Outcomes of bilateral temporomandibular joint arthroscopy: an international multicentric prospective study including 524 joints

Outcomes of bilateral temporomandibular joint arthroscopy: an international multicentric prospective study including 524 joints | Research Square window.SnipcartSettings = { analytics: { enabled: false } }; (function() { var accessVector = localStorage.getItem('access_vector') || ''; window.dataLayer = window.dataLayer || []; if (accessVector) { window.dataLayer.push({ user: { profile: { profileInfo: { snid: accessVector } } } }); } })(); (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-K279D39R'); Browse Preprints In Review Journals COVID-19 Preprints AJE Video Bytes Research Tools Research Promotion AJE Professional Editing AJE Rubriq About Preprint Platform In Review Editorial Policies Our Team Advisory Board Help Center Sign In Submit a Preprint Cite Share Download PDF Research Article Outcomes of bilateral temporomandibular joint arthroscopy: an international multicentric prospective study including 524 joints David Faustino Ângelo, Helcio Yogi Ono, Romualdo Cardoso Monteiro de Barros, and 3 more This is a preprint; it has not been peer reviewed by a journal. https://doi.org/ 10.21203/rs.3.rs-4705984/v1 This work is licensed under a CC BY 4.0 License Status: Published Journal Publication published 28 Oct, 2024 Read the published version in Oral and Maxillofacial Surgery → Version 1 posted 8 You are reading this latest preprint version Abstract Purpose : This study aimed to evaluate the efficacy of bilateral TMJ arthroscopy in patients with different Wilkes stages, comparing the results obtained in different arthroscopic levels on a larger scale, unifying similar populations. Methods : A multicentric prospective clinical study was conducted in three TMJ departments performing temporomandibular joint surgery in Portugal and Brazil, with an enrolling window active from January 1, 2019, to December 1, 2022. The primary clinical outcome was TMJ pain evaluated through a visual analog scale. The secondary clinical outcome was the maximum mouth opening (MMO). TMJ arthroscopy was performed with a 1.9-mm arthroscope, including a video system with a 2.8-mm outer protective cannula. Results : 262 patients, representing a total of 524 operated joints were enrolled. The mean age was 35.3 years. A significant decrease postoperatively in VAS pain was observed for all Wilkes stages. The lowest value of VAS pain was observed in Wilkes II compared to Wilkes III and IV. In the secondary outcome, MMO was observed to have a significant improvement in all Wilkes Stages. Conclusion : in this multicentric study, bilateral TMJ arthroscopy was shown to be an effective procedure to reduce pain and increase maximum mouth opening in patients with different Wilkes stages, representing a valid minimally invasive solution. temporomandibular joint temporomandibular disorders TMJ arthroscopy minimally invasive surgery multicentric study Figures Figure 1 Figure 2 Figure 3 Figure 4 Introduction Temporomandibular joint (TMJ) arthroscopy is a minimally invasive surgical technique used to treat arthrogenous temporomandibular disorders (TMD) under direct visualization, embracing both a diagnostic and a therapeutic role [1, 2]. It was first introduced by Onishi at 1975 [3], as a pioneering technique to treat painful temporomandibular joints, reducing the number of TMJ open surgeries [4]. The arthroscopic approach allows direct observation of the TMJ compartments with reduced invasiveness, respecting the integrity of the joint’s capsule. This ensures greater tolerance and a lighter postoperative recovery for patients if compared to open surgery [5, 6]. The operating field is mainly confined to the upper temporomandibular joint compartment, which can be divided into two recesses, the anterior and the posterior, separated by the articular eminence. In a posterior to anterior way, the most important structures are represented by medial synovial drape, retrodiscal synovium and retrodiscal ligament, posterior slope of the articular eminence and glenoid fossa, articular disk, intermediate zone, lateral pterygoid muscle shadow [7]. TMJ arthroscopy allows joint adherence lysis, joint lavage, and intra-articular surgical procedures. To classify the type of procedure, arthroscopy is divided into three levels depending on the operative procedures: level 1 includes basic diagnostic arthroscopy with lysis and lavage, level 2 is defined as operative arthroscopy with intra-articular coblation and other articular surgical techniques, and level 3 arthroscopy implicates a discopexy of the articular disc.[8, 9] The intra-articular surgical procedures include: myotomy of the lateral pterygoid muscle, cutting adhesions, coblation of synovitis spots and neo-vessels, tissue remodeling, retrodiscal ligament scarring, disc manipulation, and infiltration of substances [1, 8, 10]. TMJ arthroscopy seems to be long-term effective for relieving TMJ symptoms [1]. Recent studies have shown that TMJ arthroscopy promotes a reduction in pain and inflammatory processes, restoring the articular function with low morbidity [2, 11–13]. According to several studies, the clinical success of this technique varies between 50%-92% [5, 10, 14–21]. Many studies evaluated various arthroscopic procedures ranging from lysis and lavage to advanced operative arthroscopy, and results are not always in agreement with the effectiveness and outcomes [22]. This variability could be due to the fact that TMJ arthroscopy is performed widely and without a unified protocol. Several differences can be among surgeons, and protocol may vary. A multicentric study analyzing outcomes in TMJ arthroscopy could support the development of a rigorous study protocol, ensure uniform data collection among different centers, and give a clearer response to the effectiveness of arthroscopy on a wider population. This multicentric prospective study aimed to evaluate the efficacy of bilateral TMJ arthroscopy in patients with different Wilkes stages, comparing the results obtained in different arthroscopic levels on a larger scale, unifying similar populations. Material and Methods Study Design A multicentric prospective clinical study was conducted in three TMJ departments performing temporomandibular joint surgery in Portugal and Brazil, with an enrolling window active from January 1, 2019, to December 1, 2022. The included departments were: 1) Instituto Português da Face, Lisbon, Portugal; 2) Hospital Sirio-Libanês, São Paulo, Brazil and 3) - Hospital Municipal Carminio Carrichio, Tatuape, Sao Paulo, SP, Brazil. This study was approved by the ethics committee of the organizing center (Instituto Português da Face - PT/IPFace/RCT/1901/02). The protocol was designed in accordance with the involved institutions to uniform the development of the study among involved centers. Patient enrollment was organized to obtain similar populations between the institutions to reduce the risk of bias and inter-institutional variability. Two populations were individuated, “the Portuguese population (PT)” and “The Brazilian population (BR).” Outcome assessment and surgical treatment were developed, shared, and uniformed to be repeatable in both centers. A minor variable component related to personal preference and surgical experience was contemplated. Patients The inclusion criteria included: (1) age > 18 years; (2) clinical diagnosis of bilateral arthrogenous disorder; (3) magnetic resonance imaging (MRI) supporting the diagnosis of arthrogenous TMD; (4) conservative treatment without any improvement at least for 3 months; (5) clinical-radiological criteria for bilateral TMJ arthroscopy. The exclusion criteria included: (1) a history of facial trauma or previous TMJ surgery; (2) severe previous medical problems or impaired cognitive capacity; (3) pregnant or breastfeeding women. All the outcomes were assessed before and after surgery (1 month, 3 months, 6 months, 1 year, then every year after 1 year follow up). The final diagnosis was confirmed with magnetic resonance imaging (MRI). The clinical severity of each joint was classified according to Wilkes's classification for internal derangement [21]. Wilkes’s classification is divided into 5 stages from I to V (early, early/intermediate, intermediate, intermediate/late, late gross), based on clinical and radiological features. All patients gave their written informed consent in accordance with the current legislation and the guidelines of the Declaration of Helsinki. Outcome assessment The primary clinical outcome was TMJ pain (arthralgia) and was accessed through a Visual Analog Scale (VAS). This scale varies between 0 (no pain) and 10 (maximum insupportable pain). Arthralgia was reported if it was verified: 1) history of pain in the TMJ area and 2) pain on palpation of the lateral pole or around the lateral pole or pain on maximum unassisted or assisted opening, right or left lateral movements, or protrusive movements [23]. The secondary clinical outcome was the maximum mouth opening (MMO, in mm). MMO was measured using a certified ruler between the incisor’s teeth. To define the success criteria, authors used 2 categories to classify the TMJ pain: good if VAS ≤ 2, and failure if VAS > 2. In MMO, the authors defined the cut-off of success for MMO > 35 mm (good ≥ 35mm and acceptable between ≥ 30mm and < 35 mm) and failure for MMO < 30 mm in the postoperative evaluation. The outcomes were graded together as good, acceptable and failure in accordingly with Table 1 as described by Eriksson and Westesson [22]. Table 1 Criteria for classification of three postoperative outcomes Good No pain or only mild pain level (VAS ≤ 2 on a 0–10 scale) and MMO ≥ 35mm Acceptable No pain or only mild pain level (VAS ≤ 2 on a 0–10 scale) and MMO ≥ 30 mm and 2 on a 0–10 scale) and/or MMO < 30 mm Surgical treatment protocol The TMJ arthroscopy procedure involved the use of a 1.9-mm arthroscope equipped with a video system (Stryker, San Jose, CA, USA) and a 2.8-mm outer protective cannula. The initial step, level 1 TMJ arthroscopy, utilized a classic puncture technique with an entry point 10 mm anterior and 2 mm below the Holmlund–Hellsing (H-H) line. Subsequently, the arthroscope was inserted into the superior joint space. Another puncture, using a 21G needle, was made 30 mm anterior and 7 mm below the H-H line to irrigate the joint with Ringer solution. In level 2 TMJ arthroscopy, the second puncture was replaced by inserting a 2.8-mm outer protective cannula with a sharp trocar until reaching the joint. This cannula served as a passage for instruments, including a coblator device (Coblator II ENT, Arthrocare, USA), utilized for various procedures such as adhesion removal, synovitis management, anterior disc release, and posterior ligament coagulation. Additionally, this portal facilitated the injection of sub-synovial medication using a 22G long spinal needle. Level 3 TMJ arthroscopy employed a 3/0 polydioxanone (PDS) suture for arthroscopic discopexy. Supplementary injection with hyaluronic acid were administered. Before surgery, a prophylactic antibiotic protocol with either amoxicillin/clavulanic acid or clarithromycin was prescribed. Postoperatively, analgesic therapy was prescribed if necessary. Statistical Analysis Data were