Case Series of Hemolysis in Neonate Born to Mothers with History of SARS-CoV-2 Infection During Pregnancy

Hemolytic anemia has been associated with SARS-CoV-2 infection in adult and pediatric patients, we report a case series of preterm newborns with hemolytic anemia whose mothers had a history of SARS-CoV-2 infection. In two of the cases maternal infection occurred early in pregnancy and the newborns had a reactive SARS-CoV-2 antibody test. Hemolysis and coagulopathy improved with the use of washed blood products and prothrombin complex concentrate. Our cases highlight the need for increased awareness of a possible association between hemolysis and exposure to SARS-CoV-2 infection during intrauterine life.