95% CI 1.02-1.14). In the final model 3, adjusting for all potential confounding factors, elevated hs-CRP was still significantly associated with migraine (OR 1.14, 95% CI 1.04-1.25) and MA (OR 1.25, 95% CI 1.03-1.29) (Table 2). In supplementary analyses, using individuals with “other headache “as reference category, elevated hs-CRP was more likely among those with MA (OR 1.17, 95% CI 1.05-1.31), but not MO (OR 1.04, 95% CI 0.92-1.19). No interaction was observed. As to the impact of headache frequency, the strongest association with elevated hs-CRP was found among individuals with headache ≥ 15 days/month for any headache (OR 1.26, 95% CI 1.08-1.48), migraine (OR 1.62, 95% CI 1.21-2.17), and MA (OR 1.84, 95% CI 1.27-2.67) (Table 2). A significant linear trend between increasing headache frequency and elevated hs-CRP was found for any headache (p=0.01), migraine (p=0.01) and MA (p=0.002) (Table 2). No clear relationship was found between elevated hs-CRP and headache less than 7 days/month (Table 2). The influence of insomnia diagnosis As demonstrated by Table 3, the relationship between elevated hs-CRP and headache was only found among subjects without insomnia, whereas no such association was found among those with insomnia. Supplementary analyses considering only those with headache 7-14 days/month and ≥15 days/month did not change the results (data not shown). Discussion Cross-sectional population-based data based on a large number of participants showed that elevated hs-CRP was associated with headache ≥ 7 days/month, most evident for migraine with aura. No relationship was found between elevated hs-CRP and headache less than 7 days/month or with insomnia. In agreement with the present results, a previous study have demonstrated that women with migraine had elevated CRP compared to women without migraine [4]. In a Dutch case-control study, individuals with MA were more likely to have elevated hs-CRP in the unadjusted analyses, and a borderline tendency was found in the multi-adjusted model [24]. In contrast, in a population-based study from Iceland, no difference in CRP levels were found between participants with and without migraine [6]. In the present study, the final multi-adjusted analyses showed that MA, but not MO, was associated with elevated hs-CRP. This is in contrast with a review of previous studies on this topic, where the association to MA was not found to be consistently stronger than to MO [26]. It should be highlighted that an association between hs-CRP and average number of aura attacks and total number of years with aura were reported in the Dutch study [24]. Interpretation In accordance with findings in the Tromsø 7 Study [29], MA was most consistently associated with elevated hs-CRP. It may be of relevance that hs-CRP is associated with risk of cardiovascular events [38], and that ischemic cardiovascular disease has a stronger association to MA than to MO [39]. In this large (n=38,813) population-based study with presumably high statistical power, the association between elevated hs-CRP and headache was evident for those with headache 7-14 days/month and headache more than 14 days/month. Correspondingly, elevated hs-CRP was associated with migraine ≥7 days/month, but not migraine <7 days/month in the Tromsø study (n=20,486) [29]. This relationship with headache frequency and elevated hs-CRP has not been clearly demonstrated in other studies [3, 4, 6, 7, 8, 14, 18-22], possibly because of limited statistical power. The results of the present study may be explained by the finding that hs-CRP is related to general pain sensitivity [31]. Alternatively, our findings may be related to potential sterile inflammation in migraine [26] or other types of headaches, most prominent for those with chronic headache. However, whether sterile inflammation is an important pathological feature in migraine and other headaches is still debated. We evaluated insomnia as a modifying factor on the association between hs-CRP and headache. In contrast to the results from the Tromsø 7 Study [26], no association was found between elevated hs-CRP and headache among those with insomnia. The reason for the contrasting finding is unclear. However, it may be a spurious finding in the Tromsø 7 study. An alternative explanation may be that there are differences between participants with insomnia in the Tromsø 7 study and in the HUNT3 study. It should be highlighted that the Tromsø Study was performed at almost 70 degree north, with midnight sun and winter darkness periods, whereas the HUNT3 study was performed in middle of Norway at 63-65 degrees north where the difference between summer and winter light is less extreme. The definition of insomnia in the Tromsø 7 study was stricter [29] than the one applied in the HUNT3 study [36], demanding symptoms three or more days per week instead of “several”, and with dissatisfaction with sleep quality as mandatory. Despite this, the prevalence of insomnia was higher in Tromsø 7 than in the HUNT3 study (8.1% vs. 6.9%, p<0.001) [29, 36]. The prevalence reported in the present study is lower than other population-based studies in Norway [40], and we cannot exclude that our findings would have been different using another insomnia questionnaire The vast majority (93%) of the participants did not have insomnia, and in accordance with our main results, we found a relationship between elevated hs-CRP and headache also in this group. Strengths and limitations of the study The present study shares several strengths and limitations with the study from Tromsø [29]. The major strengths of this study are the population-based design and the possibility to perform adjustments for all potential confounding factors previously included in the Tromsø study [29]. The large number of included participants give high statistical power and small confidence intervals. The most important study limitation is the low participation rate (41%). Therefore, generalization of results should be performed with caution. It should also be highlighted that the cross-sectional design does not permit any conclusions about causality. Furthermore, it is a limitation that the diagnoses of headache and insomnia were questionnaire-based, which may have led to misclassification. On the other hand, the agreement between questionnaire-based diagnosis of migraine and interview has previously been found to be acceptable [33]. Insomnia was diagnosed by applying modified DSM-V criteria. DSM-V asks for symptoms three times or more per week [35], whereas the response option “several times per week” was used in the present study [36]. Furthermore, some types of daytime impairment are required in the DSM-V criteria [35]. In this respect it should be noted that our question “felt sleepy during the day?” may not have been optimal way to assess actual sleepiness, as it more probably reflects tiredness and fatigue [36]. Conclusions Cross-sectional data based on 38,007 participants showed that elevated hs-CRP was associated with headache ≥ 7 days/month, most evident for migraine with aura. Elevated hs-CRP was not associated with headache less than 7 days/month or with insomnia. Abbreviations Hs-CRP= high sensitivity C-reactive protein; HUNT: The Nord-Trøndelag Health Survey; OR=odds ration; CI=confidence interval; MA=Migraine with aura; MO=Migraine without aura; ICHD-2; The International Classification of Headache Disorders 2 rd edition; BMI=body mass index; DSM-V= Diagnostic and Statistical Manual of Mental Disorders, 5th ed. Declarations Acknowledgements The Nord-Trøndelag Health Study (The HUNT Study) is a collaboration between HUNT Research Centre (Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology NTNU); Trøndelag County Council, Central Norway Regional Health Authority, and the Norwegian Institute of Public Health. Funding Not applicable Competing interest None of the authors have any competing interests in the manuscript. Availability of data and materials: Part of the dataset supporting the conclusions of this article is available on request to the corresponding author. Some of the data are the property of HUNT Research Centre and can only be accessed through direct contact with the research Centre. Authors’ contributions KH: Study concept and design, collection of data, analysis and interpretation of data, writing of manuscript. LJS, KBN, ESK and BSW: Interpretation of data, critical revision of manuscript. All authors read and approved the final manuscript. Ethics approval and consent to participate This study was approved by the Regional Committee for Medical and Health Research Ethics, the Faculty of medicine, mailbox 8905, 7491 Trondheim. The approval number was #2018/2422/Rek Midt. The participants have given written informed consent. 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Tables Table 1 Characteristics of participants (n=38,813) in the HUNT3 Study related to headache types No headache Any headache MA MO Other headaches Participants, n 24,823 13,990 2139 1654 10,197 Women, n (%) 12525 (50.5) 9203 (65.8) 1600 (74.8) 1252 (75.7) 6351 (62.2) Mean age, years (SD) 56.9 (15.7) 49.2 (14.2) 47.0 (12.9) 45.3 (12.6) 50.2 (14.6) Age ≥ 60 years (%) 11280 (45.4) 3264 (23.3) 358 (16.7) 219 (13.2) 2687 (26.4) Employed, n (%) (missing=17) 14450 (58.2 ) 10087 (72.1) 1570 (73.4) 1301 (78.7) 7216 (70.8) Current daily smoking, n (%) (missing=998) 3590 (14.5) 2534 (18.1) 497 (23.2) 277 (16.7) 1760 (17.3) Mean BMI, kg/m 2 (SD) (missing=120) 27.2 (4.2) 27.2 (4.7) 27.3 (4.8) 27.1 (5.0) 27.2 (4.6) Total HADS score (missing=582) 6.7 (5.0) 8.3 (5.9) 9.4 (6.4) 8.2 (5.9) 8.1 (5.8) Alcohol abstainers during last year, n (%) (missing=956) 2215 (8.9) 1105 (7.9) 120 (7.3) 182 (8.5) 803 (7.9) Physical inactivity, n (%) (missing=615) 1231 (5.0) 574 (4.1) 69 (3.2) 63 (3.8) 442 (4.3) Self-reported hypertension, n (%) 6503 (26.2) 2462 (17.6) 359 (16.8) 215 (13.0) 1888 (18.5) Self-reported stroke and/or heart infarction (%) 1771 (7.1) 506 (3.6) 63 (2.9) 33 (2.0) 410 (4.0) Self-reported diabetes mellitus, n (%) 1326 (5.3) 466 (3.3) 60 (2.8) 34 (2.1) 372 (3.6) Modified DSM-V insomnia, n (%) 1057 (4.3) 1631 (11.7) 362 (16.9) 235 (14.2) 1034 (10.1) Mean hs-CRP (95% CI) 2.2 (2.2-2.3) 2.3 (2.2-2.3) 2.4 (2.3-2.5) 2.2 (2.1-2.4) 2.3 (2.2-2.3) MA=migraine with aura; MO=Migraine without aura; HADS=Hospital Anxiety and Depression Scale; BMI=body mass index; hs-CRP=high sensitivity C-reactive protein; CI= Confidence intervals; DSM-V=Diagnostic and statistical manual of mental disorders, 5th ed. Table 2. Odds ratio (OR) with 95% confidence interval (CI) of high sensitivity C-reactive protein (hs-CRP) defined as >3.0-20.0 mg/l related to headache types High hs-CRP Model 1 Model 2 Model 3 Total N OR (95% CI) OR (95% CI) OR (95% CI) No headache 24,823 5179 1.00 1.00 1.00 Any headache 13,990 3029 1.11 (1.05-1.17) 1.07 (1.01-1.13) 1.05 (1.00-1.11) <1 days/month 3176 581 1.02 (0.95-1.11) 0.99 (0.91-1.07) 0.97 (0.90-1.08 ) 1-6 days/month 8099 1761 1.06 (0.99-1.13) 1.01 (0.95-1.08) 0.99 (0.93-1.07) 7-14 days/month 1731 425 1.28 (1.14-1.44) 1.21 (1.08-1.37) 1.15 (1.04-1.30 ) ≥ 15 days/month 984 262 1.40 (1.21-1.62) 1.32 (1.13-1.53) 1.26 (1.08-1.48 ) P trend <0.001 0.001 0.01 Migraine 3793 864 1.23 (1.13-1.34) 1.17 (1.07-1.28) 1.14 (1.04-1.25) < 1 days/month 599 115 0.99 (0.89-1.10) 0.94 (0.84-1.05) 0.92 (0.82-1.02) 1-6 days/month 2340 526 1.19 (1.07-1.31) 1.12 (1.01-1.25) 1.10 (1.00-1.23) 7-14 days/month 625 152 1.36 (1.12-1.64) 1.32 (1.09-1.60) 1.24 (1.02-1.51 ) ≥ 15 days/month 229 71 1.88 (1.42-2.50) 1.72 (1.29-2.31) 1.62 (1.21-2.17 ) P trend <0.001 <0.001 0.01 MA 2139 509 1.26 (1.13-1.40) 1.24 (1.11-1.39) 1.15 (1.03-1.29) < 1 days/month 320 65 1.01 (0.90-1.13) 0.95 (0.85-1.07) 0.93 (0.82-1.04) 1-6 days/month 1290 293 1.19 (1.05-1.35) 1.13 (0.99-1.28) 1.09 (0.96-1.24) 7-14 days/month 391 105 1.56 (1.23-1.96) 1.51 (1.19-1.91) 1.40 (1.11-1.77 ) ≥ 15 days/month 138 46 2.15 (1.50-3.08) 2.01 (1.39-2.90) 1.84 (1.27-2.67 ) P trend <0.001 <0.001 0.002 MO 1654 355 1.17 (1.03-1.32) 1.12 (0.99-1.27) 1.09 (0.96-1.24) < 1 days/month 279 50 0.99 (0.88-1.11) 0.94 (0.84-1.06) 0.92 (0.82-1.04) 1-6 days/month 1050 233 1.18 (1.03-1.35) 1.14 (0.99-1.31) 1.13 (0.98-1.30) 7-14 days/month 234 47 1.10 (0.79-1.52) 1.08 (0.77-1.50) 1.03 (0.74-1.44 ) ≥ 15 days/month 91 25 1.58 (0.99-2.51) 1.42 (0.88-2.28) 1.37 (0.85-2.22 ) P trend 0.01 0.12 0.23 Other headaches 10,197 2165 1.08 (1.02-1.14) 1.04 (0.98-1.11) 1.04 (0.97-1.10) < 1 days/month 2577 534 1.05 (0.96-1.14) 1.01 (0.93-1.10) 1.00 (0.92-1.09) 1-6 days/month 5759 1167 1.03 (0.96-1.11) 1.00 (0.93-1.07) 0.98 (0.91-1.05) 7-14 days/month 17106 273 1.28 (1.11-1.47) 1.20 (1.04-1.39) 1.15 (1.00-1.33 ) ≥ 15 days/month 755 191 1.29 (1.09-1.53) 1.23 (1.04-1.46) 1.18 (0.99-1.41 ) P trend <0.001 0.03 0.16 MA=migraine with aura; MO=Migraine without aura. Model 1: Adjusted for ag, and sex. Model 2: Adjusted for age, sex and body mass index. Model 3: Adjusted for age, sex, body mass index, smoking, employment status, alcohol use, physical activity and Hospital Anxiety and Depression Scale score Table 3. Multi-adjusted* odds ratio (OR) with 95% confidence interval (CI) of elevated high sensitivity C-reactive protein (hs-CRP) defined as > 3.0-20.0 mg/l related to headache types and insomnia status Without insomnia With insomnia Total N OR (95% CI) N OR (95% CI) No headache 24,823 23,766 1.00 1057 1.00 Any headache 13,990 12,359 1.07 (1.01-1.13) 1631 0.83 (0.68-1.01) Migraine 3793 3,196 1.12 (1.02-1.24) 597 0.99 (0.76-1.20) MA 2139 1777 1.19 (1.06-1.35) 362 0.97 (0.71-1.33) MO 1654 1419 1.06 (0.92-1.22) 235 1.02 (0.72-1.45) Other headaches 10,197 9,163 1.06 (0.99-1.13) 1034 0.77 (0.62-0.96) MA=migraine with aura; MO=Migraine without aura * Adjusted for age, sex, body mass index, smoking, employment status, alcohol use, physical activity and Hospital Anxiety and Depression Scale score Cite Share Download PDF Status: Published Journal Publication published 26 Sep, 2019 Read the published version in BMC Neurology → Version 2 posted Editorial decision: Accept 10 Sep, 2019 Review # 2 received at journal 07 Sep, 2019 Reviewer # 2 agreed at journal 26 Aug, 2019 Review # 1 received at journal 25 Aug, 2019 Editor assigned by journal 15 Aug, 2019 Reviewers invited by journal 15 Aug, 2019 Reviewer # 1 agreed at journal 15 Aug, 2019 Submission checks completed at journal 14 Aug, 2019 Editor invited by journal 14 Aug, 2019 You are reading this latest preprint version Show more versions Research Square lets you share your work early, gain feedback from the community, and start making changes to your manuscript prior to peer review in a journal. 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Also discoverable on Platform About Our Team In Review Editorial Policies Advisory Board Help Center Resources Author Services Accessibility API Access RSS feed Manage Cookie Preferences © Research Square 2026 | ISSN 2693-5015 (online) Privacy Policy Terms of Service Do Not Sell My Personal Information {"props":{"pageProps":{"initialData":{"identity":"rs-1475","acceptedTermsAndConditions":true,"allowDirectSubmit":false,"archivedVersions":[],"articleType":"Research article","associatedPublications":[],"authors":[{"id":134081,"identity":"b845fd2a-7c4f-4973-b710-78933232a2a0","order_by":1,"name":"Knut Hagen","email":"data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAZAAAAAyAQMAAABI0h/eAAAABlBMVEX///8AAABVwtN+AAAACXBIWXMAAA7EAAAOxAGVKw4bAAAAzElEQVRIiWNgGAWjYBACCRDB2AAimQ8QrYWxAaKFLYGBKE1IWngMiNMiObvH/AHjDju7fumeb48/7jjMYM7egF+LtMwZwwbGM8nJM+ec3W5w8MxhBsseAnbJSeQAtbQxJxvcyN0mcbDtMIPBjQSitNQn29/IeUacFmmIlsN2BhI5bMRpkZyRVjgjse14gsSNNDOJs23pPAZnCPhF4kbyhg8f26rt+WckP5OobLOWMzjegF8LGABdkghTx0OEegiwJ1rlKBgFo2AUjDwAACmjRhhMrVBlAAAAAElFTkSuQmCC","orcid":"https://orcid.org/0000-0003-2111-8895","institution":"Norges Teknisk-Naturvitenskapelige Universitet Fakultet for Medisin og Helsevitenskap","correspondingAuthor":true,"prefix":"","firstName":"Knut","middleName":"","lastName":"Hagen","suffix":""},{"id":134082,"identity":"3fc2def0-100a-4155-b34e-2aa3c50b8118","order_by":2,"name":"Lars Jacob Stovner","email":"","orcid":"","institution":"Norges Teknisk-Naturvitenskapelige Universitet Fakultet for Medisin og Helsevitenskap","correspondingAuthor":false,"prefix":"","firstName":"Lars","middleName":"Jacob","lastName":"Stovner","suffix":""},{"id":134083,"identity":"f46c9bf9-35f8-45af-bb4f-1f566ef670e2","order_by":3,"name":"Kristian Bernhard Nilsen","email":"","orcid":"","institution":"Universitetet i Oslo","correspondingAuthor":false,"prefix":"","firstName":"Kristian","middleName":"Bernhard","lastName":"Nilsen","suffix":""},{"id":134084,"identity":"ebca271e-9f2e-4790-aea0-015f84cde8c9","order_by":4,"name":"Espen Saxhaug Kristoffersen","email":"","orcid":"","institution":"Universitetet i Oslo","correspondingAuthor":false,"prefix":"","firstName":"Espen","middleName":"Saxhaug","lastName":"Kristoffersen","suffix":""},{"id":134085,"identity":"232659ad-c242-4a61-8744-fa0f6a0fc183","order_by":5,"name":"Bendik Slagsvold Winsvold","email":"","orcid":"","institution":"Universitetet i Oslo","correspondingAuthor":false,"prefix":"","firstName":"Bendik","middleName":"Slagsvold","lastName":"Winsvold","suffix":""}],"badges":[],"createdAt":"2019-06-19 14:32:55","currentVersionCode":2,"declarations":"","doi":"10.21203/rs.2.10500/v2","doiUrl":"https://doi.org/10.21203/rs.2.10500/v2","draftVersion":[],"editorialEvents":[{"content":"https://doi.org/10.1186/s12883-019-1462-8","type":"published","date":"2019-09-26T12:00:00+00:00"}],"editorialNote":"","failedWorkflow":false,"files":[{"id":122146,"identity":"83313b98-49b6-4214-832e-9186187497bf","added_by":"auto","created_at":"2019-10-11 21:22:31","extension":"png","order_by":1,"title":"Figure 1","display":"","copyAsset":false,"role":"figure","size":24182,"visible":true,"origin":"","legend":"Flowchart of participation in the HUNT Study 2006-2008. Hs-CRP= high sensitivity C-reactive protein","description":"","filename":"Figure1.png","url":"https://assets-eu.researchsquare.com/files/59a38b11-da4e-4728-b72d-deb8b9a4be24/v2/Figure 1.png"},{"id":13476747,"identity":"095a029a-ed3e-4499-94d7-ab5beb88012a","added_by":"auto","created_at":"2021-09-16 21:28:38","extension":"pdf","order_by":0,"title":"","display":"","copyAsset":false,"role":"manuscript-pdf","size":326749,"visible":true,"origin":"","legend":"","description":"","filename":"manuscript.pdf","url":"https://assets-eu.researchsquare.com/files/rs-1475/v2/cd2a8cac-6879-47c2-94bd-2ecd0767266a.pdf"}],"financialInterests":"","formattedTitle":"The impact of C-reactive protein levels on headache frequency. The HUNT Study 2006-2008","fulltext":[{"header":"Background","content":"\u003cp\u003eDuring the last decade many studies have evaluated the association between migraine and high sensitivity C-reactive protein (hs-CRP) [1-25]. Several case-control studies [3, 7, 8, 14, 18-22] and some population-based studies [4, 6] have found higher CRP values in migraine patients, but negative results have been reported by others [2, 5, 6, 10, 11, 15, 16, 24]. A summary of recently published studies concluded that migraineurs had higher CRP levels than controls [26].\u003c/p\u003e\n\u003cp\u003eThe association between headache and insomnia is well-established [27], but the impact of insomnia on the relationship between hs-CRP and migraine is unclear. Previously, a prospective study has demonstrated higher level of CRP in individuals with shorter sleep duration [28]. In a recent population-based cross-sectional study from Northern Norway, elevated hs-CRP was associated with migraine, but only among those with co-existing insomnia [29]. However, since the results on hs-CRP and migraine are conflicting, and the relationship to insomnia only reported in one study, it is important to replicate the analyses in other population-based study with similar design.