Artificial Intelligence Integrated with Intraoral Digital Imaging in Dental Caries Detection, Treatment Planning, and Clinical Decision-Making: A Scoping Review

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Despite advances and growing interest in applying AI algorithms to intraoral x-rays, the methodological quality, diagnostic validity, and clinical applicability of existing studies remain unclear. Aim To synthesise and critically appraise the current evidence on AI integrated with intraoral digital radiographic imaging for detecting dental caries in adults, focusing on diagnostic accuracy compared with gold-standard methods and examining methodological quality, clinical applicability, and implementation challenges. Methods Following the JBI scoping review framework and PRISMA-ScR reporting guidelines, a comprehensive literature search was conducted across the PubMed, Scopus, and IEEE Xplore databases from January 2015 to May 2025. Studies that met the predefined eligibility criteria were included. Thematic analysis, combining inductive and deductive approaches following Braun and Clarke’s framework, identified five themes. The CASP quality appraisal was performed to ensure methodological rigour. Results Ten peer-reviewed studies were included in the final data analysis. AI systems detected a greater number of carious lesions than human clinicians, particularly in early-stage caries, with representative metrics including 88% sensitivity, 91% specificity, and 89% accuracy. Other models reported F1-scores up to 89% and AUC ≈95%. Methodological diversity was notable, with histology-validated designs providing the strongest evidence. Implementation challenges included limited external and real-world validation, clinician oversight, ethical/regulatory considerations, and inadequate model interpretability. Conclusion AI exhibits strong potential to enhance early caries detection on intraoral radiographs and support clinical decision-making in adults. Fully realising AI’s clinical potential requires overcoming implementation and methodological challenges. Standardised validation methods across diverse populations and settings are crucial to ensure AI diagnostic reliability and generalisability. Current AI applications in dentistry are primarily designed to assist clinicians in detecting caries; however, their greatest potential lies in a future where they can independently guide treatment planning decisions. " } { "@context": "http://schema.org", "@type": "BreadcrumbList", "itemListElement": [ { "@type": "ListItem", "position": "1", "item": { "@id": "https://f1000research.com/", "name": "Home" } }, { "@type": "ListItem", "position": "2", "item": { "@id": "https://f1000research.com/browse/articles", "name": "Browse" } }, { "@type": "ListItem", "position": "3", "item": { "@id": "https://f1000research.com/articles/14-1328/v1", "name": "Artificial Intelligence Integrated with Intraoral Digital Imaging..." } } ] } Home Browse Artificial Intelligence Integrated with Intraoral Digital Imaging... ALL Metrics - Views Downloads Get PDF Get XML Cite How to cite this article Kayali S, Golkari A and Mathur M. Artificial Intelligence Integrated with Intraoral Digital Imaging in Dental Caries Detection, Treatment Planning, and Clinical Decision-Making: A Scoping Review [version 1; peer review: 1 approved, 1 approved with reservations] . F1000Research 2025, 14 :1328 ( https://doi.org/10.12688/f1000research.172671.1 ) NOTE: If applicable, it is important to ensure the information in square brackets after the title is included in all citations of this article. Close Copy Citation Details Export Export Citation Sciwheel EndNote Ref. Manager Bibtex ProCite Sente EXPORT Select a format first Track Share ▬ ✚ Review Artificial Intelligence Integrated with Intraoral Digital Imaging in Dental Caries Detection, Treatment Planning, and Clinical Decision-Making: A Scoping Review [version 1; peer review: 1 approved, 1 approved with reservations] Sarah Kayali https://orcid.org/0009-0005-7601-1325 1 , Ali Golkari https://orcid.org/0000-0002-6779-7902 1 , Manu Mathur 1 Sarah Kayali https://orcid.org/0009-0005-7601-1325 1 , Ali Golkari https://orcid.org/0000-0002-6779-7902 1 , Manu Mathur 1 PUBLISHED 27 Nov 2025 Author details Author details 1 Institute of Dentistry, Queen Mary University of London, London, England, E1 2AH, UK Sarah Kayali Roles: Conceptualization, Data Curation, Formal Analysis, Investigation, Methodology, Project Administration, Resources, Visualization, Writing – Original Draft Preparation, Writing – Review & Editing Ali Golkari Roles: Conceptualization, Data Curation, Formal Analysis, Investigation, Methodology, Project Administration, Supervision, Writing – Review & Editing Manu Mathur Roles: Conceptualization, Supervision, Validation, Writing – Review & Editing OPEN PEER REVIEW DETAILS REVIEWER STATUS This article is included in the Health Services gateway. Abstract Background The emergence of AI technologies has revolutionised dentistry, with intraoral imaging being a key area for innovation. Despite advances and growing interest in applying AI algorithms to intraoral x-rays, the methodological quality, diagnostic validity, and clinical applicability of existing studies remain unclear. Aim To synthesise and critically appraise the current evidence on AI integrated with intraoral digital radiographic imaging for detecting dental caries in adults, focusing on diagnostic accuracy compared with gold-standard methods and examining methodological quality, clinical applicability, and implementation challenges. Methods Following the JBI scoping review framework and PRISMA-ScR reporting guidelines, a comprehensive literature search was conducted across the PubMed, Scopus, and IEEE Xplore databases from January 2015 to May 2025. Studies that met the predefined eligibility criteria were included. Thematic analysis, combining inductive and deductive approaches following Braun and Clarke’s framework, identified five themes. The CASP quality appraisal was performed to ensure methodological rigour. Results Ten peer-reviewed studies were included in the final data analysis. AI systems detected a greater number of carious lesions than human clinicians, particularly in early-stage caries, with representative metrics including 88% sensitivity, 91% specificity, and 89% accuracy. Other models reported F1-scores up to 89% and AUC ≈95%. Methodological diversity was notable, with histology-validated designs providing the strongest evidence. Implementation challenges included limited external and real-world validation, clinician oversight, ethical/regulatory considerations, and inadequate model interpretability. Conclusion AI exhibits strong potential to enhance early caries detection on intraoral radiographs and support clinical decision-making in adults. Fully realising AI’s clinical potential requires overcoming implementation and methodological challenges. Standardised validation methods across diverse populations and settings are crucial to ensure AI diagnostic reliability and generalisability. Current AI applications in dentistry are primarily designed to assist clinicians in detecting caries; however, their greatest potential lies in a future where they can independently guide treatment planning decisions. READ ALL READ LESS Keywords Artificial Intelligence, Computer-Assisted Image Interpretation, Dental Caries, Dental Radiography, Diagnostic Imaging, Treatment Planning, Clinical Decision-making, Clinical Decision Support System Corresponding Author(s) Ali Golkari ( [email protected] ) Close Corresponding author: Ali Golkari Competing interests: No competing interests were disclosed. Grant information: The author(s) declared that no grants were involved in supporting this work. Copyright: © 2025 Kayali S et al . This is an open access article distributed under the terms of the Creative Commons Attribution License , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. How to cite: Kayali S, Golkari A and Mathur M. Artificial Intelligence Integrated with Intraoral Digital Imaging in Dental Caries Detection, Treatment Planning, and Clinical Decision-Making: A Scoping Review [version 1; peer review: 1 approved, 1 approved with reservations] . F1000Research 2025, 14 :1328 ( https://doi.org/10.12688/f1000research.172671.1 ) First published: 27 Nov 2025, 14 :1328 ( https://doi.org/10.12688/f1000research.172671.1 ) Latest published: 05 Mar 2026, 14 :1328 ( https://doi.org/10.12688/f1000research.172671.2 )  There is a newer version of this article available. Suppress this message for one day. 1. Introduction Proper and timely detection of dental caries, along with appropriate decision-making on whether to intervene, use preventive measures, or monitor, is critical for maintaining oral health and preventing disease progression. It is the necessary first step of the process to preserve natural tooth structure, reduce the need for invasive and costly treatments, and minimise complications such as pain, infection, and abscesses. 1 – 3 From a public health perspective, accurate detection and sound treatment planning reduce the financial burden on healthcare systems by minimising the need for complex interventions. At the individual level, they support long-term function, improved quality of life, and alignment with the principles of minimally invasive dentistry. 1 , 3 – 5 Missed or incorrect diagnoses can lead to both over-treatment and under-treatment, with consequences for patient well-being, imposed costs, healthcare resources, and clinician liability. 6 , 7 Delayed or inappropriate referrals increase the likelihood of advanced disease requiring more invasive and costly treatments, while unnecessary referrals can expose patients to repeat diagnostic procedures, additional costs, and radiation exposure. 8 – 10 Improving diagnostic precision is therefore crucial for both patient care and system-level efficiency. Current diagnostic methods, which include the combination of visual-tactile examinations and viewing two-dimensional radiographs, face well-recognised limitations. 11 – 13 While more sophisticated techniques, such as 3-D scans, are not practically appropriate for general dental practice use. 14 As a result, artificial intelligence (AI) has emerged as an attractive solution. Machine learning and deep learning algorithms have shown the ability to analyse intraoral radiographs with high accuracy. 15 , 16 Intraoral radiographs, such as bitewing and periapical, have been a key focus, with AI systems demonstrating strong diagnostic metrics—high sensitivity, specificity, and AUC values—while also reducing the time required for interpretation. 17 – 19 Integrating AI into dental diagnostics offers multiple benefits that extend beyond improved accuracy. AI systems consistently demonstrate higher sensitivity for subtle lesions, provide real-time decision support, and reduce inter- and intra-observer variability. 16 , 20 They also classify lesion severity, align with frameworks such as ICDAS or ICCMS, and contribute to evidence-based treatment planning. Significantly, automated analysis improves efficiency by reducing interpretation time and freeing clinicians to focus on patient communication and holistic care. 21 , 22 1.1 Rationale for review and gap in the literature The rapid advancement of AI in dental diagnostics has led to a growing body of literature on its application for caries detection from intraoral radiographs. However, the evidence remains fragmented and methodologically heterogeneous. Studies vary widely in imaging modalities, dataset quality, annotation protocols, lesion definitions, and AI architectures. Many rely on small, single-centre samples, internal cross-validation, and non-standardised outcome reporting, with limited attention to calibration, decision thresholds, or model interpretability. Such methodological heterogeneity restricts comparability and reduces confidence in generalisability. 23 – 25 Most, if not all, of the literature focuses on the increased number of caries detection when AI is integrated. Limited attention has been given to whether AI might lead to over-detection of lesions and, consequently, unnecessary treatment. It also remains unclear whether existing studies have adequately addressed external validity through independent, multicentre validation or considered the ethical, legal, and regulatory readiness of AI systems for safe clinical deployment. 1.2 Aims and objectives This scoping review aims to map and synthesise the current literature on AI integrated with intraoral digital radiographic imaging for detecting dental caries in adults, with emphasis on studies comparing AI diagnostic performance against established gold-standard diagnostic methods. Specifically, this review (i) identify and summarise studies applying AI to bitewing and periapical radiographs; (ii) identify and categorise AI model types (e.g., machine learning, deep learning, convolutional and segmentation networks) and intraoral imaging systems; (iii) evaluate AI diagnostic accuracy in comparison to histology, expert clinician assessment, or validated diagnostic criteria; (iv) assess reported impact on clinical decision-making—including treatment planning, diagnostic confidence, and workflow efficiency; and (v) Identify evidence gaps and implementation challenges to guide future research priorities, clinical integration approaches, and policy for AI-assisted caries diagnostics. 2. Methodology 2.1 Study design This study employed a scoping review methodology, guided by the Joanna Briggs Institute (JBI) framework for evidence synthesis, 26 and reported in accordance with the PRISMA-ScR checklist to ensure transparency and reproducibility. 27 , 50 The JBI approach, which builds on the foundational framework of Arksey and O’Malley (2005) and is further refined by Levac et al. (2010), 28 , 29 provides structured yet flexible guidance, making it particularly suited to broad and emerging research areas. This methodology was selected to systematically map and appraise the diverse and heterogeneous body of literature on AI applied to intraoral radiography for caries detection in adults. Unlike systematic reviews, which typically address narrowly defined effectiveness questions, scoping reviews allow the inclusion of varied study designs, methodologies, and outcomes, thereby capturing the breadth of existing research. 30 This approach is especially appropriate given the rapidly evolving, multidisciplinary nature of AI in dentistry, where studies differ in terms of AI models, imaging systems, validation strategies, and clinical applications. This scoping review protocol was developed in advance in November 2024 to ensure a transparent and systematic methodological approach. It outlines the review’s aim, objectives, eligibility criteria, search strategy, study selection process, data extraction, and data analysis and synthesis. Additionally, although the protocol was not formally registered, all steps were thoroughly documented and consistently applied throughout the review process. 2.2 Defining the research question The research question was developed in line with the JBI methodology and framed using the Population–Concept–Context (PCC) framework to ensure clarity and transparency. The central question guiding this review is: “Among adults undergoing dental examination for caries (Population), what is the current evidence on the use of artificial intelligence (AI) integrated with intraoral digital imaging systems for caries detection and its impact on diagnostic accuracy, treatment planning, and clinical decision-making (Concept), in clinical or research settings using intraoral radiography (Context)?” 