Effect of systematic local infiltration analgesia on postoperative pain in vaginal hysterectomy: a randomized, placebo‐controlled trial

Ana‐Marija Hristovska, B. Kristensen, Marianne A. Rasmussen, Yvonne H. Rasmussen, L. Elving, Christian Viggo Nielsen, Henrik Kehlet
In: Acta Obstetricia et Gynecologica Scandinavica · 2013 · vol. 93(3) , pp. 233–238 · doi:10.1111/aogs.12319 · PMID:24576202 · W1990275681
article OA: bronze CC0
🔓 Open OA copy View on OpenAlex View on PubMed View at publisher

Abstract

OBJECTIVE: To assess the effect of systematic local infiltration analgesia on postoperative pain in vaginal hysterectomy, and describe the technique in detail. DESIGN: A randomized, double-blind, placebo-controlled study following the CONSORT criteria. SETTING: A university hospital. PATIENTS: Thirty-seven patients undergoing vaginal hysterectomy. METHODS: Patients received high-volume (50 mL) ropivacaine 0.50% (n = 20) or saline (n = 17) infiltration using a systematic technique ensuring uniform delivery to all tissues incised, handled or instrumented during the procedure. MAIN OUTCOME MEASURES: Pain, nausea, vomiting and opioid requirements were assessed for 32 h as well as time spent in the post-anesthesia care unit and time to first mobilization. RESULTS: Pain at rest was significantly reduced after one, four and eight hours in the ropivacaine group (p ≤ 0.001-0.01). Pain during coughing was significantly reduced after one and four hours (p ≤ 0.001 and p ≤ 0.003), and pain during movement was significantly reduced after four hours (p ≤ 0.02). Opioid requirements and time spent in the post-anesthesia care unit were significantly reduced in the ropivacaine group (p < 0.001 and p < 0.001, respectively), as well as the time to first mobilization (p < 0.001). CONCLUSION: Intra-operative systematic local infiltration analgesia reduces postoperative pain in patients undergoing vaginal hysterectomy, facilities mobilization and improves early recovery.

My notes (saved in your browser only)

Citation neighborhood (no data yet)

We don't have any in-corpus citations linked to this paper yet. The paper's references may be in our DB but unresolved to ``paper_id`` (resolution happens at ingest when the cited DOI matches a row we already have). Run the cross-source citation reconcile pass to retry.

References (21)

Source provenance

openalex
last seen: 2026-05-14T06:54:16.401154+00:00
License: CC0 · commercial use OK