analyzed using the IBM SPSS (v26) software. The variables were expressed as the mean (± standard deviation (SD)). Descriptive data for patients' characteristics was obtained. For the whole group of patients, the student’s paired t-test was used for variables with normal distribution (MMO), and the signed ranks test was used for variables without normal distribution (VAS pain). A Fisher-T test was used to analyze the success of the arthroscopy. In comparison of Wilkes Stage and arthroscopic level, two independent groups were established. Subsequently, Mann-Whitney test and Student t-test for unpaired data were applied for VAS pain and MMO and outcomes. To eliminate possible bias in comparation of Wilkes and arthroscopic level, the analysis relative to MMO only considered bilateral involvement with similar Wilkes and arthroscopic level performed. P < 0.05 was considered statistically significant. Results In the present multicentric study, 262 patients (61 Portuguese patients, 201 Brazilian patients) representing 524 operated joints, were enrolled. The mean age of the entire population was 35.30 ± 12.45 years. Of the 262 evaluated patients, 220 (83.97%) were female and 42 (16.03%) were male, with an equal M:F ratio of 1:4 for each population. Variables for each population are reported in Table 1 . Globally, the most common arthrogenous diagnosis were: (1) dislocated disc with reduction (DDwR) (54.77%, n = 287 joints); (2) dislocated disc without reduction (DDwoR) (41.99%; n = 220 joints); (3) arthralgia (1.91%; n = 10 joints). Percentages of distribution of preoperative intra-articular diagnosis were almost superimposable among centers. The mean preoperative VAS pain was 4.89 ± 2.62 (0–10, mean ± SD), the two populations, and the mean MMO was 34.58 ± 6.62 mm (mean ± SD). Both variables were almost identical among the two populations. Arthroscopic levels Arthroscopy level I was performed in 56 joints (10.7%), whereas level II and III were performed in 319 (60.9%) and 148 (28.2%) joints, respectively. Level I was mainly conducted in Portugal (43, 35.25% vs 13, 3.23% joints), while level III mainly was adopted in Brazil (143, 35,57%, vs 6, 4.91%). Both centers performed mostly level II arthroscopy, adopting this technique in 60% of each population. An interpersonal surgical difference was noted in the technique of discopexy: in the Portuguese population, the surgeon preferred a level II arthroscopy, with indirect discopexy through treatment of the peri-discal structures, while in the Brazilian population, a direct discopexy approach through level III was preferred. The distribution of Wilkes Classification among the two populations is shown in Table 2 . Considering the enrollment of similar patients with similar preoperative values between the two populations, outcomes were measured directly on the general population, unifying the two groups. Clinical outcomes A statistically significant reduction was observed in the primary outcome, TMJ pain, postoperatively (0.83 ± 1.63) (p < 0.0001, Fig. 1 A). The proportion of patients that showed a good outcome reducing pain was 82% (Fig. 1 B). A significant MMO improvement from 34.58 ± 6.62 preoperatively to 39.21 ± 4.74 postoperatively was observed (p < 0.0001; Fig. 2 A). 218 (83%) patients presented after the surgery MMO ≥ 35 mm (Fig. 2 B). 3 patients failed to open more than 30 mm postoperatively. Bilateral TMJ arthroscopy outcome was considered “successful” in 178 (68.32%) patients, “acceptable” in 33 (12.60%), and “failure” in 50 (19.08%) patients (Table 3 ). VAS pain, MMO, and were also evaluated in relation to the success rate were also assessed concerning the severity of the disease using the Wilkes classification (Tables 4 and 5 ). Of 524 joints, 276 (52.7%), 152 (29.0%), and 96 (18.3%) were respectively classified as Wilkes stages II, III, and IV. The mean preoperative VAS scores were 4.74 ± 2.69 for Wilkes II, 4.89 ± 2.51 for Wilkes III, and 5.23 ± 2.52 for Wilkes IV (Table 4 ). A significant decrease postoperatively in VAS pain was observed for all Wilkes stages (p < 0.0001). Significant differences were found in comparing the postoperative pain between the different Wilkes' stages when comparing the postoperative pain between the different Wilkes' stages (Fig. 3 ). The lowest value of VAS pain was observed in Wilkes II compared to Wilkes III and IV (II: 0.67 ± 1.69 vs III: 0.92 ± 1.62 and IV: 1.14 ± 1.40, p = 0.001 and p < 0.0001). Wilkes III also observed a lower VAS pain compared to Wilkes IV (0.92 ± 1.62 vs 1.14 ± 1.40, p = 0.024). In MMO, a significant improvement was observed in all Wilkes Stages (Table 4 ). There were no differences in the MMO postoperatively comparing the Wilkes Stages (Table 4 ). There were also no differences in the success rate considering the Wilkes classification (Table 5 ). Table 6 summarizes mean VAS and MMO values preoperatively and postoperatively for the different arthroscopy levels. A significant improvement postoperatively in VAS pain and MMO was observed for all arthroscopy levels (p < 0.0001, Table 6 ). Comparing the postoperative results between the different arthroscopy levels, a significant difference in pain was observed comparing level III with level I and II (p < 0.0001 and p = 0.007). No differences were found in the success rate when comparing the arthroscopy levels (Table 7 ). Figure 4 showed mean VAS values preoperatively and postoperatively for the arthroscopy surgery levels and Wilkes stages. Preoperatively was verified statistically significant differences between surgery levels I and III in Wilkes II and IV (p = 0.044 and p = 0.036). However, postoperatively, in all Wilkes stages with different arthroscopy surgery levels, it is possible to confirm a similar decrease in VAS pain in all parameters without statistically significant results (Fig. 4 ). Table 2 Baseline characteristics of the patients in the study. The Portuguese and Brazilian populations were compared. Variables n (%), or mean ± SD Portuguese population Brazilian population p-value Number of patients 61 201 --------------- Sex Number of patients(%) Number of patients (%) 0.072 Female 56 (79.6%) 164 (81.6%) Male 5 (20.4%) 37 (18.4%) Age (mean ± SD) 32.61 ± 10.94 36.35 ± 12.57 0.1356 Number of joints 122 402 --------------- Follow-up period (days) 639.3 ± 445.5 (31-1236 days) 454.7 ± 235.9 (90–730 days) 0.0009*** Preoperative intra-articular diagnosis Number of joints (%) Number of joints (%) --------------- DDwR 58 (48.33%) 229 (56.68%) DDwoR 48 (40.00%) 172 (42.57%) Arthralgia 7 (5.83%) 3 (0.74%) Disc Perforation 4 (3.33%) 0 (0.00%) Osteoarthrosis (OA) 3 (2.50%) 0 (0.00%) Wilkes Classification Number of joints (%) Number of joints (%) 0.6878 2 66 (54.10%) 210 (52.24%) 3 37 (30.33%) 115 (28.61%) 4 19 (15.57%) 77 (19.15%) Arthroscopy Surgery Level Number of joints (%) Number of joints (%) < 0.0001 I 43 (35.25%) 13 (3.23%) II 73 (59.83%) 246 (61.19%) III 6 (4.91%) 143 (35.57%) Preoperative VAS pain (0–10) 4.89 ± 3.02 4.89 ± 2.49 0.5327 Preoperative MMO (mm) 32.56 ± 8.06 34.48 ± 6.57 0.0578 Postoperative VAS pain (0–10) 0.53 ± 1.53 0.81 ± 1.44 0.0549 Postoperative MMO (mm) 40.19 ± 4.75 38.87 ± 4.69 0.0600 Table 3 The success rate of TMJ arthroscopy. Success rate Good 179 (68.32%) Acceptable 33 (12.60%) Failure 50 (19.08%) Table 4 VAS and MMO preoperatively and at follow-up according to Wilkes stages. Wilkes Stage Preoperative Postoperative p-value preoperative vs. postoperative II VAS (Mean ± SD) 4.74 ± 2.69 0.67 ± 1.69 < 0.001**** MMO (Mean ± SD) 34.74 ± 6.67 38.82 ± 5.87 < 0.001**** III VAS (Mean ± SD) 4.89 ± 2.51 0.92 ± 1.62 < 0.001**** MMO (Mean ± SD) 31.73 ± 7.69 38.20 ± 3.42 < 0.001**** IV VAS (Mean ± SD) 5.23 ± 2.52 1.14 ± 1.40 < 0.001**** MMO (Mean ± SD) 34.70 ± 5.70 38.89 ± 2.85 < 0.001**** p-value Wilkes stage vs. VAS 0.265 < 0.001**** p-value Wilkes stage vs. MMO 0.093 0.824 Table 5 Success rate of TMJ arthroscopy according to Wilkes stage. Success rate Wilkes II-II II-III III-III III-IV IV p-value Good - Acceptable 78 (79.6%) 51 (78.5%) 25 (83.3%) 24 (88.9%) 34 (81.0%) 0.845 Failure 20 (20.4%) 14 (21.5%) 5 (16.7%) 3 (11.1%) 8 (19.0%) Table 6 VAS and MMO preoperatively and at follow-up according to arthroscopy level. Surgery Level Preoperative Postoperative p-value preoperative vs. postoperative I VAS (Mean ± SD) 4.52 ± 2.95 0.78 ± 1.69 < 0.001**** MMO (Mean ± SD) 33.00 ± 7.33 39.76 ± 4.83 0.017**** II VAS (Mean ± SD) 4.98 ± 2.61 0.76 ± 1.68 < 0.001**** MMO (Mean ± SD) 34.43 ± 7.02 39.04 ± 5.00 < 0.001**** III VAS (Mean ± SD) 4.89 ± 2.50 0.98 ± 1.49 < 0.001**** MMO (Mean ± SD) 35.14 ± 5.27 39.34 ± 4.28 < 0.001**** p-value Arthroscopy Level vs. VAS 0.320 0.018* p-value Arthroscopy Level vs. MMO 0.459 0.788 Table 7 Success rate of TMJ arthroscopy according to arthroscopy level. Success rate Surgery Level (joints) I I/II II II/III III p-value Good-Acceptable 11 (78.6%) 18 (69.2%) 110 (80.9%) 20 (87.0%) 53 (84.1%) 0.515 Failure 3 (21.4%) 8 (30.8%) 26 (19.1%) 3 (13.0%) 10 (15.9%) Discussion This prospective multicenter study showed that implementing a strict protocol for TMJ arthroscopy enables satisfactory results to be obtained by different surgeons and in different populations. Bilateral TMJ arthroscopy was an effective procedure in different stages of TMD, resulting in a significant reduction of pain and improvement in MMO in all severity categories. Although better results were observed in pain reduction in Wilkes II and III patients, no differences in success rates were noticed. As expected, preoperative joint pain value distribution increased as Wilkes stage increased. This trend was observed in the postoperative stage in an opposite manner: the lowest level of arthralgia was recorded in stage II, then stage III, and finally stage IV. This can be interpreted as high levels of baseline pain are associated with higher levels of pain in the postoperative phase. In fact, level 3 arthroscopy procedures presented post-operative higher rates of post-operative pain, compatible with a greater surgical manipulation. Moreover, this difference in postoperative pain is more likely to be observed in the early post-operative weeks. This is consistent with the literature [24]: level 3 arthroscopy showed a longer period of post-operative pain than level 2 arthroscopy. Gaete C et al. [25] found a restricted number of patients undergoing level 3 arthroscopy were associated with Wilkes II but had disc perforation. In our population, we found too elongated or damaged discs, and not only in advanced Wilkes degrees, making any kind of arthroscopic discopexy unfeasible. This phenomenon is quite common in the literature due to the reduced diagnostic specificity of preoperative imaging in patients undergoing arthroscopy. Vervaeke K et al. [26] conducted a retrospective cohort study to establish the correlation between MRI and arthroscopic findings with clinical outcomes. Their study demonstrated that MRI findings can be used to predict the outcomes of TMJ arthroscopy. Disc shape and a crumpled disc's absolute/probable absence might be used as a predictive variable, a positive sign of an early damaged joint. The absence of eminence deformation on MRI also predicted good outcomes. Perioperative findings such as degenerative joint disease or absolute or probable absence of disc reduction can predict lower outcomes [27]. Predictive