2.2.1 Eligibility criteria P (Population): Adults (≥18 years) undergoing dental examination or treatment. C (Concept): Studies investigating the integration of artificial intelligence (AI), including machine learning, deep learning, or neural networks, with intraoral digital radiographic imaging (bitewing and periapical X-rays) for: • Detection of dental caries. • Comparison of AI diagnostic accuracy with established gold standard methods (e.g., histological validation, clinical visual-examination or expert consensus). • Evaluating the influence of AI on treatment planning, diagnostic confidence, and clinical decision-making. • Diagnostic accuracy measures (e.g., sensitivity, specificity, accuracy, precision, AUC, F1 score, PPV, NPV). C (Context): Clinical or research-based diagnostic settings using intraoral radiography (bitewing or periapical), and examining the application of AI in caries management, including both primary and specialist care environments. Original diagnostic accuracy studies, comparative designs, in vivo or in vitro investigations, randomised controlled clinical trials, and reviews of these original studies were included if published in English between January 2015 and May 2025. 2.3 Identifying relevant studies Relevant studies were identified through a comprehensive search of three major electronic databases: PubMed, Scopus, and IEEE Xplore . Search strategies were developed in consultation with an expert librarian at Queen Mary University of London (QMUL) to ensure methodological rigour and comprehensive coverage. A combination of controlled vocabulary, Medical Subject Headings (MeSH) terms for PubMed, and corresponding subject headings for Scopus, as well as free-text keywords and their synonyms, is used to cover the full scope of literature related to the research question, structured across five concepts groups: (i) artificial intelligence, (ii) intraoral digital radiography, (iii) dental caries, (iv) detection and diagnostic accuracy, and (v) clinical outcomes. The search strategy used Boolean operators (OR, AND) to link different concept groups; (OR) connected synonymous terms within each concept, and (AND) linked different thematic areas. Truncation symbols and wildcards were also applied, with database-specific syntax tailored for each database. The full search strategy is provided in the supplementary file in the external data repository. 50 Preliminary searches were piloted and iteratively refined to optimise sensitivity and specificity, with strategies re-visited. Backwards citation searching and manual hand-searching were also conducted. The retrieved records formed the basis of evidence for subsequent screening against predefined eligibility criteria. 2.4 Study selection The selection of studies was conducted systematically and transparently, in line with predefined eligibility criteria, to ensure the inclusion of only relevant, high-quality evidence in data extraction and subsequent phases. At each stage, screening decisions were documented using a standardised form, with reasons for exclusion recorded to maintain transparency and reproducibility. 2.4.1 Selection Step 1: Identifying duplicates After completing the database searches, all identified publications were imported into EndNote 21 (Clarivate, USA, 2023) reference management software. 31 The software’s automatic deduplication feature was initially used to remove duplicate records. The remaining references were exported from EndNote into the Rayyan screening AI tool (Rayyan Systems Inc., Qatar, 2025). 32 This tool automatically identified additional potential duplicates and flagged them, letting the researchers to choose the most complete or appropriate version and delete the other(s). 2.4.2 Selection Step 2: Title and abstract screening A thorough, systematic screening of the titles and abstracts of all records was conducted independently by two researchers (SK, AG) using the Rayyan AI tool, against the predefined eligibility criteria. Studies that clearly indicated the relevance of AI integration with intraoral imaging for caries detection were retained, while those focused on unrelated topics were excluded. Additionally, ambiguous titles or abstracts that lacked sufficient clarity were retained for further assessment at the subsequent stage. Any discrepancies at this stage were resolved through consensus discussions among the researchers to maintain methodological rigour and ensure robust decision-making. 2.4.3 Selection Step 3: Critical appraisal The full texts of all remaining studies were obtained. Where access was restricted, requests were made through QMUL library services. Each study was then critically appraised using the Critical Appraisal Skills Programme (CASP) checklist appropriate to its study design, shown in Tables (1.1 - 3 ). The critical appraisal was conducted independently by GPT-4o Team (OpenAI, USA, 2025) and one researcher (SK), both of whom were trained and calibrated by the co-author (AG). A standardised reporting format was used, comprising a study summary, CASP scoring table, and overall recommendation. Discrepancies in reviewer judgments were resolved by the co-author (AG) to ensure consistency and methodological rigour. Table 2. Breakdown of reasons and numbers of studies excluded during title and abstract screening and full text assessment. Initial title and abstract screening stage/No. of studies Full-text screening stage/No. of studies Reason 1: Studies used extraoral radiographic imaging systems (n = 46) Reason 1: Studies lacking the proper use of the gold standard (n = 40) Reason 2: Studies used intraoral photographs or intraoral scanners (n = 38) Reason 2: Studies lacking inter-rater reliability assessment and calibration standards (n = 16) Reason 3: Studies applied AI in other fields of dentistry (n = 184) Reason 3: Methodological limitations; AI reliability, heterogeneity and validation Issues (n = 10) Reason 4: Studies focused on paediatric population (n = 20) Reason 4: CASP quality appraisal (n = 5) Total n = 288 Total n = 71 Table 3. Summary of main characteristics of the included studies. ID Title of the Paper Authors/Year of Publication Journal Study Design Country Sample size Imaging System AI Methodology 1 Accuracy Assessment of Human and AI-Assisted Bitewing Radiography and NIRI-Based Methods for Interproximal Caries Detection: A Histological Validation Rodrigues et al., 2025 34 Caries Research In-vitro diagnostic accuracy study Spain A total of 171 proximal surfaces from 100 extracted posterior teeth Intraoral Bitewing radiographs and NIRI intraoral scans AI-assisted bitewing radiography assessment using a Deep CNN-based software Denti.AI; an AI model integrated with a radiographic interpretation tool 2 From inconsistent annotations to ground truth: aggregation strategies for annotations of proximal carious lesions in dental imagery Klein et al., 2025 35 Journal of Dentistry In-vitro diagnostic performance evaluation study Germany and the Czech Republic A total of 1007 proximal surfaces from 522 extracted posterior teeth Orthoradial radiographs and Near-Infrared Light Transillumination (NILT) Evaluation of annotation aggregation strategies: Majority Voting (MV), Weighted Majority Voting (WMV), Dawid-Skene (DS), Multi-Annotator Competence Estimation (MACE) 3 Performance comparison of multifarious deep networks on caries detection with tooth X-ray images Ying et al., 2024 36 Journal of Dentistry Comparative diagnostic accuracy study China A total of 392 periapical radiographs (346 training and validation dataset, 46 testing dataset); 135 teeth in the testing dataset Periapical digital radiographs Four deep networks types: 1. YOLOv5 and DETR object detection networks. 2. UNet and Trans-UNet segmentation networks 4 Developing the Benchmark: Establishing a Gold Standard for the Evaluation of AI Caries Diagnostics Boldt et al., 2024 37 Journal of Clinical Medicine In vitro diagnostic accuracy study Germany A total of 1071 bitewing radiographs from 179 extracted permanent human teeth Standardised bitewing radiographs using the parallel technique Evaluation of the performance of an AI algorithm model against a histology-based gold standard benchmark 5 Evaluating the Accuracy of AI-Based Software vs Human Interpretation in the Diagnosis of Dental Caries Using Intraoral Radiographs: An RCT Das et al., 2024 38 Journal of Pharmacy and Bioallied Sciences Randomised controlled trial (RCT) India and Saudi Arabia 200 intraoral radiographs were obtained from patients aged 18 to 65 years seeking dental care Two bitewings and two periapical radiographs per participant using digital intraoral X-ray equipment; anonymised and standardised radiographs collected prospectively Deep learning-based AI software to detect carious lesions on intraoral radiographs 6 Artificial intelligence for caries detection: a novel diagnostic tool using deep learning algorithms Liu et al., 2024 39 Oral Radiology Diagnostic accuracy study using deep learning China 4278 periapical radiographs (12,524 single-tooth images) Digital periapical radiographs from clinical settings ResNet-based CNN with Segment Anything Model (SAM); integrated Grad-CAM for visual support 7 Diagnosis of Interproximal Caries Lesions in Bitewing Radiographs Using a Deep Convolutional Neural Network-Based Software García-Cañas et al., 2022 40 Caries Research Analytical, observational, and cross-sectional study Spain 300 digital bitewing radiographs of posterior teeth taken from 150 patients aged 16-85 years Digital bitewing radiographs Deep CNN-Based Software (Denti.Ai) with different caries detection thresholds (Model 1 to Model 4) 8 Detecting Proximal Caries on Periapical Radiographs Using Convolutional Neural Networks with Different Training Strategies on Small Datasets Lin et al., 2022 41 Diagnostics Diagnostic accuracy study China 800 periapical radiographs (600 training/validation, 200 testing) from 3165 initial periapical radiographs taken from 385 men and 415 women (mean age: 45.3 years) Periapical radiographs (BMP format) from PACS system, acquired via the paralleling technique Pretrained Cifar-10Net CNN with three training strategies: IR (image recognition), EE (edge extraction), IS (image segmentation); trained using transfer learning and fine-tuning 9 Detection of Proximal Caries Lesions on Bitewing Radiographs Using Deep Learning Method Chen et al., 2022 42 Caries Research Diagnostic accuracy study China 978 bitewing radiographs;10,899 proximal surfaces analysed Digital bitewing radiographs Faster R-CNN deep learning object detection framework for caries localisation and classification 10 The ADEPT study: a comparative study of dentists’ ability to detect enamel-only proximal caries in bitewing radiographs with and without the use of AssistDent artificial intelligence software Devlin et al., 2021 43 British Dental Journal RCT-Comparative diagnostic accuracy study United Kingdom 24-bitewing radiographs.23 dentists (11 in the control group and 12 in the experimental group) Digital bitewing radiographs AssistDent AI software (machine learning algorithm) ID Dental Focus Dental Setting Diagnostic Accuracy Measures Gold Standard Validation Key Findings Limitations and Bias 1 Interproximal caries detection Laboratory research setting (in vitro); posterior teeth collected and preserved for scanning and histology evaluation AI guided radiographic assessment: Se = 13.7%, Sp = 95.9%, PPV = 71%, NPV = 59.8%, F1 = 23%, AUC = 0.548 Examiners radiographic assessment: Se = 52%, Sp = 84.6%, PPV = 71.6%, NPV = 70.3%, F1 = 60%, AUC = 0.684, K = 0.459 Histological validation using optical microscopy evaluation All methods validated against histology; Fleiss Kappa for examiner agreement; statistical comparisons via Chi-Square, McNemar, and Wilcoxon tests Human examiners’ radiographic assessments demonstrated high constant accuracy and superior early caries detection capabilities compared to the AI programme 1. In-vitro design may not fully replicate the clinical environment 2. Early-stage caries lesions (E1) were overrepresented in the sample, which may have affected the findings 3. Small dataset for generalisation 2 Primary proximal carious lesions Laboratory research setting (in vitro), using extracted human premolars and molars teeth in a simulated clinical setup AUROC, sensitivity, specificity, and F1-score across strategies and lesion depths (sound, enamel, dentin) Histological examination of sectioned teeth to assess the presence and depth of carious lesions Compared against histology as the gold standard, stratified analysis by imaging modality and lesion depth For radiographs, MACE outperformed other strategies in unimodal datasets; DS was best in multimodal datasets; MV often underperformed across all lesion depths 1. Limited to in vitro settings may lack the variability and complexity of real-world clinical imagery 2. Potential dataset imbalance, and no feasibility discussion for clinical integration 3 Proximal and multifaceted caries Clinical dental practice YOLOv5: Sensitivity 82%, Specificity 94%, Percision 93%, F1-score 0.87. Trans-UNet: Sensitivity 81%, Specificity 92% DETR: Sensitivity 72%, Specificity 96%, Precision 95%, UNet: Sensitivity 76%, Specificity 88%, Percision 85% Dentist: Sensitivity 89%, Specificity 91%, Precision 91% Expert annotations and clinical validation by senior stomatologists Internal validation against expert annotations and clinical examination 1. YOLOv5 outperformed other networks with the highest sensitivity, specificity, F1-score, and Youden index 2. No statistically significant differences between deep networks and between well-trained networks and dentists in caries detection 1. Only periapical radiographs were used with a small single-institution dataset 2. Potential for bias in clinical application 3. The performance and experience of the dentists included are not representative 4. Limited practical feasibility discussion 4 Detection and staging of proximal caries: provide a validated framework for AI model benchmarking Simulated clinical setting with high-resolution extracted human teeth datasets Sensitivity: 0.565, Specificity: 0.956, Accuracy: 0.799, AUC: 76.1, MCC: 0.578, F1-score: 0.693 Histological validation of each lesion based on thin-section microscopy, compared with examiner ratings Internal validation using blinded human examiners and statistical analysis (ICC = 0.993) High inter-examiner agreement; the dataset offers realistic lesion representations and robust histological reference standards Only one imaging system and technique were used, which lacks diversity in patient demographics. The focus was on benchmarking rather than real-time AI testing 5 Detection of dental caries (proximal and general); supports diagnostic decision-making Clinical dental care setting AI: Sensitivity 88%, Specificity 91%, Accuracy 89% Human: Sensitivity 84%, Specificity 88%, Accuracy 86% Consensus diagnosis from two experienced dental radiologists (blinded to AI and each other’s assessments) Internal validation using statistical comparison against predefined benchmark values (85/90/88%); no external dataset AI outperformed human interpretation in sensitivity, specificity, and accuracy, exceeding benchmark values AI software model specifics undisclosed; limited to intraoral radiographs; benchmark-based comparison only 6 1. Detection of dental caries on single-tooth periapical radiographs 2. supports clinical decision-making and workflow Clinical hospital dental imaging repository with expert-annotated cases Accuracy: 0.885, Sensitivity: 0.894, Specificity: 0.887, F1-score: 0.886, AUC: 0.954 (all with 95% CI) Expert clinical diagnosis from dental records and ICDAS-coded manual review by specialists Internal validation; Cohen’s and Fleiss’ kappa for inter-rater agreement; Grad-CAM and overlay visualisation used AI Model achieved high diagnostic accuracy; visual interpretation support via Grad-CAM enhanced user confidence 1. Cropping tilted teeth still requires manual image rotation, limiting full automation. 