The pathologic analysis and review of literature:synchronous primary cancer of the endometrium and cervical endometriosis with atypical hyperplasia

Objective:To investigate the clinicolpathologieal features and differential diagnosis of synchronous primary cancer of endometrium and cervical endometriosis with atypical hyperplasia.Methods: We analyzed the histopathology,immune phenotype of synchronous primary cancer of endometrium and ovary coexisting with endometriosls and atypical hyperplasia and with literature review.Results: Grossly,patient left adnexal tumor was cystic-solid,size about 5cm×4cm×3cm;inner wall attached about 3cm big solid nodules.Uterine angle was large cauliflower shape,the mass was about 3cm×2.5cm×1cm.The two tumors were both well-differentiated endometrial adenocarcinoma with the left ovarian endometriosis microscopically.At the same time,the cervical surface showed beige and cervical endometriosis with glandular epithelium atypical hyperplasia.Three sites of the tumor were positive for ER-α,PR detection,and negative for ER-β,Bcl-2.Conclusion: Synchronous primary cancer of endometrium and cervical endometriosis with atypical hyperplasia is often detedcted in premenopausal women.The prognosis is good if it was early diagnosed.Endometriosis is related with this disease to some extent.In order to reduce the omission diagnostic rate,endometriosis of multiple sites should be paid more attention during pathologic specimen cutting.