The effects of Danefukang capsule on immunocytes of endometriotic tissue in the model rats

Objective:To study the effects of Danefukang capsule on T lymphocyte subpopulations and the number of macrophages in rats with endometriosis.Methods:The rats were induced by transplanting with endometrium surgically,and then were randomly divided into 6 groups:normal control group,EMs group,the treated EMs groups with Danefukang capsule (0.50,1.00,2.00 g/kg) and Danefukang soft extract (7.59 mg/kg).After 45 days treatment,the density of CD8+T cells and CD4+T cells and the number of macrophages in endometrium and endometriotic tissue were determined by immunohistochemistry method.Results:Danefukang capsule significantly reduced the density of CD8+T cells (P0.01 or P0.05) and the number of macrophages in endometriotic tissue as compared to untreated-EMs rats (P0.05).Conclusion:The therapeutic effect of Danefukang capsule on rats with EMs is related to decreasing the density of CD8+T cells and the number of macrophages in endometriotic tissue.