factors for TMJ arthroscopy are still a topic of discussion in the literature. In a study from the group of Ulmner M et al. [11] bilateral masticatory muscle tenderness on palpation was the only preoperative factor found to have a significant impact on the outcome of TMJ arthroscopy. This evidence was supported by Ângelo DF et al. [28] in their study about inco-botulin neurotoxin A (inco-BoNT/A) used as preoperative medication in patients undergoing TMJ arthroscopy. BONT/A improved the outcomes as an adjunctive treatment in patients who were candidates for TMJ arthroscopy, reducing arthralgia and myalgia in the long term. The inco-BoNT/A group also experienced a reduced incidence of persistent symptoms after post-treatment and the subsequent necessity of further treatments [28]. TMJ arthroscopy procedure has been advanced through various surgical techniques and modifications. The current described surgical steps are portal triangulation, coblation of zones of synovitis and chondromalacia, resection of adhesions, biopsies of fibrocartilage, myotomy, and disc repositioning by capsular scarring, discopexy, subsynovial or intra-articular infiltrations with various substances such as corticosteroids, hyaluronic acid, with and without PRP. Ângelo DF [29] proposed the inverted portal technique for TMJ arthroscopy to enhance retrodiscal coblation. This technique aimed to improve the effectiveness of retrodiscal coblation in treating TMJ disorders, increasing the area to treat, particularly the posterolateral one [29]. In some specific cases, arthroscopic disc repositioning and different suturing techniques are employed. The intra-procedural variety, given the many techniques that can be performed, opens interpersonal preferences among surgeons. In this study although the populations of the two centers examined were extremely similar, differences were recorded in the choice of arthroscopic discopexy type, with a peak of level III arthroscopies in the Brazilian population. Despite this difference, postoperatively, across all Wilkes stages and varying levels of arthroscopy surgery, a comparable reduction in VAS pain scores is observed. No differences were found in the success rate when comparing the arthroscopy levels. Plus, there were no variations in the success rate when different levels of arthroscopy were compared. Santos TS et al. [24] conducted a systematic review and meta-analysis comparing open surgery versus arthroscopic techniques for disc repositioning and suturing. Their conclusions indicated that both techniques effectively achieved successful outcomes, with no significant difference in their effectiveness. This suggests that TMJ arthroscopy can provide comparable results to traditional open surgery intra-articular procedures, while offering the benefits of minimally invasive surgery [24]. Another advantage of TMJ arthroscopy is its possibility of being performed under either local or general anesthesia [22]. This procedural flexibility allows for personalized patient care and can accommodate individual preferences or medical considerations. Sah MK et al. [30] compared the modalities of TMJ arthroscopy performed under local anesthesia (LA) versus general anesthesia (GA). No significant post-operative difference was found in pain reduction outcome and mouth opening improvement. The LA group's median operative time and hospital stay duration were significantly less than the GA group. TMJ arthroscopy for LA group was performed in a minor procedure setup, reducing the surgery costs. The post-operative disc position was excellent and good, with an overall success rate of 95%. The choice of anesthesia did not significantly affect the outcomes of the procedure, indicating that both options can be equally effective, and local anesthesia arthroscopy furnished even additional benefits related to hospital costs and median operative time [22]. In this study, all procedures were performed under general anesthesia. The approach is based on two main fundaments: patients’ comfort and use of curare drugs to mobilize the joint during the procedures. We believe that these points increase the procedure's success rate granting a smooth performance. A relevant success in outcomes like MMO and VAS pain level should be attributed to TMJ arthroscopy as part of a well-defined preoperative, intraoperative and postoperative protocol. In this multicentric shared protocol we included intraoperative intra-articular injections of therapeutic substances such as hyaluronic acid. Nowadays, the injection of intra-articular substances during arthroscopic procedures is a well-established additional procedure. Gutiérrez IQ et al. [31] conducted a systematic review to evaluate the effectiveness of intra-articular injections of platelet-rich plasma (PRP) and plasma rich in growth factors (PRGF) with arthrocentesis or arthroscopy in treating TMJ disorders. The PRP and PRGF intra-articular injections demonstrated significant differences in pain reduction in three studies and improved mandibular function in two. The treatment with PRP or PRGF intra-articular injections demonstrated better clinical results than the control group. Leketas M et al. [32] conducted a randomized clinical trial to evaluate the effect of different intra-articular injection substances on the early postoperative period following TMJ arthroscopy. The study demonstrated that the choice of injection substance can influence the postoperative outcomes: hyaluronic acid injection following temporomandibular joint arthroscopy can decrease pain better than saline and platelet-rich plasma during the first postoperative week [32]. Considering the reduced invasiveness of the procedure, the complications related to the arthroscopic technique are not numerous. They are mainly represented by extravasation of the fluids used for irrigation with the possibility of pharyngeal edema, intra-articular bleeding during myotomy in the anterior recess, iatrogenic joint damage (disc perforations, fragmentation of the articular eminence, excessive synovial fibrillation), and damage to the external auditory canal or middle ear [8, 33]. From a technical point of view, double portal procedures have a higher incidence of intra-operative complications if compare with single portal ones, especially for articular bleeding and preauricular area edema [34]. In cases where the outcome is unsatisfactory, the further step could be open surgery, but some authors suggest repeating the arthroscopic procedure. Re-arthroscopy should be offered to patients where it is still possible to perform further operative and more advanced techniques, especially when the previous stage is not advanced (Wilkes stage IV or V) [12]. One of the possible limitations of our study is the differences between the two populations; although similar, they are not totally equal. Similarly, concerns interpersonal surgical preferences: although the end result is still disc repositioning, discopexy in level 2 and level 3 have different disability criteria. Conclusion In this prospective multicentric study, the implementation of a unified protocol by different surgeons shows that bilateral TMJ arthroscopy is a safe technique with a high degree of efficacy in reducing pain and increasing maximum mouth opening, regardless of the degree of severity and complexity of the technique. The results were stable throughout the follow-up period. Through advancements in surgical techniques and research, TMJ arthroscopy continues to evolve and improve, providing better outcomes for patients with TMJ disorders. Healthcare professionals dealing with temporomandibular joint surgery need to stay updated with the latest research and advancements in TMJ arthroscopy to ensure the delivery of optimal care to patients. We encourage more multicenter studies to be conducted, involving more centers and a larger population. Declarations Funding The authors declare that no funds, grants, or other support were received during the preparation of this manuscript. Competing interests The authors have no relevant financial or non-financial interests to disclose. Ethics approval This study was approved by the ethics committee of the organizing center (Instituto Português da Face - PT/IPFace/RCT/1901/02). Consent to participate and to publish Informed consent was obtained from all individual participants included in the study. Availability of data and materials Not applicable. References Murakami K, Segami N, Okamoto M, Yamamura I, Takahashi K, Tsuboi Y (2000) Outcome of arthroscopic surgery for internal derangement of the temporomandibular joint: long-term results covering 10 years. J Craniomaxillofac Surg 28(5):264-71. https://doi.org/10.1054/jcms.2000.0162 Ângelo DF, Araújo RAD, Sanz D (2021) Surgical complications related to temporomandibular joint arthroscopy: a prospective analysis of 39 single-portal versus 43 double-portal procedures. Int J Oral Maxillofac Surg 50(8):1089-94. https://doi.org/10.1016/j.ijom.2020.07.020 Onishi M (1975) [Arthroscopy of the temporomandibular joint (author's transl)]. Kokubyo Gakkai Zasshi 42(2):207-13. Holmlund A, Gynther G, Axelsson S (1994) Efficacy of arthroscopic lysis and lavage in patients with chronic locking of the temporomandibular joint. Int J Oral Maxillofac Surg 23(5):262-5. https://doi.org/10.1016/s0901-5027(05)80104-3 McCain JP, Sanders B, Koslin MG, Quinn JH, Peters PB, Indresano AT (1992) Temporomandibular joint arthroscopy: a 6-year multicenter retrospective study of 4,831 joints. J Oral Maxillofac Surg 50(9):926-30. https://doi.org/10.1016/0278-2391(92)90047-4 Kondoh T, Dolwick MF, Hamada Y, Seto K (2003) Visually guided irrigation for patients with symptomatic internal derangement of the temporomandibular joint: a preliminary report. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 95(5):544-51. https://doi.org/10.1067/moe.2003.160 Miloro M, Ghali GE, Larsen P, Waite P (2004) Peterson's Principles of Oral and Maxillofacial Surgery: BC Decker. González LV, López JP, Díaz-Báez D, Martin-Granizo López R (2022) Intraoperative complications in temporomandibular joint arthroscopy: A retrospective observational analysis of 899 arthroscopies. J Craniomaxillofac Surg 50(8):651-6. https://doi.org/10.1016/j.jcms.2022.06.011 Ângelo DF, Sanz D, Cardoso HJ (2023) Bilateral arthroscopy of the temporomandibular joint: clinical outcomes and the role of a second intervention-a prospective study. Clin Oral Investig 27(10):6167-76. https://doi.org/10.1007/s00784-023-05233-6 Silva PA, Lopes MT, Freire FS (2015) A prospective study of 138 arthroscopies of the temporomandibular joint. Braz J Otorhinolaryngol 81(4):352-7. https://doi.org/10.1016/j.bjorl.2014.08.021 Ulmner M, Weiner CK, Lund B (2020) Predictive factors in temporomandibular joint arthroscopy: a prospective cohort short-term outcome study. Int J Oral Maxillofac Surg 49(5):614-20. https://doi.org/10.1016/j.ijom.2019.09.002 Martin Granizo R, Correa Muñoz DC, Varela Reyes E (2018) Rearthroscopy of the temporomandibular joint: A retrospective study of 600 arthroscopies. Journal of Cranio-Maxillofacial Surgery 46(9):1555-60. https://doi.org/10.1016/j.jcms.2017.12.007 Ângelo DF, Moreira A, Sanz D, São João R (2021) Hearing changes after temporomandibular joint arthroscopy: a prospective study. Int J Oral Maxillofac Surg. https://doi.org/10.1016/j.ijom.2021.02.013 Indresano AT (1989) Arthroscopic surgery of the temporomandibular joint: report of 64 patients with long-term follow-up. J Oral Maxillofac Surg 47(5):439-41. https://doi.org/10.1016/0278-2391(89)90274-7 Dimitroulis G (2002) A review of 56 cases of chronic closed lock treated with temporomandibular joint arthroscopy. J Oral Maxillofac Surg 60(5):519-24; discussion 25. https://doi.org/10.1053/joms.2002.31848 Holmlund A, Gynther G, Axelsson S (1994) Efficacy of arthroscopic lysis and lavage in patients with chronic locking of the temporomandibular joint. International Journal of Oral and Maxillofacial Surgery 23(5):262-5. https://doi.org/10.1016/S0901-5027(05)80104-3 Machoň V, Levorová J, Hirjak D, Beňo M, Drahoš M, Foltán R (2021) Does arthroscopic lysis and lavage in subjects with Wilkes III internal derangement reduce pain? Oral Maxillofac Surg. https://doi.org/10.1007/s10006-020-00935-7 Perrott DH, Alborzi A, Kaban LB, Helms CA (1990) A prospective evaluation of the effectiveness of temporomandibular joint arthroscopy. Journal of Oral and Maxillofacial Surgery 48(10):1029-32. https://doi.org/10.1016/0278-2391(90)90283-8 Sorel B, Piecuch JF (2000) Long-term evaluation following temporomandibular joint arthroscopy with lysis and lavage. Int J Oral Maxillofac Surg 29(4):259-63. Kurita K, Goss AN, Ogi N, Toyama M (1998) Correlation between preoperative mouth opening and surgical outcome after arthroscopic lysis and lavage in patients with disc displacement without reduction. Journal of Oral and Maxillofacial Surgery 56(12):1394-7. https://doi.org/10.1016/S0278-2391(98)90401-3 Kondoh T, Dolwick MF, Hamada Y, Seto K (2003) Visually guided irrigation for patients with symptomatic internal derangement of the temporomandibular joint: A preliminary report. Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontology 95(5):544-51. https://doi.org/10.1067/moe.2003.160 Indresano AT (2001) Surgical arthroscopy as the preferred treatment for internal derangements of the temporomandibular joint. J Oral Maxillofac Surg 59(3):308-12. https://doi.org/10.1053/joms.2001.21001 Schiffman E, Ohrbach R, Truelove E, Look J, Anderson G, Goulet JP, et al. (2014) Diagnostic Criteria for Temporomandibular Disorders (DC/TMD) for Clinical and Research Applications. J Oral Facial Pain Headache 28(1):6-27. https://doi.org/10.11607/jop.1151 Santos TS, Pagotto LEC, Santos Nascimento E, Rezende da Cunha L, Serra Cassano D, Gonçalves JR (2021) Effectiveness of disk repositioning and suturing comparing open-joint versus arthroscopic techniques: a systematic review and meta-analysis. Oral Surg Oral Med Oral Pathol Oral Radiol 132(5):506-13. https://doi.org/10.1016/j.oooo.2021.02.015 Gaete C, Droguett C, Sáez F, Astorga P (2024) Clinical and demographic factors associated with the effectiveness of temporomandibular joint arthroscopy. Oral Maxillofac Surg 28(1):405-11. https://doi.org/10.1007/s10006-023-01158-2 Vervaeke K, Verhelst PJ, Orhan K, Lund B, Benchimol D, Van der Cruyssen F, et al. (2022) Correlation of MRI and arthroscopic findings with clinical outcome in temporomandibular joint disorders: a retrospective cohort study. Head Face Med 18(1):2. https://doi.org/10.1186/s13005-021-00305-y Tzanidakis K, Sidebottom AJ (2013) How accurate is arthroscopy of the temporomandibular joint? A comparison of findings in patients who had open operations after arthroscopic management failed. Br J Oral Maxillofac Surg 51(8):968-70. https://doi.org/10.1016/j.bjoms.2013.05.149 Ângelo DF, Sanz D, Maffia F, Cardoso HJ (2023) Outcomes of IncobotulinumtoxinA Injection on Myalgia and Arthralgia in Patients Undergoing Temporomandibular Joint Arthroscopy: A Randomized Controlled Trial. Toxins (Basel) 15(6). https://doi.org/10.3390/toxins15060376 Ângelo DF (2022) Temporomandibular joint arthroscopy: inverted portal technique for more effective retrodiscal coblation. Int J Oral Maxillofac Surg 51(8):1074-7. https://doi.org/10.1016/j.ijom.2022.01.013 Sah MK, Abdelrehem A, Nie X, Yang C (2024) The hue of temporomandibular joint arthroscopy under local versus general anaesthesia. J Oral Rehabil 51(3):510-6. https://doi.org/10.1111/joor.13611 Gutiérrez IQ, Sábado-Bundó H, Gay-Escoda C (2022) Intraarticular injections of platelet rich plasma and plasma rich in growth factors with arthrocenthesis or arthroscopy in the treatment of temporomandibular joint disorders: A systematic review. J Stomatol Oral Maxillofac Surg 123(5):e327-e35. https://doi.org/10.1016/j.jormas.2021.12.006 Leketas M, Dvylys D, Sakalys D, Simuntis R (2022) Different intra-articular injection substances following temporomandibular joint arthroscopy and their effect on early postoperative period: A randomized clinical trial. Cranio:1-6. https://doi.org/10.1080/08869634.2022.2081445 Nogueira EFC, Lemos CAA, Vasconcellos RJH, Moraes SLD, Vasconcelos BCE, Pellizzer EP (2021) Does arthroscopy cause more complications than arthrocentesis in patients with internal temporomandibular joint disorders? Systematic review and meta-analysis. Br J Oral Maxillofac Surg 59(10):1166-73. https://doi.org/10.1016/j.bjoms.2021.05.007 Ângelo DF, Moreira A, Sanz D, São João R (2021) Hearing changes after temporomandibular joint arthroscopy: a prospective study. Int J Oral Maxillofac Surg 50(11):1491-5. https://doi.org/10.1016/j.ijom.2021.02.013 Additional Declarations No competing interests reported. Cite Share Download PDF Status: Published Journal Publication published 28 Oct, 2024 Read the published version in Oral and Maxillofacial Surgery → Version 1 posted Editorial decision: Revision requested 20 Sep, 2024 Reviews received at journal 31 Jul, 2024 Reviewers agreed at journal 29 Jul, 2024 Reviewers agreed at journal 28 Jul, 2024 Reviewers invited by journal 28 Jul, 2024 Editor assigned by journal 11 Jul, 2024 Submission checks completed at journal 11 Jul, 2024 First submitted to journal 08 Jul, 2024 You are reading this latest preprint version Research Square lets you share your work early, gain feedback from the community, and start making changes to your manuscript prior to peer review in a journal. As a division of Research Square Company, we’re committed to making research communication faster, fairer, and more useful. We do this by developing innovative software and high quality services for the global research community. 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Also discoverable on Platform About Our Team In Review Editorial Policies Advisory Board Help Center Resources Author Services Accessibility API Access RSS feed Manage Cookie Preferences © Research Square 2026 | ISSN 2693-5015 (online) Privacy Policy Terms of Service Do Not Sell My Personal Information {"props":{"pageProps":{"initialData":{"identity":"rs-4705984","acceptedTermsAndConditions":true,"allowDirectSubmit":false,"archivedVersions":[],"articleType":"Research Article","associatedPublications":[],"authors":[{"id":335326315,"identity":"67a30e5d-bfbd-4db2-b21c-a52337e96ab0","order_by":0,"name":"David Faustino Ângelo","email":"","orcid":"","institution":"Instituto Português da Face","correspondingAuthor":false,"prefix":"","firstName":"David","middleName":"Faustino","lastName":"Ângelo","suffix":""},{"id":335326323,"identity":"9784d031-7832-4b84-9114-ef46a16c666d","order_by":1,"name":"Helcio Yogi Ono","email":"","orcid":"","institution":"Hospital Sirio Libanes","correspondingAuthor":false,"prefix":"","firstName":"Helcio","middleName":"Yogi","lastName":"Ono","suffix":""},{"id":335326325,"identity":"e56e3cf7-a147-4704-bc13-9397160eddd0","order_by":2,"name":"Romualdo Cardoso Monteiro de Barros","email":"","orcid":"","institution":"Hospital Sirio Libanes","correspondingAuthor":false,"prefix":"","firstName":"Romualdo","middleName":"Cardoso Monteiro","lastName":"de Barros","suffix":""},{"id":335326328,"identity":"8381d387-285b-4533-bf4a-878074fb830c","order_by":3,"name":"Francesco Maffia","email":"data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAZAAAAAyAQMAAABI0h/eAAAABlBMVEX///8AAABVwtN+AAAACXBIWXMAAA7EAAAOxAGVKw4bAAABDklEQVRIiWNgGAWjYBAC9gZkXoWNBAM/iJFQgFsLzwFk3pk0CQZJkCEJBsRrYWAwAIvg0yJ9+NmDHxV18vwM3IkfDiRYyBufX5344YEBgzy/2AHsWvjSzA17zhw2nNnAu1niQIKE4bYbbzdLAB1mOHN2AlYt9jwMZtKMbQcSDA7wbpD++EOCcduNsxtAWhIMbmPXwsPD/k2a8V8dSMvmH0Bb7DfPOLv5B34tPEBbGphBWraBHJa4gb93GwFbeMoke44B/dLMu80CqCV5xg0gI8FAAqdfgA7bJvGjBhhi7L2bbxxIqLPt7z+7+eaPCht5fmnsWhCAGcaQAKuUIKAcBfAfIEX1KBgFo2AUjAAAAO4uXSkCqiqpAAAAAElFTkSuQmCC","orcid":"","institution":"University of Naples “Federico II”","correspondingAuthor":true,"prefix":"","firstName":"Francesco","middleName":"","lastName":"Maffia","suffix":""},{"id":335326330,"identity":"75f65b7f-9ad6-4620-86ef-22a154dfcde6","order_by":4,"name":"David Sanz","email":"","orcid":"","institution":"Instituto Português da Face","correspondingAuthor":false,"prefix":"","firstName":"David","middleName":"","lastName":"Sanz","suffix":""},{"id":335326333,"identity":"92f3a42d-ffd3-47a9-81f8-a031a6c5ac8b","order_by":5,"name":"Henrique Cardoso","email":"","orcid":"","institution":"Instituto Português da Face","correspondingAuthor":false,"prefix":"","firstName":"Henrique","middleName":"","lastName":"Cardoso","suffix":""}],"badges":[],"createdAt":"2024-07-08 13:41:31","currentVersionCode":1,"declarations":"","doi":"10.21203/rs.3.rs-4705984/v1","doiUrl":"https://doi.org/10.21203/rs.3.rs-4705984/v1","draftVersion":[],"editorialEvents":[{"content":"https://doi.org/10.1007/s10006-024-01299-y","type":"published","date":"2024-10-28T16:20:23+00:00"}],"editorialNote":"","failedWorkflow":false,"files":[{"id":62185072,"identity":"9c26ed2d-78d8-48a9-8ed5-c03d6b9e93b7","added_by":"auto","created_at":"2024-08-10 11:49:21","extension":"png","order_by":1,"title":"Figure 1","display":"","copyAsset":false,"role":"figure","size":85528,"visible":true,"origin":"","legend":"\u003cp\u003e\u003cstrong\u003eStatistical test results (A) and outcomes (B) for VAS comparing preoperative and postoperative VAS results\u003c/strong\u003e. Error bars indicate mean ± SD; **** p \u0026lt; 0.0001 compared to preoperative VAS pain.\u003c/p\u003e","description":"","filename":"floatimage1.png","url":"https://assets-eu.researchsquare.com/files/rs-4705984/v1/dc25392b5b51b5e2b712e4d6.png"},{"id":62185069,"identity":"38eb6bda-6b42-4bac-ab71-0ec9a6b31752","added_by":"auto","created_at":"2024-08-10 11:49:21","extension":"png","order_by":2,"title":"Figure 2","display":"","copyAsset":false,"role":"figure","size":82465,"visible":true,"origin":"","legend":"\u003cp\u003e\u003cstrong\u003eStatistical test results (A) and outcomes (B) for MMO comparing preoperative and postoperative MMO results\u003c/strong\u003e. Error bars indicate mean ± SD; **** p \u0026lt; 0.0001 compared to preoperative MMO.\u003c/p\u003e","description":"","filename":"floatimage2.png","url":"https://assets-eu.researchsquare.com/files/rs-4705984/v1/bf11e9d14fa91ffb3f5a06a7.png"},{"id":62185070,"identity":"56a120c9-61ba-4011-a24c-51b1ef06f0b2","added_by":"auto","created_at":"2024-08-10 11:49:21","extension":"png","order_by":3,"title":"Figure 3","display":"","copyAsset":false,"role":"figure","size":69167,"visible":true,"origin":"","legend":"\u003cp\u003e\u003cstrong\u003eVAS pain in different Wilkes stages pre-and- postoperatively. \u003c/strong\u003e* p\u0026lt;0.001 and ****p\u0026lt;0.0001 comparing with Wilkes II; \u003csup\u003e# \u003c/sup\u003ep\u0026lt;0.05 comparing with Wilkes III.