\u003c/p\u003e\n\u003cp\u003eThe aim of this large-scale population-based study was to evaluate the cross-sectional association between hs-CRP and types of headache, and to see whether the relationship to insomnia could be reproduced. \u0026nbsp;\u003c/p\u003e"},{"header":"Methods","content":"\u003cp\u003e\u003cem\u003eStudy design\u003c/em\u003e\u003c/p\u003e\n\u003cp\u003eThe present population-based study of a large unselected adult population replicate the methodological design used in the Troms\u0026oslash; Study [29], including similar questionnaire-based diagnoses for headache and insomnia, identical categories of hs-CRP, and replication of the statistical analyses with adjustments for the same type of potential confounders.\u0026nbsp;\u003c/p\u003e\n\u003cp\u003e\u003cem\u003eThe \u003c/em\u003e\u003cem\u003eNord-Tr\u0026oslash;ndelag Health Study\u003c/em\u003e\u003c/p\u003e\n\u003cp\u003eThe total population of the Nord-Tr\u0026oslash;ndelag county aged \u0026ge;20 years has been invited four times between 1984 and 2019. All participant answered questionnaires and were invited to interview, clinical examination, and blood sampling [30]. \u0026nbsp;\u003c/p\u003e\n\u003cp\u003e\u003cem\u003eStudy population\u003c/em\u003e\u003c/p\u003e\n\u003cp\u003eIn HUNT3 (2006-2008), a total of 94,194 individuals aged \u0026ge; 20 years were invited, whereof 93,860 were eligible. Of these, 50,807 (54%) accepted the invitation. The diagnoses of headache and insomnia was questionnaire-based. The present study included data from 38,813 participants (41%) (mean age 54.1 years, range 20-97 years) who had answered questions about headache and insomnia and had hs-CRP measured from non-fasting blood samples (Fig. 1).\u003c/p\u003e\n\u003cp\u003e\u003cem\u003eC-reactive protein\u003c/em\u003e\u003c/p\u003e\n\u003cp\u003eHs-CRP was analyzed at the Central Laboratory, Levanger Hospital, using Architect cSystem ci8200, by latex immunoassay method. The detection limit was 0.03 mg/L, and samples without detectable hs-CRP were assigned this value. In the present study we replicated the strategy used in previous published studies from the Troms\u0026oslash; study [29, 31] defining normal hs-CRP as 0-3.00 mg/L and elevated as 3.01-20.00 mg/L. Participants with hs-CRP values \u0026gt;20.00 mg/L, which probably indicate some acute or chronic disease [32], were excluded (n=527) (Fig.1). Blood samples for hs-CRP analyzes were drawn without any knowledge about last headache attack.\u003c/p\u003e\n\u003cp\u003e\u003cem\u003eHeadache questionnaire\u003c/em\u003e\u003c/p\u003e\n\u003cp\u003eAll details of the headache questionnaire have been published elsewhere [33], and all questionnaire-based headache diagnoses were identical to those presented in the Troms\u0026oslash; study [29]. Subjects who answered \u0026ldquo;no\u0026rdquo; to the screening question (\u0026ldquo;Have you suffered from headache during the last 12 months?\u0026rdquo;) were included in the reference group without headache.\u003c/p\u003e\n\u003cp\u003eParticipants who answered \u0026ldquo;yes\u0026rdquo; completed 12 additional questions, mainly to diagnose migraine according to the second version of the International Classification of Headache Disorders (ICHD-2) [34]. Regarding attack duration, \u0026lt;4 hours were accepted for those who reported visual disturbance before headache. Participants who fulfilled the migraine diagnosis and reported visual disturbance prior to headache were classified as migraine with aura (MA), whereas the remaining with migraine had migraine without aura (MO). The remaining participants with headache were classified as having \u0026ldquo;other headache\u0026rdquo;. The merged group of \u0026ldquo;any headache\u0026rdquo; consisted of participants with migraine or other headache. Furthermore, based to answer on the question about headache frequency, subjects were subdivided into five groups; no headache, headache \u0026lt; 1 days/month, headache 1-6 days/month, headache 7-14 days/month, or headache \u0026ge;15 days/month. \u0026nbsp;\u003c/p\u003e\n\u003cp\u003eThe validity of the questionnaire-based headache diagnoses has been published in a separate paper [39]. The agreement between the validation interview and questionnaire-based headache categories were very good for any headache (kappa value at 0.70, 95 % CI 0.61-0.79) and moderate for migraine (kappa value 0.50, 95 % CI 0.32-0.68), whereas the specificity for MA was high (95 %) (kappa value 0.44, 95 % CI 0.38-0.50) (33).\u003c/p\u003e\n\u003cp\u003e\u003cem\u003eQuestionnaire-based diagnosis of insomnia \u003c/em\u003e\u003c/p\u003e\n\u003cp\u003eThe questionnaire-based diagnosis of insomnia was based on the DSM-V (Diagnostic and Statistical Manual of Mental Disorders, 5th ed.), and was nearly identical to the insomnia diagnosis used in the Troms\u0026oslash; study [29]. To fulfil the proxy diagnosis of insomnia the participants had to answer \u0026ldquo;several times a week\u0026rdquo; to at least one out of the three questions, asking whether they had \u0026ldquo;difficulties falling asleep at night\u0026rdquo;,\u0026nbsp; whether they \u0026ldquo;woke up repeatedly during the night\u0026rdquo;, and/or whether they \u0026ldquo;woke up too early and could not get back to sleep\u0026rdquo; [36]. In addition, they also had to report \u0026ldquo;several times a week\u0026rdquo; to the question \u0026ldquo;felt sleepy during day\u0026rdquo; [36]. The overall agreement between questionnaire and interview for the first three questions has previously been found to be moderate (kappa value 0.51, 95% CI 0.40-0.63) [37].\u003c/p\u003e\n\u003cp\u003e\u003cem\u003ePotential \u003c/em\u003e\u003cem\u003econfounders\u003c/em\u003e\u003c/p\u003e\n\u003cp\u003eThe selection of potential confounders used in the Troms\u0026oslash; study [29] was based on previous literature [35, 37, 42]. To replicate the Troms\u0026oslash; study [29], we included almost identical potential confounders, with two exceptions: employment status was used instead of education level, and Hospital Anxiety and Depression Scale instead of Hopkins symptom checklist (HSCL-10). The remaining potential confounders were identical; age (continuous variable); gender; body mass index (BMI) (\u0026lt;25, 25.0-29.9, and \u0026ge;30 kg/m\u003csup\u003e2\u003c/sup\u003e) (28, 32); smoking (current, previous, and never); physical activity (never, \u0026le; 1 time per week, \u0026ge;2 times per week); alcohol consumption (never, \u0026lt;2 times/week, \u0026ge;2times/week); self-reported diabetes (yes/no); self-reported stroke and/or heart infarction (yes/no); and self-reported hypertension (yes/no).\u003c/p\u003e\n\u003cp\u003e\u003cem\u003eEthics\u003c/em\u003e\u003c/p\u003e\n\u003cp\u003eThis study was approved by the Regional Committee for Medical and Health Research Ethics, the Faculty of medicine, mailbox 8905, 7491 Trondheim. The approval number was #2018/2422/Rek Midt. The participants have given written informed consent.\u003c/p\u003e\n\u003cp\u003e\u003cem\u003eStatistical analysis\u003c/em\u003e\u003c/p\u003e\n\u003cp\u003eThe statistical method was identical to that presented in the Troms\u0026oslash; Study [29] and based on multivariate analyses using multiple logistic regression. The precision of the odds ratio (OR) was assessed with 95% confidence interval (CI). We present results for three different statistical models separated by number of confounders included; model 1 (age and sex), model 2 (age, sex and BMI), and model 3 (all other factors were tested). In model 3 we excluded factors if they did not change OR when evaluating each factor separately or when including several factors grouped together (i.e. self-reported diabetes, stroke/heart infarction, and hypertension). Potential interaction between two variables was evaluated by including the product of the variable in the logistic regression analyses, and the interaction was tested using Wald \u0026chi;\u003csup\u003e2\u003c/sup\u003e statistics. To evaluate the probability of a linear relationship between elevated hs-CRP and headache frequency, the five categories were treated as a single variable and was incorporated in a two-sided test for trend.\u0026nbsp; Subjects with missing data of confounding factors (numbers reported in Table 1) were included in the analysis to reduce the impact of possible bias.\u003c/p\u003e\n\u003cp\u003eTo evaluate insomnia as a modifying factor on the association between hs-CRP and types of headache, we repeated the multi-adjusted analyses in model 3 in those with and without insomnia.\u003c/p\u003e\n\u003cp\u003eAnalyses were performed with the IBM SPSS version 25 (SPSS, Chicago, Illinois, USA)\u003c/p\u003e"},{"header":"Results","content":"\u003cp\u003eSubjects with headache were more likely to be women, younger, and to be employed in paid work compared to those without headache (Table 1).\u003c/p\u003e\n\u003cp\u003e\u003cem\u003ePrevalence of headache\u003c/em\u003e\u003c/p\u003e\n\u003cp\u003eA total of 13,990 (36.0%) participants suffered from headache during the last year, 3793 (9.8%) fulfilled the criteria of migraine, 2139 (5.5%) had migraine with aura (MA), 1654 (4.3%) migraine without aura (MO), and 10,197 (26.3%) had other headaches.\u003c/p\u003e\n\u003cp\u003e\u003cem\u003eThe association between elevated hs-CRP and headache\u003c/em\u003e\u003c/p\u003e\n\u003cp\u003eIn the multivariate analyses, adjusting for age and sex, elevated hs-CRP was associated with any headache (OR 1.11, 95% CI 1.05-1.17), migraine (OR 1.23, 95% CI 1.13-1.34), MA (OR 1.26, 95% CI 1.13-1.40), MO (OR 1.17, 95% CI 1.03-1.32), and other headache (OR 1.08, 95% CI 1.02-1.14).\u0026nbsp; In the final model 3, adjusting for all potential confounding factors, elevated hs-CRP was still significantly associated with migraine (OR 1.14, 95% CI 1.04-1.25) and MA (OR 1.25, 95% CI 1.03-1.29) (Table 2). In supplementary analyses, using individuals with \u0026ldquo;other headache \u0026ldquo;as reference category, elevated hs-CRP was more likely among those with MA (OR 1.17, 95% CI 1.05-1.31), but not MO (OR 1.04, 95% CI 0.92-1.19).\u003c/p\u003e\n\u003cp\u003eNo interaction was observed. As to the impact of headache frequency, the strongest association with elevated hs-CRP was found among individuals with headache \u0026ge; 15 days/month for any headache (OR 1.26, 95% CI 1.08-1.48), migraine (OR 1.62, 95% CI 1.21-2.17), and MA (OR 1.84, 95% CI 1.27-2.67) (Table 2). A significant linear trend between increasing headache frequency and elevated hs-CRP was found for any headache (p=0.01), migraine (p=0.01) and MA (p=0.002) (Table 2). No clear relationship was found between elevated hs-CRP and headache less than 7 days/month (Table 2).\u003c/p\u003e\n\u003cp\u003e\u003cem\u003eThe influence of insomnia diagnosis\u003c/em\u003e\u003c/p\u003e\n\u003cp\u003eAs demonstrated by Table 3, the relationship between elevated hs-CRP and headache was only found among subjects without insomnia, whereas no such association was found among those with insomnia. Supplementary analyses considering only those with headache 7-14 days/month and \u0026ge;15 days/month did not change the results (data not shown).\u003c/p\u003e"},{"header":"Discussion","content":"\u003cp\u003eCross-sectional population-based data based on a large number of participants showed that elevated hs-CRP was associated with headache \u0026ge; 7 days/month, most evident for migraine with aura. No relationship was found between elevated hs-CRP and headache less than 7 days/month or with insomnia.\u003c/p\u003e\n\u003cp\u003eIn agreement with the present results, a previous study have demonstrated that women with migraine had elevated CRP compared to women without migraine [4]. In a Dutch case-control study, individuals with MA were more likely to have elevated hs-CRP in the unadjusted analyses, and a borderline tendency was found in the multi-adjusted model [24]. In contrast, in a population-based study from Iceland, no difference in CRP levels were found between participants with and without migraine [6].\u003c/p\u003e\n\u003cp\u003eIn the present study, the final multi-adjusted analyses showed that MA, but not MO, was associated with elevated hs-CRP. This is in contrast with a review of previous studies on this topic, where the association to MA was not found to be consistently stronger than to MO [26]. It should be highlighted that an association between hs-CRP and average number of aura attacks and total number of years with aura were reported in the Dutch study [24].\u003c/p\u003e\n\u003cp\u003e\u003cem\u003eInterpretation\u003c/em\u003e\u003c/p\u003e\n\u003cp\u003eIn accordance with findings in the Troms\u0026oslash; 7 Study [29], MA was most consistently associated with elevated hs-CRP. It may be of relevance that hs-CRP is associated with risk of cardiovascular events [38], and that ischemic cardiovascular disease has a stronger association to MA than to MO [39].\u003c/p\u003e\n\u003cp\u003eIn this large (n=38,813) population-based study with presumably high statistical power, the association between elevated hs-CRP and headache was evident for those with headache 7-14 days/month and headache more than 14 days/month. Correspondingly, elevated hs-CRP was associated with migraine \u0026ge;7 days/month, but not migraine \u0026lt;7 days/month in the Troms\u0026oslash; study (n=20,486) [29]. This relationship with headache frequency and elevated hs-CRP has not been clearly demonstrated in other studies [3, 4, 6, 7, 8, 14, 18-22], possibly because of limited statistical power. The results of the present study may be explained by the finding that hs-CRP is related to general pain sensitivity [31]. Alternatively, our findings may be related to potential sterile inflammation in migraine [26] or other types of headaches, most prominent for those with chronic headache. However, whether sterile inflammation is an important pathological feature in migraine and other headaches is still debated. \u0026nbsp;\u0026nbsp;\u0026nbsp;\u003c/p\u003e\n\u003cp\u003eWe evaluated insomnia as a modifying factor on the association between hs-CRP and headache. In contrast to the results from the Troms\u0026oslash; 7 Study [26], no association was found between elevated hs-CRP and headache among those with insomnia. The reason for the contrasting finding is unclear. However, it may be a spurious finding in the Troms\u0026oslash; 7 study.\u003c/p\u003e\n\u003cp\u003eAn alternative explanation may be that there are differences between participants with insomnia in the Troms\u0026oslash; 7 study and in the HUNT3 study. It should be highlighted that the Troms\u0026oslash; Study was performed at almost 70 degree north, with midnight sun and winter darkness periods, whereas the HUNT3 study was performed in middle of Norway at 63-65 degrees north where the difference between summer and winter light is less extreme. The definition of insomnia in the Troms\u0026oslash; 7 study was stricter [29] than the one applied in the HUNT3 study [36], demanding symptoms three or more days per week instead of \u0026ldquo;several\u0026rdquo;, and with dissatisfaction with sleep quality as mandatory. Despite this, the prevalence of insomnia was higher in Troms\u0026oslash; 7 than in the HUNT3 study (8.1% vs. 6.9%, p\u0026lt;0.001) [29, 36]. The prevalence reported in the present study is lower than other population-based studies in Norway [40], and we cannot exclude that our findings would have been different using another insomnia questionnaire\u003c/p\u003e\n\u003cp\u003eThe vast majority (93%) of the participants did not have insomnia, and in accordance with our main results, we found a relationship between elevated hs-CRP and headache also in this group.\u003c/p\u003e\n\u003cp\u003e\u003cem\u003eStrengths and limitations of the study\u003c/em\u003e\u003c/p\u003e\n\u003cp\u003eThe present study shares several strengths and limitations with the study from Troms\u0026oslash; [29]. The major strengths of this study are the population-based design and the possibility to perform adjustments for all potential confounding factors previously included in the Troms\u0026oslash; study [29]. The large number of included participants give high statistical power and small confidence intervals.\u003c/p\u003e\n\u003cp\u003eThe most important study limitation is the low participation rate (41%). Therefore, generalization of results should be performed with caution. It should also be highlighted that the cross-sectional design does not permit any conclusions about causality. Furthermore, it is a limitation that the diagnoses of headache and insomnia were questionnaire-based, which may have led to misclassification. On the other hand, the agreement between questionnaire-based diagnosis of migraine and interview has previously been found to be acceptable [33]. Insomnia was diagnosed by applying modified DSM-V criteria. DSM-V asks for symptoms three times or more per week [35], whereas the response option \u0026ldquo;several times per week\u0026rdquo; was used in the present study [36]. Furthermore, some types of daytime impairment are required in the DSM-V criteria [35]. In this respect it should be noted that our question \u0026ldquo;felt sleepy during the day?\u0026rdquo; may not have been optimal way to assess actual sleepiness, as it more probably reflects tiredness and fatigue [36].\u003c/p\u003e"},{"header":"Conclusions","content":"\u003cp\u003eCross-sectional data based on 38,007 participants showed that elevated hs-CRP was associated with headache \u0026ge; 7 days/month, most evident for migraine with aura. Elevated hs-CRP was not associated with headache less than 7 days/month or with insomnia.\u003c/p\u003e"},{"header":"Abbreviations","content":"\u003cp\u003eHs-CRP= high sensitivity C-reactive protein; HUNT: The Nord-Tr\u0026oslash;ndelag Health Survey; OR=odds ration; CI=confidence interval; MA=Migraine with aura; MO=Migraine without aura; ICHD-2; The International Classification of Headache Disorders 2\u003csup\u003erd\u003c/sup\u003e edition; BMI=body mass index; DSM-V= Diagnostic and Statistical Manual of Mental Disorders, 5th ed.\u003c/p\u003e"},{"header":"Declarations","content":"\u003cp\u003e\u003cstrong\u003eAcknowledgements\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eThe Nord-Tr\u0026oslash;ndelag Health Study (The HUNT Study) is a collaboration between HUNT Research Centre (Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology NTNU); Tr\u0026oslash;ndelag County Council, Central Norway Regional Health Authority, and the Norwegian Institute of Public Health.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eFunding \u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eNot applicable\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eCompeting interest\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eNone of the authors have any competing interests in the manuscript.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eAvailability of data and materials: \u003c/strong\u003ePart of the dataset supporting the conclusions of this article is available on request to the corresponding author. Some of the data are the property of HUNT Research Centre and can only be accessed through direct contact with the research Centre.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eAuthors\u0026rsquo; contributions \u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eKH: Study concept and design, collection of data, analysis and interpretation of data, writing of manuscript. LJS, KBN, ESK and BSW: Interpretation of data, critical revision of manuscript. All authors read and approved the final manuscript.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eEthics approval and consent to participate\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eThis study was approved by the Regional Committee for Medical and Health Research Ethics, the Faculty of medicine, mailbox 8905, 7491 Trondheim.