2. Diagnoses were subjective and dependent on dentists’ clinical experience, which may affect the reliability of the training dataset 7 1. Detection of interproximal caries lesions 2. Clinical support in early caries identification Private dental clinic Best model (Model 2): Accuracy 82%, Sensitivity 69.8%, Specificity 85.4%, AUC 0.777 (95% CI 0.729–0.824) Clinical-visual examination, radiographic inspection, and/or cavity opening for dentin caries validated by two experienced dentists Internal validation with ROC and AUC analyses; confidence intervals reported for all major metrics AI software demonstrated acceptable diagnostic performance, particularly at moderate lesion thresholds (≥25% probability) No external multicenter validation; focused mainly on interproximal lesions; dependence on predefined thresholds 8 Detection of proximal caries on posterior teeth using periapical radiographs Hospital of Stomatology, Fujian Medical University (clinical image source); lab-based CNN development AUC: EE = 0.860, IR = 0.805, IS = 0.549; Accuracy: EE = 85.9%, IR = 82.1%, IS = 60.6%; Sensitivity: EE = 86.9%, Specificity: EE = 85.2%, F1-score: EE = 0.837 Consensus annotation by three endodontists; test dataset evaluated according to predefined evaluation criteria, which were used to compare the performance of IR, IS, EE and human observers Internal validation using a separate test set; statistical comparisons (Z-test, chi-square) with 95% CI; comparison with human observer consensus The edge extraction (EE) strategy significantly outperformed others and human eyes in detecting both enamel and dentin lesions. EE achieved the highest AUC, F1-score, and sensitivity Lack of standardisation of the radiological dosage.; small sample size; no clinical outcome data; no external or cross-institution validation; IS strategy underperformed 9 Detection of proximal caries lesions: early, moderate, and advanced stage differentiation Clinical imaging dataset from a university school and hospital of stomatology in Beijing, China AI Model: Accuracy 87%, Sensitivity 72%, Specificity 93%, F1-score 0.74 Students: Accuracy 82%, Sensitivity 47%, Specificity 94%, F1-score 0.57 Annotations by two endodontists and a radiologist based on clinical and radiographic criteria Statistical significance tested via McNemar’s test; ROC curves analysed; p < 0.001 Faster R-CNN significantly outperformed postgraduate students in detecting proximal caries, especially in early lesions Limited to comparison against student raters; not tested against highly experienced clinicians; internal dataset only 10 Enamel-only proximal caries detection General dental practice and dental teaching hospital Sensitivity: 75.8% with AI vs. 44.3% without AI; Specificity: 85.4% with AI vs. 96.3% without AI Expert panel annotations (at least three independent dento-maxillofacial radiologists/professors) Internal validation with an expert panel Use of AssistDent significantly improved sensitivity (71% increase) while slightly reducing specificity (11% decrease). Significant improvement (p < 0.01) Feasibility, practicality, and cost-effectiveness of AI are not discussed; there is a higher false-positive rate with AI use ID Conclusion Recommendation 1 1. AI models require further refinement for higher early lesion sensitivity improvement 2. NIRI may be a promising adjunct to radiography 1. There is a need to modify the current diagnostic criteria for AI programmes to allow for early caries detection 2. Future research to optimise the digital methods to ensure their effectiveness and reliability in clinical dental practice 2 Optimal aggregation strategies vary by dataset type; DS and MACE are recommended over traditional MV Informed strategy selection is essential; future research should assess clinical feasibility and include in vivo datasets 3 Deep networks demonstrate comparable diagnostic performance to that of experienced dentists and show promising potential clinical applications, with YOLOv5 recommended due to its superior metrics 1. Further research is recommended for practical implementation across diverse clinical settings 2. Future research is needed using more advanced deep networks, in collaboration with dentists across diverse hospitals and institutes, to broaden the generalisability of the findings 4 Provides a standardised dataset and gold standard for future AI benchmarking in caries diagnostics Encourages researchers to adopt standardised databases and protocols for AI validation and clinical performance comparison against an established histology-based gold standard 5 AI demonstrated higher diagnostic accuracy than expert interpretation, making it a promising second opinion or adjunctive tool Support for AI implementation in caries detection is warranted, with future research required to enhance model transparency and facilitate external validation 6 ResNet + SAM system effectively identifies caries in periapical images with high performance and supports visual interpretability Encourages clinical integration of deep learning as an assessment tool for clinical decision-making and future external validation studies for general use in caries diagnostics 7 AI software can assist in detecting interproximal caries lesions and may complement clinical evaluation in practice Further studies should explore AI integration across broader caries types and validate across diverse clinical settings 8 Preprocessing via EE significantly improves CNN detection performance, even on small datasets. Therefore, the proposed method should be regarded as a computer-aided caries detection system in clinical practice, considering its application and generalisability Further research should increase the dataset size, utilise clinical comparisons, standardise radiographic parameters, and evaluate the influence of treatment decisions in real-world practice 9 Faster R-CNN demonstrated strong potential for assisting clinical caries detection, improving sensitivity without compromising specificity 1. Future research should involve validation against expert dentists and across multiple institutions 2. The generalisability of the AI model needs to be well-evidenced in future studies 10 AssistDent AI significantly enhances the detection of enamel-only proximal caries, which is beneficial for preventive dentistry, despite a slight decrease in specificity AI software is recommended as a supportive diagnostic tool in general dental practice for preventive dentistry, but further developments could include monitoring the progression of caries Table 4. Theme distribution: AI and intraoral imaging in dental caries detection studies. Theme Supporting Studies ID Total no. of Studies Main Outcomes Theme 1: AI Effectiveness: Diagnostic Accuracy and Comparison with the Gold Standard 1-10 10 AI demonstrated comparable or superior accuracy in caries detection compared to clinicians, especially for early-stage lesions, with higher F1 and sensitivity scores. Its performance was validated against the gold standard, including histological validation, clinical visual examination, and expert panel consensus annotations. Theme 2: Clinical Implications and Relevance: AI as a Clinical Decision Support Tool, Impact on Treatment Planning 5, 6, 7, 8, 10 5 AI enhanced clinicians' sensitivity and diagnostic confidence, particularly in early caries detection; served as a clinical support decision-making tool and treatment planning aid without replacing clinician judgment. Significant positive impact on preventive and minimally invasive treatment planning, workflow efficiency, and patient communication. Theme 3: Imaging Modalities and Diagnostic Variation by Radiograph Type and Lesion Severity 1, 3, 6, 7, 8, 9, 10 7 Bitewing radiographs were the most common; image quality and lesion stage significantly affected outcomes, and manual preprocessing was required in some studies. Further, performance variability was observed between bitewing and periapical radiographs. Theme 4: Methodological Considerations: AI Model Strategies, Technical Design, Validation Approaches, and Limitations 2, 3, 4, 6, 7, 8, 9, 10 8 Diverse AI methodologies, such as CNNs, YOLOv5, and ResNet, were utilised; techniques like edge extraction and transfer learning enhanced performance. Robust internal validations, but were constrained by methodological issues, including single-centred studies and small datasets. The limitations included overfitting, limited external validation, challenges with clinical realism, and issues with imaging variability that affected generalisability. Theme 5: Implementation Challenges, Recommendations for Practical Integration, and Future Research Directions 1-10 10 Clinicians retain diagnostic authority; however, there is a need for explainable AI tools benchmarked against a histology-based gold standard or integrated with ICDAS/ICCMS systems for the unbiased evaluation of AI-based caries detection. Practical integration barriers include transparency, cost-effectiveness, and workflow integration. A common recommendation is made for larger, longitudinal, and multicentre research studies and standardisation. Table 1.1 Summary of the CASP appraisal quality assessment for Diagnostic accuracy studies. CASP factors Rodrigues et al. Klein et al. Ying et al. Boldt et al. Liu et al. Chen et al. Lin et al. 1. Did the study address a clearly formulated research question? Yes Yes Yes Yes Yes Yes Yes 2. Was there a comparison with an appropriate reference standard? Yes Yes Yes Yes Yes Yes Yes 3. Did all patients get the diagnostic test and reference standard? Yes Yes Yes Yes Yes Yes Yes 4. Could the results of the test have been influenced by the results of the reference standard? No No No No No No No 5. Is the disease status of the tested population clearly described? Yes Yes Yes Yes Yes Yes Yes 6. Were the methods for performing the test described in sufficient detail? Yes Yes Yes Yes Yes Yes Yes 7. What are the results? Yes Yes Yes Yes Yes Yes Yes 8. How sure are we about the results? Consequences and cost of alternatives performed? Yes Yes Yes Yes Yes Yes Yes 9. Can the results be applied to your patients/the population of interest? Yes Yes Yes Yes Yes Yes Yes 10. Can the test be applied to your patient or population of interest? Yes Partially Partially Yes Yes Yes Yes 11. Were all outcomes important to the individual or population considered? Yes Yes Yes Yes Yes Yes Yes 12. What would be the impact of using this test on your patients/population? Support early detection and minimise invasive treatment, especially with potential improvement of AI models. Findings will influence annotation practices in AI research and improve data quality for training diagnostic models. Supports the clinical use of YOLOv5 and Trans-UNet for caries detection; networks showed performance comparable to dentists. Establishing standardised gold standard enhances reliability and transparency of AI diagnostics, leading to improved diagnostic accuracy and patient care in dentistry. The tool would improve early caries detection accuracy, enhance clinical decision-making, and potentially decrease unnecessary treatments. Could significantly enhance early detection of proximal caries, potentially leading to more timely preventive interventions and improved oral health outcomes. EE strategy could improve sensitivity in detecting early proximal caries, aiding non-invasive management and treatment planning. Table 1.2 Summary of the CASP appraisal quality assessment for the RCT studies. CASP factors Das et al. Devlin et al. 1. Did the study address a clearly formulated research question? Yes Yes 2. Was the assignment of participants to interventions randomised? Yes Can’t Tell 3. Were all participants who entered the study accounted for at its conclusion? Yes Yes 4. (a) Were the participants ‘blind’ to intervention they were given? Can’t Tell Yes 4. (b) Were the investigators ‘blind’ to the intervention they were giving to participants? No Yes 4. (c) Were the people assessing/analysing outcome/s ‘blinded’? No Yes 5. Were the study groups similar at the start of the randomised controlled trial? Yes Yes 6. Apart from the experimental intervention, did each study group receive the same level of care (that is, were they treated equally)? Yes Yes 7. Were the effects of intervention reported comprehensively? Yes Yes 8. Was the precision of the estimate of the intervention or treatment effect reported? Yes Yes 9. Do the benefits of the experimental intervention outweigh the harms and costs? Yes Can’t Tell 10. Can the results be applied to your local population/in your context? Yes Yes 11. Would the experimental intervention provide greater value to the people in your care than any of the existing interventions? Yes Yes Table 1.3 Summary of the CASP appraisal quality assessment for the cross-sectional study. CASP factors García-Cañas et al. 1. Did the study address a clearly focused issue? Yes 2. Did the authors use an appropriate method to answer their question? Yes 3. Were the subjects recruited in an acceptable way? Yes 4. Were the measures accurately measured to reduce bias? Yes 5. Were the data collected in a way that addressed the research issue? Yes 6. Did the study have enough participants to minimise the play of chance? Yes 7. How are the results presented, and what is the main result? Yes 8. Was the data analysis sufficiently rigorous? Yes 9. Is there a clear statement of findings? Yes 10. Can the results be applied to the local population? Yes 11. How valuable is the research? Yes A structured scoring system was applied to the quality appraisal process, with responses coded as Yes = 1 , No = 0 , and Unclear/Maybe/Not applicable = 0.5. Studies achieving full or full-minus-one scores were rated as high quality and were included. Those with full minus two scores were rated as medium quality, with inclusion determined on a case-by-case basis depending on relevance. Studies with less than full minus two scores were considered low quality and were excluded. All CASP scores were documented with justifications for inclusion, potential inclusion, or exclusion. This dual-review approach ensured transparency, reproducibility, and accountability, while allowing flexibility to retain studies of potential value despite minor quality limitations. 2.4.4 Selection Step 4: Full-text assessment The full texts of all remaining studies were independently reviewed by the researcher (SK) to assess methodological rigour, with particular attention to the use of appropriate gold-standard validation methods. Those that mixed adults with children or adolescents, lacked inter-rater reliability assessment and calibration standards, lacked clinical or external validation, and had a high or unclear risk of bias were excluded. Conference proceedings and Duplicate records of the same studies with overlapping datasets were also excluded. Ambiguous cases were discussed in detail with the co-author (AG) until consensus was reached. All studies agreed upon through this structured process formed the final sample for data extraction and synthesis. The review process was documented in a standardised Excel spreadsheet, recording reasons for exclusion to ensure transparency and reproducibility. 