\u003c/p\u003e","description":"","filename":"floatimage3.png","url":"https://assets-eu.researchsquare.com/files/rs-4705984/v1/c97c9cade4c444a9658bd7e6.png"},{"id":62185071,"identity":"dd43fb85-a7b2-4473-b359-cd1cf1b6dbcd","added_by":"auto","created_at":"2024-08-10 11:49:21","extension":"png","order_by":4,"title":"Figure 4","display":"","copyAsset":false,"role":"figure","size":197091,"visible":true,"origin":"","legend":"\u003cp\u003e\u003cstrong\u003eVAS pain in Wilkes II (A), Wilkes III (B), and Wilkes IV (C) among the different surgery levels.\u003c/strong\u003e *p\u0026lt;0.05 compared with surgery level I.\u003c/p\u003e","description":"","filename":"floatimage4.png","url":"https://assets-eu.researchsquare.com/files/rs-4705984/v1/042b5bee6cb46fd45144c6d8.png"},{"id":68207336,"identity":"d25d5c89-812d-44bd-950b-4f743dba652b","added_by":"auto","created_at":"2024-11-04 16:36:50","extension":"pdf","order_by":0,"title":"","display":"","copyAsset":false,"role":"manuscript-pdf","size":1145710,"visible":true,"origin":"","legend":"","description":"","filename":"manuscript.pdf","url":"https://assets-eu.researchsquare.com/files/rs-4705984/v1/333fc2bd-7aad-490e-8d30-8fb4a2353f54.pdf"}],"financialInterests":"No competing interests reported.","formattedTitle":"Outcomes of bilateral temporomandibular joint arthroscopy: an international multicentric prospective study including 524 joints","fulltext":[{"header":"Introduction","content":"\u003cp\u003eTemporomandibular joint (TMJ) arthroscopy is a minimally invasive surgical technique used to treat arthrogenous temporomandibular disorders (TMD) under direct visualization, embracing both a diagnostic and a therapeutic role [1, 2]. It was first introduced by Onishi at 1975 [3], as a pioneering technique to treat painful temporomandibular joints, reducing the number of TMJ open surgeries [4]. The arthroscopic approach allows direct observation of the TMJ compartments with reduced invasiveness, respecting the integrity of the joint\u0026rsquo;s capsule. This ensures greater tolerance and a lighter postoperative recovery for patients if compared to open surgery [5, 6].\u003c/p\u003e \u003cp\u003eThe operating field is mainly confined to the upper temporomandibular joint compartment, which can be divided into two recesses, the anterior and the posterior, separated by the articular eminence. In a posterior to anterior way, the most important structures are represented by medial synovial drape, retrodiscal synovium and retrodiscal ligament, posterior slope of the articular eminence and glenoid fossa, articular disk, intermediate zone, lateral pterygoid muscle shadow [7].\u003c/p\u003e \u003cp\u003eTMJ arthroscopy allows joint adherence lysis, joint lavage, and intra-articular surgical procedures. To classify the type of procedure, arthroscopy is divided into three levels depending on the operative procedures: level 1 includes basic diagnostic arthroscopy with lysis and lavage, level 2 is defined as operative arthroscopy with intra-articular coblation and other articular surgical techniques, and level 3 arthroscopy implicates a discopexy of the articular disc.[8, 9] The intra-articular surgical procedures include: myotomy of the lateral pterygoid muscle, cutting adhesions, coblation of synovitis spots and neo-vessels, tissue remodeling, retrodiscal ligament scarring, disc manipulation, and infiltration of substances [1, 8, 10].\u003c/p\u003e \u003cp\u003eTMJ arthroscopy seems to be long-term effective for relieving TMJ symptoms [1]. Recent studies have shown that TMJ arthroscopy promotes a reduction in pain and inflammatory processes, restoring the articular function with low morbidity [2, 11\u0026ndash;13]. According to several studies, the clinical success of this technique varies between 50%-92% [5, 10, 14\u0026ndash;21]. Many studies evaluated various arthroscopic procedures ranging from lysis and lavage to advanced operative arthroscopy, and results are not always in agreement with the effectiveness and outcomes [22]. This variability could be due to the fact that TMJ arthroscopy is performed widely and without a unified protocol. Several differences can be among surgeons, and protocol may vary.\u003c/p\u003e \u003cp\u003eA multicentric study analyzing outcomes in TMJ arthroscopy could support the development of a rigorous study protocol, ensure uniform data collection among different centers, and give a clearer response to the effectiveness of arthroscopy on a wider population. This multicentric prospective study aimed to evaluate the efficacy of bilateral TMJ arthroscopy in patients with different Wilkes stages, comparing the results obtained in different arthroscopic levels on a larger scale, unifying similar populations.\u003c/p\u003e"},{"header":"Material and Methods","content":"\u003cdiv id=\"Sec3\" class=\"Section2\"\u003e \u003ch2\u003eStudy Design\u003c/h2\u003e \u003cp\u003eA multicentric prospective clinical study was conducted in three TMJ departments performing temporomandibular joint surgery in Portugal and Brazil, with an enrolling window active from January 1, 2019, to December 1, 2022. The included departments were: 1) Instituto Portugu\u0026ecirc;s da Face, Lisbon, Portugal; 2) Hospital Sirio-Liban\u0026ecirc;s, S\u0026atilde;o Paulo, Brazil and 3) - Hospital Municipal Carminio Carrichio, Tatuape, Sao Paulo, SP, Brazil.\u003c/p\u003e \u003cp\u003e This study was approved by the ethics committee of the organizing center (Instituto Portugu\u0026ecirc;s da Face - PT/IPFace/RCT/1901/02). The protocol was designed in accordance with the involved institutions to uniform the development of the study among involved centers. Patient enrollment was organized to obtain similar populations between the institutions to reduce the risk of bias and inter-institutional variability. Two populations were individuated, \u0026ldquo;the Portuguese population (PT)\u0026rdquo; and \u0026ldquo;The Brazilian population (BR).\u0026rdquo; Outcome assessment and surgical treatment were developed, shared, and uniformed to be repeatable in both centers. A minor variable component related to personal preference and surgical experience was contemplated.\u003c/p\u003e \u003c/div\u003e \u003cdiv id=\"Sec4\" class=\"Section2\"\u003e \u003ch2\u003ePatients\u003c/h2\u003e \u003cp\u003eThe inclusion criteria included: (1) age\u0026thinsp;\u0026gt;\u0026thinsp;18 years; (2) clinical diagnosis of bilateral arthrogenous disorder; (3) magnetic resonance imaging (MRI) supporting the diagnosis of arthrogenous TMD; (4) conservative treatment without any improvement at least for 3 months; (5) clinical-radiological criteria for bilateral TMJ arthroscopy. The exclusion criteria included: (1) a history of facial trauma or previous TMJ surgery; (2) severe previous medical problems or impaired cognitive capacity; (3) pregnant or breastfeeding women. All the outcomes were assessed before and after surgery (1 month, 3 months, 6 months, 1 year, then every year after 1 year follow up). The final diagnosis was confirmed with magnetic resonance imaging (MRI). The clinical severity of each joint was classified according to Wilkes's classification for internal derangement [21]. Wilkes\u0026rsquo;s classification is divided into 5 stages from I to V (early, early/intermediate, intermediate, intermediate/late, late gross), based on clinical and radiological features. All patients gave their written informed consent in accordance with the current legislation and the guidelines of the Declaration of Helsinki.\u003c/p\u003e \u003c/div\u003e \u003cdiv id=\"Sec5\" class=\"Section2\"\u003e \u003ch2\u003eOutcome assessment\u003c/h2\u003e \u003cp\u003eThe primary clinical outcome was TMJ pain (arthralgia) and was accessed through a Visual Analog Scale (VAS). This scale varies between 0 (no pain) and 10 (maximum insupportable pain). Arthralgia was reported if it was verified: 1) history of pain in the TMJ area and 2) pain on palpation of the lateral pole \u003cem\u003eor\u003c/em\u003e around the lateral pole or pain on maximum unassisted or assisted opening, right or left lateral movements, or protrusive movements [23]. The secondary clinical outcome was the maximum mouth opening (MMO, in mm). MMO was measured using a certified ruler between the incisor\u0026rsquo;s teeth. To define the success criteria, authors used 2 categories to classify the TMJ pain: good if VAS\u0026thinsp;\u0026le;\u0026thinsp;2, and failure if VAS\u0026thinsp;\u0026gt;\u0026thinsp;2. In MMO, the authors defined the cut-off of success for MMO\u0026thinsp;\u0026gt;\u0026thinsp;35 mm (good\u0026thinsp;\u0026ge;\u0026thinsp;35mm and acceptable between \u0026ge;\u0026thinsp;30mm and \u0026lt;\u0026thinsp;35 mm) and failure for MMO\u0026thinsp;\u0026lt;\u0026thinsp;30 mm in the postoperative evaluation. The outcomes were graded together as good, acceptable and failure in accordingly with Table\u0026nbsp;\u003cspan refid=\"Tab1\" class=\"InternalRef\"\u003e1\u003c/span\u003e as described by Eriksson and Westesson [22].\u003c/p\u003e \u003cp\u003e \u003cdiv class=\"gridtable\"\u003e\u003ctable float=\"Yes\" id=\"Tab1\" border=\"1\"\u003e \u003ccaption language=\"En\"\u003e \u003cdiv class=\"CaptionNumber\"\u003eTable 1\u003c/div\u003e \u003cdiv class=\"CaptionContent\"\u003e \u003cp\u003eCriteria for classification of three postoperative outcomes\u003c/p\u003e \u003c/div\u003e \u003c/caption\u003e \u003ccolgroup cols=\"2\"\u003e \u003cdiv align=\"left\" class=\"colspec\" colname=\"c1\" colnum=\"1\"\u003e\u003c/div\u003e \u003cdiv align=\"left\" class=\"colspec\" colname=\"c2\" colnum=\"2\"\u003e\u003c/div\u003e \u003cthead\u003e \u003ctr\u003e \u003cth align=\"left\" colname=\"c1\"\u003e \u003cp\u003eGood\u003c/p\u003e \u003c/th\u003e \u003cth align=\"left\" colname=\"c2\"\u003e \u003cp\u003eNo pain or only mild pain level (VAS\u0026thinsp;\u0026le;\u0026thinsp;2 on a 0\u0026ndash;10 scale) and MMO\u0026thinsp;\u0026ge;\u0026thinsp;35mm\u003c/p\u003e \u003c/th\u003e \u003c/tr\u003e \u003c/thead\u003e \u003ctbody\u003e \u003ctr\u003e \u003ctd align=\"left\" colname=\"c1\"\u003e \u003cp\u003eAcceptable\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c2\"\u003e \u003cp\u003eNo pain or only mild pain level (VAS\u0026thinsp;\u0026le;\u0026thinsp;2 on a 0\u0026ndash;10 scale) and MMO\u0026thinsp;\u0026ge;\u0026thinsp;30 mm and \u0026lt;\u0026thinsp;35 mm\u003c/p\u003e \u003c/td\u003e \u003c/tr\u003e \u003ctr\u003e \u003ctd align=\"left\" colname=\"c1\"\u003e \u003cp\u003eFailure\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c2\"\u003e \u003cp\u003ePain constantly or moderate (VAS\u0026thinsp;\u0026gt;\u0026thinsp;2 on a 0\u0026ndash;10 scale) and/or MMO\u0026thinsp;\u0026lt;\u0026thinsp;30 mm\u003c/p\u003e \u003c/td\u003e \u003c/tr\u003e \u003c/tbody\u003e \u003c/colgroup\u003e \u003c/table\u003e\u003c/div\u003e \u003c/p\u003e \u003c/div\u003e \u003cdiv id=\"Sec6\" class=\"Section2\"\u003e \u003ch2\u003eSurgical treatment protocol\u003c/h2\u003e \u003cp\u003eThe TMJ arthroscopy procedure involved the use of a 1.9-mm arthroscope equipped with a video system (Stryker, San Jose, CA, USA) and a 2.8-mm outer protective cannula. The initial step, level 1 TMJ arthroscopy, utilized a classic puncture technique with an entry point 10 mm anterior and 2 mm below the Holmlund\u0026ndash;Hellsing (H-H) line. Subsequently, the arthroscope was inserted into the superior joint space. Another puncture, using a 21G needle, was made 30 mm anterior and 7 mm below the H-H line to irrigate the joint with Ringer solution. In level 2 TMJ arthroscopy, the second puncture was replaced by inserting a 2.8-mm outer protective cannula with a sharp trocar until reaching the joint. This cannula served as a passage for instruments, including a coblator device (Coblator II ENT, Arthrocare, USA), utilized for various procedures such as adhesion removal, synovitis management, anterior disc release, and posterior ligament coagulation. Additionally, this portal facilitated the injection of sub-synovial medication using a 22G long spinal needle. Level 3 TMJ arthroscopy employed a 3/0 polydioxanone (PDS) suture for arthroscopic discopexy. Supplementary injection with hyaluronic acid were administered. Before surgery, a prophylactic antibiotic protocol with either amoxicillin/clavulanic acid or clarithromycin was prescribed. Postoperatively, analgesic therapy was prescribed if necessary.