Effect for inhibition of MMP-2 and PGE2 in mouse model of endometriosis.

Sayantan Jana (3190551), Kasturi Chatterjee (3190545), Amlan K. Ray (3190548), Pramathes DasMahapatra (3190542), Snehasikta Swarnakar (232461)
2016 · doi:10.1371/journal.pone.0163540.g008 · W6960769332
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Abstract

Mouse model of endometriosis were developed by inoculation of endometrial cells into peritoneum of the recipient mice as described in the ‘material and methods’. MMP-2i (20mg/kg) and COX-2i (40mg/kg) were administrated every alternate day for 10days. Mice (n = 4 for each group) were sacrificed on day 10 from the day of endometriosis induction. (A) Histogram for numbers of developed lesions in mice peritoneum. Inset shows the developed lesions. (B) Gelatin zymography was performed for MMP-2 activities of endometriosis. (C) Western blot was performed with the whole tissue lysate for mouse model of endometriosis. Means ± SEM. p < 0.05 was accepted as level of significance; * p < 0.05.
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Regulation of Matrix Metalloproteinase-2 Activity by COX-2-PGE2-pAKT Axis Promotes Angiogenesis in Endometriosis Fig 8 Effect for inhibition of MMP-2 and PGE2 in mouse model of endometriosis. Mouse model of endometriosis were developed by inoculation of endometrial cells into peritoneum of the recipient mice as described in the ‘material and methods’. MMP-2i (20mg/kg) and COX-2i (40mg/kg) were administrated every alternate day for 10days. Mice (n = 4 for each group) were sacrificed on day 10 from the day of endometriosis induction. (A) Histogram for numbers of developed lesions in mice peritoneum. Inset shows the developed lesions. (B) Gelatin zymography was performed for MMP-2 activities of endometriosis. (C) Western blot was performed with the whole tissue lysate for mouse model of endometriosis. Means ± SEM. p < 0.05 was accepted as level of significance; * p < 0.05.

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