2.5 Data extraction and charting A standardised data charting form was developed to ensure systematic and consistent extraction of key information across all included studies. Ultimately, it supported a coherent synthesis and presentation of findings across the diverse body of literature. The predefined categories captured study characteristics (title, authors, year of publication, country), journal and study design, sample size, dental focus and dental setting, AI methodology, imaging system, gold standard reference, diagnostic accuracy measures, validation approaches, key findings, limitations and bias, study conclusions, and recommendations for research or practice. Data were extracted independently by two authors (SK & AG), with discrepancies resolved through discussion. Citations were managed in EndNote 21 and transferred to Microsoft Excel, where the extracted data were recorded for organisation and analysis. 2.6 Data analysis and synthesis Following data extraction, the findings were collated and summarised to provide an overview of the included evidence. A descriptive numerical analysis, consistent with the JBI framework, was conducted to map key study characteristics. The analysis quantified the number and types of included studies, their geographical distribution, the AI models used, the intraoral imaging modalities, the validation methods, the gold standards, and the reported diagnostic performance metrics (e.g., sensitivity, specificity, AUC). This approach not only mapped the scope and distribution of existing evidence but also highlighted gaps in the literature, providing a foundation for the subsequent thematic synthesis. The descriptive analysis thus established a structured understanding of the evidence base, supporting the review’s objectives and informing practice, policy, and future research. A narrative synthesis and thematic analysis were conducted to identify and integrate key patterns across the included studies, following Braun and Clarke’s six-phase thematic analysis framework to ensure transparency and rigour. 33 Included studies were reviewed in full and coded using a combined deductive–inductive approach, guided by the review objectives. Codes capturing methodological features, diagnostic performance, clinical relevance, validation strategies, and implementation barriers were organised into thematic categories. These themes were iteratively refined, supported by representative data, and presented through narrative synthesis alongside visual outputs (tables, matrices, heatmaps, and a thematic concept map). Coding and synthesis were performed manually using structured Excel tools, enabling integration of qualitative and quantitative insights with implications for research, practice, and policy. 3. Results 3.1 Selection of sources of evidence The PRISMA-ScR flowchart ( Figure 1 ) illustrates the screening and selection process. Database searches retrieved 414 records (238 from PubMed, 69 from Scopus, 107 from IEEE Xplore) and five from manual searching, yielding 419 in total. After deduplication, 369 records remained for title and abstract screening, of which 288 were excluded for being irrelevant ( Table 2 ). Eighty-one articles progressed to full-text review with CASP appraisal. Seventy-one were excluded—five due to poor methodological quality and 66 because of the absence of a gold-standard comparator, inter-rater calibration, or adequate validation ( Table 2 ). Ten studies met all criteria and were included in the final analysis. Figure 1. PRSMA flowchart for the scooping review selection of sources process. 3.2 Characteristics of sources of evidence Ten peer-reviewed studies were included in this scoping review ( Figure 2 ). The key characteristics of these studies are summarised in Table 3 . The included studies represented diverse geographical settings: China (n = 4), Spain (n = 2), Germany (n = 2), the United Kingdom (n = 1), and a multinational collaboration between India and Saudi Arabia (n = 1). All were published in well-known dental and medical journals. 34 – 43 Figure 2. Distribution of studies by publication year. 3.2.1 Study designs, settings and sample size The ten included studies comprised diagnostic accuracy studies (n = 4), in vitro diagnostic performance studies (n = 3), randomised controlled trials (n = 2), and one cross-sectional observational study. Most were conducted in laboratory or simulated environments using extracted human teeth, while others took place in university hospitals or private dental practices. 34 – 43 The two RCTs directly examined AI’s impact on dentists’ diagnostic performance in both teaching and general practice settings, supporting AI’s potential role in clinical decision-making. 38 , 43 Sample sizes ranged widely, from 171 proximal surfaces in extracted teeth to over 12,000 tooth-level images from clinical radiographs. Clinical datasets included adults aged 16–85 years, with examples such as García-Cañas et al. (n = 150 patients, 300 bitewings), 40 Lin et al. (n = 800 periapicals), 41 and Das et al. (n = 200 intraoral radiographs). 38 One study (Devlin et al.) uniquely explored AI’s role in education by involving 23 dentists in the interpretation of 24 bitewings. 43 While sample sizes supported both proof-of-concept and large-scale validation, detailed demographic reporting was generally absent. 3.2.2 Diagnostic approaches and AI integration Most studies focused on detecting proximal carious lesions (n = 9), with one specifically addressing enamel-only caries. Some, such as Klein et al., targeted primary proximal lesions, while others (e.g., Ying et al., Chen et al.) examined both enamel and dentine involvement, and several proposed frameworks for grading lesion severity to improve benchmarking. All studies used intraoral radiographic imaging, most commonly digital bitewings (n = 5) and periapicals (n = 3), with one study combining both and another employing orthoradial radiographs. Acquisition techniques were generally standardised, though sensor brands were inconsistently reported ( Figure 3 ). 34 – 43 Figure 3. Distribution of radiograph types among included studies. AI methodologies were dominated by deep learning and convolutional neural networks, with tools such as Denti.AI and AssistDent integrated into radiographic interpretation. Object detection models (YOLOv5, DETR, Faster R-CNN) were applied for lesion localisation, while segmentation approaches (UNet, Trans-UNet, Segment Anything Model) supported precise lesion mapping. Some studies employed Grad-CAM to improve interpretability, and training strategies frequently included transfer learning, fine-tuning, and the use of pre-trained networks. Annotation aggregation techniques (e.g., majority voting, weighted voting, Dawid–Skene, MACE) were also used to enhance labelling reliability. 34 – 43 3.2.3 Gold standards and validation All studies employed a gold standard to evaluate AI accuracy in detecting dental caries from intraoral radiographs. Histological validation through thin-section microscopy was employed in three studies, while ICDAS-based clinical examination with cavity opening was used in two, and expert consensus with high calibration and inter-rater reliability was utilised in the remaining five ( Figure 4 ). While internal validation with expert panels, clinical examination, or blinded reviewers was most common, only one study conducted external benchmarking using a histology-based dataset. 37 Performance and agreement were assessed using statistical methods, including Cohen’s and Fleiss’ kappa, ICC, ROC curve and AUC analyses, as well as significance testing (Chi-square, McNemar’s, Wilcoxon, and Z-tests), with 95% confidence intervals typically reported. Some studies additionally employed Grad-CAM visualisation or benchmark thresholds to support interpretability and validate findings. 34 – 43 Figure 4. Gold standard validation methods were used in the included studies. 3.3 Thematic analysis The analysis identified five overarching themes that capture key insights on AI integration with intraoral radiographic imaging for caries detection in adults: (i) diagnostic accuracy performance, (ii) clinical relevance and implications, (iii) imaging-related factors, (iv) methodological considerations, and (v) recommendations for future integration. Each theme is described below with illustrative examples. The distribution of themes across studies and their primary outcomes is summarised in Table 4 . Figure 5 presents a heatmap illustrating theme coverage and the strength of evidence, while Figure 6 displays the thematic concept map. Figure 5. Theme coverage across included studies, stratified by strength of evidence. Figure 6. Thematic concept map: AI integration in dental caries detection. 3.3.1 Theme 1: AI effectiveness: Diagnostic accuracy and comparison with the gold standard Across the included studies, AI consistently demonstrated strong diagnostic potential, often matching or surpassing clinician performance, particularly in detecting early-stage and proximal caries. Reported sensitivity, specificity, accuracy, and F1-scores were generally higher for AI models than for human examiners. For instance, Devlin et al.’s study found that dentists using AI achieved 75.8% sensitivity and 85.4% specificity, compared with 44.3% and 96.3% without AI in detecting enamel-only caries. 43 In comparison, Das et al.’s RCT reported AI software performance of 88% sensitivity, 91% specificity, and 89% accuracy, exceeding human interpretation. 38 Chen et al.’s study also observed AI superiority over dental students, with 87% accuracy, 72% sensitivity, 93% specificity, and an F1-score of 0.74, compared with 82%, 47%, 94%, and 0.57, respectively. 42 Benchmarking against gold standards varied: histology-based studies reported the most stringent results, with specificity consistently >90% 34 , 35 , 37 ; ICDAS and cavity-opening studies, such as Liu et al. and García-Cañas et al., demonstrated accuracies of 82–88% and AUCs of 77–95% 39 , 40 ; and expert consensus–based studies, such as Ying et al. and Lin et al., confirmed AI’s higher sensitivity than human eyes for both enamel and dentine caries ( p < 0.05). 36 , 41 Collectively, these findings highlight AI’s consistent diagnostic reliability across diverse methodologies, settings, and comparator standards, underscoring its potential clinical utility in caries detection. 3.3.2 Theme 2: Clinical implications and relevance: AI as a clinical decision support tool and impact on treatment planning AI integration with intraoral radiographs carries significant clinical implications, consistently enhancing diagnostic sensitivity, clinician confidence, and decision-making. Devlin et al.’s study demonstrated a 71% increase in sensitivity for enamel-only proximal caries when dentists used AI prompts (AssistDent), enabling earlier intervention and minimally invasive treatment planning. 43 Similarly, Chen et al.’s study demonstrated that AI enhanced the detection of early enamel and outer dentine lesions without substantially increasing false positives, particularly benefiting less experienced practitioners and highlighting its potential in dental education. 42 Across studies, AI was positioned as a decision-support tool rather than a substitute for clinicians, with the capacity to reduce overtreatment, support preventive care planning, and alleviate clinician workload through precise and timely detection of early lesions. 34 – 43 Moreover, Devlin et al.’s study proposed that AI-supported sensitivity could serve as the basis for an audit standard for caries detection, underscoring AI’s transformative potential to promote evidence-based, patient-centred dental care. 43 3.3.3 Theme 3: Imaging modalities and diagnostic variation by radiograph type and lesion severity Digital bitewing radiographs emerged as the predominant modality (n = 5), reflecting their widespread clinical use for detecting proximal caries. The remaining studies utilised periapical radiographs, with one combining bitewing and periapical images and another employing an orthoradial radiograph. Diagnostic performance varied according to lesion depth, severity, and radiograph type, with reduced accuracy frequently observed on images with tilted or low-quality radiographs. Studies by Liu et al. (2024) and Lin et al. (2022) highlighted how artefacts, anatomical variability, and positioning inconsistencies influenced outcomes, emphasising the importance of methodological refinement and improved standardisation of imaging and preprocessing. 39 , 41 Several studies also reported that manual preprocessing tasks (e.g., image rotation or cropping) limited workflow efficiency, underscoring the need for automated solutions and more robust AI models capable of handling variations in real-world clinical imaging. 3.3.4 Theme 4: Methodological considerations: AI model strategies, technical design, validation approaches, and limitations Substantial methodological diversity influenced the robustness and reliability of the included studies. A variety of convolutional neural networks (CNNs) were employed, including YOLOv5, Faster R-CNN, and ResNet variants, often enhanced with techniques such as edge extraction, transfer learning, and annotation aggregation strategies (e.g., MACE, Dawid–Skene) to optimise performance on small or imbalanced datasets. Validation approaches varied considerably: studies using histological ground truth provided the most objective benchmarks, while those relying on expert-labelled annotations introduced greater subjectivity and variability in results. Common limitations included the risk of overfitting, absence of multicentre validation, and reliance on imbalanced datasets, all of which restrict the generalisability of findings and underscore the need for more rigorous, standardised methodologies in future research. 34 – 43 3.3.5 Theme 5: Implementation challenges, recommendations for practical integration, and future research directions Implementation considerations featured prominently across the studies, with AI consistently framed as a supportive adjunct rather than an autonomous tool, reinforcing the principle that clinicians retain ultimate responsibility for diagnostic decisions. Central to effective integration were the development of interpretability mechanisms (e.g., Grad-CAM) to build clinician trust, alongside clear boundaries of clinical accountability, ethical safeguards, and regulatory clarity. Barriers to real-world adoption included the need for explainability, clinician training, and seamless incorporation of AI into established diagnostic frameworks such as ICDAS and ICCMS. To address these challenges, studies recommended comprehensive pilot testing, longitudinal and multi-centre validation, integration with risk-based caries management frameworks, and the use of AI for education and quality improvement feedback. 34 – 43 Collectively, these recommendations emphasise the importance of establishing structured pathways to ensure the reliable, ethical, and effective clinical adoption of AI in caries detection. 4. Discussion 4.1 Interpretation of the main themes Across the ten included studies, AI consistently demonstrated diagnostic performance comparable to, and in many cases exceeding, that of clinicians, particularly in detecting early-stage enamel and outer dentine caries. 34 – 43 Metrics such as sensitivity, specificity, and AUC confirmed this trend. For instance, Das et al.’s study reported AI sensitivity and specificity above 88%, outperforming clinicians, 38 while Chen et al.’s study highlighted AI’s superior accuracy compared with dental students. 