Liquid Morphologies in Open Microfluidic Intersections

preprint OA: closed
Full text JSON View at publisher
AI-generated deep summary by claude@2026-06, 2026-06-24 · read from full text

The paper investigates liquid “front” morphologies in open microfluidic networks with intersections, specifically crossing V-shaped and Gaussian microchannels, using gradient descent simulations in Surface Evolver to study minimal-energy shapes and how evaporation affects dewetting. For systems connected to an infinite reservoir, it finds that for a wetting liquid the minimal-energy state is a flat liquid surface and that no steady-state can be identified for wetting liquids. It further reports that the energy contribution from the intersection is negatively proportional to the energy contribution scaling with the filling length of single microchannels, enabling prediction of dewetting under evaporation and guidelines for designing intersection geometries that resist dewetting. A key limitation is that the work is simulation-based and framed around infinite-reservoir boundary conditions and quasi-steady front assumptions. The paper does not explicitly discuss endometriosis or adenomyosis; it was included in the corpus via a keyword match in the upstream search index.

Read from the paper's body, not the abstract. Not a substitute for reading the paper. No clinical advice. How this works

Full text 10,665 characters · extracted from preprint-html · click to expand
Liquid Morphologies in Open Microfluidic Intersections | Research Square window.SnipcartSettings = { analytics: { enabled: false } }; (function() { var accessVector = localStorage.getItem('access_vector') || ''; window.dataLayer = window.dataLayer || []; if (accessVector) { window.dataLayer.push({ user: { profile: { profileInfo: { snid: accessVector } } } }); } })(); (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-K279D39R'); Browse Preprints In Review Journals COVID-19 Preprints AJE Video Bytes Research Tools Research Promotion AJE Professional Editing AJE Rubriq About Preprint Platform In Review Editorial Policies Our Team Advisory Board Help Center Sign In Submit a Preprint Cite Share Download PDF Research Article Liquid Morphologies in Open Microfluidic Intersections Tina Mitteramskogler, Sebastian Lang, Bernhard Jakoby This is a preprint; it has not been peer reviewed by a journal. https://doi.org/ 10.21203/rs.3.rs-8344692/v1 This work is licensed under a CC BY 4.0 License Status: Posted Version 1 posted You are reading this latest preprint version Abstract When a liquid fills an open capillary, the shape of the liquid “front” can be treated as quasi-steady, since its shape remains virtually unchanged when the liquid advances through the channel. Previous investigations have shown that the associated morphology for steady-state flow represents a shape that is bulged inwards at the liquid front (caused by the capillary pressure) and becomes flat when the flow has stopped for a system connected to an infinite reservoir. Even though complex liquid networks inherently require intersections, the morphologies or minimal energy shapes formed at intersections have not yet been investigated in detail. In this work, we are investigating liquid morphologies inside crossing V-shaped and Gaussian microchannels and derive guidelines on how to hinder dewetting when evaporation is present. To this end, we perform gradient descent simulations with the “Surface Evolver”. Similar to the case of single microchannels, we find that the minimal energy shapes of a system being connected to an infinite reservoir are represented by a flat liquid surface for a wetting liquid, and that no steady-state can be found for wetting liquids. Additionally, we find that the energy contribution stemming from the intersection is negatively proportional to the energy contribution scaling with the filling length of single microchannels. This allows us to predict whether dewetting will happen when evaporation is present and allows us to design liquid intersections, where dewetting will not happen. Full Text Additional Declarations No competing interests reported. Cite Share Download PDF Status: Posted Version 1 posted You are reading this latest preprint version Research Square lets you share your work early, gain feedback from the community, and start making changes to your manuscript prior to peer review in a journal. As a division of Research Square Company, we’re committed to making research communication faster, fairer, and more useful. We do this by developing innovative software and high quality services for the global research community. Our growing team is made up of researchers and industry professionals working together to solve the most critical problems facing scientific publishing. Also discoverable on Platform About Our Team In Review Editorial Policies Advisory Board Help Center Resources Author Services Accessibility API Access RSS feed Manage Cookie Preferences © Research Square 2026 | ISSN 2693-5015 (online) Privacy Policy Terms of Service Do Not Sell My Personal Information {"props":{"pageProps":{"initialData":{"identity":"rs-8344692","acceptedTermsAndConditions":true,"allowDirectSubmit":true,"archivedVersions":[],"articleType":"Research Article","associatedPublications":[],"authors":[{"id":587841444,"identity":"fe21aef6-a613-4b77-8661-74fad559e25e","order_by":0,"name":"Tina Mitteramskogler","email":"data:image/png;base64,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","orcid":"","institution":"Johannes Kepler University Linz","correspondingAuthor":true,"prefix":"","firstName":"Tina","middleName":"","lastName":"Mitteramskogler","suffix":""},{"id":587841445,"identity":"a9a77703-48fb-4963-aa6b-456a8e56e25f","order_by":1,"name":"Sebastian Lang","email":"","orcid":"","institution":"Johannes Kepler University Linz","correspondingAuthor":false,"prefix":"","firstName":"Sebastian","middleName":"","lastName":"Lang","suffix":""},{"id":587841446,"identity":"4207e4c0-543a-4eed-b63f-0389d9b15d83","order_by":2,"name":"Bernhard