\u003c/p\u003e \u003c/div\u003e \u003cdiv id=\"Sec7\" class=\"Section2\"\u003e \u003ch2\u003eStatistical Analysis\u003c/h2\u003e \u003cp\u003eData were analyzed using the IBM SPSS (v26) software. The variables were expressed as the mean (\u0026plusmn;\u0026thinsp;standard deviation (SD)). Descriptive data for patients' characteristics was obtained. For the whole group of patients, the student\u0026rsquo;s paired t-test was used for variables with normal distribution (MMO), and the signed ranks test was used for variables without normal distribution (VAS pain). A Fisher-T test was used to analyze the success of the arthroscopy. In comparison of Wilkes Stage and arthroscopic level, two independent groups were established. Subsequently, Mann-Whitney test and Student t-test for unpaired data were applied for VAS pain and MMO and outcomes. To eliminate possible bias in comparation of Wilkes and arthroscopic level, the analysis relative to MMO only considered bilateral involvement with similar Wilkes and arthroscopic level performed. P\u0026thinsp;\u0026lt;\u0026thinsp;0.05 was considered statistically significant.\u003c/p\u003e \u003c/div\u003e"},{"header":"Results","content":"\u003cp\u003eIn the present multicentric study, 262 patients (61 Portuguese patients, 201 Brazilian patients) representing 524 operated joints, were enrolled. The mean age of the entire population was 35.30\u0026thinsp;\u0026plusmn;\u0026thinsp;12.45 years. Of the 262 evaluated patients, 220 (83.97%) were female and 42 (16.03%) were male, with an equal M:F ratio of 1:4 for each population. Variables for each population are reported in Table\u0026nbsp;\u003cspan refid=\"Tab1\" class=\"InternalRef\"\u003e1\u003c/span\u003e. Globally, the most common arthrogenous diagnosis were: (1) dislocated disc with reduction (DDwR) (54.77%, n\u0026thinsp;=\u0026thinsp;287 joints); (2) dislocated disc without reduction (DDwoR) (41.99%; n\u0026thinsp;=\u0026thinsp;220 joints); (3) arthralgia (1.91%; n\u0026thinsp;=\u0026thinsp;10 joints). Percentages of distribution of preoperative intra-articular diagnosis were almost superimposable among centers.\u003c/p\u003e \u003cp\u003eThe mean preoperative VAS pain was 4.89\u0026thinsp;\u0026plusmn;\u0026thinsp;2.62 (0\u0026ndash;10, mean\u0026thinsp;\u0026plusmn;\u0026thinsp;SD), the two populations, and the mean MMO was 34.58\u0026thinsp;\u0026plusmn;\u0026thinsp;6.62 mm (mean\u0026thinsp;\u0026plusmn;\u0026thinsp;SD). Both variables were almost identical among the two populations.\u003c/p\u003e \u003cdiv id=\"Sec9\" class=\"Section2\"\u003e \u003ch2\u003eArthroscopic levels\u003c/h2\u003e \u003cp\u003eArthroscopy level I was performed in 56 joints (10.7%), whereas level II and III were performed in 319 (60.9%) and 148 (28.2%) joints, respectively. Level I was mainly conducted in Portugal (43, 35.25% vs 13, 3.23% joints), while level III mainly was adopted in Brazil (143, 35,57%, vs 6, 4.91%). Both centers performed mostly level II arthroscopy, adopting this technique in 60% of each population. An interpersonal surgical difference was noted in the technique of discopexy: in the Portuguese population, the surgeon preferred a level II arthroscopy, with indirect discopexy through treatment of the peri-discal structures, while in the Brazilian population, a direct discopexy approach through level III was preferred. The distribution of Wilkes Classification among the two populations is shown in Table\u0026nbsp;\u003cspan refid=\"Tab2\" class=\"InternalRef\"\u003e2\u003c/span\u003e. Considering the enrollment of similar patients with similar preoperative values between the two populations, outcomes were measured directly on the general population, unifying the two groups.\u003c/p\u003e \u003c/div\u003e \u003cdiv id=\"Sec10\" class=\"Section2\"\u003e \u003ch2\u003eClinical outcomes\u003c/h2\u003e \u003cp\u003eA statistically significant reduction was observed in the primary outcome, TMJ pain, postoperatively (0.83\u0026thinsp;\u0026plusmn;\u0026thinsp;1.63) (p\u0026thinsp;\u0026lt;\u0026thinsp;0.0001, Fig.\u0026nbsp;\u003cspan refid=\"Fig1\" class=\"InternalRef\"\u003e1\u003c/span\u003eA). The proportion of patients that showed a good outcome reducing pain was 82% (Fig.\u0026nbsp;\u003cspan refid=\"Fig1\" class=\"InternalRef\"\u003e1\u003c/span\u003eB). A significant MMO improvement from 34.58\u0026thinsp;\u0026plusmn;\u0026thinsp;6.62 preoperatively to 39.21\u0026thinsp;\u0026plusmn;\u0026thinsp;4.74 postoperatively was observed (p\u0026thinsp;\u0026lt;\u0026thinsp;0.0001; Fig.\u0026nbsp;\u003cspan refid=\"Fig2\" class=\"InternalRef\"\u003e2\u003c/span\u003eA). 218 (83%) patients presented after the surgery MMO\u0026thinsp;\u0026ge;\u0026thinsp;35 mm (Fig.\u0026nbsp;\u003cspan refid=\"Fig2\" class=\"InternalRef\"\u003e2\u003c/span\u003eB). 3 patients failed to open more than 30 mm postoperatively. Bilateral TMJ arthroscopy outcome was considered \u0026ldquo;successful\u0026rdquo; in 178 (68.32%) patients, \u0026ldquo;acceptable\u0026rdquo; in 33 (12.60%), and \u0026ldquo;failure\u0026rdquo; in 50 (19.08%) patients (Table\u0026nbsp;\u003cspan refid=\"Tab3\" class=\"InternalRef\"\u003e3\u003c/span\u003e).\u003c/p\u003e \u003cp\u003eVAS pain, MMO, and were also evaluated in relation to the success rate were also assessed concerning the severity of the disease using the Wilkes classification (Tables\u0026nbsp;\u003cspan refid=\"Tab4\" class=\"InternalRef\"\u003e4\u003c/span\u003e and \u003cspan refid=\"Tab5\" class=\"InternalRef\"\u003e5\u003c/span\u003e). Of 524 joints, 276 (52.7%), 152 (29.0%), and 96 (18.3%) were respectively classified as Wilkes stages II, III, and IV. The mean preoperative VAS scores were 4.74\u0026thinsp;\u0026plusmn;\u0026thinsp;2.69 for Wilkes II, 4.89\u0026thinsp;\u0026plusmn;\u0026thinsp;2.51 for Wilkes III, and 5.23\u0026thinsp;\u0026plusmn;\u0026thinsp;2.52 for Wilkes IV (Table\u0026nbsp;\u003cspan refid=\"Tab4\" class=\"InternalRef\"\u003e4\u003c/span\u003e). A significant decrease postoperatively in VAS pain was observed for all Wilkes stages (p\u0026thinsp;\u0026lt;\u0026thinsp;0.0001). Significant differences were found in comparing the postoperative pain between the different Wilkes' stages when comparing the postoperative pain between the different Wilkes' stages (Fig.\u0026nbsp;\u003cspan refid=\"Fig3\" class=\"InternalRef\"\u003e3\u003c/span\u003e). The lowest value of VAS pain was observed in Wilkes II compared to Wilkes III and IV (II: 0.67\u0026thinsp;\u0026plusmn;\u0026thinsp;1.69 vs III: 0.92\u0026thinsp;\u0026plusmn;\u0026thinsp;1.62 and IV: 1.14\u0026thinsp;\u0026plusmn;\u0026thinsp;1.40, p\u0026thinsp;=\u0026thinsp;0.001 and p\u0026thinsp;\u0026lt;\u0026thinsp;0.0001). Wilkes III also observed a lower VAS pain compared to Wilkes IV (0.92\u0026thinsp;\u0026plusmn;\u0026thinsp;1.62 vs 1.14\u0026thinsp;\u0026plusmn;\u0026thinsp;1.40, p\u0026thinsp;=\u0026thinsp;0.024). In MMO, a significant improvement was observed in all Wilkes Stages (Table\u0026nbsp;\u003cspan refid=\"Tab4\" class=\"InternalRef\"\u003e4\u003c/span\u003e). There were no differences in the MMO postoperatively comparing the Wilkes Stages (Table\u0026nbsp;\u003cspan refid=\"Tab4\" class=\"InternalRef\"\u003e4\u003c/span\u003e). There were also no differences in the success rate considering the Wilkes classification (Table\u0026nbsp;\u003cspan refid=\"Tab5\" class=\"InternalRef\"\u003e5\u003c/span\u003e).\u003c/p\u003e \u003cp\u003eTable\u0026nbsp;\u003cspan refid=\"Tab6\" class=\"InternalRef\"\u003e6\u003c/span\u003e summarizes mean VAS and MMO values preoperatively and postoperatively for the different arthroscopy levels. A significant improvement postoperatively in VAS pain and MMO was observed for all arthroscopy levels (p\u0026thinsp;\u0026lt;\u0026thinsp;0.0001, Table\u0026nbsp;\u003cspan refid=\"Tab6\" class=\"InternalRef\"\u003e6\u003c/span\u003e). Comparing the postoperative results between the different arthroscopy levels, a significant difference in pain was observed comparing level III with level I and II (p\u0026thinsp;\u0026lt;\u0026thinsp;0.0001 and p\u0026thinsp;=\u0026thinsp;0.007). No differences were found in the success rate when comparing the arthroscopy levels (Table\u0026nbsp;\u003cspan refid=\"Tab7\" class=\"InternalRef\"\u003e7\u003c/span\u003e).\u003c/p\u003e \u003cp\u003eFigure \u003cspan refid=\"Fig4\" class=\"InternalRef\"\u003e4\u003c/span\u003e showed mean VAS values preoperatively and postoperatively for the arthroscopy surgery levels and Wilkes stages. Preoperatively was verified statistically significant differences between surgery levels I and III in Wilkes II and IV (p\u0026thinsp;=\u0026thinsp;0.044 and p\u0026thinsp;=\u0026thinsp;0.036). However, postoperatively, in all Wilkes stages with different arthroscopy surgery levels, it is possible to confirm a similar decrease in VAS pain in all parameters without statistically significant results (Fig.\u0026nbsp;\u003cspan refid=\"Fig4\" class=\"InternalRef\"\u003e4\u003c/span\u003e).\u003c/p\u003e \u003cp\u003e \u003cdiv class=\"gridtable\"\u003e\u003ctable float=\"Yes\" id=\"Tab2\" border=\"1\"\u003e \u003ccaption language=\"En\"\u003e \u003cdiv class=\"CaptionNumber\"\u003eTable 2\u003c/div\u003e \u003cdiv class=\"CaptionContent\"\u003e \u003cp\u003e\u003cb\u003eBaseline characteristics of the patients in the study.\u003c/b\u003e The Portuguese and Brazilian populations were compared.