42 These findings align with broader systematic reviews, which show pooled CNN accuracies of 73–99% and sensitivities of 72–95%. 44 Nevertheless, performance varied considerably across AI model types, datasets, and lesion severity, with some models underperforming on subtle enamel lesions despite high specificity. 34 – 43 This reinforces AI’s value as a diagnostic adjunct but highlights its current limitations for the most challenging lesion types. A significant source of variability was the type of gold standard used for diagnostic comparison. Studies employing histology-based validation provided the most objective benchmarks, with specificity consistently reported to exceed 90%. 34 , 35 , 37 In contrast, reliance on expert panel consensus annotations alone introduced subjectivity and moderate uncertainty, potentially inflating performance estimates. 36 , 41 , 42 Inconsistent reference standards undermine comparability, echoing concerns raised by the STARD guidelines on diagnostic research. 45 Furthermore, annotation protocols varied widely—ranging from single experts to multi-clinician panels with consensus methods—introducing heterogeneity in “ground truth” labelling and creating inherent limitations in validation accuracy. Since AI learns from the quality of its input data, variability in annotation reduces reproducibility and may embed systematic human errors into AI algorithms. 35 , 46 This inconsistency in the gold standard, validation methods, and outcome measures used raises concerns about the generalisability and comparability of results across the evidence base. Moreover, the absence of consistent and reliable gold-standard methods for evaluating the accuracy of AI in detecting dental caries also exist as a significant gap in the current literature across numerous studies, this critical limitation undermines the validity and reliability of reported AI performance metrics, resulting in a series of issues that impact clinical translation, regulatory approval, and meaningful comparison between different AI models. 34 , 35 , 37 The lack of robust reference standards is one of the most significant methodological challenges in contemporary dental AI research. This review highlights significant clinical implications, particularly the role of AI as a decision-support tool. AI-enhanced radiographs improved clinicians’ sensitivity for early lesions, supported preventive interventions, and increased confidence in treatment planning. Devlin et al.’s study demonstrated a 71% increase in sensitivity for enamel-only lesions when clinicians utilised AI prompts. 43 In contrast, Chen et al.’s study reported improved performance with fewer false positives, particularly benefiting less experienced practitioners. 42 These outcomes align with evidence that AI augments diagnostic confidence, reduces variability, and facilitates minimally invasive dentistry. 34 , 39 , 40 , 42 Importantly, AI was consistently positioned as an adjunct, not a replacement for clinical expertise, reinforcing its role in supporting evidence-based, patient-centred care. Beyond diagnosis, AI demonstrated value in treatment planning, workflow efficiency, and education. The RCTs confirmed that clinicians supported by AI reduced false negatives and improved decision-making between preventive and operative strategies. 38 , 43 Devlin et al.’s study also suggested AI could serve as an audit tool for caries detection. 43 This aligns with the broader literature; for instance, Pul et al.’s study highlighted its benefits for junior dentists, including improved diagnostic confidence and reduced overtreatment. 47 These findings suggest that AI may standardise diagnostic quality across different levels of experience, reducing disparities in dental care. However, evidence linking AI-supported diagnosis to long-term clinical outcomes (e.g., lesion progression, patient satisfaction) remains limited, highlighting an essential gap for future research. Bitewing radiographs were the most widely used modality and consistently demonstrated higher diagnostic accuracy than periapical, particularly for proximal and early lesions. For instance, García-Cañas et al.’s study confirmed the superiority of bitewings for detecting enamel lesions. 40 In contrast, Lin et al.’s study reported lower sensitivity for periapical images due to angulation and anatomical overlap. 41 These findings align with those of Takahashi et al.’s study, who found that sensitivity for enamel caries was more than double in bitewings compared to periapical radiographs. 48 However, AI performance declined with low-quality, tilted, or artefact-affected images, often requiring manual preprocessing. This raises concerns about efficiency and standardisation, as real-world imaging rarely achieves the laboratory-quality standards. Hence, automating preprocessing and testing cross-modality generalisability remains a critical priority. The methodological diversity across studies significantly influenced reported outcomes. Convolutional neural networks (CNN) architectures such as YOLOv5, ResNet, DETR, UNet, and SAM were employed, often enhanced with transfer learning, edge extraction, and aggregation strategies (e.g., MACE) to address dataset limitations. While some models achieved superior performance (e.g., YOLOv5 outperforming DETR and UNet), external benchmarking was rare. Most studies relied on internal validation, which limited generalisability. 34 – 43 Methodological reviews in medical AI confirm that internal validation alone risks overfitting and inflated performance claims. Furthermore, inconsistent reporting of model parameters and outcome definitions undermines reproducibility. These issues reflect broader calls, such as those from the FUTURE-AI Consortium, for transparent reporting and external validation. 49 Lastly, practical integration faces significant barriers. While AI shows strong diagnostic promise, studies consistently emphasised its supportive role under clinician oversight. Barriers include a lack of standardised interpretability tools, unclear regulatory pathways, ethical considerations around patient consent, and infrastructural demands in smaller practices. Tools like Grad-CAM were proposed to enhance trust by visualising AI reasoning; however, real-world deployment remains limited. Furthermore, integrating AI into established frameworks, such as ICDAS and ICCMS, was recommended to align AI outputs with risk-based caries management; however, evidence of feasibility remains limited. Hence, pilot studies and clinician training in AI literacy are essential to ensure responsible adoption, prevent over-reliance, and establish robust regulatory frameworks. 4.2 Strengths and limitations This scoping review has several notable strengths. The rigorous methodological design ensured transparency, reproducibility, and comprehensiveness throughout study identification, selection, data charting, and synthesis, which enhanced the robustness and reliability of the findings. The inclusion of both technical and clinical studies provided broad coverage, ranging from in vitro validations of extracted teeth to in vivo evaluations in practical settings. This breadth offers a holistic understanding of AI integration into intraoral radiographic imaging for caries detection, bridging technical innovation with clinical relevance. Additionally, thematic synthesis enabled effective mapping across diverse study designs, methodologies, and outcomes, providing cross-disciplinary insights into areas of consensus, divergence, research gaps, and practical implications for clinical care. Additionally, all included studies were recent peer-reviewed publications (2021–2025), ensuring that the findings reflect the most current evidence on AI applications, validation standards, and emerging diagnostic trends. In contrast, several limitations should also be acknowledged. Restriction to English-language publications may have introduced language and publication bias, potentially excluding relevant evidence. The small number of included studies (n = 10) and their methodological heterogeneity—particularly in definitions of gold standards, outcome measures, and study design—limited comparability and prevented the conduct of a meta-analysis. Furthermore, most studies were preclinical or early diagnostic accuracy trials, with few addressing patient-centred outcomes such as lesion progression, treatment effectiveness, or long-term impacts on caries management, thereby limiting clinical relevance. Furthermore, small sample sizes, reliance on single-centre datasets, and lack of multicentre validation further restrict generalisability. Finally, potential bias may have arisen from the use of overlapping datasets or developer involvement in multiple studies, which could inflate diagnostic accuracy estimates. These limitations highlight the need for independent, multicentre studies employing standardised methods to strengthen the evidence base for AI-assisted dental diagnostics. 4.3 Implications for clinical practice The findings of this scoping review highlight essential implications for dental practice. The integration of AI into intraoral radiographic diagnostics supports minimally invasive dentistry by enabling the earlier and more accurate detection of carious lesions, particularly at incipient stages. This allows clinicians to prioritise timely preventive interventions over invasive restorative treatments. AI-assisted diagnostics also offer the potential to standardise clinical decision-making, reducing inter-examiner variability and enhancing consistency in patient care across practitioners with differing levels of experience. Successful adoption of AI in practice, however, requires robust clinician training and oversight to ensure that these tools are used as adjuncts to, rather than replacements for, clinical judgment. Embedding AI literacy into dental education and continuing professional development is therefore essential. Training should equip clinicians to interpret AI outputs critically, recognise potential biases, and address the ethical and practical challenges of AI-assisted care. Such educational investment will be pivotal to optimising patient outcomes, fostering clinician confidence, and ensuring responsible integration of AI into routine dental diagnostics. 4.4 Recommendations for future research This review highlights key priorities for advancing AI integration into dental caries detection. Standardising validation protocols is crucial; future research should include robust, universally accepted benchmarks such as histological gold standards, multicentre validation, and longitudinal follow-up in clinical settings. Such consistency would enhance comparability across studies and strengthen conclusions about diagnostic accuracy. Furthermore, prospective real-world clinical trials are necessary to assess AI systems in routine practice, considering feasibility, performance, and impacts across diverse populations, imaging techniques, and workflows to ensure generalisability. Beyond diagnostic accuracy, future research should evaluate cost-effectiveness, usability, clinician and patient acceptability, and patient-centred outcomes, including lesion progression, treatment effectiveness, and quality of life. Exploring patient trust and satisfaction with AI-driven diagnostics represents a remarkably underexplored dimension. Comparative analyses of various AI architectures are also necessary to determine the most effective ones for radiographic caries detection, with semantic segmentation and explainable AI methods, such as Grad-CAM, showing potential. Research into AI as a primary screening tool or as an adjunct, supporting dental professionals in capturing and interpreting radiographs with less reliance on direct supervision, could guide its integration into diagnostic pathways, enhancing workflow efficiency while maintaining diagnostic standards. 5. Conclusions This scoping review highlights the substantial diagnostic potential of AI integrated with intraoral digital radiographic imaging systems for detecting dental caries in adults. AI has shown promise, particularly in identifying early-stage and proximal lesions, thereby supporting minimally invasive and preventive treatment strategies. However, the full realisation of AI’s clinical potential depends on overcoming key limitations, such as the lack of standardised external validation across diverse populations and clinical settings, and the need for comprehensive clinician training to ensure accurate interpretation of AI outputs and foster professional trust. AI should be regarded as a supportive tool that augments, rather than replaces, clinical expertise. Adopting this collaborative model, where AI enhances diagnostic precision, standardises care, and enables earlier interventions, offers a pathway to advancing minimally invasive dentistry and improving patient outcomes. Ultimately, the integration of AI into intraoral radiographic diagnostics represents a transformative step towards more accurate, efficient, and patient-centred dental care. Data availability All supplementary files can be found in the external repository: “Data set and Prisma checklist-Artificial Intelligence Integrated with Intra-oral Digital Imaging in Dental Caries Detection, Treatment Planning, and Clinical Decision-Making: A Scoping Review” https://qmro.qmul.ac.uk/xmlui/handle/123456789/113231 . Data are available under the terms of the Creative Commons Zero “No rights reserved” data waiver (CC0 1.0 Public domain dedication) Acknowledgements This research was conducted as part of Sarah Kayali’s MSc dissertation at Queen Mary University of London. The review was completed under the supervision of Dr. Ali Golkari, whose guidance and support were invaluable throughout the project. References 1. 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Qmulacuk. 