Changes in Proteomics of Endometrial Tissue During Secretion of Polycystic Ovary Syndrome May Affect Endometrial Receptivity

Embryo implantation is a complex developmental process that requires coordinated interactions of embryo, endometrium and microenvirment of endometrium factors. Although impaired endometrial receptivity of patients of PCOS have been identified, our understanding of endometrial receptivity is limited. To understand impaired endometrial receptivity of patients of PCOS during luteal phases, a proteomics study in three PCOS patients and 3 fertility women was performed. Isobaric tags for relative and absolute quantitation (iTRAQ) analyses identified 232 unique proteins involved in metabolism, inflammation and cell adhesion molecule. Finally, novel clues suggest that energy metabolism may affect embryo implantation, whlie inflammation and cell adhesion molecule may affect both endometrial conversion and receptivity. Taken together, our results show that the endometrial receptive damage in PCOS patients is not a single factor, caused by multiple proteins, pathways, systems and other abnormalities, and they also interact with each other, which greatly increases the difficulty of endometrial receptive research.