\u003c/p\u003e \u003c/div\u003e \u003c/caption\u003e \u003ccolgroup cols=\"5\"\u003e \u003cdiv align=\"left\" class=\"colspec\" colname=\"c1\" colnum=\"1\"\u003e\u003c/div\u003e \u003cdiv align=\"left\" class=\"colspec\" colname=\"c2\" colnum=\"2\"\u003e\u003c/div\u003e \u003cdiv align=\"left\" class=\"colspec\" colname=\"c3\" colnum=\"3\"\u003e\u003c/div\u003e \u003cdiv align=\"left\" class=\"colspec\" colname=\"c4\" colnum=\"4\"\u003e\u003c/div\u003e \u003cdiv align=\"left\" class=\"colspec\" colname=\"c5\" colnum=\"5\"\u003e\u003c/div\u003e \u003cthead\u003e \u003ctr\u003e \u003cth align=\"left\" colspan=\"2\" nameend=\"c2\" namest=\"c1\"\u003e \u003cp\u003eVariables\u003c/p\u003e \u003c/th\u003e \u003cth align=\"left\" colspan=\"3\" nameend=\"c5\" namest=\"c3\"\u003e \u003cp\u003en (%), or mean\u0026thinsp;\u0026plusmn;\u0026thinsp;SD\u003c/p\u003e \u003c/th\u003e \u003c/tr\u003e \u003ctr\u003e \u003cth align=\"left\" colspan=\"2\" nameend=\"c2\" namest=\"c1\"\u003e\u0026nbsp;\u003c/th\u003e \u003cth align=\"left\" colname=\"c3\"\u003e \u003cp\u003ePortuguese population\u003c/p\u003e \u003c/th\u003e \u003cth align=\"left\" colname=\"c4\"\u003e \u003cp\u003eBrazilian population\u003c/p\u003e \u003c/th\u003e \u003cth align=\"left\" colname=\"c5\"\u003e \u003cp\u003ep-value\u003c/p\u003e \u003c/th\u003e \u003c/tr\u003e \u003c/thead\u003e \u003ctbody\u003e \u003ctr\u003e \u003ctd align=\"left\" colspan=\"2\" nameend=\"c2\" namest=\"c1\"\u003e \u003cp\u003eNumber of patients\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c3\"\u003e \u003cp\u003e61\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c4\"\u003e \u003cp\u003e201\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c5\"\u003e \u003cp\u003e---------------\u003c/p\u003e \u003c/td\u003e \u003c/tr\u003e \u003ctr\u003e \u003ctd align=\"left\" colname=\"c1\" morerows=\"2\" rowspan=\"3\"\u003e \u003cp\u003eSex\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c2\"\u003e\u0026nbsp;\u003c/td\u003e \u003ctd align=\"left\" colname=\"c3\"\u003e \u003cp\u003eNumber of patients(%)\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c4\"\u003e \u003cp\u003eNumber of patients (%)\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c5\" morerows=\"2\" rowspan=\"3\"\u003e \u003cp\u003e0.072\u003c/p\u003e \u003c/td\u003e \u003c/tr\u003e \u003ctr\u003e \u003ctd align=\"left\" colname=\"c2\"\u003e \u003cp\u003eFemale\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c3\"\u003e \u003cp\u003e56 (79.6%)\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c4\"\u003e \u003cp\u003e164 (81.6%)\u003c/p\u003e \u003c/td\u003e \u003c/tr\u003e \u003ctr\u003e \u003ctd align=\"left\" colname=\"c2\"\u003e \u003cp\u003eMale\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c3\"\u003e \u003cp\u003e5 (20.4%)\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c4\"\u003e \u003cp\u003e37 (18.4%)\u003c/p\u003e \u003c/td\u003e \u003c/tr\u003e \u003ctr\u003e \u003ctd align=\"left\" colspan=\"2\" nameend=\"c2\" namest=\"c1\"\u003e \u003cp\u003eAge (mean\u0026thinsp;\u0026plusmn;\u0026thinsp;SD)\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c3\"\u003e \u003cp\u003e32.61\u0026thinsp;\u0026plusmn;\u0026thinsp;10.94\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c4\"\u003e \u003cp\u003e36.35\u0026thinsp;\u0026plusmn;\u0026thinsp;12.57\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c5\"\u003e \u003cp\u003e0.1356\u003c/p\u003e \u003c/td\u003e \u003c/tr\u003e \u003ctr\u003e \u003ctd align=\"left\" colspan=\"2\" nameend=\"c2\" namest=\"c1\"\u003e \u003cp\u003eNumber of joints\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c3\"\u003e \u003cp\u003e122\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c4\"\u003e \u003cp\u003e402\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c5\"\u003e \u003cp\u003e---------------\u003c/p\u003e \u003c/td\u003e \u003c/tr\u003e \u003ctr\u003e \u003ctd align=\"left\" colspan=\"2\" nameend=\"c2\" namest=\"c1\"\u003e \u003cp\u003eFollow-up\u003c/p\u003e \u003cp\u003eperiod (days)\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c3\"\u003e \u003cp\u003e639.3\u0026thinsp;\u0026plusmn;\u0026thinsp;445.5 (31-1236 days)\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c4\"\u003e \u003cp\u003e454.7\u0026thinsp;\u0026plusmn;\u0026thinsp;235.9 (90\u0026ndash;730 days)\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c5\"\u003e \u003cp\u003e0.0009***\u003c/p\u003e \u003c/td\u003e \u003c/tr\u003e \u003ctr\u003e \u003ctd align=\"left\" colname=\"c1\" morerows=\"5\" rowspan=\"6\"\u003e \u003cp\u003ePreoperative intra-articular diagnosis\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c2\"\u003e\u0026nbsp;\u003c/td\u003e \u003ctd align=\"left\" colname=\"c3\"\u003e \u003cp\u003eNumber of joints (%)\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c4\"\u003e \u003cp\u003eNumber of joints (%)\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c5\" morerows=\"5\" rowspan=\"6\"\u003e \u003cp\u003e---------------\u003c/p\u003e \u003c/td\u003e \u003c/tr\u003e \u003ctr\u003e \u003ctd align=\"left\" colname=\"c2\"\u003e \u003cp\u003eDDwR\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c3\"\u003e \u003cp\u003e58 (48.33%)\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c4\"\u003e \u003cp\u003e229 (56.68%)\u003c/p\u003e \u003c/td\u003e \u003c/tr\u003e \u003ctr\u003e \u003ctd align=\"left\" colname=\"c2\"\u003e \u003cp\u003eDDwoR\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c3\"\u003e \u003cp\u003e48 (40.00%)\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c4\"\u003e \u003cp\u003e172 (42.57%)\u003c/p\u003e \u003c/td\u003e \u003c/tr\u003e \u003ctr\u003e \u003ctd align=\"left\" colname=\"c2\"\u003e \u003cp\u003eArthralgia\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c3\"\u003e \u003cp\u003e7 (5.83%)\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c4\"\u003e \u003cp\u003e3 (0.74%)\u003c/p\u003e \u003c/td\u003e \u003c/tr\u003e \u003ctr\u003e \u003ctd align=\"left\" colname=\"c2\"\u003e \u003cp\u003eDisc Perforation\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c3\"\u003e \u003cp\u003e4 (3.33%)\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c4\"\u003e \u003cp\u003e0 (0.00%)\u003c/p\u003e \u003c/td\u003e \u003c/tr\u003e \u003ctr\u003e \u003ctd align=\"left\" colname=\"c2\"\u003e \u003cp\u003eOsteoarthrosis (OA)\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c3\"\u003e \u003cp\u003e3 (2.50%)\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c4\"\u003e \u003cp\u003e0 (0.00%)\u003c/p\u003e \u003c/td\u003e \u003c/tr\u003e \u003ctr\u003e \u003ctd align=\"left\" colname=\"c1\" morerows=\"3\" rowspan=\"4\"\u003e \u003cp\u003eWilkes Classification\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c2\"\u003e\u0026nbsp;\u003c/td\u003e \u003ctd align=\"left\" colname=\"c3\"\u003e \u003cp\u003eNumber of joints (%)\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c4\"\u003e \u003cp\u003eNumber of joints (%)\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c5\" morerows=\"3\" rowspan=\"4\"\u003e \u003cp\u003e0.6878\u003c/p\u003e \u003c/td\u003e \u003c/tr\u003e \u003ctr\u003e \u003ctd align=\"left\" colname=\"c2\"\u003e \u003cp\u003e2\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c3\"\u003e \u003cp\u003e66 (54.10%)\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c4\"\u003e \u003cp\u003e210 (52.24%)\u003c/p\u003e \u003c/td\u003e \u003c/tr\u003e \u003ctr\u003e \u003ctd align=\"left\" colname=\"c2\"\u003e \u003cp\u003e3\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c3\"\u003e \u003cp\u003e37 (30.33%)\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c4\"\u003e \u003cp\u003e115 (28.61%)\u003c/p\u003e \u003c/td\u003e \u003c/tr\u003e \u003ctr\u003e \u003ctd align=\"left\" colname=\"c2\"\u003e \u003cp\u003e4\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c3\"\u003e \u003cp\u003e19 (15.57%)\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c4\"\u003e \u003cp\u003e77 (19.15%)\u003c/p\u003e \u003c/td\u003e \u003c/tr\u003e \u003ctr\u003e \u003ctd align=\"left\" colname=\"c1\" morerows=\"3\" rowspan=\"4\"\u003e \u003cp\u003eArthroscopy Surgery Level\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c2\"\u003e\u0026nbsp;\u003c/td\u003e \u003ctd align=\"left\" colname=\"c3\"\u003e \u003cp\u003eNumber of joints (%)\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c4\"\u003e \u003cp\u003eNumber of joints (%)\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c5\" morerows=\"3\" rowspan=\"4\"\u003e \u003cp\u003e\u0026lt;\u0026thinsp;0.0001\u003c/p\u003e \u003c/td\u003e \u003c/tr\u003e \u003ctr\u003e \u003ctd align=\"left\" colname=\"c2\"\u003e \u003cp\u003eI\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c3\"\u003e \u003cp\u003e43 (35.25%)\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c4\"\u003e \u003cp\u003e13 (3.23%)\u003c/p\u003e \u003c/td\u003e \u003c/tr\u003e \u003ctr\u003e \u003ctd align=\"left\" colname=\"c2\"\u003e \u003cp\u003eII\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c3\"\u003e \u003cp\u003e73 (59.83%)\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c4\"\u003e \u003cp\u003e246 (61.19%)\u003c/p\u003e \u003c/td\u003e \u003c/tr\u003e \u003ctr\u003e \u003ctd align=\"left\" colname=\"c2\"\u003e \u003cp\u003eIII\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c3\"\u003e \u003cp\u003e6 (4.91%)\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c4\"\u003e \u003cp\u003e143 (35.57%)\u003c/p\u003e \u003c/td\u003e \u003c/tr\u003e \u003ctr\u003e \u003ctd align=\"left\" colspan=\"2\" nameend=\"c2\" namest=\"c1\"\u003e \u003cp\u003ePreoperative VAS pain (0\u0026ndash;10)\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c3\"\u003e \u003cp\u003e4.89\u0026thinsp;\u0026plusmn;\u0026thinsp;3.02\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c4\"\u003e \u003cp\u003e4.89\u0026thinsp;\u0026plusmn;\u0026thinsp;2.49\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c5\"\u003e \u003cp\u003e0.5327\u003c/p\u003e \u003c/td\u003e \u003c/tr\u003e \u003ctr\u003e \u003ctd align=\"left\" colspan=\"2\" nameend=\"c2\" namest=\"c1\"\u003e \u003cp\u003ePreoperative MMO (mm)\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c3\"\u003e \u003cp\u003e32.56\u0026thinsp;\u0026plusmn;\u0026thinsp;8.06\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c4\"\u003e \u003cp\u003e34.48\u0026thinsp;\u0026plusmn;\u0026thinsp;6.57\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c5\"\u003e \u003cp\u003e0.0578\u003c/p\u003e \u003c/td\u003e \u003c/tr\u003e \u003ctr\u003e \u003ctd align=\"left\" colspan=\"2\" nameend=\"c2\" namest=\"c1\"\u003e \u003cp\u003ePostoperative VAS pain (0\u0026ndash;10)\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c3\"\u003e \u003cp\u003e0.53\u0026thinsp;\u0026plusmn;\u0026thinsp;1.53\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c4\"\u003e \u003cp\u003e0.81\u0026thinsp;\u0026plusmn;\u0026thinsp;1.44\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c5\"\u003e \u003cp\u003e0.0549\u003c/p\u003e \u003c/td\u003e \u003c/tr\u003e \u003ctr\u003e \u003ctd align=\"left\" colspan=\"2\" nameend=\"c2\" namest=\"c1\"\u003e \u003cp\u003ePostoperative MMO (mm)\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c3\"\u003e \u003cp\u003e40.19\u0026thinsp;\u0026plusmn;\u0026thinsp;4.75\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c4\"\u003e \u003cp\u003e38.87\u0026thinsp;\u0026plusmn;\u0026thinsp;4.69\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c5\"\u003e \u003cp\u003e0.0600\u003c/p\u003e \u003c/td\u003e \u003c/tr\u003e \u003c/tbody\u003e \u003c/colgroup\u003e \u003c/table\u003e\u003c/div\u003e \u003c/p\u003e \u003cp\u003e \u003c/p\u003e \u003cp\u003e \u003c/p\u003e \u003cp\u003e \u003cdiv class=\"gridtable\"\u003e\u003ctable float=\"Yes\" id=\"Tab3\" border=\"1\"\u003e \u003ccaption language=\"En\"\u003e \u003cdiv class=\"CaptionNumber\"\u003eTable 3\u003c/div\u003e \u003cdiv class=\"CaptionContent\"\u003e \u003cp\u003eThe success rate of TMJ arthroscopy.