2025 [cited 2025 Nov 6]. Reference Source Comments on this article Comments (0) Version 2 VERSION 2 PUBLISHED 27 Nov 2025 ADD YOUR COMMENT Comment Author details Author details 1 Institute of Dentistry, Queen Mary University of London, London, England, E1 2AH, UK Sarah Kayali Roles: Conceptualization, Data Curation, Formal Analysis, Investigation, Methodology, Project Administration, Resources, Visualization, Writing – Original Draft Preparation, Writing – Review & Editing Ali Golkari Roles: Conceptualization, Data Curation, Formal Analysis, Investigation, Methodology, Project Administration, Supervision, Writing – Review & Editing Manu Mathur Roles: Conceptualization, Supervision, Validation, Writing – Review & Editing Competing interests No competing interests were disclosed. Grant information The author(s) declared that no grants were involved in supporting this work. Article Versions (2) version 2 Revised Published: 05 Mar 2026, 14:1328 https://doi.org/10.12688/f1000research.172671.2 version 1 Published: 27 Nov 2025, 14:1328 https://doi.org/10.12688/f1000research.172671.1 Copyright © 2025 Kayali S et al . This is an open access article distributed under the terms of the Creative Commons Attribution License , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Download Export To Sciwheel Bibtex EndNote ProCite Ref. Manager (RIS) Sente metrics Views Downloads F1000Research - - PubMed Central info_outline Data from PMC are received and updated monthly. - - Citations open_in_new 0 open_in_new 0 open_in_new SEE MORE DETAILS CITE how to cite this article Kayali S, Golkari A and Mathur M. Artificial Intelligence Integrated with Intraoral Digital Imaging in Dental Caries Detection, Treatment Planning, and Clinical Decision-Making: A Scoping Review [version 1; peer review: 1 approved, 1 approved with reservations] . F1000Research 2025, 14 :1328 ( https://doi.org/10.12688/f1000research.172671.1 ) NOTE: If applicable, it is important to ensure the information in square brackets after the title is included in all citations of this article. COPY CITATION DETAILS track receive updates on this article Track an article to receive email alerts on any updates to this article. TRACK THIS ARTICLE Share Open Peer Review Current Reviewer Status: ? Key to Reviewer Statuses VIEW HIDE Approved The paper is scientifically sound in its current form and only minor, if any, improvements are suggested Approved with reservations A number of small changes, sometimes more significant revisions are required to address specific details and improve the papers academic merit. Not approved Fundamental flaws in the paper seriously undermine the findings and conclusions Version 1 VERSION 1 PUBLISHED 27 Nov 2025 Views 0 Cite How to cite this report: Melendez Rojas P. Reviewer Report For: Artificial Intelligence Integrated with Intraoral Digital Imaging in Dental Caries Detection, Treatment Planning, and Clinical Decision-Making: A Scoping Review [version 1; peer review: 1 approved, 1 approved with reservations] . F1000Research 2025, 14 :1328 ( https://doi.org/10.5256/f1000research.190413.r449986 ) The direct URL for this report is: https://f1000research.com/articles/14-1328/v1#referee-response-449986 NOTE: it is important to ensure the information in square brackets after the title is included in this citation. Close Copy Citation Details Reviewer Report 03 Feb 2026 Patricio Melendez Rojas , Universidad de Valparaíso, Valparaíso, Chile Approved with Reservations VIEWS 0 https://doi.org/10.5256/f1000research.190413.r449986 The scoping review by Kayali et al. (2025) provides a systematic mapping of artificial intelligence (AI) applications in dental caries detection, utilizing the Joanna Briggs Institute (JBI) framework and PRISMA-ScR guidelines to ensure methodological transparency. While the study successfully synthesizes ... Continue reading READ ALL The scoping review by Kayali et al. (2025) provides a systematic mapping of artificial intelligence (AI) applications in dental caries detection, utilizing the Joanna Briggs Institute (JBI) framework and PRISMA-ScR guidelines to ensure methodological transparency. While the study successfully synthesizes 10 high-quality investigations published between 2021 and 2025, its scope is mainly limited to proximal caries, despite the title suggesting broader coverage of all dental caries. Factual accuracy is well supported by primary sources, which indicate that AI models—particularly those based on deep learning—frequently achieve superior diagnostic performance compared with human clinicians. The following recommendations are proposed to improve the scientific rigor and accessibility of the article: Enhance Technical Accessibility : Explicitly define diagnostic metrics such as sensitivity, specificity, accuracy, precision, AUC , F1-score , PPV , and NPV upon their first mention in the text to ensure the content is accessible to general dental practitioners. Clarify Anatomical Scope : Could you explain in the conclusions that the reported data and AI performance metrics relate specifically to proximal caries? The authors should recognize that buccal and occlusal caries are often underdiagnosed through radiographic methods and were not adequately represented in the studies included. Standardize Reporting of Reference Methods : Incorporate a dedicated column in the summary tables to identify the specific gold standard used in each study, such as histological validation or expert consensus. Expand Discussion on Implementation Barriers : Provide a more detailed analysis of the current lack of external and multicentre validation in dental AI research. Just to let you know, the reliance on single-centre datasets remains a primary obstacle to the clinical generalizability and regulatory approval of these diagnostic tools. Streamline and Decompartmentalize Table 3 : Given that Table 3 is exceptionally dense and spans seven consecutive pages, it is recommended to reorganize the data into smaller, thematic sub-tables to reduce cognitive load for the reader. The authors should consider separating Study Characteristics (e.g., Design, Country, and Imaging System) from Diagnostic Performance and Outcomes (e.g., Accuracy Measures, Gold Standards, and Key Findings). Full Transparency of Search Strings : Although the authors describe the conceptual framework of the literature search—including five thematic groups and the use of Boolean operators —the actual, reproducible search strings are currently relegated to an external data repository. For a scoping review following PRISMA-ScR guidelines, it is a best practice to include the complete, verbatim search query for at least one major database (e.g., PubMed) directly within the manuscript or as a formal appendix. Consolidate Quality Appraisal Tables : Tables 1.1, 1.2, and 1.3 are highly repetitive, with the majority of studies scoring "Yes" across nearly all CASP criteria. To improve flow, these detailed checklists should be moved to the Annexes , with the main text providing only a concise narrative summary of the high methodological quality observed across the sample. Is the topic of the review discussed comprehensively in the context of the current literature? Partly Are all factual statements correct and adequately supported by citations? Yes Is the review written in accessible language? Partly Are the conclusions drawn appropriate in the context of the current research literature? Yes Competing Interests: No competing interests were disclosed. Reviewer Expertise: Dento-maxillofacial radiology. AI applications in Health. I confirm that I have read this submission and believe that I have an appropriate level of expertise to confirm that it is of an acceptable scientific standard, however I have significant reservations, as outlined above. Close READ LESS CITE CITE HOW TO CITE THIS REPORT Melendez Rojas P. Reviewer Report For: Artificial Intelligence Integrated with Intraoral Digital Imaging in Dental Caries Detection, Treatment Planning, and Clinical Decision-Making: A Scoping Review [version 1; peer review: 1 approved, 1 approved with reservations] . F1000Research 2025, 14 :1328 ( https://doi.org/10.5256/f1000research.190413.r449986 ) The direct URL for this report is: https://f1000research.com/articles/14-1328/v1#referee-response-449986 NOTE: it is important to ensure the information in square brackets after the title is included in all citations of this article. COPY CITATION DETAILS Report a concern Author Response 05 Mar 2026 Ali Golkari , Institute of Dentistry, Queen Mary University of London, London, E1 2AH, UK 05 Mar 2026 Author Response The authors sincerely thank the respected reviewer for accepting the peer-review and for the time they have spent to go through the manuscript in detail and provide us with such ... Continue reading The authors sincerely thank the respected reviewer for accepting the peer-review and for the time they have spent to go through the manuscript in detail and provide us with such a valuable and constructive comment. The authors have done their best to amend the manuscript based on the reviewer’s comments and hope the changes are acceptable. However, any further comment or feedback is welcome. Please see below a point by point response: Comment 1: Enhance Technical Accessibility Thank you for this valuable suggestion. We have now explicitly defined all diagnostic performance metrics at their first occurrence in the manuscript's methods section to enhance accessibility for general dental practitioners and non-technical readers. Comment 2: Clarify Anatomical Scope We thank the reviewer for highlighting this important limitation. We have revised the Discussion, Limitations and Conclusions sections to explicitly state that the reported diagnostic performance metrics primarily relate to proximal caries detection and that buccal and occlusal lesions were inadequately represented in the included studies. Comment 3: Standardize Reporting of Reference Methods We thank the reviewer for this helpful suggestion. We would like to clarify that Table 3 already includes a dedicated column specifying the reference standard (gold standard) used in each study, such as histological validation or expert consensus. Comment 4: Expand Discussion on Implementation Barriers Thank you for this important observation. We have expanded the Discussion section to provide a more detailed analysis of reliance on single-centre datasets, the lack of external and multicentre validation in dental AI research, and their implications for clinical generalisability and regulatory approval. Comment 5: Streamline and Decompartmentalize Table 3 We thank the reviewer for this thoughtful suggestion and appreciate the concern regarding the density of this table. While we carefully considered reorganising the table into separate thematic sub-tables, we found that study characteristics, reference standards, and diagnostic performance outcomes are closely interrelated and are most meaningfully interpreted together. Separating these elements would risk fragmenting the key contextual information required to interpret reported accuracy measures appropriately within each study’s methodological framework. Comment 6: Full Transparency of Search Strings We thank the reviewer for this recommendation. In accordance with PRISMA-ScR best practices, we have now included the complete, verbatim PubMed search strategy in the Methods to ensure full transparency and reproducibility. Comment 7: Consolidate Quality Appraisal Tables We agree with this suggestion. More details as a concise narrative summary of the overall quality appraisal in now included in the result section. The CASP appraisal tables have originally uploaded as appendices when submitting the paper. The journal brought them into the main text. We will ask the production team to see if they can move them to appendices. The authors sincerely thank the respected reviewer for accepting the peer-review and for the time they have spent to go through the manuscript in detail and provide us with such a valuable and constructive comment. The authors have done their best to amend the manuscript based on the reviewer’s comments and hope the changes are acceptable. However, any further comment or feedback is welcome. Please see below a point by point response: Comment 1: Enhance Technical Accessibility Thank you for this valuable suggestion. We have now explicitly defined all diagnostic performance metrics at their first occurrence in the manuscript's methods section to enhance accessibility for general dental practitioners and non-technical readers. Comment 2: Clarify Anatomical Scope We thank the reviewer for highlighting this important limitation. We have revised the Discussion, Limitations and Conclusions sections to explicitly state that the reported diagnostic performance metrics primarily relate to proximal caries detection and that buccal and occlusal lesions were inadequately represented in the included studies. Comment 3: Standardize Reporting of Reference Methods We thank the reviewer for this helpful suggestion. We would like to clarify that Table 3 already includes a dedicated column specifying the reference standard (gold standard) used in each study, such as histological validation or expert consensus. Comment 4: Expand Discussion on Implementation Barriers Thank you for this important observation. We have expanded the Discussion section to provide a more detailed analysis of reliance on single-centre datasets, the lack of external and multicentre validation in dental AI research, and their implications for clinical generalisability and regulatory approval. Comment 5: Streamline and Decompartmentalize Table 3 We thank the reviewer for this thoughtful suggestion and appreciate the concern regarding the density of this table. While we carefully considered reorganising the table into separate thematic sub-tables, we found that study characteristics, reference standards, and diagnostic performance outcomes are closely interrelated and are most meaningfully interpreted together. Separating these elements would risk fragmenting the key contextual information required to interpret reported accuracy measures appropriately within each study’s methodological framework. Comment 6: Full Transparency of Search Strings We thank the reviewer for this recommendation. In accordance with PRISMA-ScR best practices, we have now included the complete, verbatim PubMed search strategy in the Methods to ensure full transparency and reproducibility. Comment 7: Consolidate Quality Appraisal Tables We agree with this suggestion. More details as a concise narrative summary of the overall quality appraisal in now included in the result section. The CASP appraisal tables have originally uploaded as appendices when submitting the paper. The journal brought them into the main text. We will ask the production team to see if they can move them to appendices. Competing Interests: No competing interest. Close Report a concern Respond or Comment COMMENTS ON THIS REPORT Author Response 05 Mar 2026 Ali Golkari , Institute of Dentistry, Queen Mary University of London, London, E1 2AH, UK 05 Mar 2026 Author Response The authors sincerely thank the respected reviewer for accepting the peer-review and for the time they have spent to go through the manuscript in detail and provide us with such ... Continue reading The authors sincerely thank the respected reviewer for accepting the peer-review and for the time they have spent to go through the manuscript in detail and provide us with such a valuable and constructive comment. The authors have done their best to amend the manuscript based on the reviewer’s comments and hope the changes are acceptable. However, any further comment or feedback is welcome. Please see below a point by point response: Comment 1: Enhance Technical Accessibility Thank you for this valuable suggestion. We have now explicitly defined all diagnostic performance metrics at their first occurrence in the manuscript's methods section to enhance accessibility for general dental practitioners and non-technical readers. Comment 2: Clarify Anatomical Scope We thank the reviewer for highlighting this important limitation. We have revised the Discussion, Limitations and Conclusions sections to explicitly state that the reported diagnostic performance metrics primarily relate to proximal caries detection and that buccal and occlusal lesions were inadequately represented in the included studies. Comment 3: Standardize Reporting of Reference Methods We thank the reviewer for this helpful suggestion. We would like to clarify that Table 3 already includes a dedicated column specifying the reference standard (gold standard) used in each study, such as histological validation or expert consensus. Comment 4: Expand Discussion on Implementation Barriers Thank you for this important observation. We have expanded the Discussion section to provide a more detailed analysis of reliance on single-centre datasets, the lack of external and multicentre validation in dental AI research, and their implications for clinical generalisability and regulatory approval. Comment 5: Streamline and Decompartmentalize Table 3 We thank the reviewer for this thoughtful suggestion and appreciate the concern regarding the density of this table. While we