Subclinical elevations of thyroid-stimulating hormone and assisted reproductive technology outcomes

Michalakis KG, Konstantinos G Michalakis, Tolga B. Mesen, Mesen TB, Lynae M Brayboy, Brayboy LM, Bo Yu, Yu B, Kevin S. Richter, K.S. Richter, Levy M, Michael Levy, Eric Widra, Widra E, James H. Segars
Fertility and sterility · 2011 · vol. 95(8) , pp. 2634–7 · doi:10.1016/j.fertnstert.2011.02.056 · PMID:21457968 · PMC3124612
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In a cohort of 1,231 women pursuing assisted reproductive technologies, subclinical hypothyroidism was associated with diminished ovarian reserve but not with adverse treatment or pregnancy outcomes.

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Abstract

The prevalence of moderately elevated TSH levels consistent with subclinical hypothyroidism (2.5-4.0 μIU/mL) was 23% in a cohort of 1,231 women pursuing assisted reproductive technologies. Preconception elevated levels of TSH were associated with diminished ovarian reserve but were not associated with adverse assisted reproductive technology or pregnancy outcomes.

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MeSH descriptors

Hypothyroidism Ovary Reproductive Techniques, Assisted Reproductive Techniques, Assisted Thyrotropin Adult Analysis of Variance Asymptomatic Diseases Biomarkers Biomarkers Chi-Square Distribution Female Humans Hypothyroidism Hypothyroidism Hypothyroidism Hypothyroidism Ovary Pregnancy Pregnancy Complications

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europepmc
last seen: 2026-10-25T09:32:14.900964+00:00
pubmed
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