\u0026nbsp; The approval number was #2018/2422/Rek Midt. The participants have given written informed consent.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eCompeting interest\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eNone of the authors have any competing interests in the manuscript.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eConsent for publication \u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eNot applicable\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eCompeting interest\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eNone of the authors have any competing interests in the manuscript.\u003c/p\u003e"},{"header":"References","content":"1.\tWelch KM, Brandes AW, Salerno L, Brandes JL. C-reactive protein may be increased in migraine patients who present with complex clinical features. Headache 2006; 46: 197-199. \n2.\tSilva FA, Rueda-Clausen CF, Silva SY, Zarruk JG, Guzmán JC, Morillo CA, Vesga B, Pradilla G, Flórez M, López-Jaramillo P. Endothelial function in patients with migraine during the interictal period. Headache 2007; 47: 45-51. \n3.\tVanmolkot FH, de Hoon JN. Increased C-reactive protein in young adult patients with migraine. Cephalalgia 2007; 27: 843-846. \n4.\tKurth T, Ridker PM, Buring JE. Migraine and biomarkers of cardiovascular disease in women. Cephalalgia 2008; 28: 49-56.\n5.\tGuldiken B, Guldiken S, Demir M, Turgut N, Kabayel L, Ozkan H, Ozcelik E, Tugrul A. Insulin resistance and high sensitivity C-reactive protein in migraine. Can J Neurol Sci 2008; 35: 448-451. \n6.\tGudmundsson LS, Aspelund T, Scher AI, Thorgeirsson G, Johannsson M, Launer LJ, Gudnason V. C-reactive protein in migraine sufferers similar to that of non-migraineurs: the Reykjavik Study. Cephalalgia 2009: 29: 1301-1310. \n7.\tTietjen GE, Herial NA, White L, Utley C, Kosmyna JM, Khuder SA. Migraine and biomarkers of endothelial activation in young women. Stroke 2009; 40: 2977-2982.\n8.\tHamed SA, Hamed EA, Ezz Eldin AM, Mahmoud NM.Vascular risk factors, endothelial function, and carotid thickness in patients with migraine: relationship to atherosclerosis. J Stroke Cerebrovasc Dis 2010; 19: 92-103.\n9.\tNelson KB, Richardson AK, He J, Lateef TM, Khoromi S, Merikangas KR. Headache and biomarkers predictive of vascular disease in a representative sample of US children. Arch Pediatr Adolesc Med 2010; 164: 358-362.\n10.\tGuldiken S, Guldiken B, Demir M, Kabayel L, Ozkan H, Turgut N, Hunkar R, Kat S. Soluble CD40 ligand and prolactin levels in migraine patients during interictal period. J Headache Pain 2011; 12: 355-360.\n11.\tYilmaz N, Aydin O, Yegin A, Tiltak A, Eren E. Increased levels of total oxidant status and decreased activity of arylesterase in migraineurs. Clin Biochem 2011; 44: 832-837.\n12.\tTheodoropoulos DS, Katzenberger DR, Jones WM, Morris DL, Her C, Cullen NA, Morrisa DL. 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Cephalalgia March 12, 2019 [Epub ahead of print]\n30.\tKrokstad S, Langhammer A, Hveem K, et al. Cohort profile: the HUNT Study, Norway. Int J Epidemiol 2013; 42: 968-977.\n31.\tSchistad EI, Stubhaug A, Furberg AS, Engdahl BL, Nielsen CS. C-reactive protein and cold-pressor tolerance in the general population: the Tromsø Study. Pain 2017; 158: 1280-1288.\n32.\tKushner I, Rzewnicki D, Samols D. What does minor elevation of C-reactive protein signify? Am J Med 2006; 119: 17–28.\n33.\tHagen K, Zwart JA, Aamodt AH, et al. The validity of questionnaire-based diagnoses: The third Nord-Trøndelag Health Study 2006-2008. J Headache Pain 2010; 11: 67-73.\n34.\tHeadache Classificiation Committee of the International Headache Society (IHS). The International Classification of Headache Disorders 2nd Edition. Cephalalgia 2004; 24 Suppl 1: 2-150.\n35.\tAssociation AP. Diagnostic and statistical manual of mental disorders: DSM-V. Washington (DC). American Psychiatric Publishing; 2013.\n36.\tUhlig BL, Sand T, Ødegård SS, Hagen K. Prevalence and associated factors of DSM-V Insomnia in Norway. The HUNT 3 study. Sleep Med 2014; 15: 708-713. \n37.\tEngstrøm M, Ødegård SS, Sand T, Stovner LJ, Zwart JA, Hagen K. The reliability of a sleep questionnaire in a large population-based study: The third Nord-Trøndelag Health study. Open Sleep J 2011; 4: 14-19.\n38.\tWang TJ, Larson MG, Levy D, Benjamin EJ, Kupka MJ, Manning WJ, Clouse ME, D'Agostino RB, Wilson PW, O'Donnell CJ. C-reactive protein is associated with subclinical epicardial coronary calcification in men and women: the Framingham Heart Study. Circulation 2002; 106: 1189-91. \n39.\tSacco S, Kurth T. Migraine and the risk for stroke and cardiovascular disease. Curr Cardiol Rep 2014; 16: 524.\n40.\tPallesen S, Sivertsen B, Nordhus IH, Bjorvatn B. A 10-year trend of insomnia prevalence in the adult Norwegian population. Sleep Med 2014; 15: 173-179.\n"},{"header":"Tables","content":"\u003cp style=\"page-break-after: avoid;\"\u003e\u003cstrong\u003e\u003cspan style=\"font-size: 10.0pt; font-family: 'Times New Roman',serif; color: windowtext;\"\u003eTable 1 \u003c/span\u003e\u003c/strong\u003e\u003cspan style=\"font-size: 10.0pt; font-family: 'Times New Roman',serif; color: windowtext;\"\u003eCharacteristics of participants (n=38,813) in the HUNT3 Study related to headache types\u003c/span\u003e\u003c/p\u003e\n\u003ctable style=\"width: 10.1in; border-collapse: collapse; border: none;\" width=\"970\"\u003e\n\u003ctbody\u003e\n\u003ctr style=\"height: 16.6pt;\"\u003e\n\u003ctd style=\"border-top: solid black 1.0pt; border-left: none; border-bottom: solid black 1.0pt; border-right: none; background: white; padding: 0in 5.4pt 0in 5.4pt; height: 16.6pt;\"\u003e\n\u003cp style=\"line-height: 150%;\"\u003e\u003cstrong\u003e\u003cem\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 150%; font-family: 'Times New Roman',serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/em\u003e\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"border-top: solid black 1.0pt; border-left: none; border-bottom: solid black 1.0pt; border-right: none; background: white; padding: 0in 5.4pt 0in 5.4pt; height: 16.6pt;\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cstrong\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 150%; font-family: 'Times New Roman',serif; color: black;\"\u003eNo headache \u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 91.5pt; border-top: solid black 1.0pt; border-left: none; border-bottom: solid black 1.0pt; border-right: none; background: white; padding: 0in 5.4pt 0in 5.4pt; height: 16.6pt;\" width=\"122\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cstrong\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 150%; font-family: 'Times New Roman',serif; color: black;\"\u003eAny headache\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 92.65pt; border-top: solid black 1.0pt; border-left: none; border-bottom: solid black 1.0pt; border-right: none; background: white; padding: 0in 5.4pt 0in 5.4pt; height: 16.6pt;\" width=\"124\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cstrong\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 150%; font-family: 'Times New Roman',serif; color: black;\"\u003eMA\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.55pt; border-top: solid black 1.0pt; border-left: none; border-bottom: solid black 1.0pt; border-right: none; background: white; padding: 0in 5.4pt 0in 5.4pt; height: 16.6pt;\" width=\"114\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cstrong\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 150%; font-family: 'Times New Roman',serif; color: black;\"\u003eMO\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 146.15pt; border-top: solid black 1.0pt; border-left: none; border-bottom: solid black 1.0pt; border-right: none; background: white; padding: 0in 5.4pt 0in 5.4pt; height: 16.6pt;\" width=\"195\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cstrong\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 150%; font-family: 'Times New Roman',serif; color: black;\"\u003eOther headaches\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 8.5pt;\"\u003e\n\u003ctd style=\"border: none; background: white; padding: 0in 5.4pt 0in 5.4pt; height: 8.5pt;\"\u003e\n\u003cp style=\"line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 150%; font-family: 'Times New Roman',serif; color: black;\"\u003eParticipants, n\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"border: none; background: white; padding: 0in 5.4pt 0in 5.4pt; height: 8.5pt;\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 150%; font-family: 'Times New Roman',serif; color: black;\"\u003e24,823\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 91.5pt; border: none; background: white; padding: 0in 5.4pt 0in 5.4pt; height: 8.5pt;\" width=\"122\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 150%; font-family: 'Times New Roman',serif; color: black;\"\u003e13,990\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 92.65pt; border: none; background: white; padding: 0in 5.4pt 0in 5.4pt; height: 8.5pt;\" width=\"124\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 150%; font-family: 'Times New Roman',serif; color: black;\"\u003e2139\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.55pt; border: none; background: white; padding: 0in 5.4pt 0in 5.4pt; height: 8.5pt;\" width=\"114\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 150%; font-family: 'Times New Roman',serif; color: black;\"\u003e1654\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 146.15pt; border: none; background: white; padding: 0in 5.4pt 0in 5.4pt; height: 8.5pt;\" width=\"195\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 150%; font-family: 'Times New Roman',serif; color: black;\"\u003e10,197\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 8.5pt;\"\u003e\n\u003ctd style=\"border: none; background: white; padding: 0in 5.4pt 0in 5.4pt; height: 8.5pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 150%; font-family: 'Times New Roman',serif; color: black;\"\u003eWomen, n (%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"border: none; background: white; padding: 0in 5.4pt 0in 5.4pt; height: 8.5pt;\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 150%; font-family: 'Times New Roman',serif; color: black;\"\u003e12525 (50.5)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 91.5pt; border: none; background: white; padding: 0in 5.4pt 0in 5.4pt; height: 8.5pt;\" width=\"122\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 150%; font-family: 'Times New Roman',serif; color: black;\"\u003e9203 (65.8)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 92.65pt; border: none; background: white; padding: 0in 5.4pt 0in 5.4pt; height: 8.5pt;\" width=\"124\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 150%; font-family: 'Times New Roman',serif; color: black;\"\u003e1600 (74.8)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.55pt; border: none; background: white; padding: 0in 5.4pt 0in 5.4pt; height: 8.5pt;\" width=\"114\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 150%; font-family: 'Times New Roman',serif; color: black;\"\u003e1252 (75.7)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 146.15pt; border: none; background: white; padding: 0in 5.4pt 0in 5.4pt; height: 8.5pt;\" width=\"195\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 150%; font-family: 'Times New Roman',serif; color: black;\"\u003e6351 (62.2)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 8.5pt;\"\u003e\n\u003ctd style=\"border: none; background: white; padding: 0in 5.4pt 0in 5.4pt; height: 8.5pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 150%; font-family: 'Times New Roman',serif; color: black;\"\u003eMean age, years (SD)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"border: none; background: white; padding: 0in 5.4pt 0in 5.4pt; height: 8.5pt;\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 150%; font-family: 'Times New Roman',serif; color: black;\"\u003e56.9 (15.7)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 91.5pt; border: none; background: white; padding: 0in 5.4pt 0in 5.4pt; height: 8.5pt;\" width=\"122\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 150%; font-family: 'Times New Roman',serif; color: black;\"\u003e49.2 (14.2)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 92.65pt; border: none; background: white; padding: 0in 5.4pt 0in 5.4pt; height: 8.5pt;\" width=\"124\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 150%; font-family: 'Times New Roman',serif; color: black;\"\u003e47.0 (12.9)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.55pt; border: none; background: white; padding: 0in 5.4pt 0in 5.4pt; height: 8.5pt;\" width=\"114\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 150%; font-family: 'Times New Roman',serif; color: black;\"\u003e45.3 (12.6)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 146.15pt; border: none; background: white; padding: 0in 5.4pt 0in 5.4pt; height: 8.5pt;\" width=\"195\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 150%; font-family: 'Times New Roman',serif; color: black;\"\u003e50.2 (14.6)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 8.5pt;\"\u003e\n\u003ctd style=\"border: none; background: white; padding: 0in 5.4pt 0in 5.4pt; height: 8.5pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 150%; font-family: 'Times New Roman',serif; color: black;\"\u003eAge \u0026ge; 60 years (%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"border: none; background: white; padding: 0in 5.4pt 0in 5.4pt; height: 8.5pt;\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 150%; font-family: 'Times New Roman',serif; color: black;\"\u003e11280 (45.4)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 91.5pt; border: none; background: white; padding: 0in 5.4pt 0in 5.4pt; height: 8.5pt;\" width=\"122\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 150%; font-family: 'Times New Roman',serif; color: black;\"\u003e3264 (23.3)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 92.65pt; border: none; background: white; padding: 0in 5.4pt 0in 5.4pt; height: 8.5pt;\" width=\"124\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 150%; font-family: 'Times New Roman',serif; color: black;\"\u003e358 (16.7)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.55pt; border: none; background: white; padding: 0in 5.4pt 0in 5.4pt; height: 8.5pt;\" width=\"114\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 150%; font-family: 'Times New Roman',serif; color: black;\"\u003e219 (13.2)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 146.15pt; border: none; background: white; padding: 0in 5.4pt 0in 5.4pt; height: 8.5pt;\" width=\"195\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 150%; font-family: 'Times New Roman',serif; color: black;\"\u003e2687 (26.4)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 8.5pt;\"\u003e\n\u003ctd style=\"border: none; background: white; padding: 0in 5.4pt 0in 5.4pt; height: 8.5pt;\"\u003e\n\u003cp style=\"line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 150%; font-family: 'Times New Roman',serif; color: black;\"\u003eEmployed, n (%) (missing=17)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"border: none; background: white; padding: 0in 5.4pt 0in 5.4pt; height: 8.5pt;\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 150%; font-family: 'Times New Roman',serif; color: black;\"\u003e14450 (58.2\u003c/span\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 150%; font-family: 'Times New Roman',serif; color: black;\"\u003e)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 91.5pt; border: none; background: white; padding: 0in 5.4pt 0in 5.4pt; height: 8.5pt;\" width=\"122\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 150%; font-family: 'Times New Roman',serif; color: black;\"\u003e10087 (72.1)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 92.65pt; border: none; background: white; padding: 0in 5.4pt 0in 5.4pt; height: 8.5pt;\" width=\"124\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 150%; font-family: 'Times New Roman',serif; color: black;\"\u003e1570 (73.4)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.55pt; border: none; background: white; padding: 0in 5.4pt 0in 5.4pt; height: 8.5pt;\" width=\"114\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 150%; font-family: 'Times New Roman',serif; color: black;\"\u003e1301 (78.7)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 146.15pt; border: none; background: white; padding: 0in 5.4pt 0in 5.4pt; height: 8.5pt;\" width=\"195\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 150%; font-family: 'Times New Roman',serif; color: black;\"\u003e7216 (70.8)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 8.5pt;\"\u003e\n\u003ctd style=\"border: none; background: white; padding: 0in 5.4pt 0in 5.4pt; height: 8.5pt;\"\u003e\n\u003cp style=\"line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 150%; font-family: 'Times New Roman',serif; color: black;\"\u003eCurrent daily smoking, n (%) (missing=998)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"border: none; background: white; padding: 0in 5.4pt 0in 5.4pt; height: 8.5pt;\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 150%; font-family: 'Times New Roman',serif; color: black;\"\u003e3590 (14.5)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 91.5pt; border: none; background: white; padding: 0in 5.4pt 0in 5.4pt; height: 8.5pt;\" width=\"122\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 150%; font-family: 'Times New Roman',serif; color: black;\"\u003e2534 (18.1)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 92.65pt; border: none; background: white; padding: 0in 5.4pt 0in 5.4pt; height: 8.5pt;\" width=\"124\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 150%; font-family: 'Times New Roman',serif; color: black;\"\u003e497 (23.2)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.55pt; border: none; background: white; padding: 0in 5.4pt 0in 5.4pt; height: 8.5pt;\" width=\"114\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 150%; font-family: 'Times New Roman',serif; color: black;\"\u003e277 (16.7)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 146.15pt; border: none; background: white; padding: 0in 5.4pt 0in 5.4pt; height: 8.5pt;\" width=\"195\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 150%; font-family: 'Times New Roman',serif; color: black;\"\u003e1760 (17.3)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 8.5pt;\"\u003e\n\u003ctd style=\"border: none; background: white; padding: 0in 5.4pt 0in 5.4pt; height: 8.5pt;\"\u003e\n\u003cp style=\"line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 150%; font-family: 'Times New Roman',serif; color: black;\"\u003eMean BMI,\u003c/span\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 150%; font-family: 'Times New Roman',serif; color: black;\"\u003e kg/m\u003csup\u003e2\u003c/sup\u003e\u003c/span\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 150%; font-family: 'Times New Roman',serif; color: black;\"\u003e (SD) (missing=120)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"border: none; background: white; padding: 0in 5.4pt 0in 5.4pt; height: 8.5pt;\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 150%; font-family: 'Times New Roman',serif; color: black;\"\u003e27.2 (4.2)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 91.5pt; border: none; background: white; padding: 0in 5.4pt 0in 5.4pt; height: 8.5pt;\" width=\"122\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 150%; font-family: 'Times New Roman',serif; color: black;\"\u003e27.2 (4.7)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 92.65pt; border: none; background: white; padding: 0in 5.4pt 0in 5.4pt; height: 8.5pt;\" width=\"124\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 150%; font-family: 'Times New Roman',serif; color: black;\"\u003e27.3 (4.8)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.55pt; border: none; background: white; padding: 0in 5.4pt 0in 5.4pt; height: 8.5pt;\" width=\"114\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 150%; font-family: 'Times New Roman',serif; color: black;\"\u003e27.1 (5.0)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 146.15pt; border: none; background: white; padding: 0in 5.4pt 0in 5.4pt; height: 8.5pt;\" width=\"195\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 150%; font-family: 'Times New Roman',serif; color: black;\"\u003e27.2 (4.6)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 8.5pt;\"\u003e\n\u003ctd style=\"border: none; background: white; padding: 0in 5.4pt 0in 5.4pt; height: 8.5pt;\"\u003e\n\u003cp style=\"line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 150%; font-family: 'Times New Roman',serif; color: black;\"\u003eTotal HADS score (missing=582)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"border: none; background: white; padding: 0in 5.4pt 0in 5.4pt; height: 8.5pt;\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 150%; font-family: 'Times New Roman',serif; color: black;\"\u003e6.7 (5.0)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 91.5pt; border: none; background: white; padding: 0in 5.4pt 0in 5.4pt; height: 8.5pt;\" width=\"122\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 150%; font-family: 'Times New Roman',serif; color: black;\"\u003e8.3 (5.9)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 92.65pt; border: none; background: white; padding: 0in 5.4pt 0in 5.4pt; height: 8.5pt;\" width=\"124\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 150%; font-family: 'Times New Roman',serif; color: black;\"\u003e9.4 (6.4)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.55pt; border: none; background: white; padding: 0in 5.4pt 0in 5.4pt; height: 8.5pt;\" width=\"114\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 150%; font-family: 'Times New Roman',serif; color: black;\"\u003e8.2 (5.9)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 146.15pt; border: none; background: white; padding: 0in 5.4pt 0in 5.4pt; height: 8.5pt;\" width=\"195\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 150%; font-family: 'Times New Roman',serif; color: black;\"\u003e8.1 (5.8)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 8.5pt;\"\u003e\n\u003ctd style=\"border: none; background: white; padding: 0in 5.4pt 0in 5.4pt; height: 8.5pt;\"\u003e\n\u003cp style=\"line-height: 150%; tab-stops: 405.0pt;\"\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 150%; font-family: 'Times New Roman',serif; color: black;\"\u003eAlcohol abstainers during last year, n (%) (missing=956)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"border: none; background: white; padding: 0in 5.4pt 0in 5.4pt; height: 8.5pt;\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 150%; font-family: 'Times New Roman',serif; color: black;\"\u003e2215 (8.9)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 91.5pt; border: none; background: white; padding: 0in 5.4pt 0in 5.4pt; height: 8.5pt;\" width=\"122\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 150%; font-family: 'Times New Roman',serif; color: black;\"\u003e1105 (7.9)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 92.65pt; border: none; background: white; padding: 0in 5.4pt 0in 5.4pt; height: 8.5pt;\" width=\"124\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 150%; font-family: 'Times New Roman',serif; color: black;\"\u003e120 (7.3)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.55pt; border: none; background: white; padding: 0in 5.4pt 0in 5.4pt; height: 8.5pt;\" width=\"114\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 150%; font-family: 'Times New Roman',serif; color: black;\"\u003e182 (8.5)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 146.15pt; border: none; background: white; padding: 0in 5.4pt 0in 5.4pt; height: 8.5pt;\" width=\"195\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 150%; font-family: 'Times New Roman',serif; color: black;\"\u003e803 (7.9)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 8.5pt;\"\u003e\n\u003ctd style=\"border: none; background: white; padding: 0in 5.4pt 0in 5.4pt; height: 8.5pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 150%; tab-stops: 405.0pt;\"\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 150%; font-family: 'Times New Roman',serif; color: black;\"\u003ePhysical inactivity, n (%) (missing=615)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"border: none; background: white; padding: 0in 5.4pt 0in 5.4pt; height: 8.5pt;\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 150%; font-family: 'Times New Roman',serif; color: black;\"\u003e1231 (5.0)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 91.5pt; border: none; background: white; padding: 0in 5.4pt 0in 5.4pt; height: 8.5pt;\" width=\"122\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 150%; font-family: 'Times New Roman',serif; color: black;\"\u003e574 (4.1)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 92.65pt; border: none; background: white; padding: 0in 5.4pt 0in 5.4pt; height: 8.5pt;\" width=\"124\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 150%; font-family: 'Times New Roman',serif; color: black;\"\u003e69 (3.2)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.55pt; border: none; background: white; padding: 0in 5.4pt 0in 5.4pt; height: 8.5pt;\" width=\"114\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 150%; font-family: 'Times New Roman',serif; color: black;\"\u003e63 (3.8)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 146.15pt; border: none; background: white; padding: 0in 5.4pt 0in 5.4pt; height: 8.5pt;\" width=\"195\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 150%; font-family: 'Times New Roman',serif; color: black;\"\u003e442 (4.3)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 8.5pt;\"\u003e\n\u003ctd style=\"border: none; background: white; padding: 0in 5.4pt 0in 5.4pt; height: 8.5pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 150%; tab-stops: 405.0pt;\"\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 150%; font-family: 'Times New Roman',serif; color: black;\"\u003eSelf-reported hypertension, n (%) \u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"border: none; background: white; padding: 0in 5.4pt 0in 5.4pt; height: 8.5pt;\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 150%; font-family: 'Times New Roman',serif; color: black;\"\u003e6503 (26.2)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 91.5pt; border: none; background: white; padding: 0in 5.4pt 0in 5.4pt; height: 8.5pt;\" width=\"122\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 150%; font-family: 'Times New Roman',serif; color: black;\"\u003e2462 (17.6)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 92.65pt; border: none; background: white; padding: 0in 5.4pt 0in 5.4pt; height: 8.5pt;\" width=\"124\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 150%; font-family: 'Times New Roman',serif; color: black;\"\u003e359 (16.8)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.55pt; border: none; background: white; padding: 0in 5.4pt 0in 5.4pt; height: 8.5pt;\" width=\"114\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 150%; font-family: 'Times New Roman',serif; color: black;\"\u003e215 (13.0)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 146.15pt; border: none; background: white; padding: 0in 5.4pt 0in 5.4pt; height: 8.5pt;\" width=\"195\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 150%; font-family: 'Times New Roman',serif; color: black;\"\u003e1888 (18.5)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 8.5pt;\"\u003e\n\u003ctd style=\"border: none; background: white; padding: 0in 5.4pt 0in 5.4pt; height: 8.5pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 150%; tab-stops: 405.0pt;\"\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 150%; font-family: 'Times New Roman',serif; color: black;\"\u003eSelf-reported stroke and/or heart infarction (%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"border: none; background: white; padding: 0in 5.4pt 0in 5.4pt; height: 8.5pt;\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 150%; font-family: 'Times New Roman',serif; color: black;\"\u003e1771 (7.1)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 91.5pt; border: none; background: white; padding: 0in 5.4pt 0in 5.4pt; height: 8.5pt;\" width=\"122\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 150%; font-family: 'Times New Roman',serif; color: black;\"\u003e506 (3.6)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 92.65pt; border: none; background: white; padding: 0in 5.4pt 0in 5.4pt; height: 8.5pt;\" width=\"124\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 150%; font-family: 'Times New Roman',serif; color: black;\"\u003e63 (2.9)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.55pt; border: none; background: white; padding: 0in 5.4pt 0in 5.4pt; height: 8.5pt;\" width=\"114\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 150%; font-family: 'Times New Roman',serif; color: black;\"\u003e33 (2.0)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 146.15pt; border: none; background: white; padding: 0in 5.4pt 0in 5.4pt; height: 8.5pt;\" width=\"195\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 150%; font-family: 'Times New Roman',serif; color: black;\"\u003e410 (4.0)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 8.5pt;\"\u003e\n\u003ctd style=\"border: none; background: white; padding: 0in 5.4pt 0in 5.4pt; height: 8.5pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 150%; tab-stops: 405.0pt;\"\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 150%; font-family: 'Times New Roman',serif; color: black;\"\u003eSelf-reported diabetes mellitus, n (%) \u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"border: none; background: white; padding: 0in 5.4pt 0in 5.4pt; height: 8.5pt;\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 150%; font-family: 'Times New Roman',serif; color: black;\"\u003e1326 (5.3)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 91.5pt; border: none; background: white; padding: 0in 5.4pt 0in 5.4pt; height: 8.5pt;\" width=\"122\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 150%; font-family: 'Times New Roman',serif; color: black;\"\u003e466 (3.3)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 92.65pt; border: none; background: white; padding: 0in 5.4pt 0in 5.4pt; height: 8.5pt;\" width=\"124\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 150%; font-family: 'Times New Roman',serif; color: black;\"\u003e60 (2.8)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.55pt; border: none; background: white; padding: 0in 5.4pt 0in 5.4pt; height: 8.5pt;\" width=\"114\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 150%; font-family: 'Times New Roman',serif; color: black;\"\u003e34 (2.1)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 146.15pt; border: none; background: white; padding: 0in 5.4pt 0in 5.4pt; height: 8.5pt;\" width=\"195\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 150%; font-family: 'Times New Roman',serif; color: black;\"\u003e372 (3.6)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 8.5pt;\"\u003e\n\u003ctd style=\"border: none; background: white; padding: 0in 5.4pt 0in 5.4pt; height: 8.5pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 150%; tab-stops: 405.0pt;\"\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 150%; font-family: 'Times New Roman',serif; color: black;\"\u003eModified DSM-V insomnia, n (%) \u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"border: none; background: white; padding: 0in 5.4pt 0in 5.4pt; height: 8.5pt;\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 150%; font-family: 'Times New Roman',serif; color: black;\"\u003e1057 (4.3)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 91.5pt; border: none; background: white; padding: 0in 5.4pt 0in 5.4pt; height: 8.5pt;\" width=\"122\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 150%; font-family: 'Times New Roman',serif; color: black;\"\u003e1631 (11.7)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 92.65pt; border: none; background: white; padding: 0in 5.4pt 0in 5.4pt; height: 8.5pt;\" width=\"124\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 150%; font-family: 'Times New Roman',serif; color: black;\"\u003e362 (16.9)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.55pt; border: none; background: white; padding: 0in 5.4pt 0in 5.4pt; height: 8.5pt;\" width=\"114\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 150%; font-family: 'Times New Roman',serif; color: black;\"\u003e235 (14.2)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 146.15pt; border: none; background: white; padding: 0in 5.4pt 0in 5.4pt; height: 8.5pt;\" width=\"195\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 150%; font-family: 'Times New Roman',serif; color: black;\"\u003e1034 (10.1)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 8.5pt;\"\u003e\n\u003ctd style=\"border: none; border-bottom: solid black 1.0pt; background: white; padding: 0in 5.4pt 0in 5.4pt; height: 8.5pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 150%; tab-stops: 405.0pt;\"\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 150%; font-family: 'Times New Roman',serif; color: black;\"\u003eMean hs-CRP (95% CI)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"border: none; border-bottom: solid black 1.0pt; background: white; padding: 0in 5.4pt 0in 5.4pt; height: 8.5pt;\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 150%; font-family: 'Times New Roman',serif; color: black;\"\u003e2.2 (2.2-2.3)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 91.5pt; border: none; border-bottom: solid black 1.0pt; background: white; padding: 0in 5.4pt 0in 5.4pt; height: 8.5pt;\" width=\"122\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 150%; font-family: 'Times New Roman',serif; color: black;\"\u003e2.3 (2.2-2.3)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 92.65pt; border: none; border-bottom: solid black 1.0pt; background: white; padding: 0in 5.4pt 0in 5.4pt; height: 8.5pt;\" width=\"124\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 150%; font-family: 'Times New Roman',serif; color: black;\"\u003e2.4 (2.3-2.5)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.55pt; border: none; border-bottom: solid black 1.0pt; background: white; padding: 0in 5.4pt 0in 5.4pt; height: 8.5pt;\" width=\"114\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 150%; font-family: 'Times New Roman',serif; color: black;\"\u003e2.2 (2.1-2.4)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 146.15pt; border: none; border-bottom: solid black 1.0pt; background: white; padding: 0in 5.4pt 0in 5.4pt; height: 8.5pt;\" width=\"195\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10.0pt; line-height: 150%; font-family: 'Times New Roman',serif; color: black;\"\u003e2.3 (2.2-2.3)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003c/tbody\u003e\n\u003c/table\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 8.0pt; line-height: 107%; font-family: 'Times New Roman',serif;\"\u003eMA=migraine with aura; MO=Migraine without aura; HADS=Hospital Anxiety and Depression Scale; BMI=body mass index; hs-CRP=high sensitivity C-reactive protein; CI= Confidence intervals; DSM-V=Diagnostic and statistical manual of mental disorders, 5th ed.\u003c/span\u003e\u003c/p\u003e\u003c/br\u003e\u003c/br\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 107%; font-family: 'Times New Roman',serif;\"\u003eTable 2. \u003c/span\u003e\u003c/strong\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 107%; font-family: 'Times New Roman',serif;\"\u003eOdds ratio (OR) with 95% confidence interval (CI) of high sensitivity C-reactive protein (hs-CRP) defined as \u003c/span\u003e\u003cspan style=\"font-family: 'Times New Roman',serif;\"\u003e\u0026gt;3.0-20.0 mg/l\u003c/span\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 107%; font-family: 'Times New Roman',serif;\"\u003e related to headache types\u003c/span\u003e\u003c/p\u003e\n\u003ctable style=\"width: 100.0%; border-collapse: collapse; border: none;\" width=\"100%\"\u003e\n\u003ctbody\u003e\n\u003ctr style=\"height: 20.7pt;\"\u003e\n\u003ctd style=\"width: 19.74%; border-top: solid black 1.0pt; border-left: none; border-bottom: solid black 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt; height: 20.7pt;\" width=\"19%\"\u003e\n\u003cp style=\"line-height: 150%;\"\u003e\u003cstrong\u003e\u003cspan style=\"font-family: 'Times New Roman',serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 8.94%; border-top: solid black 1.0pt; border-left: none; border-bottom: solid black 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt; height: 20.7pt;\" width=\"8%\"\u003e\n\u003cp style=\"line-height: 150%;\"\u003e\u003cstrong\u003e\u003cspan style=\"font-family: 'Times New Roman',serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 2.42%; border-top: solid black 1.0pt; border-left: none; border-bottom: solid black 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt; height: 20.7pt;\" width=\"2%\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cstrong\u003e\u003cspan style=\"font-family: 'Times New Roman',serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 12.28%; border-top: solid black 1.0pt; border-left: none; border-bottom: solid black 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt; height: 20.7pt;\" width=\"12%\"\u003e\n\u003cp style=\"text-align: right; line-height: normal;\"\u003e\u003cspan style=\"font-family: 'Times New Roman',serif;\"\u003eHigh hs-CRP \u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 18.34%; border-top: solid black 1.0pt; border-left: none; border-bottom: solid black 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt; height: 20.7pt;\" width=\"18%\"\u003e\n\u003cp style=\"text-align: center; line-height: normal;\"\u003e\u003cstrong\u003e\u003cspan style=\"font-family: 'Times New Roman',serif;\"\u003eModel 1\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 2.42%; border-top: solid black 1.0pt; border-left: none; border-bottom: solid black 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt; height: 20.7pt;\" width=\"2%\"\u003e\n\u003cp style=\"line-height: 150%;\"\u003e\u003cstrong\u003e\u003cspan style=\"font-family: 'Times New Roman',serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 17.94%; border-top: solid black 1.0pt; border-left: none; border-bottom: solid black 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt; height: 20.7pt;\" width=\"17%\"\u003e\n\u003cp style=\"line-height: 150%;\"\u003e\u003cstrong\u003e\u003cspan style=\"font-family: 'Times New Roman',serif;\"\u003eModel 2\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 17.92%; border-top: solid black 1.0pt; border-left: none; border-bottom: solid black 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt; height: 20.7pt;\" width=\"17%\"\u003e\n\u003cp style=\"line-height: 150%;\"\u003e\u003cstrong\u003e\u003cspan style=\"font-family: 'Times New Roman',serif;\"\u003eModel 3\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 19.74%; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"19%\"\u003e\n\u003cp style=\"line-height: normal;\"\u003e\u003cspan style=\"font-family: 'Times New Roman',serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 8.94%; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"8%\"\u003e\n\u003cp style=\"text-align: right; line-height: normal;\"\u003e\u003cspan style=\"font-family: 'Times New Roman',serif;\"\u003eTotal \u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 2.42%; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"2%\"\u003e\n\u003cp style=\"text-align: right; line-height: normal;\"\u003e\u003cspan style=\"font-family: 'Times