PCOS, Hashimoto's disease, celiac disease, endometriosis - genetically conditioned autoimmune disorder causing infertility?

Katarzyna Jankowska, Aleksandra Kaźmierczak-Dejewska
In: Kwartalnik Naukowy Fides et Ratio · 2021 · vol. 47(3) , pp. 110–129 · doi:10.34766/fetr.v47i3.922 · W3202050424
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⚙ AI-generated summary by claude@2026-06, 2026-06-07 ⓘ

This paper explores the potential common autoimmune basis and genetic predisposition linking polycystic ovary syndrome, Hashimoto's disease, endometriosis, and celiac disease as causes of infertility.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-07 ⓘ

This paper discusses infertility as a consequence of multiple female and male causes, focusing on polycystic ovary syndrome (PCOS) and its frequent coexistence with autoimmune thyroiditis (Hashimoto’s disease). It reports that in patients with PCOS and autoimmune thyroiditis, endometriosis and celiac disease are also found, and it proposes that PCOS, Hashimoto’s disease, endometriosis, and celiac disease may share a common autoimmune basis requiring genetic predisposition for disease manifestation. The main caveat is that the article is presented as a narrative overview rather than an original empirical study with defined methods, recruitment, and outcomes. Relevance to endometriosis: the paper explicitly states that endometriosis is also found in many patients with PCOS and autoimmune thyroiditis, framing a potentially shared autoimmune basis, though its main focus is infertility in the context of PCOS and other autoimmune disorders rather than endometriosis mechanisms.

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Abstract

Infertility is a social problem today. The causes of infertility can be both on the side of the woman and on the side of the man. One of the most common causes of infertility in women is polycystic ovary syndrome (PCOS). It has been proven that it often coexists with autoimmune thyroiditis (AIT), i.e. with Hashimoto's disease. In many patients with PCOS and AIT, endometriosis and celiac disease are also found. It seems that these disorders: PCOS, AIT, endometriosis and celiac disease may have a common autoimmune basis. More and more patients with infertility or recurrent miscarriages have autoimmune problems. Probably a genetic predisposition is necessary to reveal the disease.

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endometriosisinfertility

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