carefully considered reorganising the table into separate thematic sub-tables, we found that study characteristics, reference standards, and diagnostic performance outcomes are closely interrelated and are most meaningfully interpreted together. Separating these elements would risk fragmenting the key contextual information required to interpret reported accuracy measures appropriately within each study’s methodological framework. Comment 6: Full Transparency of Search Strings We thank the reviewer for this recommendation. In accordance with PRISMA-ScR best practices, we have now included the complete, verbatim PubMed search strategy in the Methods to ensure full transparency and reproducibility. Comment 7: Consolidate Quality Appraisal Tables We agree with this suggestion. More details as a concise narrative summary of the overall quality appraisal in now included in the result section. The CASP appraisal tables have originally uploaded as appendices when submitting the paper. The journal brought them into the main text. We will ask the production team to see if they can move them to appendices. The authors sincerely thank the respected reviewer for accepting the peer-review and for the time they have spent to go through the manuscript in detail and provide us with such a valuable and constructive comment. The authors have done their best to amend the manuscript based on the reviewer’s comments and hope the changes are acceptable. However, any further comment or feedback is welcome. Please see below a point by point response: Comment 1: Enhance Technical Accessibility Thank you for this valuable suggestion. We have now explicitly defined all diagnostic performance metrics at their first occurrence in the manuscript's methods section to enhance accessibility for general dental practitioners and non-technical readers. Comment 2: Clarify Anatomical Scope We thank the reviewer for highlighting this important limitation. We have revised the Discussion, Limitations and Conclusions sections to explicitly state that the reported diagnostic performance metrics primarily relate to proximal caries detection and that buccal and occlusal lesions were inadequately represented in the included studies. Comment 3: Standardize Reporting of Reference Methods We thank the reviewer for this helpful suggestion. We would like to clarify that Table 3 already includes a dedicated column specifying the reference standard (gold standard) used in each study, such as histological validation or expert consensus. Comment 4: Expand Discussion on Implementation Barriers Thank you for this important observation. We have expanded the Discussion section to provide a more detailed analysis of reliance on single-centre datasets, the lack of external and multicentre validation in dental AI research, and their implications for clinical generalisability and regulatory approval. Comment 5: Streamline and Decompartmentalize Table 3 We thank the reviewer for this thoughtful suggestion and appreciate the concern regarding the density of this table. While we carefully considered reorganising the table into separate thematic sub-tables, we found that study characteristics, reference standards, and diagnostic performance outcomes are closely interrelated and are most meaningfully interpreted together. Separating these elements would risk fragmenting the key contextual information required to interpret reported accuracy measures appropriately within each study’s methodological framework. Comment 6: Full Transparency of Search Strings We thank the reviewer for this recommendation. In accordance with PRISMA-ScR best practices, we have now included the complete, verbatim PubMed search strategy in the Methods to ensure full transparency and reproducibility. Comment 7: Consolidate Quality Appraisal Tables We agree with this suggestion. More details as a concise narrative summary of the overall quality appraisal in now included in the result section. The CASP appraisal tables have originally uploaded as appendices when submitting the paper. The journal brought them into the main text. We will ask the production team to see if they can move them to appendices. Competing Interests: No competing interest. Close Report a concern COMMENT ON THIS REPORT Views 0 Cite How to cite this report: Yeo XH. Reviewer Report For: Artificial Intelligence Integrated with Intraoral Digital Imaging in Dental Caries Detection, Treatment Planning, and Clinical Decision-Making: A Scoping Review [version 1; peer review: 1 approved, 1 approved with reservations] . F1000Research 2025, 14 :1328 ( https://doi.org/10.5256/f1000research.190413.r437139 ) The direct URL for this report is: https://f1000research.com/articles/14-1328/v1#referee-response-437139 NOTE: it is important to ensure the information in square brackets after the title is included in this citation. Close Copy Citation Details Reviewer Report 26 Dec 2025 Xin Hui Yeo , Bart´s Health NHS Trust, England, UK Approved VIEWS 0 https://doi.org/10.5256/f1000research.190413.r437139 A comprehensive review and thorough methodology, well done to the authors. A few comments for consideration: - It would be useful to define sensitivity, specificity, accuracy, precision, AUC, F1 score, PPC and NPV when first mentioned in the manuscript ... Continue reading READ ALL A comprehensive review and thorough methodology, well done to the authors. A few comments for consideration: - It would be useful to define sensitivity, specificity, accuracy, precision, AUC, F1 score, PPC and NPV when first mentioned in the manuscript and then refer back to them if any studies reported those data. - The study's aim/concept is dental caries detection by AI and intraoral imaging. Dental caries can involve any tooth surfaces but only proximal caries has been reported. Is buccal or occlusal caries included in the inclusion criteria? Buccal caries can be more challenging to diagnosed on radiograph due to overlapping with the pulp chamber, resulting in under-diagnosis. If buccal caries is not part of the review or has not been reported by other primary studies, then perhaps consider adding this to the limitations and adjusting the conclusion to specify supporting data relevant to proximal caries instead of dental caries in general. - For table 3, it would be easier for the reader to have a column for gold standard reference used in each study (e.g. histology or expert consensus) for what the AI methodology was compared against. Is the topic of the review discussed comprehensively in the context of the current literature? Yes Are all factual statements correct and adequately supported by citations? Yes Is the review written in accessible language? Yes Are the conclusions drawn appropriate in the context of the current research literature? Yes Competing Interests: No competing interests were disclosed. Reviewer Expertise: review methodology, implant dentistry, digital dentistry I confirm that I have read this submission and believe that I have an appropriate level of expertise to confirm that it is of an acceptable scientific standard. Close READ LESS CITE CITE HOW TO CITE THIS REPORT Yeo XH. Reviewer Report For: Artificial Intelligence Integrated with Intraoral Digital Imaging in Dental Caries Detection, Treatment Planning, and Clinical Decision-Making: A Scoping Review [version 1; peer review: 1 approved, 1 approved with reservations] . F1000Research 2025, 14 :1328 ( https://doi.org/10.5256/f1000research.190413.r437139 ) The direct URL for this report is: https://f1000research.com/articles/14-1328/v1#referee-response-437139 NOTE: it is important to ensure the information in square brackets after the title is included in all citations of this article. COPY CITATION DETAILS Report a concern Author Response 05 Mar 2026 Ali Golkari , Institute of Dentistry, Queen Mary University of London, London, E1 2AH, UK 05 Mar 2026 Author Response We sincerely thank the reviewer for these insightful and constructive comments. Please see below a point by point response to the comments. 1. Definition of diagnostic metrics: In response ... Continue reading We sincerely thank the reviewer for these insightful and constructive comments. Please see below a point by point response to the comments. 1. Definition of diagnostic metrics: In response to this suggestion, we have now explicitly defined all diagnostic performance metrics (sensitivity, specificity, accuracy, precision, positive predictive value [PPV], negative predictive value [NPV], F1-score, and area under the curve [AUC]) at their first occurrence in the Methods section. Subsequent references to these metrics in the Results section now refer back to these definitions to enhance clarity and accessibility for general dental practitioners and non-technical readers. 2. Clarification of anatomical scope (proximal vs. buccal/occlusal caries) We appreciate this important observation. Although the inclusion criteria did not restrict caries detection to a specific anatomical surface, the primary studies meeting eligibility criteria predominantly evaluated proximal caries using bitewing radiographs. Buccal and occlusal lesions were not adequately represented in the included evidence base. To address this, we have: 1. Clarified in the Discussion that the reported AI performance metrics relate primarily to proximal caries detection. 2. Added a statement to the Limitations section acknowledging that buccal and occlusal caries—particularly buccal lesions, which may be underdiagnosed radiographically due to anatomical overlap—were underrepresented. 3. Revised the Conclusion to specify that the supporting diagnostic performance data relate to proximal caries rather than dental caries in general. We believe these revisions improve the precision, transparency, and clinical interpretation of the findings. However, we greatly appreciate any further comment that can help improve the quality of this manuscript. We sincerely thank the reviewer for these insightful and constructive comments. Please see below a point by point response to the comments. 1. Definition of diagnostic metrics: In response to this suggestion, we have now explicitly defined all diagnostic performance metrics (sensitivity, specificity, accuracy, precision, positive predictive value [PPV], negative predictive value [NPV], F1-score, and area under the curve [AUC]) at their first occurrence in the Methods section. Subsequent references to these metrics in the Results section now refer back to these definitions to enhance clarity and accessibility for general dental practitioners and non-technical readers. 2. Clarification of anatomical scope (proximal vs. buccal/occlusal caries) We appreciate this important observation. Although the inclusion criteria did not restrict caries detection to a specific anatomical surface, the primary studies meeting eligibility criteria predominantly evaluated proximal caries using bitewing radiographs. Buccal and occlusal lesions were not adequately represented in the included evidence base. To address this, we have: 1. Clarified in the Discussion that the reported AI performance metrics relate primarily to proximal caries detection. 2. Added a statement to the Limitations section acknowledging that buccal and occlusal caries—particularly buccal lesions, which may be underdiagnosed radiographically due to anatomical overlap—were underrepresented. 3. Revised the Conclusion to specify that the supporting diagnostic performance data relate to proximal caries rather than dental caries in general. We believe these revisions improve the precision, transparency, and clinical interpretation of the findings. However, we greatly appreciate any further comment that can help improve the quality of this manuscript. Competing Interests: No competing interest. Close Report a concern Respond or Comment COMMENTS ON THIS REPORT Author Response 05 Mar 2026 Ali Golkari , Institute of Dentistry, Queen Mary University of London, London, E1 2AH, UK 05 Mar 2026 Author Response We sincerely thank the reviewer for these insightful and constructive comments. Please see below a point by point response to the comments. 1. Definition of diagnostic metrics: In response ... Continue reading We sincerely thank the reviewer for these insightful and constructive comments. Please see below a point by point response to the comments. 1. Definition of diagnostic metrics: In response to this suggestion, we have now explicitly defined all diagnostic performance metrics (sensitivity, specificity, accuracy, precision, positive predictive value [PPV], negative predictive value [NPV], F1-score, and area under the curve [AUC]) at their first occurrence in the Methods section. Subsequent references to these metrics in the Results section now refer back to these definitions to enhance clarity and accessibility for general dental practitioners and non-technical readers. 2. Clarification of anatomical scope (proximal vs. buccal/occlusal caries) We appreciate this important observation. Although the inclusion criteria did not restrict caries detection to a specific anatomical surface, the primary studies meeting eligibility criteria predominantly evaluated proximal caries using bitewing radiographs. Buccal and occlusal lesions were not adequately represented in the included evidence base. To address this, we have: 1. Clarified in the Discussion that the reported AI performance metrics relate primarily to proximal caries detection. 2. Added a statement to the Limitations section acknowledging that buccal and occlusal caries—particularly buccal lesions, which may be underdiagnosed radiographically due to anatomical overlap—were underrepresented. 3. Revised the Conclusion to specify that the supporting diagnostic performance data relate to proximal caries rather than dental caries in general. We believe these revisions improve the precision, transparency, and clinical interpretation of the findings. However, we greatly appreciate any further comment that can help improve the quality of this manuscript. We sincerely thank the reviewer for these insightful and constructive comments. Please see below a point by point response to the comments. 1. Definition of diagnostic metrics: In response to this suggestion, we have now explicitly defined all diagnostic performance metrics (sensitivity, specificity, accuracy, precision, positive predictive value [PPV], negative predictive value [NPV], F1-score, and area under the curve [AUC]) at their first occurrence in the Methods section. Subsequent references to these metrics in the Results section now refer back to these definitions to enhance clarity and accessibility for general dental practitioners and non-technical readers. 2. Clarification of anatomical scope (proximal vs. buccal/occlusal caries) We appreciate this important observation. Although the inclusion criteria did not restrict caries detection to a specific anatomical surface, the primary studies meeting eligibility criteria predominantly evaluated proximal caries using bitewing radiographs. Buccal and occlusal lesions were not adequately represented in the included evidence base. To address this, we have: 1. Clarified in the Discussion that the reported AI performance metrics relate primarily to proximal caries detection. 2. Added a statement to the Limitations section acknowledging that buccal and occlusal caries—particularly buccal lesions, which may be underdiagnosed radiographically due to anatomical overlap—were underrepresented. 