Interaction effects of Irritability and Anhedonia on ERP and Time-Frequency Measures of Reward Sensitivity

Irritability and anhedonia are two prevalent, co-occurring, and impairing symptoms of major depression that are proposed to result from dysfunctions in reward processing. While irritability is associated with heightened sensitivity to reward receipt, anhedonia is linked to blunted sensitivity to reward receipt. Given these supposed paradoxical effects on reward sensitivity, it is noteworthy that no studies have examined how both symptoms interact to affect reward sensitivity. In a community sample of young adults (N=73, Mage=21.21±2.27, 56.16% females), we evaluated the interacting effects of dimensionally-assessed irritability and anhedonia symptoms on neural (i.e., event-related potentials and time-frequency) measures of reward and loss sensitivity during the Doors task, a well-known reward paradigm. We used univariate and multivariate (based on generalized eigendecomposition) approaches to isolate patterns of delta and theta activity in response to reward and loss. Linear-mixed models tested the unique and interacting effects of irritability and anhedonia on EEG measures of reward sensitivity (FRN/N2, theta, and delta power). Participants with above-average irritability and anhedonia displayed larger (more negative) FRN/N2 amplitudes across feedback valence, and reduced theta power following reward feedback, whereas no associations were observed at lower symptom levels. These effects remained significant when controlling for broader depressive symptoms, gender, and income. These findings provide preliminary evidence of an interactive effect of anhedonia and irritability on neural sensitivity to feedback in individuals without clinical levels of symptoms. Awaiting validation in clinical samples, our results highlight the importance of considering symptom interactions to better understand reward-related mechanisms in depression.