Prevalence of Medical Comorbidities in Adults with Autism Spectrum Disorder.

Autism spectrum disorder (ASD) is characterized by difficulties in socioemotional reciprocity and communication.1 Impairments in communication represent an important obstacle when clinicians are confronted with the challenge of diagnosing comorbidities in ASD. In fact, nonverbal or minimally verbal individuals with ASD could have difficulties in communicating symptoms, and problem behaviors, such as self-injury or aggression, could be sometimes the only manifestation of an underlying medical problem. Additionally, due to sensory impairment or refusal to initiate requested tasks, noncompliance to medical examination (i.e., palpation or auscultation) or different types of medical procedure (i.e., MRI, venipuncture) is extremely common.2 These difficulties may result in important unmet medical needs in this population. Only one study3 has actually investigated the presence of medical comorbidities in adult with ASD, while the others have relied on patient/caregiver survey or medical charts/registers. The aim of the present study is to evaluate medical comorbidities in a sample of adults with ASD.

This is a cross-sectional observational study performed at the Autism Laboratory of the University of Pavia, Italy, between January 2013 and January 2018. Individuals were considered eligible if they had a diagnosis of ASD performed in the past or during the current assessment. Level of severity for each of the two main criteria of DSM 5 was attributed to each subject. Medical history was recorded, and each reported diagnosis (i.e., allergic reactions, metabolic disorders) was reinvestigated to obtain a clinical confirmation. Congenital diseases for which appropriate documentation and genetic testing were provided were not reinvestigated. Additionally, each patient underwent a complete neurological and physical evaluation. Each observed sign or symptom was subsequently investigated by specific instrumental testing or by referral to the appropriate medical specialist. Blood tests were prescribed if performed more than 6 months before evaluation. All comorbidities were classified according to the ICD-10 system.

During the study period, 191 subjects received a diagnosis of ASD and were included in the study (Table 1). Presence of at least one medical comorbidity was observed in 114 subjects (59.7%). The number of comorbidities per subject varied from one to four (Table 2). Overall, epilepsy is the most represented medical condition (n = 29, 15.18%), followed by allergic rhinitis (n = 17, 8.9%) and irritable bowel syndrome (n = 13, 6.8%). Presence of medical conditions was not different between men and women (χ2 = 0.17, p = 0.68). Patients with ASD and ID displayed more frequently medical comorbidities (71.3% vs 52.3%, χ2 = 6.93, p = 0.01). Additionally, ASD individuals taking psychotropic medications were more likely to have medical conditions compared with ASD individuals not taking medications (72.0% vs 43.8%, χ2 = 15.17, p < 0.001). There was a positive correlation between the number of medical comorbidities and age (rho = 0.17, p = 0.02) and DSM 5-rated severity of ASD (rho = 0.27, p < 0.001).

Our study showed a complex picture of medical comorbidities in ASD. Prevalence rate of epilepsy was higher in our sample compared with that in general population (15.18% vs 7.9%), but in line with data from the adult ASD population .4 Prevalence of allergic rhinitis was low compared with that in the Italian population (8.9 vs 15–25%) and that in an autistic sample (16%).5 As people with ASD were examined throughout different years and seasons, it is possible that we have underestimated the true prevalence of seasonal allergic rhinitis. Our findings did not report significant sex differences in accord with a previous investigation.4 The same report4 showed a reduction in the rate of comorbidities with aging, in contrast with our results. However, Supekar mainly investigated medical conditions typical of childhood and did not consider metabolic disorders which may appear later in life. Subjects with ASD and comorbid ID presented a higher rate of medical comorbidities. This could be related to the higher health risk burden of people with ID in general.6 This is the first comorbidity study based on direct observation and examination of patients by experienced clinicians. Additionally, this is the first study to actually screen for a variety of medical comorbidities in adults with ASD, which represent an understudied population. In conclusion, people with ASD presented a mixed pattern of medical comorbidities. Physicians caring for adults with ASD should be aware of the possible presence of comorbid conditions, which could go unnoticed given the communication impairment inherent to ASD.

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