3. Revised the Conclusion to specify that the supporting diagnostic performance data relate to proximal caries rather than dental caries in general. We believe these revisions improve the precision, transparency, and clinical interpretation of the findings. However, we greatly appreciate any further comment that can help improve the quality of this manuscript. Competing Interests: No competing interest. Close Report a concern COMMENT ON THIS REPORT Comments on this article Comments (0) Version 2 VERSION 2 PUBLISHED 27 Nov 2025 ADD YOUR COMMENT Comment keyboard_arrow_left keyboard_arrow_right Open Peer Review Reviewer Status info_outline Alongside their report, reviewers assign a status to the article: Approved The paper is scientifically sound in its current form and only minor, if any, improvements are suggested Approved with reservations A number of small changes, sometimes more significant revisions are required to address specific details and improve the papers academic merit. Not approved Fundamental flaws in the paper seriously undermine the findings and conclusions Reviewer Reports Invited Reviewers 1 2 Version 2 (revision) 05 Mar 26 Version 1 27 Nov 25 read read Xin Hui Yeo , Bart´s Health NHS Trust, England, UK Patricio Melendez Rojas , Universidad de Valparaíso, Valparaíso, Chile Comments on this article All Comments (0) Add a comment Sign up for content alerts Sign Up You are now signed up to receive this alert Browse by related subjects keyboard_arrow_left Back to all reports Reviewer Report 0 Views copyright © 2026 Melendez Rojas P. This is an open access peer review report distributed under the terms of the Creative Commons Attribution License , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. 03 Feb 2026 | for Version 1 Patricio Melendez Rojas , Universidad de Valparaíso, Valparaíso, Chile 0 Views copyright © 2026 Melendez Rojas P. This is an open access peer review report distributed under the terms of the Creative Commons Attribution License , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. format_quote Cite this report speaker_notes Responses (1) Approved With Reservations info_outline Alongside their report, reviewers assign a status to the article: Approved The paper is scientifically sound in its current form and only minor, if any, improvements are suggested Approved with reservations A number of small changes, sometimes more significant revisions are required to address specific details and improve the papers academic merit. Not approved Fundamental flaws in the paper seriously undermine the findings and conclusions The scoping review by Kayali et al. (2025) provides a systematic mapping of artificial intelligence (AI) applications in dental caries detection, utilizing the Joanna Briggs Institute (JBI) framework and PRISMA-ScR guidelines to ensure methodological transparency. While the study successfully synthesizes 10 high-quality investigations published between 2021 and 2025, its scope is mainly limited to proximal caries, despite the title suggesting broader coverage of all dental caries. Factual accuracy is well supported by primary sources, which indicate that AI models—particularly those based on deep learning—frequently achieve superior diagnostic performance compared with human clinicians. The following recommendations are proposed to improve the scientific rigor and accessibility of the article: Enhance Technical Accessibility : Explicitly define diagnostic metrics such as sensitivity, specificity, accuracy, precision, AUC , F1-score , PPV , and NPV upon their first mention in the text to ensure the content is accessible to general dental practitioners. Clarify Anatomical Scope : Could you explain in the conclusions that the reported data and AI performance metrics relate specifically to proximal caries? The authors should recognize that buccal and occlusal caries are often underdiagnosed through radiographic methods and were not adequately represented in the studies included. Standardize Reporting of Reference Methods : Incorporate a dedicated column in the summary tables to identify the specific gold standard used in each study, such as histological validation or expert consensus. Expand Discussion on Implementation Barriers : Provide a more detailed analysis of the current lack of external and multicentre validation in dental AI research. Just to let you know, the reliance on single-centre datasets remains a primary obstacle to the clinical generalizability and regulatory approval of these diagnostic tools. Streamline and Decompartmentalize Table 3 : Given that Table 3 is exceptionally dense and spans seven consecutive pages, it is recommended to reorganize the data into smaller, thematic sub-tables to reduce cognitive load for the reader. The authors should consider separating Study Characteristics (e.g., Design, Country, and Imaging System) from Diagnostic Performance and Outcomes (e.g., Accuracy Measures, Gold Standards, and Key Findings). Full Transparency of Search Strings : Although the authors describe the conceptual framework of the literature search—including five thematic groups and the use of Boolean operators —the actual, reproducible search strings are currently relegated to an external data repository. For a scoping review following PRISMA-ScR guidelines, it is a best practice to include the complete, verbatim search query for at least one major database (e.g., PubMed) directly within the manuscript or as a formal appendix. Consolidate Quality Appraisal Tables : Tables 1.1, 1.2, and 1.3 are highly repetitive, with the majority of studies scoring "Yes" across nearly all CASP criteria. To improve flow, these detailed checklists should be moved to the Annexes , with the main text providing only a concise narrative summary of the high methodological quality observed across the sample. Is the topic of the review discussed comprehensively in the context of the current literature? Partly Are all factual statements correct and adequately supported by citations? Yes Is the review written in accessible language? Partly Are the conclusions drawn appropriate in the context of the current research literature? Yes Competing Interests No competing interests were disclosed. Reviewer Expertise Dento-maxillofacial radiology. AI applications in Health. I confirm that I have read this submission and believe that I have an appropriate level of expertise to confirm that it is of an acceptable scientific standard, however I have significant reservations, as outlined above. reply Respond to this report Responses (1) Author Response 05 Mar 2026 Ali Golkari, Institute of Dentistry, Queen Mary University of London, London, E1 2AH, UK The authors sincerely thank the respected reviewer for accepting the peer-review and for the time they have spent to go through the manuscript in detail and provide us with such a valuable and constructive comment. The authors have done their best to amend the manuscript based on the reviewer’s comments and hope the changes are acceptable. However, any further comment or feedback is welcome. Please see below a point by point response: Comment 1: Enhance Technical Accessibility Thank you for this valuable suggestion. We have now explicitly defined all diagnostic performance metrics at their first occurrence in the manuscript's methods section to enhance accessibility for general dental practitioners and non-technical readers. Comment 2: Clarify Anatomical Scope We thank the reviewer for highlighting this important limitation. We have revised the Discussion, Limitations and Conclusions sections to explicitly state that the reported diagnostic performance metrics primarily relate to proximal caries detection and that buccal and occlusal lesions were inadequately represented in the included studies. Comment 3: Standardize Reporting of Reference Methods We thank the reviewer for this helpful suggestion. We would like to clarify that Table 3 already includes a dedicated column specifying the reference standard (gold standard) used in each study, such as histological validation or expert consensus. Comment 4: Expand Discussion on Implementation Barriers Thank you for this important observation. We have expanded the Discussion section to provide a more detailed analysis of reliance on single-centre datasets, the lack of external and multicentre validation in dental AI research, and their implications for clinical generalisability and regulatory approval. Comment 5: Streamline and Decompartmentalize Table 3 We thank the reviewer for this thoughtful suggestion and appreciate the concern regarding the density of this table. While we carefully considered reorganising the table into separate thematic sub-tables, we found that study characteristics, reference standards, and diagnostic performance outcomes are closely interrelated and are most meaningfully interpreted together. Separating these elements would risk fragmenting the key contextual information required to interpret reported accuracy measures appropriately within each study’s methodological framework. Comment 6: Full Transparency of Search Strings We thank the reviewer for this recommendation. In accordance with PRISMA-ScR best practices, we have now included the complete, verbatim PubMed search strategy in the Methods to ensure full transparency and reproducibility. Comment 7: Consolidate Quality Appraisal Tables We agree with this suggestion. More details as a concise narrative summary of the overall quality appraisal in now included in the result section. The CASP appraisal tables have originally uploaded as appendices when submitting the paper. The journal brought them into the main text. We will ask the production team to see if they can move them to appendices. View more View less Competing Interests No competing interest. reply Respond Report a concern Melendez Rojas P. Peer Review Report For: Artificial Intelligence Integrated with Intraoral Digital Imaging in Dental Caries Detection, Treatment Planning, and Clinical Decision-Making: A Scoping Review [version 1; peer review: 1 approved, 1 approved with reservations] . F1000Research 2025, 14 :1328 ( https://doi.org/10.5256/f1000research.190413.r449986) NOTE: it is important to ensure the information in square brackets after the title is included in this citation. The direct URL for this report is: https://f1000research.com/articles/14-1328/v1#referee-response-449986 keyboard_arrow_left Back to all reports Reviewer Report 0 Views copyright © 2025 Yeo X. This is an open access peer review report distributed under the terms of the Creative Commons Attribution License , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. 26 Dec 2025 | for Version 1 Xin Hui Yeo , Bart´s Health NHS Trust, England, UK 0 Views copyright © 2025 Yeo X. This is an open access peer review report distributed under the terms of the Creative Commons Attribution License , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. format_quote Cite this report speaker_notes Responses (1) Approved info_outline Alongside their report, reviewers assign a status to the article: Approved The paper is scientifically sound in its current form and only minor, if any, improvements are suggested Approved with reservations A number of small changes, sometimes more significant revisions are required to address specific details and improve the papers academic merit. Not approved Fundamental flaws in the paper seriously undermine the findings and conclusions A comprehensive review and thorough methodology, well done to the authors. A few comments for consideration: - It would be useful to define sensitivity, specificity, accuracy, precision, AUC, F1 score, PPC and NPV when first mentioned in the manuscript and then refer back to them if any studies reported those data. - The study's aim/concept is dental caries detection by AI and intraoral imaging. Dental caries can involve any tooth surfaces but only proximal caries has been reported. Is buccal or occlusal caries included in the inclusion criteria? Buccal caries can be more challenging to diagnosed on radiograph due to overlapping with the pulp chamber, resulting in under-diagnosis. If buccal caries is not part of the review or has not been reported by other primary studies, then perhaps consider adding this to the limitations and adjusting the conclusion to specify supporting data relevant to proximal caries instead of dental caries in general. - For table 3, it would be easier for the reader to have a column for gold standard reference used in each study (e.g. histology or expert consensus) for what the AI methodology was compared against. Is the topic of the review discussed comprehensively in the context of the current literature? Yes Are all factual statements correct and adequately supported by citations? Yes Is the review written in accessible language? Yes Are the conclusions drawn appropriate in the context of the current research literature? Yes Competing Interests No competing interests were disclosed. Reviewer Expertise review methodology, implant dentistry, digital dentistry I confirm that I have read this submission and believe that I have an appropriate level of expertise to confirm that it is of an acceptable scientific standard. reply Respond to this report Responses (1) Author Response 05 Mar 2026 Ali Golkari, Institute of Dentistry, Queen Mary University of London, London, E1 2AH, UK We sincerely thank the reviewer for these insightful and constructive comments. Please see below a point by point response to the comments. 1. Definition of diagnostic metrics: In response to this suggestion, we have now explicitly defined all diagnostic performance metrics (sensitivity, specificity, accuracy, precision, positive predictive value [PPV], negative predictive value [NPV], F1-score, and area under the curve [AUC]) at their first occurrence in the Methods section. Subsequent references to these metrics in the Results section now refer back to these definitions to enhance clarity and accessibility for general dental practitioners and non-technical readers. 2. Clarification of anatomical scope (proximal vs. buccal/occlusal caries) We appreciate this important observation. Although the inclusion criteria did not restrict caries detection to a specific anatomical surface, the primary studies meeting eligibility criteria predominantly evaluated proximal caries using bitewing radiographs. Buccal and occlusal lesions were not adequately represented in the included evidence base. To address this, we have: 1. Clarified in the Discussion that the reported AI performance metrics relate primarily to proximal caries detection. 2. Added a statement to the Limitations section acknowledging that buccal and occlusal caries—particularly buccal lesions, which may be underdiagnosed radiographically due to anatomical overlap—were underrepresented. 3. Revised the Conclusion to specify that the supporting diagnostic performance data relate to proximal caries rather than dental caries in general. We believe these revisions improve the precision, transparency, and clinical interpretation of the findings. However, we greatly appreciate any further comment that can help improve the quality of this manuscript. View more View less Competing Interests No competing interest. reply Respond Report a concern Yeo XH. Peer Review Report For: Artificial Intelligence Integrated with Intraoral Digital Imaging in Dental Caries Detection, Treatment Planning, and Clinical Decision-Making: A Scoping Review [version 1; peer review: 1 approved, 1 approved with reservations] . F1000Research 2025, 14 :1328 ( https://doi.org/10.5256/f1000research.190413.r437139) NOTE: it is important to ensure the information in square brackets after the title is included in this citation. 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