Role of allograft inflammatory factor-1 in pathogenesis of diseases

Mateusz Sikora, Bartosz Kopeć, Katarzyna Piotrowska, Andrzej Pawlik
Immunology letters · 2020 · doi:10.1016/j.imlet.2019.12.002 · PMID:31830499
review OA: closed public-domain-us
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Abstract

Allograft inflammatory factor-1 (AIF-1) is a 17 kDa calcium-binding protein produced by monocytes, macrophages, and lymphocytes; its synthesis is induced by INF-γ. The AIF-1 gene is located in the major histocompatibility complex (MHC) class III region on chromosome 6p21.3, surrounded by surface glycoprotein genes and complement cascade protein genes as well as TNF-α, TNF-β, and NF-κB genes. Increased expression of AIF-1 was observed in several diseases, including endometriosis, breast cancer, atherosclerosis, rheumatoid arthritis, and fibrosis. In this review, we summarise the role of AIF-1 in allograft rejection and the pathogenesis of diseases.

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endometriosis

MeSH descriptors

Calcium-Binding Proteins Calcium-Binding Proteins Disease Susceptibility Microfilament Proteins Microfilament Proteins Allografts Allografts Allografts Animals Calcium-Binding Proteins Gene Expression Regulation Graft Rejection Graft Rejection Graft Rejection Graft Rejection Humans Lymphocytes Lymphocytes Lymphocytes Macrophages

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europepmc
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pubmed
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