Comprehensive Analysis of Aberrantly Expressed Profiles of ncRNAs Revealed lncRNA AGPAT4-IT1 is a Potential Prognostic Marker for Breast Cancer Metastasis

Abstract Aims: we investigated the relationship between long non-coding RNAs (lncRNAs) and breast cancer lung metastasis (BCLM). Methods: We performed lncRNA microarray analyses to establish the lncRNA profile of BCLM. Bioinformatics analyses were carried out to analyzed functional roles of identified lncRNAs. Kaplan-meier analysis was conducted to determine the relation between lncRNA AGPAT4-IT1 and prognosis of breast cancer. Results: We found 317 upregulated and 166 downregulated lncRNAs in BCLM group. We showed AGPAT4-IT1 was positively correlated with its parental gene APGAT4. Furthermore, we suggested AGPAT4-IT1 were highly expressed in higher tumour grade and predicted poorer prognosis. Conclusions: These findings provide evidence for exploring the mechanisms of BCLM and indicate AGPAT4-IT1 is a prospective prognostic marker for breast cancer metastasis.