New Roman',serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 12.28%; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"12%\"\u003e\n\u003cp style=\"text-align: center; line-height: normal;\"\u003e\u003cspan style=\"font-family: 'Times New Roman',serif;\"\u003eN\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 18.34%; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"18%\"\u003e\n\u003cp style=\"line-height: normal;\"\u003e\u003cspan style=\"font-family: 'Times New Roman',serif;\"\u003eOR (95% CI)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 2.42%; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"2%\"\u003e\n\u003cp style=\"line-height: normal;\"\u003e\u003cspan style=\"font-family: 'Times New Roman',serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 17.94%; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"17%\"\u003e\n\u003cp style=\"line-height: normal;\"\u003e\u003cspan style=\"font-family: 'Times New Roman',serif;\"\u003eOR (95% CI)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 17.92%; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"17%\"\u003e\n\u003cp style=\"line-height: normal;\"\u003e\u003cspan style=\"font-family: 'Times New Roman',serif;\"\u003eOR (95% CI)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 19.74%; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"19%\"\u003e\n\u003cp style=\"line-height: normal;\"\u003e\u003cspan style=\"font-family: 'Times New Roman',serif;\"\u003eNo headache\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 8.94%; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"8%\"\u003e\n\u003cp style=\"text-align: right; line-height: normal;\"\u003e\u003cspan style=\"font-family: 'Times New Roman',serif;\"\u003e24,823\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 2.42%; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"2%\"\u003e\n\u003cp style=\"text-align: right; line-height: normal;\"\u003e\u003cspan style=\"font-family: 'Times New Roman',serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 12.28%; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"12%\"\u003e\n\u003cp style=\"text-align: center; line-height: normal;\"\u003e\u003cspan style=\"font-family: 'Times New Roman',serif;\"\u003e5179\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 18.34%; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"18%\"\u003e\n\u003cp style=\"line-height: normal;\"\u003e\u003cspan style=\"font-family: 'Times New Roman',serif;\"\u003e1.00 \u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 2.42%; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"2%\"\u003e\n\u003cp style=\"line-height: normal;\"\u003e\u003cspan style=\"font-family: 'Times New Roman',serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 17.94%; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"17%\"\u003e\n\u003cp style=\"line-height: normal;\"\u003e\u003cspan style=\"font-family: 'Times New Roman',serif;\"\u003e1.00 \u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 17.92%; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"17%\"\u003e\n\u003cp style=\"line-height: normal;\"\u003e\u003cspan style=\"font-family: 'Times New Roman',serif;\"\u003e1.00 \u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 19.74%; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"19%\"\u003e\n\u003cp style=\"line-height: normal;\"\u003e\u003cstrong\u003e\u003cspan style=\"font-family: 'Times New Roman',serif;\"\u003eAny headache\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 8.94%; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"8%\"\u003e\n\u003cp style=\"text-align: right; line-height: normal;\"\u003e\u003cspan style=\"font-family: 'Times New Roman',serif;\"\u003e13,990\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 2.42%; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"2%\"\u003e\n\u003cp style=\"text-align: right; line-height: normal;\"\u003e\u003cspan style=\"font-family: 'Times New Roman',serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 12.28%; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"12%\"\u003e\n\u003cp style=\"text-align: center; line-height: normal;\"\u003e\u003cspan style=\"font-family: 'Times New Roman',serif;\"\u003e3029\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 18.34%; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"18%\"\u003e\n\u003cp style=\"line-height: normal;\"\u003e\u003cspan style=\"font-family: 'Times New Roman',serif;\"\u003e1.11 (1.05-1.17)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 2.42%; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"2%\"\u003e\n\u003cp style=\"line-height: normal;\"\u003e\u003cspan style=\"font-family: 'Times New Roman',serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 17.94%; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"17%\"\u003e\n\u003cp style=\"line-height: normal;\"\u003e\u003cspan style=\"font-family: 'Times New Roman',serif;\"\u003e1.07 (1.01-1.13)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 17.92%; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"17%\"\u003e\n\u003cp style=\"line-height: normal;\"\u003e\u003cspan style=\"font-family: 'Times New Roman',serif;\"\u003e1.05 (1.00-1.11)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 19.74%; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"19%\"\u003e\n\u003cp style=\"line-height: normal;\"\u003e\u003cspan style=\"font-family: 'Times New Roman',serif;\"\u003e\u0026lt;1 days/month\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 8.94%; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"8%\"\u003e\n\u003cp style=\"text-align: right; line-height: normal;\"\u003e\u003cspan style=\"font-family: 'Times New Roman',serif;\"\u003e3176\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 2.42%; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"2%\"\u003e\n\u003cp style=\"text-align: right; line-height: normal;\"\u003e\u003cspan style=\"font-family: 'Times New Roman',serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 12.28%; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"12%\"\u003e\n\u003cp style=\"text-align: center; line-height: normal;\"\u003e\u003cspan style=\"font-family: 'Times New Roman',serif;\"\u003e581\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 18.34%; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"18%\"\u003e\n\u003cp style=\"line-height: normal;\"\u003e\u003cspan style=\"font-family: 'Times New Roman',serif;\"\u003e1.02 (0.95-1.11)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 2.42%; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"2%\"\u003e\n\u003cp style=\"line-height: normal;\"\u003e\u003cspan style=\"font-family: 'Times New Roman',serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 17.94%; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"17%\"\u003e\n\u003cp style=\"line-height: normal;\"\u003e\u003cspan style=\"font-family: 'Times New Roman',serif;\"\u003e0.99 (0.91-1.07)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 17.92%; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"17%\"\u003e\n\u003cp style=\"line-height: normal;\"\u003e\u003cspan style=\"font-family: 'Times New Roman',serif;\"\u003e0.97 (0.90-1.08\u003cstrong\u003e)\u003c/strong\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 19.74%; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"19%\"\u003e\n\u003cp style=\"line-height: normal;\"\u003e\u003cspan style=\"font-family: 'Times New Roman',serif;\"\u003e1-6 days/month\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 8.94%; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"8%\"\u003e\n\u003cp style=\"text-align: right; line-height: normal;\"\u003e\u003cspan style=\"font-family: 'Times New Roman',serif;\"\u003e8099\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 2.42%; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"2%\"\u003e\n\u003cp style=\"text-align: right; line-height: normal;\"\u003e\u003cspan style=\"font-family: 'Times New Roman',serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 12.28%; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"12%\"\u003e\n\u003cp style=\"text-align: center; line-height: normal;\"\u003e\u003cspan style=\"font-family: 'Times New Roman',serif;\"\u003e1761\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 18.34%; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"18%\"\u003e\n\u003cp style=\"line-height: normal;\"\u003e\u003cspan style=\"font-family: 'Times New Roman',serif;\"\u003e1.06 (0.99-1.13)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 2.42%; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"2%\"\u003e\n\u003cp style=\"line-height: normal;\"\u003e\u003cspan style=\"font-family: 'Times New Roman',serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 17.94%; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"17%\"\u003e\n\u003cp style=\"line-height: normal;\"\u003e\u003cspan style=\"font-family: 'Times New Roman',serif;\"\u003e1.01 (0.95-1.08)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 17.92%; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"17%\"\u003e\n\u003cp style=\"line-height: normal;\"\u003e\u003cspan style=\"font-family: 'Times New Roman',serif;\"\u003e0.99 (0.93-1.07)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 19.74%; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"19%\"\u003e\n\u003cp style=\"line-height: normal;\"\u003e\u003cspan style=\"font-family: 'Times New Roman',serif;\"\u003e7-14 days/month\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 8.94%; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"8%\"\u003e\n\u003cp style=\"text-align: right; line-height: normal;\"\u003e\u003cspan style=\"font-family: 'Times New Roman',serif;\"\u003e1731\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 2.42%; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"2%\"\u003e\n\u003cp style=\"text-align: right; line-height: normal;\"\u003e\u003cspan style=\"font-family: 'Times New Roman',serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 12.28%; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"12%\"\u003e\n\u003cp style=\"text-align: center; line-height: normal;\"\u003e\u003cspan style=\"font-family: 'Times New Roman',serif;\"\u003e425\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 18.34%; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"18%\"\u003e\n\u003cp style=\"line-height: normal;\"\u003e\u003cspan style=\"font-family: 'Times New Roman',serif;\"\u003e1.28 (1.14-1.44)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 2.42%; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"2%\"\u003e\n\u003cp style=\"line-height: normal;\"\u003e\u003cspan style=\"font-family: 'Times New Roman',serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 17.94%; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"17%\"\u003e\n\u003cp style=\"line-height: normal;\"\u003e\u003cspan style=\"font-family: 'Times New Roman',serif;\"\u003e1.21 (1.08-1.37)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 17.92%; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"17%\"\u003e\n\u003cp style=\"line-height: normal;\"\u003e\u003cspan style=\"font-family: 'Times New Roman',serif;\"\u003e1.15 (1.04-1.30\u003cstrong\u003e)\u003c/strong\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 19.74%; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"19%\"\u003e\n\u003cp style=\"line-height: normal;\"\u003e\u003cspan style=\"font-family: 'Times New Roman',serif;\"\u003e\u0026ge; 15 days/month\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 8.94%; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"8%\"\u003e\n\u003cp style=\"text-align: right; line-height: normal;\"\u003e\u003cspan style=\"font-family: 'Times New Roman',serif;\"\u003e984\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 2.42%; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"2%\"\u003e\n\u003cp style=\"text-align: right; line-height: normal;\"\u003e\u003cspan style=\"font-family: 'Times New Roman',serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 12.28%; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"12%\"\u003e\n\u003cp style=\"text-align: center; line-height: normal;\"\u003e\u003cspan style=\"font-family: 'Times New Roman',serif;\"\u003e262\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 18.34%; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"18%\"\u003e\n\u003cp style=\"line-height: normal;\"\u003e\u003cspan style=\"font-family: 'Times New Roman',serif;\"\u003e1.40 (1.21-1.62)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 2.42%; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"2%\"\u003e\n\u003cp style=\"line-height: normal;\"\u003e\u003cspan style=\"font-family: 'Times New Roman',serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 17.94%; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"17%\"\u003e\n\u003cp style=\"line-height: normal;\"\u003e\u003cspan style=\"font-family: 'Times New Roman',serif;\"\u003e1.32 (1.13-1.53)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 17.92%; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"17%\"\u003e\n\u003cp style=\"line-height: normal;\"\u003e\u003cspan style=\"font-family: 'Times New Roman',serif;\"\u003e1.26 (1.08-1.48\u003cstrong\u003e)\u003c/strong\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 19.74%; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"19%\"\u003e\n\u003cp style=\"line-height: normal;\"\u003e\u003cspan style=\"font-family: 'Times New Roman',serif;\"\u003eP trend\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 8.94%; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"8%\"\u003e\n\u003cp style=\"text-align: right; line-height: normal;\"\u003e\u003cspan style=\"font-family: 'Times New Roman',serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 2.42%; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"2%\"\u003e\n\u003cp style=\"text-align: right; line-height: normal;\"\u003e\u003cspan style=\"font-family: 'Times New Roman',serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 12.28%; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"12%\"\u003e\n\u003cp style=\"text-align: center; line-height: normal;\"\u003e\u003cspan style=\"font-family: 'Times New Roman',serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 18.34%; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"18%\"\u003e\n\u003cp style=\"line-height: normal;\"\u003e\u003cspan style=\"font-family: 'Times New Roman',serif;\"\u003e\u0026lt;0.001\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 2.42%; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"2%\"\u003e\n\u003cp style=\"line-height: normal;\"\u003e\u003cspan style=\"font-family: 'Times New Roman',serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 17.94%; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"17%\"\u003e\n\u003cp style=\"line-height: normal;\"\u003e\u003cspan style=\"font-family: 'Times New Roman',serif;\"\u003e0.001\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 17.92%; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"17%\"\u003e\n\u003cp style=\"line-height: normal;\"\u003e\u003cspan style=\"font-family: 'Times New Roman',serif;\"\u003e0.01\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 19.74%; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"19%\"\u003e\n\u003cp style=\"line-height: normal;\"\u003e\u003cstrong\u003e\u003cspan style=\"font-family: 'Times New Roman',serif;\"\u003eMigraine\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 8.94%; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"8%\"\u003e\n\u003cp style=\"text-align: right; line-height: normal;\"\u003e\u003cspan style=\"font-family: 'Times New Roman',serif;\"\u003e3793\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 2.42%; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"2%\"\u003e\n\u003cp style=\"text-align: right; line-height: normal;\"\u003e\u003cspan style=\"font-family: 'Times New Roman',serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 12.28%; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"12%\"\u003e\n\u003cp style=\"text-align: center; line-height: normal;\"\u003e\u003cspan style=\"font-family: 'Times New Roman',serif;\"\u003e864\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 18.34%; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"18%\"\u003e\n\u003cp style=\"line-height: normal;\"\u003e\u003cspan style=\"font-family: 'Times New Roman',serif;\"\u003e1.23 (1.13-1.34)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 2.42%; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"2%\"\u003e\n\u003cp style=\"line-height: normal;\"\u003e\u003cspan style=\"font-family: 'Times New Roman',serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 17.94%; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"17%\"\u003e\n\u003cp style=\"line-height: normal;\"\u003e\u003cspan style=\"font-family: 'Times New Roman',serif;\"\u003e1.17 (1.07-1.28)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 17.92%; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"17%\"\u003e\n\u003cp style=\"line-height: normal;\"\u003e\u003cspan style=\"font-family: 'Times New Roman',serif;\"\u003e1.14 (1.04-1.25)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 19.74%; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"19%\"\u003e\n\u003cp style=\"line-height: normal;\"\u003e\u003cspan style=\"font-family: 'Times New Roman',serif;\"\u003e\u0026lt; 1 days/month\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 8.94%; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"8%\"\u003e\n\u003cp style=\"text-align: right; line-height: normal;\"\u003e\u003cspan style=\"font-family: 'Times New Roman',serif;\"\u003e599\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 2.42%; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"2%\"\u003e\n\u003cp style=\"text-align: right; line-height: normal;\"\u003e\u003cspan style=\"font-family: 'Times New Roman',serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 12.28%; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"12%\"\u003e\n\u003cp style=\"text-align: center; line-height: normal;\"\u003e\u003cspan style=\"font-family: 'Times New Roman',serif;\"\u003e115\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 18.34%; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"18%\"\u003e\n\u003cp style=\"line-height: normal;\"\u003e\u003cspan style=\"font-family: 'Times New Roman',serif;\"\u003e0.99 (0.89-1.10)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 2.42%; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"2%\"\u003e\n\u003cp style=\"line-height: normal;\"\u003e\u003cspan style=\"font-family: 'Times New Roman',serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 17.94%; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"17%\"\u003e\n\u003cp style=\"line-height: normal;\"\u003e\u003cspan style=\"font-family: 'Times New Roman',serif;\"\u003e0.94 (0.84-1.05)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 17.92%; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"17%\"\u003e\n\u003cp style=\"line-height: normal;\"\u003e\u003cspan style=\"font-family: 'Times New Roman',serif;\"\u003e0.92 (0.82-1.02)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 19.74%; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"19%\"\u003e\n\u003cp style=\"line-height: normal;\"\u003e\u003cspan style=\"font-family: 'Times New Roman',serif;\"\u003e1-6 days/month\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 8.94%; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"8%\"\u003e\n\u003cp style=\"text-align: right; line-height: normal;\"\u003e\u003cspan style=\"font-family: 'Times New Roman',serif;\"\u003e2340\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 2.42%; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"2%\"\u003e\n\u003cp style=\"text-align: right; line-height: normal;\"\u003e\u003cspan style=\"font-family: 'Times New