Elevated STIL predicts poor prognosis in patients with hepatocellular carcinoma

Background: Overexpression of STIL centriolar assembly protein (STIL) has been observed in a variety of cancers. However, the functional significance of STIL in hepatocellular carcinoma remains unknow. Results STIL expression were abnormal in HCC tissues, and HCC patients with increased STIL expression had poor prognosis. In addition, increased STIL expression was correlated with T stage, pathologic stage, histologic grade, AFP, age, tumor status. STIL was an independent predictor of poor prognosis in HCC patients, as verified with a nomogram based on a Cox regression model. STIL was involved in HCC progression by modulating the cell cycle, DNA replication, oocyte meiosis, etc. Correlation analysis indicated TUBG1 mRNA expression was correlated with immune infiltrates. Conclusion STIL plays a vital role in HCC progression and prognosis; it may, therefore, serve as an effective biomarker for the prediction of patient survival.