Human Reproduction vol.13 no.5 pp.1194–1199, 1998 The role of monocyte chemotactic protein-1 in intraperitoneal adhesion formation*

1To whom correspondence should be addressed Abdomino-pelvic adhesions arise from infection, endometriosis, or peritoneal injury during surgery, and represent a significant source of morbidity in women of reproductive age. Monocyte chemotactic protein-1 (MCP-1) plays a role in the chemotaxis of mononuclear cells and fibroblasts in a murine wound repair model. To evaluate the role of MCP-1 in intraperitoneal adhesion formation, we investigated peritoneal fluid MCP-1 levels of women undergoing laparoscopy. Patients without endometriosis were divided into two groups: normal fertile women undergoing bilateral tubal ligation without intraperitoneal adhesions (n � 14) and women with pelvic adhesions (n � 8). Patients with endometriosis were arranged into two groups: women with (n � 17) and without (n � 17) adhesions. Peritoneal fluid