Influence of Glomerular Filtration Rate on Potentially Inappropriate Medications in Older Adults: A Cross-Sectional Study

Influence of Glomerular Filtration Rate on Potentially Inappropriate Medications in Older Adults: A Cross-Sectional Study | Authorea try { document.documentElement.classList.add('js'); } catch (e) { } var _gaq = _gaq || []; _gaq.push(['_setAccount', 'G-8VDV14Y67G']); _gaq.push(['_trackPageview']); (function() { var ga = document.createElement('script'); ga.type = 'text/javascript'; ga.async = true; ga.src = ('https:' == document.location.protocol ? 'https://ssl' : 'http://www') + '.google-analytics.com/ga.js'; var s = document.getElementsByTagName('script')[0]; s.parentNode.insertBefore(ga, s); })(); Skip to main content Preprints Collections Wiley Open Research IET Open Research Ecological Society of Japan All Collections About About Authorea FAQs Contact Us Quick Search anywhere Search for preprint articles, keywords, etc. Search Search ADVANCED SEARCH SCROLL This is a preprint and has not been peer reviewed. Data may be preliminary. 31 May 2025 V1 Latest version Share on Influence of Glomerular Filtration Rate on Potentially Inappropriate Medications in Older Adults: A Cross-Sectional Study Authors : Qingmin Yao , Ting Yuan , Yanxia Liu , Wen Zhang , Yahui Zhang , Wen Chen , xiaojuan Zhu , and Jianchun Wang 0009-0002-0243-1018 [email protected] Authors Info & Affiliations https://doi.org/10.22541/au.174868758.80415310/v1 219 views 113 downloads Contents Abstract Supplementary Material Information & Authors Metrics & Citations View Options References Figures Tables Media Share Abstract Aims: This study aimd to assess the association between estimated glomerular filtration rate (eGFR) levels and the prevalence of potentially inappropriate medications (PIMs) based on three criteria: the Beers (2019 version), Chinese and STOPP criteria. Methods: This retrospective cross-sectional study analysed 191 inpatients aged ≥65 years. Using the Beers, Chinese, and STOPP criteria, we assessed the prevalence of PIMs across stratified eGFR levels. Non-parametric analyses (Mann-Whitney U test), chi-square tests, and Logistic regression analysis were employed to evaluate the association between eGFR and PIMs exposure. Results: Participants were stratified into three groups based on eGFR: Group I (≥90 mL/min/1.73m²), Group II (60-89 mL/min/1.73m²), and Group III (<60 mL/min/1.73m²). Prevalence rates of PIMs were 72.25% by Beers criteria, 60.73% by Chinese criteria, and 28.80% by STOPP criteria, with STOPP demonstrating significantly lower PIMs detection rates than the other two criteria. Analysis by eGFR stratification revealed escalating PIMs prevalence with declining kidney function under Beers criteria: 67.35% in Group I, 74.29% in Group II, and 86.96% in Group III (P<0.05). Notably, Group III (eGFR <60 mL/min/1.73m²) exhibited higher proportions of patients with ≥2 PIMs across all criteria. By Beers criteria, 56.52% of Group III patients had ≥2 PIMs versus 22.45% (Group I) and 25.71% (Group II). Similar trends were observed by Chinese and STOPP criteria (P<0.05). Logistic regression analysis identified polypharmacy and eGFR decline as independent risk factors for PIMs exposure. Conclusion: The prevalence of PIMs gradually increases with the decline of eGFR in older adults, particularly when compounded by polypharmacy. Supplementary Material File (figure 4.tif) Download 1017.84 KB File (manuscript.docx) Download 75.13 KB Information & Authors Information Version history V1 Version 1 31 May 2025 Copyright This work is licensed under a Non Exclusive No Reuse License. Keywords clinical pharmacology clinical pharmacy geriatric medicine geriatrics medication safety Authors Affiliations Qingmin Yao Shandong Provincial Hospital Affiliated to Shandong First Medical University View all articles by this author Ting Yuan Shandong Provincial Hospital Affiliated to Shandong First Medical University View all articles by this author Yanxia Liu Shandong Provincial Hospital Affiliated to Shandong First Medical University View all articles by this author Wen Zhang Shandong Provincial Hospital Affiliated to Shandong First Medical University View all articles by this author Yahui Zhang Shandong Provincial Hospital Affiliated to Shandong First Medical University View all articles by this author Wen Chen Shandong Provincial Hospital Affiliated to Shandong First Medical University View all articles by this author xiaojuan Zhu Shandong Provincial Hospital Affiliated to Shandong First Medical University View all articles by this author Jianchun Wang 0009-0002-0243-1018 [email protected] Shandong Provincial Hospital Affiliated to Shandong First Medical University View all articles by this author Metrics & Citations Metrics Article Usage 219 views 113 downloads .FvxKWukQNSOunydq8rnd { width: 100px; } Citations Download citation Qingmin Yao, Ting Yuan, Yanxia Liu, et al. Influence of Glomerular Filtration Rate on Potentially Inappropriate Medications in Older Adults: A Cross-Sectional Study. Authorea . 31 May 2025. DOI: https://doi.org/10.22541/au.174868758.80415310/v1 If you have the appropriate software installed, you can download article citation data to the citation manager of your choice. Simply select your manager software from the list below and click Download. For more information or tips please see 'Downloading to a citation manager' in the Help menu . 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