Exclusive patent, know-how and technology license to develop, make, have made, use, have used, register, promote, market, distribute, sell, and have sold any product comprising an anti-GnRH or an antiGnRH receptor immunogen construct for use in the diagnosis, treatment and prevention of gonadotropin, gonadal steroid hormones or GnRH receptors associated diseases and cancers in humans including endometriosis, polycystic ovaries, uterine fibroids, contraception, infertility, precocious puberty, prostate cancer, breast cancer, ovarian cancer and endometrial cancer.