Roman',serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 12.28%; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"12%\"\u003e\n\u003cp style=\"text-align: center; line-height: normal;\"\u003e\u003cspan style=\"font-family: 'Times New Roman',serif;\"\u003e526\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 18.34%; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"18%\"\u003e\n\u003cp style=\"line-height: normal;\"\u003e\u003cspan style=\"font-family: 'Times New Roman',serif;\"\u003e1.19 (1.07-1.31)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 2.42%; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"2%\"\u003e\n\u003cp style=\"line-height: normal;\"\u003e\u003cspan style=\"font-family: 'Times New Roman',serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 17.94%; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"17%\"\u003e\n\u003cp style=\"line-height: normal;\"\u003e\u003cspan style=\"font-family: 'Times New Roman',serif;\"\u003e1.12 (1.01-1.25)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 17.92%; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"17%\"\u003e\n\u003cp style=\"line-height: normal;\"\u003e\u003cspan style=\"font-family: 'Times New Roman',serif;\"\u003e1.10 (1.00-1.23)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 19.74%; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"19%\"\u003e\n\u003cp style=\"line-height: normal;\"\u003e\u003cspan style=\"font-family: 'Times New Roman',serif;\"\u003e7-14 days/month\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 8.94%; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"8%\"\u003e\n\u003cp style=\"text-align: right; line-height: normal;\"\u003e\u003cspan style=\"font-family: 'Times New Roman',serif;\"\u003e625\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 2.42%; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"2%\"\u003e\n\u003cp style=\"text-align: right; line-height: normal;\"\u003e\u003cspan style=\"font-family: 'Times New Roman',serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 12.28%; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"12%\"\u003e\n\u003cp style=\"text-align: center; line-height: normal;\"\u003e\u003cspan style=\"font-family: 'Times New Roman',serif;\"\u003e152\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 18.34%; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"18%\"\u003e\n\u003cp style=\"line-height: normal;\"\u003e\u003cspan style=\"font-family: 'Times New Roman',serif;\"\u003e1.36 (1.12-1.64)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 2.42%; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"2%\"\u003e\n\u003cp style=\"line-height: normal;\"\u003e\u003cspan style=\"font-family: 'Times New Roman',serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 17.94%; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"17%\"\u003e\n\u003cp style=\"line-height: normal;\"\u003e\u003cspan style=\"font-family: 'Times New Roman',serif;\"\u003e1.32 (1.09-1.60)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 17.92%; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"17%\"\u003e\n\u003cp style=\"line-height: normal;\"\u003e\u003cspan style=\"font-family: 'Times New Roman',serif;\"\u003e1.24 (1.02-1.51\u003cstrong\u003e)\u003c/strong\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 19.74%; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"19%\"\u003e\n\u003cp style=\"line-height: normal;\"\u003e\u003cspan style=\"font-family: 'Times New Roman',serif;\"\u003e\u0026ge; 15 days/month\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 8.94%; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"8%\"\u003e\n\u003cp style=\"text-align: right; line-height: normal;\"\u003e\u003cspan style=\"font-family: 'Times New Roman',serif;\"\u003e229\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 2.42%; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"2%\"\u003e\n\u003cp style=\"text-align: right; line-height: normal;\"\u003e\u003cspan style=\"font-family: 'Times New Roman',serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 12.28%; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"12%\"\u003e\n\u003cp style=\"text-align: center; line-height: normal;\"\u003e\u003cspan style=\"font-family: 'Times New Roman',serif;\"\u003e71\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 18.34%; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"18%\"\u003e\n\u003cp style=\"line-height: normal;\"\u003e\u003cspan style=\"font-family: 'Times New Roman',serif;\"\u003e1.88 (1.42-2.50)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 2.42%; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"2%\"\u003e\n\u003cp style=\"line-height: normal;\"\u003e\u003cspan style=\"font-family: 'Times New Roman',serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 17.94%; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"17%\"\u003e\n\u003cp style=\"line-height: normal;\"\u003e\u003cspan style=\"font-family: 'Times New Roman',serif;\"\u003e1.72 (1.29-2.31)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 17.92%; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"17%\"\u003e\n\u003cp style=\"line-height: normal;\"\u003e\u003cspan style=\"font-family: 'Times New Roman',serif;\"\u003e1.62 (1.21-2.17\u003cstrong\u003e)\u003c/strong\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 19.74%; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"19%\"\u003e\n\u003cp style=\"line-height: normal;\"\u003e\u003cspan style=\"font-family: 'Times New Roman',serif;\"\u003eP trend\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 8.94%; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"8%\"\u003e\n\u003cp style=\"text-align: right; line-height: normal;\"\u003e\u003cspan style=\"font-family: 'Times New Roman',serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 2.42%; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"2%\"\u003e\n\u003cp style=\"text-align: right; line-height: normal;\"\u003e\u003cspan style=\"font-family: 'Times New Roman',serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 12.28%; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"12%\"\u003e\n\u003cp style=\"text-align: center; line-height: normal;\"\u003e\u003cspan style=\"font-family: 'Times New Roman',serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 18.34%; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"18%\"\u003e\n\u003cp style=\"line-height: normal;\"\u003e\u003cspan style=\"font-family: 'Times New Roman',serif;\"\u003e\u0026lt;0.001\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 2.42%; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"2%\"\u003e\n\u003cp style=\"line-height: normal;\"\u003e\u003cspan style=\"font-family: 'Times New Roman',serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 17.94%; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"17%\"\u003e\n\u003cp style=\"line-height: normal;\"\u003e\u003cspan style=\"font-family: 'Times New Roman',serif;\"\u003e\u0026lt;0.001\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 17.92%; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"17%\"\u003e\n\u003cp style=\"line-height: normal;\"\u003e\u003cspan style=\"font-family: 'Times New Roman',serif;\"\u003e0.01\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 19.74%; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"19%\"\u003e\n\u003cp style=\"line-height: normal;\"\u003e\u003cstrong\u003e\u003cspan style=\"font-family: 'Times New Roman',serif;\"\u003eMA\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 8.94%; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"8%\"\u003e\n\u003cp style=\"text-align: right; line-height: normal;\"\u003e\u003cspan style=\"font-family: 'Times New Roman',serif;\"\u003e2139\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 2.42%; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"2%\"\u003e\n\u003cp style=\"text-align: right; line-height: normal;\"\u003e\u003cspan style=\"font-family: 'Times New Roman',serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 12.28%; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"12%\"\u003e\n\u003cp style=\"text-align: center; line-height: normal;\"\u003e\u003cspan style=\"font-family: 'Times New Roman',serif;\"\u003e509\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 18.34%; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"18%\"\u003e\n\u003cp style=\"line-height: normal;\"\u003e\u003cspan style=\"font-family: 'Times New Roman',serif;\"\u003e1.26 (1.13-1.40)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 2.42%; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"2%\"\u003e\n\u003cp style=\"line-height: normal;\"\u003e\u003cspan style=\"font-family: 'Times New Roman',serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 17.94%; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"17%\"\u003e\n\u003cp style=\"line-height: normal;\"\u003e\u003cspan style=\"font-family: 'Times New Roman',serif;\"\u003e1.24 (1.11-1.39)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 17.92%; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"17%\"\u003e\n\u003cp style=\"line-height: normal;\"\u003e\u003cspan style=\"font-family: 'Times New Roman',serif;\"\u003e1.15 (1.03-1.29)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 19.74%; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"19%\"\u003e\n\u003cp style=\"line-height: normal;\"\u003e\u003cspan style=\"font-family: 'Times New Roman',serif;\"\u003e\u0026lt; 1 days/month\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 8.94%; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"8%\"\u003e\n\u003cp style=\"text-align: right; line-height: normal;\"\u003e\u003cspan style=\"font-family: 'Times New Roman',serif;\"\u003e320\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 2.42%; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"2%\"\u003e\n\u003cp style=\"text-align: right; line-height: normal;\"\u003e\u003cspan style=\"font-family: 'Times New Roman',serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 12.28%; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"12%\"\u003e\n\u003cp style=\"text-align: center; line-height: normal;\"\u003e\u003cspan style=\"font-family: 'Times New Roman',serif;\"\u003e65\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 18.34%; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"18%\"\u003e\n\u003cp style=\"line-height: normal;\"\u003e\u003cspan style=\"font-family: 'Times New Roman',serif;\"\u003e1.01 (0.90-1.13)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 2.42%; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"2%\"\u003e\n\u003cp style=\"line-height: normal;\"\u003e\u003cspan style=\"font-family: 'Times New Roman',serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 17.94%; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"17%\"\u003e\n\u003cp style=\"line-height: normal;\"\u003e\u003cspan style=\"font-family: 'Times New Roman',serif;\"\u003e0.95 (0.85-1.07)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 17.92%; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"17%\"\u003e\n\u003cp style=\"line-height: normal;\"\u003e\u003cspan style=\"font-family: 'Times New Roman',serif;\"\u003e0.93 (0.82-1.04)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 19.74%; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"19%\"\u003e\n\u003cp style=\"line-height: normal;\"\u003e\u003cspan style=\"font-family: 'Times New Roman',serif;\"\u003e1-6 days/month\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 8.94%; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"8%\"\u003e\n\u003cp style=\"text-align: right; line-height: normal;\"\u003e\u003cspan style=\"font-family: 'Times New Roman',serif;\"\u003e1290\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 2.42%; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"2%\"\u003e\n\u003cp style=\"text-align: right; line-height: normal;\"\u003e\u003cspan style=\"font-family: 'Times New Roman',serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 12.28%; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"12%\"\u003e\n\u003cp style=\"text-align: center; line-height: normal;\"\u003e\u003cspan style=\"font-family: 'Times New Roman',serif;\"\u003e293\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 18.34%; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"18%\"\u003e\n\u003cp style=\"line-height: normal;\"\u003e\u003cspan style=\"font-family: 'Times New Roman',serif;\"\u003e1.19 (1.05-1.35)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 2.42%; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"2%\"\u003e\n\u003cp style=\"line-height: normal;\"\u003e\u003cspan style=\"font-family: 'Times New Roman',serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 17.94%; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"17%\"\u003e\n\u003cp style=\"line-height: normal;\"\u003e\u003cspan style=\"font-family: 'Times New Roman',serif;\"\u003e1.13 (0.99-1.28)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 17.92%; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"17%\"\u003e\n\u003cp style=\"line-height: normal;\"\u003e\u003cspan style=\"font-family: 'Times New Roman',serif;\"\u003e1.09 (0.96-1.24)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 19.74%; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"19%\"\u003e\n\u003cp style=\"line-height: normal;\"\u003e\u003cspan style=\"font-family: 'Times New Roman',serif;\"\u003e7-14 days/month\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 8.94%; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"8%\"\u003e\n\u003cp style=\"text-align: right; line-height: normal;\"\u003e\u003cspan style=\"font-family: 'Times New Roman',serif;\"\u003e391\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 2.42%; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"2%\"\u003e\n\u003cp style=\"text-align: right; line-height: normal;\"\u003e\u003cspan style=\"font-family: 'Times New Roman',serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 12.28%; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"12%\"\u003e\n\u003cp style=\"text-align: center; line-height: normal;\"\u003e\u003cspan style=\"font-family: 'Times New Roman',serif;\"\u003e105\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 18.34%; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"18%\"\u003e\n\u003cp style=\"line-height: normal;\"\u003e\u003cspan style=\"font-family: 'Times New Roman',serif;\"\u003e1.56 (1.23-1.96)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 2.42%; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"2%\"\u003e\n\u003cp style=\"line-height: normal;\"\u003e\u003cspan style=\"font-family: 'Times New Roman',serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 17.94%; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"17%\"\u003e\n\u003cp style=\"line-height: normal;\"\u003e\u003cspan style=\"font-family: 'Times New Roman',serif;\"\u003e1.51 (1.19-1.91)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 17.92%; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"17%\"\u003e\n\u003cp style=\"line-height: normal;\"\u003e\u003cspan style=\"font-family: 'Times New Roman',serif;\"\u003e1.40 (1.11-1.77\u003cstrong\u003e)\u003c/strong\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 19.74%; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"19%\"\u003e\n\u003cp style=\"line-height: normal;\"\u003e\u003cspan style=\"font-family: 'Times New Roman',serif;\"\u003e\u0026ge; 15 days/month\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 8.94%; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"8%\"\u003e\n\u003cp style=\"text-align: right; line-height: normal;\"\u003e\u003cspan style=\"font-family: 'Times New Roman',serif;\"\u003e138\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 2.42%; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"2%\"\u003e\n\u003cp style=\"text-align: right; line-height: normal;\"\u003e\u003cspan style=\"font-family: 'Times New Roman',serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 12.28%; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"12%\"\u003e\n\u003cp style=\"text-align: center; line-height: normal;\"\u003e\u003cspan style=\"font-family: 'Times New Roman',serif;\"\u003e46\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 18.34%; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"18%\"\u003e\n\u003cp style=\"line-height: normal;\"\u003e\u003cspan style=\"font-family: 'Times New Roman',serif;\"\u003e2.15 (1.50-3.08)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 2.42%; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"2%\"\u003e\n\u003cp style=\"line-height: normal;\"\u003e\u003cspan style=\"font-family: 'Times New Roman',serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 17.94%; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"17%\"\u003e\n\u003cp style=\"line-height: normal;\"\u003e\u003cspan style=\"font-family: 'Times New Roman',serif;\"\u003e2.01 (1.39-2.90)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 17.92%; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"17%\"\u003e\n\u003cp style=\"line-height: normal;\"\u003e\u003cspan style=\"font-family: 'Times New Roman',serif;\"\u003e1.84 (1.27-2.67\u003cstrong\u003e)\u003c/strong\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 19.74%; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"19%\"\u003e\n\u003cp style=\"line-height: normal;\"\u003e\u003cspan style=\"font-family: 'Times New Roman',serif;\"\u003eP trend\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 8.94%; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"8%\"\u003e\n\u003cp style=\"text-align: right; line-height: normal;\"\u003e\u003cspan style=\"font-family: 'Times New Roman',serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 2.42%; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"2%\"\u003e\n\u003cp style=\"text-align: right; line-height: normal;\"\u003e\u003cspan style=\"font-family: 'Times New Roman',serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 12.28%; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"12%\"\u003e\n\u003cp style=\"text-align: center; line-height: normal;\"\u003e\u003cspan style=\"font-family: 'Times New Roman',serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 18.34%; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"18%\"\u003e\n\u003cp style=\"line-height: normal;\"\u003e\u003cspan style=\"font-family: 'Times New Roman',serif;\"\u003e\u0026lt;0.001\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 2.42%; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"2%\"\u003e\n\u003cp style=\"line-height: normal;\"\u003e\u003cspan style=\"font-family: 'Times New Roman',serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 17.94%; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"17%\"\u003e\n\u003cp style=\"line-height: normal;\"\u003e\u003cspan style=\"font-family: 'Times New Roman',serif;\"\u003e\u0026lt;0.001\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 17.92%; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"17%\"\u003e\n\u003cp style=\"line-height: normal;\"\u003e\u003cspan style=\"font-family: 'Times New Roman',serif;\"\u003e0.002\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 19.74%; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"19%\"\u003e\n\u003cp style=\"line-height: normal;\"\u003e\u003cstrong\u003e\u003cspan style=\"font-family: 'Times New Roman',serif;\"\u003eMO\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 8.94%; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"8%\"\u003e\n\u003cp style=\"text-align: right; line-height: normal;\"\u003e\u003cspan style=\"font-family: 'Times New Roman',serif;\"\u003e1654\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 2.42%; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"2%\"\u003e\n\u003cp style=\"text-align: right; line-height: normal;\"\u003e\u003cspan style=\"font-family: 'Times New