Jakoby","email":"","orcid":"","institution":"Johannes Kepler University Linz","correspondingAuthor":false,"prefix":"","firstName":"Bernhard","middleName":"","lastName":"Jakoby","suffix":""}],"badges":[],"createdAt":"2025-12-12 10:23:47","currentVersionCode":1,"declarations":"","doi":"10.21203/rs.3.rs-8344692/v1","doiUrl":"https://doi.org/10.21203/rs.3.rs-8344692/v1","draftVersion":[],"editorialEvents":[],"editorialNote":"","failedWorkflow":false,"files":[{"id":102747212,"identity":"55765267-47be-4c44-83b1-8520d28c6a19","added_by":"auto","created_at":"2026-02-16 09:04:11","extension":"pdf","order_by":1,"title":"","display":"","copyAsset":false,"role":"manuscript-pdf","size":1254458,"visible":true,"origin":"","legend":"","description":"","filename":"CrossingPaperv8.pdf","url":"https://assets-eu.researchsquare.com/files/rs-8344692/v1_covered_dbce808c-42f4-4aba-a4a8-3d45d26e689d.pdf"}],"financialInterests":"No competing interests reported.","formattedTitle":"Liquid Morphologies in Open Microfluidic Intersections","fulltext":[],"fulltextSource":"","fullText":"","funders":[],"hasAdminPriorityOnWorkflow":false,"hasManuscriptDocX":false,"hasOptedInToPreprint":true,"hasPassedJournalQc":"","hasAnyPriority":false,"hideJournal":true,"highlight":"","institution":"","isAcceptedByJournal":false,"isAuthorSuppliedPdf":true,"isDeskRejected":"","isHiddenFromSearch":false,"isInQc":false,"isInWorkflow":false,"isPdf":true,"isPdfUpToDate":true,"isWithdrawnOrRetracted":false,"journal":{"display":true,"email":"[email protected]","identity":"researchsquare","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":true,"externalIdentity":"","sideBox":"","snPcode":"","submissionUrl":"/submission","title":"Research Square","twitterHandle":"researchsquare","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"","reportingPortfolio":"","inReviewEnabled":false,"inReviewRevisionsEnabled":true},"keywords":"","lastPublishedDoi":"10.21203/rs.3.rs-8344692/v1","lastPublishedDoiUrl":"https://doi.org/10.21203/rs.3.rs-8344692/v1","license":{"name":"CC BY 4.0","url":"https://creativecommons.org/licenses/by/4.0/"},"manuscriptAbstract":"\u003cp\u003eWhen a liquid fills an open capillary, the shape of the liquid \u0026ldquo;front\u0026rdquo; can be treated as quasi-steady, since its shape remains virtually unchanged when the liquid advances through the channel. Previous investigations have shown that the associated morphology for steady-state flow represents a shape that is bulged inwards at the liquid front (caused by the capillary pressure) and becomes flat when the flow has stopped for a system connected to an infinite reservoir.\u003c/p\u003e \u003cp\u003eEven though complex liquid networks inherently require intersections, the morphologies or minimal energy shapes formed at intersections have not yet been investigated in detail. In this work, we are investigating liquid morphologies inside crossing V-shaped and Gaussian microchannels and derive guidelines on how to hinder dewetting when evaporation is present. To this end, we perform gradient descent simulations with the \u0026ldquo;Surface Evolver\u0026rdquo;. Similar to the case of single microchannels, we find that the minimal energy shapes of a system being connected to an infinite reservoir are represented by a flat liquid surface for a wetting liquid, and that no steady-state can be found for wetting liquids. Additionally, we find that the energy contribution stemming from the intersection is negatively proportional to the energy contribution scaling with the filling length of single microchannels. This allows us to predict whether dewetting will happen when evaporation is present and allows us to design liquid intersections, where dewetting will not happen.\u003c/p\u003e","manuscriptTitle":"Liquid Morphologies in Open Microfluidic Intersections","msid":"","msnumber":"","nonDraftVersions":[{"code":1,"date":"2026-02-12 23:06:03","doi":"10.21203/rs.3.rs-8344692/v1","editorialEvents":[{"type":"communityComments","content":0}],"status":"published","journal":{"display":true,"email":"[email protected]","identity":"researchsquare","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":true,"externalIdentity":"","sideBox":"","snPcode":"","submissionUrl":"/submission","title":"Research Square","twitterHandle":"researchsquare","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"","reportingPortfolio":"","inReviewEnabled":false,"inReviewRevisionsEnabled":true}}],"origin":"","ownerIdentity":"f174474a-b417-4376-848e-c3feb9fb396f","owner":[],"postedDate":"February 12th, 2026","published":true,"recentEditorialEvents":[],"rejectedJournal":[],"revision":"","amendment":"","status":"posted","subjectAreas":[],"tags":[],"updatedAt":"2026-04-10T10:08:10+00:00","versionOfRecord":[],"versionCreatedAt":"2026-02-12 23:06:03","video":"","vorDoi":"","vorDoiUrl":"","workflowStages":[]},"version":"v1","identity":"rs-8344692","journalConfig":"researchsquare"},"__N_SSP":true},"page":"/article/[identity]/[[...version]]","query":{"redirect":"/article/rs-8344692","identity":"rs-8344692","version":["v1"]},"buildId":"XKTyCvWXoU3ODBz1xrDgd","isFallback":false,"isExperimentalCompile":false,"dynamicIds":[84888],"gssp":true,"scriptLoader":[]}

Text is read by the "Ask this paper" AI Q&A widget below. Extraction quality varies by source — PMC NXML preserves structure cleanly, OA-HTML may include some navigation residue, and OA-PDF can have broken hyphenation. The publisher copy (via DOI) is the canonical version.

My notes (saved in your browser only)

Ask this paper AI returns verbatim quotes from the full text · source: preprint-html

Answers must be backed by verbatim quotes from this paper's full text. Hallucinated quotes are dropped automatically; if no verbatim passage answers the question, we say so. How this works

Citation neighborhood (no data yet)

We don't have any in-corpus citations linked to this paper yet. This is a recent paper (2026) — citers typically take a year or two to land, and the OpenAlex reference graph may still be filling in.

Source provenance

europepmc
last seen: 2026-05-20T01:45:00.602351+00:00