Peculiarities of systemic violations in patients with genital endometriosis in combination with benign diseases of genitalia and syndrome of chronic pelvic pain.

Peculiarities of systemic violations in patients with genital endometriosis in combination with benign diseases of genitalia and syndrome of chronic pelvic pain. DOI: https://doi.org/10.26641/2307-0404.2017.4.117670Keywords: genital endometriosis, chronic pelvic pain, cytokines ІL-10, ІL-6, TNF-α, depressionAbstract The aim of the work is determination of intercommunication of cytokines ІL-10, ІL-6 levels, TNF-α with subjective estimation of pain, processes of the nervous system desadaptation in patients with genital endometriosis in combination with benign hormonal pathology of the genitaliafollowed by chronic pelvic pain (CPP). There were 120 women in research divided into several groups, depending on visual analogue scale (VAS) and durations of disease: 1st group (n=44), VAS was 7-10 points; 2-d group (n=41) VAS – 4-6 points; 3-d group (n=35) VAS – 0-3 points. Along with progress of CPP there was marked decline of cytokines ІL-10, and increase of ІL-6, TNF -α comparatively with 3-d group (р<0,05);this correlated with the higher points of intensity of pain syndrome in the 1st group, with pain anamnesis duration and increased level of anxiety and depression. Imbalance of cytokines towards the proinflammatory link in definite clinical provoking factors of pain can be considered as a predictor of CPP. References Moskalenko VF, Gul'chіy OP, Golubchikov MV, et al. [Biostatistics]. Kyiv, Kniga plyus. 2009;184. Ukrainian. Strizhakov AN, Davydov AI, Pashkov VM, Lebedev VA. [Benign diseases of a uterus]. Moskva, GEOTAR-Media; 2010. Russian. Dubossarskaya Y,. Dubossarskaya Z. [Syndrome of chronic pelvic pain at the level of cross-disciplinary communication]. Meditsinskie aspekty zdorov'ya zhenshchiny. 2013;3(67):5-16. Russian. Kuznetsova IV. [Chronic pelvic pain]. Akusherstvo i ginekologiya. 2013;5:91-97. Russian. Minutko VP. [ Depression]. Moskva, GEOTAR-Media; 2006. Russian. Harchenko YuA. [Adequate assessment of pain is the pledge of successful treatmtnt]. Meditsina i farmakologiya. 2014;4(5). Available from: http://7niversum.com/ru/med/archive/item/3966. Russian. Cheong Y, William Stones R. Chronic pelvic pain: aetiology and therapy. Best Pract. Res. Clin. Obstet. Gynaecol. 2006;20(5):695-711. Graziottin A,SkaperSD, Fusco M. Inflammation and Chronic Pelvic Pain: A Biological Trigger for Depression in Women? Depress Anxiety J. 2013;3:142. Dowlati Y, Herrmann N, Swardfager W, et al. Meta-Analysis of Cytokines in Major Depression. Biol Psychiatry J. 2010;67:446-57. Uceyler N, Valenza R, Stock M, et al. Reduced levels of antiinflammatory cytokines in patients with chronic widespread pain. Arthritis Rheum. 2006;54:2656–64. Sommer C, Kress M. Recent findings on how proinflammatory cytokines cause pain: peripheral mechanism in inflammatory and neuropathic hyperalgesia. Neurosci. Lett. 2004;361:184-7. Downloads Published How to Cite Issue Section License Copyright (c) 2017 Medicni perspektivi (Medical perspectives) This work is licensed under a Creative Commons Attribution 4.0 International License. Submitting manuscript to the journal "Medicni perspektivi" the author(s) agree with transferring copyright from the author(s) to publisher (including photos, figures, tables, etc.) editor, reproducing materials of the manuscript in the journal, Internet, translation into other languages, export and import of the issue with the author’s article, spreading without limitation of their period of validity both on the territory of Ukraine and other countries. This and other mutual duties of the author and all co-authors separately and editorial board are secured by written agreement by special form to use the article, the sample of which is presented on the site. Author signs a written agreement and sends it to Editorial Board simultaneously with submission of the manuscript.