Roman',serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 12.28%; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"12%\"\u003e\n\u003cp style=\"text-align: center; line-height: normal;\"\u003e\u003cspan style=\"font-family: 'Times New Roman',serif;\"\u003e355\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 18.34%; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"18%\"\u003e\n\u003cp style=\"line-height: normal;\"\u003e\u003cspan style=\"font-family: 'Times New Roman',serif;\"\u003e1.17 (1.03-1.32)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 2.42%; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"2%\"\u003e\n\u003cp style=\"line-height: normal;\"\u003e\u003cspan style=\"font-family: 'Times New Roman',serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 17.94%; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"17%\"\u003e\n\u003cp style=\"line-height: normal;\"\u003e\u003cspan style=\"font-family: 'Times New Roman',serif;\"\u003e1.12 (0.99-1.27)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 17.92%; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"17%\"\u003e\n\u003cp style=\"line-height: normal;\"\u003e\u003cspan style=\"font-family: 'Times New Roman',serif;\"\u003e1.09 (0.96-1.24)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 19.74%; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"19%\"\u003e\n\u003cp style=\"line-height: normal;\"\u003e\u003cspan style=\"font-family: 'Times New Roman',serif;\"\u003e\u0026lt; 1 days/month\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 8.94%; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"8%\"\u003e\n\u003cp style=\"text-align: right; line-height: normal;\"\u003e\u003cspan style=\"font-family: 'Times New Roman',serif;\"\u003e279\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 2.42%; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"2%\"\u003e\n\u003cp style=\"text-align: right; line-height: normal;\"\u003e\u003cspan style=\"font-family: 'Times New Roman',serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 12.28%; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"12%\"\u003e\n\u003cp style=\"text-align: center; line-height: normal;\"\u003e\u003cspan style=\"font-family: 'Times New Roman',serif;\"\u003e50\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 18.34%; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"18%\"\u003e\n\u003cp style=\"line-height: normal;\"\u003e\u003cspan style=\"font-family: 'Times New Roman',serif;\"\u003e0.99 (0.88-1.11)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 2.42%; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"2%\"\u003e\n\u003cp style=\"line-height: normal;\"\u003e\u003cspan style=\"font-family: 'Times New Roman',serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 17.94%; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"17%\"\u003e\n\u003cp style=\"line-height: normal;\"\u003e\u003cspan style=\"font-family: 'Times New Roman',serif;\"\u003e0.94 (0.84-1.06)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 17.92%; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"17%\"\u003e\n\u003cp style=\"line-height: normal;\"\u003e\u003cspan style=\"font-family: 'Times New Roman',serif;\"\u003e0.92 (0.82-1.04)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 19.74%; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"19%\"\u003e\n\u003cp style=\"line-height: normal;\"\u003e\u003cspan style=\"font-family: 'Times New Roman',serif;\"\u003e1-6 days/month\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 8.94%; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"8%\"\u003e\n\u003cp style=\"text-align: right; line-height: normal;\"\u003e\u003cspan style=\"font-family: 'Times New Roman',serif;\"\u003e1050\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 2.42%; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"2%\"\u003e\n\u003cp style=\"text-align: right; line-height: normal;\"\u003e\u003cspan style=\"font-family: 'Times New Roman',serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 12.28%; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"12%\"\u003e\n\u003cp style=\"text-align: center; line-height: normal;\"\u003e\u003cspan style=\"font-family: 'Times New Roman',serif;\"\u003e233\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 18.34%; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"18%\"\u003e\n\u003cp style=\"line-height: normal;\"\u003e\u003cspan style=\"font-family: 'Times New Roman',serif;\"\u003e1.18 (1.03-1.35)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 2.42%; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"2%\"\u003e\n\u003cp style=\"line-height: normal;\"\u003e\u003cspan style=\"font-family: 'Times New Roman',serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 17.94%; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"17%\"\u003e\n\u003cp style=\"line-height: normal;\"\u003e\u003cspan style=\"font-family: 'Times New Roman',serif;\"\u003e1.14 (0.99-1.31)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 17.92%; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"17%\"\u003e\n\u003cp style=\"line-height: normal;\"\u003e\u003cspan style=\"font-family: 'Times New Roman',serif;\"\u003e1.13 (0.98-1.30)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 19.74%; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"19%\"\u003e\n\u003cp style=\"line-height: normal;\"\u003e\u003cspan style=\"font-family: 'Times New Roman',serif;\"\u003e7-14 days/month\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 8.94%; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"8%\"\u003e\n\u003cp style=\"text-align: right; line-height: normal;\"\u003e\u003cspan style=\"font-family: 'Times New Roman',serif;\"\u003e234\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 2.42%; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"2%\"\u003e\n\u003cp style=\"text-align: right; line-height: normal;\"\u003e\u003cspan style=\"font-family: 'Times New Roman',serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 12.28%; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"12%\"\u003e\n\u003cp style=\"text-align: center; line-height: normal;\"\u003e\u003cspan style=\"font-family: 'Times New Roman',serif;\"\u003e47\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 18.34%; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"18%\"\u003e\n\u003cp style=\"line-height: normal;\"\u003e\u003cspan style=\"font-family: 'Times New Roman',serif;\"\u003e1.10 (0.79-1.52)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 2.42%; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"2%\"\u003e\n\u003cp style=\"line-height: normal;\"\u003e\u003cspan style=\"font-family: 'Times New Roman',serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 17.94%; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"17%\"\u003e\n\u003cp style=\"line-height: normal;\"\u003e\u003cspan style=\"font-family: 'Times New Roman',serif;\"\u003e1.08 (0.77-1.50)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 17.92%; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"17%\"\u003e\n\u003cp style=\"line-height: normal;\"\u003e\u003cspan style=\"font-family: 'Times New Roman',serif;\"\u003e1.03 (0.74-1.44\u003cstrong\u003e)\u003c/strong\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 19.74%; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"19%\"\u003e\n\u003cp style=\"line-height: normal;\"\u003e\u003cspan style=\"font-family: 'Times New Roman',serif;\"\u003e\u0026ge; 15 days/month\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 8.94%; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"8%\"\u003e\n\u003cp style=\"text-align: right; line-height: normal;\"\u003e\u003cspan style=\"font-family: 'Times New Roman',serif;\"\u003e91\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 2.42%; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"2%\"\u003e\n\u003cp style=\"text-align: right; line-height: normal;\"\u003e\u003cspan style=\"font-family: 'Times New Roman',serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 12.28%; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"12%\"\u003e\n\u003cp style=\"text-align: center; line-height: normal;\"\u003e\u003cspan style=\"font-family: 'Times New Roman',serif;\"\u003e25\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 18.34%; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"18%\"\u003e\n\u003cp style=\"line-height: normal;\"\u003e\u003cspan style=\"font-family: 'Times New Roman',serif;\"\u003e1.58 (0.99-2.51)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 2.42%; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"2%\"\u003e\n\u003cp style=\"line-height: normal;\"\u003e\u003cspan style=\"font-family: 'Times New Roman',serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 17.94%; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"17%\"\u003e\n\u003cp style=\"line-height: normal;\"\u003e\u003cspan style=\"font-family: 'Times New Roman',serif;\"\u003e1.42 (0.88-2.28)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 17.92%; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"17%\"\u003e\n\u003cp style=\"line-height: normal;\"\u003e\u003cspan style=\"font-family: 'Times New Roman',serif;\"\u003e1.37 (0.85-2.22\u003cstrong\u003e)\u003c/strong\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 19.74%; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"19%\"\u003e\n\u003cp style=\"line-height: normal;\"\u003e\u003cspan style=\"font-family: 'Times New Roman',serif;\"\u003eP trend\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 8.94%; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"8%\"\u003e\n\u003cp style=\"text-align: right; line-height: normal;\"\u003e\u003cspan style=\"font-family: 'Times New Roman',serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 2.42%; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"2%\"\u003e\n\u003cp style=\"text-align: right; line-height: normal;\"\u003e\u003cspan style=\"font-family: 'Times New Roman',serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 12.28%; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"12%\"\u003e\n\u003cp style=\"text-align: center; line-height: normal;\"\u003e\u003cspan style=\"font-family: 'Times New Roman',serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 18.34%; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"18%\"\u003e\n\u003cp style=\"line-height: normal;\"\u003e\u003cspan style=\"font-family: 'Times New Roman',serif;\"\u003e0.01\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 2.42%; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"2%\"\u003e\n\u003cp style=\"line-height: normal;\"\u003e\u003cspan style=\"font-family: 'Times New Roman',serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 17.94%; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"17%\"\u003e\n\u003cp style=\"line-height: normal;\"\u003e\u003cspan style=\"font-family: 'Times New Roman',serif;\"\u003e0.12\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 17.92%; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"17%\"\u003e\n\u003cp style=\"line-height: normal;\"\u003e\u003cspan style=\"font-family: 'Times New Roman',serif;\"\u003e0.23\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 19.74%; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"19%\"\u003e\n\u003cp style=\"line-height: normal;\"\u003e\u003cstrong\u003e\u003cspan style=\"font-family: 'Times New Roman',serif;\"\u003eOther headaches\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 8.94%; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"8%\"\u003e\n\u003cp style=\"text-align: right; line-height: normal;\"\u003e\u003cspan style=\"font-family: 'Times New Roman',serif;\"\u003e10,197\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 2.42%; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"2%\"\u003e\n\u003cp style=\"text-align: right; line-height: normal;\"\u003e\u003cspan style=\"font-family: 'Times New Roman',serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 12.28%; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"12%\"\u003e\n\u003cp style=\"text-align: center; line-height: normal;\"\u003e\u003cspan style=\"font-family: 'Times New Roman',serif;\"\u003e2165\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 18.34%; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"18%\"\u003e\n\u003cp style=\"line-height: normal;\"\u003e\u003cspan style=\"font-family: 'Times New Roman',serif;\"\u003e1.08 (1.02-1.14)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 2.42%; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"2%\"\u003e\n\u003cp style=\"line-height: normal;\"\u003e\u003cspan style=\"font-family: 'Times New Roman',serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 17.94%; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"17%\"\u003e\n\u003cp style=\"line-height: normal;\"\u003e\u003cspan style=\"font-family: 'Times New Roman',serif;\"\u003e1.04 (0.98-1.11)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 17.92%; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"17%\"\u003e\n\u003cp style=\"line-height: normal;\"\u003e\u003cspan style=\"font-family: 'Times New Roman',serif;\"\u003e1.04 (0.97-1.10)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 19.74%; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"19%\"\u003e\n\u003cp style=\"line-height: normal;\"\u003e\u003cspan style=\"font-family: 'Times New Roman',serif;\"\u003e\u0026lt; 1 days/month\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 8.94%; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"8%\"\u003e\n\u003cp style=\"text-align: right; line-height: normal;\"\u003e\u003cspan style=\"font-family: 'Times New Roman',serif;\"\u003e2577\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 2.42%; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"2%\"\u003e\n\u003cp style=\"text-align: right; line-height: normal;\"\u003e\u003cspan style=\"font-family: 'Times New Roman',serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 12.28%; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"12%\"\u003e\n\u003cp style=\"text-align: center; line-height: normal;\"\u003e\u003cspan style=\"font-family: 'Times New Roman',serif;\"\u003e534\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 18.34%; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"18%\"\u003e\n\u003cp style=\"line-height: normal;\"\u003e\u003cspan style=\"font-family: 'Times New Roman',serif;\"\u003e1.05 (0.96-1.14)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 2.42%; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"2%\"\u003e\n\u003cp style=\"line-height: normal;\"\u003e\u003cspan style=\"font-family: 'Times New Roman',serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 17.94%; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"17%\"\u003e\n\u003cp style=\"line-height: normal;\"\u003e\u003cspan style=\"font-family: 'Times New Roman',serif;\"\u003e1.01 (0.93-1.10)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 17.92%; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"17%\"\u003e\n\u003cp style=\"line-height: normal;\"\u003e\u003cspan style=\"font-family: 'Times New Roman',serif;\"\u003e1.00 (0.92-1.09)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 19.74%; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"19%\"\u003e\n\u003cp style=\"line-height: normal;\"\u003e\u003cspan style=\"font-family: 'Times New Roman',serif;\"\u003e1-6 days/month\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 8.94%; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"8%\"\u003e\n\u003cp style=\"text-align: right; line-height: normal;\"\u003e\u003cspan style=\"font-family: 'Times New Roman',serif;\"\u003e5759\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 2.42%; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"2%\"\u003e\n\u003cp style=\"text-align: right; line-height: normal;\"\u003e\u003cspan style=\"font-family: 'Times New Roman',serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 12.28%; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"12%\"\u003e\n\u003cp style=\"text-align: center; line-height: normal;\"\u003e\u003cspan style=\"font-family: 'Times New Roman',serif;\"\u003e1167\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 18.34%; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"18%\"\u003e\n\u003cp style=\"line-height: normal;\"\u003e\u003cspan style=\"font-family: 'Times New Roman',serif;\"\u003e1.03 (0.96-1.11)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 2.42%; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"2%\"\u003e\n\u003cp style=\"line-height: normal;\"\u003e\u003cspan style=\"font-family: 'Times New Roman',serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 17.94%; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"17%\"\u003e\n\u003cp style=\"line-height: normal;\"\u003e\u003cspan style=\"font-family: 'Times New Roman',serif;\"\u003e1.00 (0.93-1.07)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 17.92%; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"17%\"\u003e\n\u003cp style=\"line-height: normal;\"\u003e\u003cspan style=\"font-family: 'Times New Roman',serif;\"\u003e0.98 (0.91-1.05)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 19.74%; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"19%\"\u003e\n\u003cp style=\"line-height: normal;\"\u003e\u003cspan style=\"font-family: 'Times New Roman',serif;\"\u003e7-14 days/month\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 8.94%; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"8%\"\u003e\n\u003cp style=\"text-align: right; line-height: normal;\"\u003e\u003cspan style=\"font-family: 'Times New Roman',serif;\"\u003e17106\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 2.42%; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"2%\"\u003e\n\u003cp style=\"text-align: right; line-height: normal;\"\u003e\u003cspan style=\"font-family: 'Times New Roman',serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 12.28%; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"12%\"\u003e\n\u003cp style=\"text-align: center; line-height: normal;\"\u003e\u003cspan style=\"font-family: 'Times New Roman',serif;\"\u003e273\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 18.34%; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"18%\"\u003e\n\u003cp style=\"line-height: normal;\"\u003e\u003cspan style=\"font-family: 'Times New Roman',serif;\"\u003e1.28 (1.11-1.47)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 2.42%; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"2%\"\u003e\n\u003cp style=\"line-height: normal;\"\u003e\u003cspan style=\"font-family: 'Times New Roman',serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 17.94%; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"17%\"\u003e\n\u003cp style=\"line-height: normal;\"\u003e\u003cspan style=\"font-family: 'Times New Roman',serif;\"\u003e1.20 (1.04-1.39)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 17.92%; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"17%\"\u003e\n\u003cp style=\"line-height: normal;\"\u003e\u003cspan style=\"font-family: 'Times New Roman',serif;\"\u003e1.15 (1.00-1.33\u003cstrong\u003e)\u003c/strong\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 19.74%; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"19%\"\u003e\n\u003cp style=\"line-height: normal;\"\u003e\u003cspan style=\"font-family: 'Times New Roman',serif;\"\u003e\u0026ge; 15 days/month\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 8.94%; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"8%\"\u003e\n\u003cp style=\"text-align: right; line-height: normal;\"\u003e\u003cspan style=\"font-family: 'Times New Roman',serif;\"\u003e755\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 2.42%; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"2%\"\u003e\n\u003cp style=\"text-align: right; line-height: normal;\"\u003e\u003cspan style=\"font-family: 'Times New Roman',serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 12.28%; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"12%\"\u003e\n\u003cp style=\"text-align: center; line-height: normal;\"\u003e\u003cspan style=\"font-family: 'Times New Roman',serif;\"\u003e191\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 18.34%; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"18%\"\u003e\n\u003cp style=\"line-height: normal;\"\u003e\u003cspan style=\"font-family: 'Times New Roman',serif;\"\u003e1.29 (1.09-1.53)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 2.42%; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"2%\"\u003e\n\u003cp style=\"line-height: normal;\"\u003e\u003cspan style=\"font-family: 'Times New Roman',serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 17.94%; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"17%\"\u003e\n\u003cp style=\"line-height: normal;\"\u003e\u003cspan style=\"font-family: 'Times New Roman',serif;\"\u003e1.23 (1.04-1.46)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 17.92%; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"17%\"\u003e\n\u003cp style=\"line-height: normal;\"\u003e\u003cspan style=\"font-family: 'Times New Roman',serif;\"\u003e1.18 (0.99-1.41\u003cstrong\u003e)\u003c/strong\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 19.74%; border: none; border-bottom: solid black 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"19%\"\u003e\n\u003cp style=\"line-height: normal;\"\u003e\u003cspan style=\"font-family: 'Times New Roman',serif;\"\u003eP trend\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 8.94%; border: none; border-bottom: solid black 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"8%\"\u003e\n\u003cp style=\"text-align: right; line-height: normal;\"\u003e\u003cspan style=\"font-family: 'Times New Roman',serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 2.42%; border: none; border-bottom: solid black 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"2%\"\u003e\n\u003cp style=\"text-align: right; line-height: normal;\"\u003e\u003cspan style=\"font-family: 'Times New Roman',serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 12.28%; border: none; border-bottom: solid black 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"12%\"\u003e\n\u003cp style=\"text-align: center; line-height: normal;\"\u003e\u003cspan style=\"font-family: 'Times New Roman',serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 18.34%; border: none; border-bottom: solid black 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"18%\"\u003e\n\u003cp style=\"line-height: normal;\"\u003e\u003cspan style=\"font-family: 'Times New Roman',serif;\"\u003e\u0026lt;0.001\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 2.42%; border: none; border-bottom: solid black 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"2%\"\u003e\n\u003cp style=\"line-height: normal;\"\u003e\u003cspan style=\"font-family: 'Times New Roman',serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 17.94%; border: none; border-bottom: solid black 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"17%\"\u003e\n\u003cp style=\"line-height: normal;\"\u003e\u003cspan style=\"font-family: 'Times New Roman',serif;\"\u003e0.03\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 17.92%; border: none; border-bottom: solid black 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"17%\"\u003e\n\u003cp style=\"line-height: normal;\"\u003e\u003cspan style=\"font-family: 'Times New Roman',serif;\"\u003e0.16\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003c/tbody\u003e\n\u003c/table\u003e\n\u003cp style=\"line-height: normal;\"\u003e\u003cspan style=\"font-size: 10.0pt; font-family: 'Times New Roman',serif;\"\u003eMA=migraine with aura; MO=Migraine without aura. \u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;Model 1: Adjusted for ag, and sex. \u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;Model 2: Adjusted for age, sex and body mass index.\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; \u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;Model 3: Adjusted for age, sex, body mass index, smoking, employment status, alcohol use, physical activity and Hospital Anxiety and Depression Scale score\u003c/span\u003e\u003c/p\u003e\u003c/br\u003e\u003c/br\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 107%; font-family: 'Times New Roman',serif;\"\u003eTable 3. \u003c/span\u003e\u003c/strong\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 107%; font-family: 'Times New Roman',serif;\"\u003eMulti-adjusted* \u003c/span\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 107%; font-family: 'Times New Roman',serif;\"\u003eodds ratio (OR) with 95% confidence interval (CI) of elevated high sensitivity C-reactive protein (hs-CRP) defined as \u0026gt;\u003c/span\u003e\u003cspan style=\"font-family: 'Times New Roman',serif;\"\u003e3.0-20.0 mg/l\u003c/span\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 107%; font-family: 'Times New Roman',serif;\"\u003e related to headache types and insomnia status\u003c/span\u003e\u003c/p\u003e\n\u003ctable style=\"width: 100.0%; border-collapse: collapse; border: none;\" width=\"100%\"\u003e\n\u003ctbody\u003e\n\u003ctr style=\"height: 20.7pt;\"\u003e\n\u003ctd style=\"width: 22.68%; border-top: solid black 1.0pt; border-left: none; border-bottom: solid black 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt; height: 20.7pt;\" width=\"22%\"\u003e\n\u003cp style=\"line-height: 150%;\"\u003e\u003cstrong\u003e\u003cspan style=\"font-family: 'Times New Roman',serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 10.24%; border-top: solid black 1.0pt; border-left: none; border-bottom: solid black 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt; height: 20.7pt;\" width=\"10%\"\u003e\n\u003cp style=\"line-height: 150%;\"\u003e\u003cstrong\u003e\u003cspan style=\"font-family: 'Times New Roman',serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 2.7%; border-top: solid black 1.0pt; border-left: none; border-bottom: solid black 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt; height: 20.7pt;\" width=\"2%\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cstrong\u003e\u003cspan style=\"font-family: 'Times New Roman',serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 9.06%; border-top: solid black 1.0pt; border-left: none; border-bottom: solid black 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt; height: 20.7pt;\" width=\"9%\"\u003e\n\u003cp style=\"text-align: center; line-height: normal;\"\u003e\u003cspan style=\"font-family: 'Times New Roman',serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 23.92%; border-top: solid black 1.0pt; border-left: none; border-bottom: solid black 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt; height: 20.7pt;\" width=\"23%\"\u003e\n\u003cp style=\"line-height: normal;\"\u003e\u003cstrong\u003e\u003cspan style=\"font-family: 'Times New Roman',serif;\"\u003eWithout insomnia\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 2.7%; border-top: solid black 1.0pt; border-left: none; border-bottom: solid black 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt; height: 20.7pt;\" width=\"2%\"\u003e\n\u003cp style=\"line-height: 150%;\"\u003e\u003cstrong\u003e\u003cspan style=\"font-family: 'Times New Roman',serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 8.14%; border-top: solid black 1.0pt; border-left: none; border-bottom: solid black 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt; height: 20.7pt;\" width=\"8%\"\u003e\n\u003cp style=\"line-height: 150%;\"\u003e\u003cstrong\u003e\u003cspan style=\"font-family: 'Times New Roman',serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 20.58%; border-top: solid black 1.0pt; border-left: none; border-bottom: solid black 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt; height: 20.7pt;\" width=\"20%\"\u003e\n\u003cp style=\"line-height: 150%;\"\u003e\u003cstrong\u003e\u003cspan style=\"font-family: 'Times New Roman',serif;\"\u003eWith insomnia\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 22.68%; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"22%\"\u003e\n\u003cp style=\"line-height: normal;\"\u003e\u003cspan style=\"font-family: 'Times New Roman',serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 10.24%; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"10%\"\u003e\n\u003cp style=\"text-align: right; line-height: normal;\"\u003e\u003cspan style=\"font-family: 'Times New Roman',serif;\"\u003eTotal \u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 2.7%; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"2%\"\u003e\n\u003cp style=\"text-align: right; line-height: normal;\"\u003e\u003cspan style=\"font-family: 'Times New Roman',serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 9.06%; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"9%\"\u003e\n\u003cp style=\"text-align: right; line-height: normal;\"\u003e\u003cspan style=\"font-family: 'Times New Roman',serif;\"\u003eN\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 23.92%; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"23%\"\u003e\n\u003cp style=\"line-height: normal;\"\u003e\u003cspan style=\"font-family: 'Times New Roman',serif;\"\u003eOR (95% CI)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 2.7%; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"2%\"\u003e\n\u003cp style=\"line-height: normal;\"\u003e\u003cspan style=\"font-family: 'Times New Roman',serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 8.14%; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"8%\"\u003e\n\u003cp style=\"text-align: right; line-height: normal;\"\u003e\u003cspan style=\"font-family: 'Times New Roman',serif;\"\u003eN\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 20.58%; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"20%\"\u003e\n\u003cp style=\"line-height: normal;\"\u003e\u003cspan style=\"font-family: 'Times New Roman',serif;\"\u003eOR (95% CI)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 22.68%; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"22%\"\u003e\n\u003cp style=\"line-height: normal;\"\u003e\u003cspan style=\"font-family: 'Times New Roman',serif;\"\u003eNo headache\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 10.24%; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"10%\"\u003e\n\u003cp style=\"text-align: right; line-height: normal;\"\u003e\u003cspan style=\"font-size: 10.0pt; font-family: 'Times New Roman',serif;\"\u003e24,823\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 2.7%; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"2%\"\u003e\n\u003cp style=\"text-align: right; line-height: normal;\"\u003e\u003cspan style=\"font-family: 'Times New Roman',serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 9.06%; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"9%\"\u003e\n\u003cp style=\"text-align: right; line-height: normal;\"\u003e\u003cspan style=\"font-family: 'Times New Roman',serif;\"\u003e23,766\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 23.92%; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"23%\"\u003e\n\u003cp style=\"line-height: normal;\"\u003e\u003cspan style=\"font-family: 'Times New Roman',serif;\"\u003e1.00 \u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 2.7%; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"2%\"\u003e\n\u003cp style=\"line-height: normal;\"\u003e\u003cspan style=\"font-family: 'Times New Roman',serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 8.14%; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"8%\"\u003e\n\u003cp style=\"text-align: right; line-height: normal;\"\u003e\u003cspan style=\"font-family: 'Times New Roman',serif;\"\u003e1057\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 20.58%; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"20%\"\u003e\n\u003cp style=\"line-height: normal;\"\u003e\u003cspan style=\"font-family: 'Times New Roman',serif;\"\u003e1.00 \u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 22.68%; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"22%\"\u003e\n\u003cp style=\"line-height: normal;\"\u003e\u003cspan style=\"font-family: 'Times New Roman',serif;\"\u003eAny headache\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 10.24%; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"10%\"\u003e\n\u003cp style=\"text-align: right; line-height: normal;\"\u003e\u003cspan style=\"font-size: 10.0pt; font-family: 'Times New Roman',serif;\"\u003e13,990\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 2.7%; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"2%\"\u003e\n\u003cp style=\"text-align: right; line-height: normal;\"\u003e\u003cspan style=\"font-family: 'Times New Roman',serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 9.06%; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"9%\"\u003e\n\u003cp style=\"text-align: right; line-height: normal;\"\u003e\u003cspan style=\"font-family: 'Times New Roman',serif;\"\u003e12,359\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 23.92%; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"23%\"\u003e\n\u003cp style=\"line-height: normal;\"\u003e\u003cspan style=\"font-family: 'Times New Roman',serif;\"\u003e1.07 (1.01-1.13)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 2.7%; 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padding: 0in 5.4pt 0in 5.4pt;\" width=\"23%\"\u003e\n\u003cp style=\"line-height: normal;\"\u003e\u003cspan style=\"font-family: 'Times New Roman',serif;\"\u003e1.06 (0.99-1.13)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 2.7%; border: none; border-bottom: solid black 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"2%\"\u003e\n\u003cp style=\"line-height: normal;\"\u003e\u003cspan style=\"font-family: 'Times New Roman',serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 8.14%; border: none; border-bottom: solid black 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"8%\"\u003e\n\u003cp style=\"text-align: right; line-height: normal;\"\u003e\u003cspan style=\"font-family: 'Times New Roman',serif;\"\u003e1034\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 20.58%; border: none; border-bottom: solid black 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"20%\"\u003e\n\u003cp style=\"line-height: normal;\"\u003e\u003cspan style=\"font-family: 'Times New Roman',serif;\"\u003e0.77 (0.62-0.96)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003c/tbody\u003e\n\u003c/table\u003e\n\u003cp style=\"line-height: normal;\"\u003e\u003cspan style=\"font-size: 10.0pt; font-family: 'Times New Roman',serif;\"\u003eMA=migraine with aura; MO=Migraine without aura\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; * Adjusted for age, sex, body mass index, smoking, employment status, alcohol use, physical activity and Hospital Anxiety and Depression Scale score\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; \u003c/span\u003e\u003c/p\u003e"}],"fulltextSource":"","fullText":"","funders":[],"hasAdminPriorityOnWorkflow":false,"hasManuscriptDocX":true,"hasOptedInToPreprint":true,"hasPassedJournalQc":"","hasAnyPriority":false,"hideJournal":false,"highlight":"","institution":"","isAcceptedByJournal":true,"isAuthorSuppliedPdf":false,"isDeskRejected":"","isHiddenFromSearch":false,"isInQc":false,"isInWorkflow":false,"isPdf":false,"isPdfUpToDate":true,"isWithdrawnOrRetracted":false,"journal":{"display":true,"email":"[email protected]","identity":"bmc-neurology","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":false,"externalIdentity":"nurl","sideBox":"Learn more about [BMC Neurology](http://bmcneurol.biomedcentral.com/)","snPcode":"","submissionUrl":"https://www.editorialmanager.com/nurl","title":"BMC Neurology","twitterHandle":"BMC_series","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"em","reportingPortfolio":"BMC Series","inReviewEnabled":true,"inReviewRevisionsEnabled":true},"keywords":"","lastPublishedDoi":"10.21203/rs.2.10500/v2","lastPublishedDoiUrl":"https://doi.org/10.21203/rs.2.10500/v2","license":{"name":"CC BY 4.0","url":"https://creativecommons.org/licenses/by/4.0/"},"manuscriptAbstract":"Background Increased high sensitivity C- reactive protein (hs-CRP) levels have been found in many earlier studies on migraine, and recently also in persons with migraine and insomnia. The aim of this study was to see whether these findings could be reproduced in a large-scale population-based study.\nMethods A total of 50,807 (54%) out of 94,194 invited aged ≥ 20 years or older participated in the third wave of the Nord-Trøndelag Health Study study performed in 2006-2008. Among these, 38,807 (41%) had valid measures of hs-CRP and answered questions on headache and insomnia. Elevated hs-CRP was defined as \u003e3.0 mg/L. The cross-sectional association with headache was estimated by multivariate analyses using multiple logistic regression. The precision of the odds ratio (OR) was assessed with 95% confidence interval (CI).\nResults In the fully adjusted model, elevated hs-CRP was associated with migraine (OR 1.14, 95% CI 1.04-1.25) and migraine with aura (OR 1.15, 95% CI 1.03-1.29). The association was strongest among individuals with headache ≥ 15 days/month for any headache (OR 1.26, 95% CI 1.08-1.48), migraine (OR 1.62, 95% CI 1.21-2.17), and migraine with aura (OR 1.84, 95% CI 1.27-2.67). No clear relationship was found between elevated hs-CRP and headache less than 7 days/month or with insomnia.\nConclusions Cross-sectional data from this large-scale population-based study showed that elevated hs-CRP was associated with headache ≥ 7 days/month, especially evident for migraine with aura.","manuscriptTitle":"The impact of C-reactive protein levels on headache frequency. The HUNT Study 2006-2008","msid":"","msnumber":"","nonDraftVersions":[{"code":2,"date":"2019-10-11 21:22:30","doi":"10.21203/rs.2.10500/v2","editorialEvents":[{"type":"communityComments","content":0},{"type":"decision","content":"Accept","date":"2019-09-10T12:00:00+00:00","index":"","fulltext":""},{"type":"editorInvitedReview","content":"","date":"2019-09-07T12:00:00+00:00","index":2,"fulltext":"Recommendation: Accept without revision\nForm responses:\n---\n* Are the methods appropriate and well described?: **Yes**\n* Does the work include the necessary controls?: **Yes**\n* Are the conclusions drawn adequately supported by the data shown?: **Yes**\n* Are you able to assess any statistics in the manuscript or would you recommend an additional statistical review?: **I am able to assess the statistics**\n* Quality of written English: **Acceptable**\n* Declaration of competing interests: **I declare that I have no competing interests**\n\nComments to Author:\n---\nComments to the Authors and Editor\nDear Authors, Dear Editor,\nThe Authors fully addressed each suggestion. The manuscript is suitable for publication in the present form.\nBest regards"},{"type":"reviewerAgreed","content":"","date":"2019-08-26T12:00:00+00:00","index":2,"fulltext":""},{"type":"editorInvitedReview","content":"","date":"2019-08-25T12:00:00+00:00","index":1,"fulltext":"Recommendation: Accept without revision\nForm responses:\n---\n* Are the methods appropriate and well described?: **Yes**\n* Does the work include the necessary controls?: **Yes**\n* Are the conclusions drawn adequately supported by the data shown?: **Yes**\n* Are you able to assess any statistics in the manuscript or would you recommend an additional statistical review?: **I am able to assess the statistics**\n* Quality of written English: **Acceptable**\n* Declaration of competing interests: **I have no competing interests in revising the revised version of manuscript**\n\nComments to Author:\n---\nThe revised version of manuscript has been improved respect the orignal one that I liked really.\nI have no other 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