\u003c/p\u003e \u003c/div\u003e \u003c/caption\u003e \u003ccolgroup cols=\"2\"\u003e \u003cdiv align=\"left\" class=\"colspec\" colname=\"c1\" colnum=\"1\"\u003e\u003c/div\u003e \u003cdiv align=\"left\" class=\"colspec\" colname=\"c2\" colnum=\"2\"\u003e\u003c/div\u003e \u003cthead\u003e \u003ctr\u003e \u003cth align=\"left\" colspan=\"2\" nameend=\"c2\" namest=\"c1\"\u003e \u003cp\u003eSuccess rate\u003c/p\u003e \u003c/th\u003e \u003c/tr\u003e \u003c/thead\u003e \u003ctbody\u003e \u003ctr\u003e \u003ctd align=\"left\" colname=\"c1\"\u003e \u003cp\u003eGood\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c2\"\u003e \u003cp\u003e179 (68.32%)\u003c/p\u003e \u003c/td\u003e \u003c/tr\u003e \u003ctr\u003e \u003ctd align=\"left\" colname=\"c1\"\u003e \u003cp\u003eAcceptable\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c2\"\u003e \u003cp\u003e33 (12.60%)\u003c/p\u003e \u003c/td\u003e \u003c/tr\u003e \u003ctr\u003e \u003ctd align=\"left\" colname=\"c1\"\u003e \u003cp\u003eFailure\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c2\"\u003e \u003cp\u003e50 (19.08%)\u003c/p\u003e \u003c/td\u003e \u003c/tr\u003e \u003c/tbody\u003e \u003c/colgroup\u003e \u003c/table\u003e\u003c/div\u003e \u003c/p\u003e \u003cp\u003e \u003cdiv class=\"gridtable\"\u003e\u003ctable float=\"Yes\" id=\"Tab4\" border=\"1\"\u003e \u003ccaption language=\"En\"\u003e \u003cdiv class=\"CaptionNumber\"\u003eTable 4\u003c/div\u003e \u003cdiv class=\"CaptionContent\"\u003e \u003cp\u003eVAS and MMO preoperatively and at follow-up according to Wilkes stages.\u003c/p\u003e \u003c/div\u003e \u003c/caption\u003e \u003ccolgroup cols=\"5\"\u003e \u003cdiv align=\"left\" class=\"colspec\" colname=\"c1\" colnum=\"1\"\u003e\u003c/div\u003e \u003cdiv align=\"left\" class=\"colspec\" colname=\"c2\" colnum=\"2\"\u003e\u003c/div\u003e \u003cdiv align=\"left\" class=\"colspec\" colname=\"c3\" colnum=\"3\"\u003e\u003c/div\u003e \u003cdiv align=\"left\" class=\"colspec\" colname=\"c4\" colnum=\"4\"\u003e\u003c/div\u003e \u003cdiv align=\"left\" class=\"colspec\" colname=\"c5\" colnum=\"5\"\u003e\u003c/div\u003e \u003cthead\u003e \u003ctr\u003e \u003cth align=\"left\" colname=\"c1\"\u003e \u003cp\u003eWilkes Stage\u003c/p\u003e \u003c/th\u003e \u003cth align=\"left\" colname=\"c2\"\u003e\u0026nbsp;\u003c/th\u003e \u003cth align=\"left\" colname=\"c3\"\u003e \u003cp\u003ePreoperative\u003c/p\u003e \u003c/th\u003e \u003cth align=\"left\" colname=\"c4\"\u003e \u003cp\u003ePostoperative\u003c/p\u003e \u003c/th\u003e \u003cth align=\"left\" colname=\"c5\"\u003e \u003cp\u003e\u003cem\u003ep-value\u003c/em\u003e\u003c/p\u003e \u003cp\u003epreoperative vs. postoperative\u003c/p\u003e \u003c/th\u003e \u003c/tr\u003e \u003c/thead\u003e \u003ctbody\u003e \u003ctr\u003e \u003ctd align=\"left\" colname=\"c1\" morerows=\"1\" rowspan=\"2\"\u003e \u003cp\u003eII\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c2\"\u003e \u003cp\u003eVAS\u003c/p\u003e \u003cp\u003e(Mean\u0026thinsp;\u0026plusmn;\u0026thinsp;SD)\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c3\"\u003e \u003cp\u003e4.74\u0026thinsp;\u0026plusmn;\u0026thinsp;2.69\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c4\"\u003e \u003cp\u003e0.67\u0026thinsp;\u0026plusmn;\u0026thinsp;1.69\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c5\"\u003e \u003cp\u003e\u003cb\u003e\u0026lt;\u0026thinsp;0.001****\u003c/b\u003e\u003c/p\u003e \u003c/td\u003e \u003c/tr\u003e \u003ctr\u003e \u003ctd align=\"left\" colname=\"c2\"\u003e \u003cp\u003eMMO\u003c/p\u003e \u003cp\u003e(Mean\u0026thinsp;\u0026plusmn;\u0026thinsp;SD)\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c3\"\u003e \u003cp\u003e34.74\u0026thinsp;\u0026plusmn;\u0026thinsp;6.67\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c4\"\u003e \u003cp\u003e38.82\u0026thinsp;\u0026plusmn;\u0026thinsp;5.87\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c5\"\u003e \u003cp\u003e\u003cb\u003e\u0026lt;\u0026thinsp;0.001****\u003c/b\u003e\u003c/p\u003e \u003c/td\u003e \u003c/tr\u003e \u003ctr\u003e \u003ctd align=\"left\" colname=\"c1\" morerows=\"1\" rowspan=\"2\"\u003e \u003cp\u003eIII\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c2\"\u003e \u003cp\u003eVAS\u003c/p\u003e \u003cp\u003e(Mean\u0026thinsp;\u0026plusmn;\u0026thinsp;SD)\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c3\"\u003e \u003cp\u003e4.89\u0026thinsp;\u0026plusmn;\u0026thinsp;2.51\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c4\"\u003e \u003cp\u003e0.92\u0026thinsp;\u0026plusmn;\u0026thinsp;1.62\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c5\"\u003e \u003cp\u003e\u003cb\u003e\u0026lt;\u0026thinsp;0.001****\u003c/b\u003e\u003c/p\u003e \u003c/td\u003e \u003c/tr\u003e \u003ctr\u003e \u003ctd align=\"left\" colname=\"c2\"\u003e \u003cp\u003eMMO\u003c/p\u003e \u003cp\u003e(Mean\u0026thinsp;\u0026plusmn;\u0026thinsp;SD)\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c3\"\u003e \u003cp\u003e31.73\u0026thinsp;\u0026plusmn;\u0026thinsp;7.69\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c4\"\u003e \u003cp\u003e38.20\u0026thinsp;\u0026plusmn;\u0026thinsp;3.42\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c5\"\u003e \u003cp\u003e\u003cb\u003e\u0026lt;\u0026thinsp;0.001****\u003c/b\u003e\u003c/p\u003e \u003c/td\u003e \u003c/tr\u003e \u003ctr\u003e \u003ctd align=\"left\" colname=\"c1\" morerows=\"1\" rowspan=\"2\"\u003e \u003cp\u003eIV\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c2\"\u003e \u003cp\u003eVAS\u003c/p\u003e \u003cp\u003e(Mean\u0026thinsp;\u0026plusmn;\u0026thinsp;SD)\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c3\"\u003e \u003cp\u003e5.23\u0026thinsp;\u0026plusmn;\u0026thinsp;2.52\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c4\"\u003e \u003cp\u003e1.14\u0026thinsp;\u0026plusmn;\u0026thinsp;1.40\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c5\"\u003e \u003cp\u003e\u003cb\u003e\u0026lt;\u0026thinsp;0.001****\u003c/b\u003e\u003c/p\u003e \u003c/td\u003e \u003c/tr\u003e \u003ctr\u003e \u003ctd align=\"left\" colname=\"c2\"\u003e \u003cp\u003eMMO\u003c/p\u003e \u003cp\u003e(Mean\u0026thinsp;\u0026plusmn;\u0026thinsp;SD)\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c3\"\u003e \u003cp\u003e34.70\u0026thinsp;\u0026plusmn;\u0026thinsp;5.70\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c4\"\u003e \u003cp\u003e38.89\u0026thinsp;\u0026plusmn;\u0026thinsp;2.85\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c5\"\u003e \u003cp\u003e\u003cb\u003e\u0026lt;\u0026thinsp;0.001****\u003c/b\u003e\u003c/p\u003e \u003c/td\u003e \u003c/tr\u003e \u003ctr\u003e \u003ctd align=\"left\" colspan=\"2\" nameend=\"c2\" namest=\"c1\"\u003e \u003cp\u003e\u003cem\u003ep-value\u003c/em\u003e\u003c/p\u003e \u003cp\u003eWilkes stage vs. VAS\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c3\"\u003e \u003cp\u003e0.265\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c4\"\u003e \u003cp\u003e\u003cb\u003e\u0026lt;\u0026thinsp;0.001****\u003c/b\u003e\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c5\" morerows=\"1\" rowspan=\"2\"\u003e\u0026nbsp;\u003c/td\u003e \u003c/tr\u003e \u003ctr\u003e \u003ctd align=\"left\" colspan=\"2\" nameend=\"c2\" namest=\"c1\"\u003e \u003cp\u003e\u003cem\u003ep-value\u003c/em\u003e\u003c/p\u003e \u003cp\u003eWilkes stage vs. MMO\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c3\"\u003e \u003cp\u003e0.093\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c4\"\u003e \u003cp\u003e0.824\u003c/p\u003e \u003c/td\u003e \u003c/tr\u003e \u003c/tbody\u003e \u003c/colgroup\u003e \u003c/table\u003e\u003c/div\u003e \u003c/p\u003e \u003cp\u003e \u003c/p\u003e \u003cp\u003e \u003cdiv class=\"gridtable\"\u003e\u003ctable float=\"Yes\" id=\"Tab5\" border=\"1\"\u003e \u003ccaption language=\"En\"\u003e \u003cdiv class=\"CaptionNumber\"\u003eTable 5\u003c/div\u003e \u003cdiv class=\"CaptionContent\"\u003e \u003cp\u003eSuccess rate of TMJ arthroscopy according to Wilkes stage.\u003c/p\u003e \u003c/div\u003e \u003c/caption\u003e \u003ccolgroup cols=\"10\"\u003e \u003cdiv align=\"left\" class=\"colspec\" colname=\"c1\" colnum=\"1\"\u003e\u003c/div\u003e \u003cdiv align=\"left\" class=\"colspec\" colname=\"c2\" colnum=\"2\"\u003e\u003c/div\u003e \u003cdiv align=\"left\" class=\"colspec\" colname=\"c3\" colnum=\"3\"\u003e\u003c/div\u003e \u003cdiv align=\"left\" class=\"colspec\" colname=\"c4\" colnum=\"4\"\u003e\u003c/div\u003e \u003cdiv align=\"left\" class=\"colspec\" colname=\"c5\" colnum=\"5\"\u003e\u003c/div\u003e \u003cdiv align=\"left\" class=\"colspec\" colname=\"c6\" colnum=\"6\"\u003e\u003c/div\u003e \u003cdiv align=\"left\" class=\"colspec\" colname=\"c7\" colnum=\"7\"\u003e\u003c/div\u003e \u003cdiv align=\"left\" class=\"colspec\" colname=\"c8\" colnum=\"8\"\u003e\u003c/div\u003e \u003cdiv align=\"left\" class=\"colspec\" colname=\"c9\" colnum=\"9\"\u003e\u003c/div\u003e \u003cdiv align=\"left\" class=\"colspec\" colname=\"c10\" colnum=\"10\"\u003e\u003c/div\u003e \u003cthead\u003e \u003ctr\u003e \u003cth align=\"left\" colspan=\"3\" nameend=\"c3\" namest=\"c1\"\u003e\u0026nbsp;\u003c/th\u003e \u003cth align=\"left\" colspan=\"5\" nameend=\"c8\" namest=\"c4\"\u003e \u003cp\u003eSuccess rate\u003c/p\u003e \u003c/th\u003e \u003cth align=\"left\" colname=\"c9\"\u003e\u0026nbsp;\u003c/th\u003e \u003cth align=\"left\" colname=\"c10\"\u003e\u0026nbsp;\u003c/th\u003e \u003c/tr\u003e \u003c/thead\u003e \u003ctbody\u003e \u003ctr\u003e \u003ctd align=\"left\" colspan=\"4\" nameend=\"c4\" namest=\"c1\"\u003e \u003cp\u003eWilkes\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c5\"\u003e \u003cp\u003eII-II\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c6\"\u003e \u003cp\u003eII-III\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c7\"\u003e \u003cp\u003eIII-III\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c8\"\u003e \u003cp\u003eIII-IV\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c9\"\u003e \u003cp\u003eIV\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c10\"\u003e \u003cp\u003ep-value\u003c/p\u003e \u003c/td\u003e \u003c/tr\u003e \u003ctr\u003e \u003ctd align=\"left\" colspan=\"2\" nameend=\"c2\" namest=\"c1\"\u003e \u003cp\u003eGood - Acceptable\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colspan=\"2\" nameend=\"c4\" namest=\"c3\"\u003e\u0026nbsp;\u003c/td\u003e \u003ctd align=\"left\" colname=\"c5\"\u003e \u003cp\u003e78 (79.6%)\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c6\"\u003e \u003cp\u003e51 (78.5%)\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c7\"\u003e \u003cp\u003e25 (83.3%)\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c8\"\u003e \u003cp\u003e24 (88.9%)\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c9\"\u003e \u003cp\u003e34 (81.0%)\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c10\" morerows=\"1\" rowspan=\"2\"\u003e \u003cp\u003e0.845\u003c/p\u003e \u003c/td\u003e \u003c/tr\u003e \u003ctr\u003e \u003ctd align=\"left\" colname=\"c1\"\u003e \u003cp\u003eFailure\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colspan=\"3\" nameend=\"c4\" namest=\"c2\"\u003e\u0026nbsp;\u003c/td\u003e \u003ctd align=\"left\" colname=\"c5\"\u003e \u003cp\u003e20 (20.4%)\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c6\"\u003e \u003cp\u003e14 (21.5%)\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c7\"\u003e \u003cp\u003e5 (16.7%)\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c8\"\u003e \u003cp\u003e3 (11.1%)\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c9\"\u003e \u003cp\u003e8 (19.0%)\u003c/p\u003e \u003c/td\u003e \u003c/tr\u003e \u003c/tbody\u003e \u003c/colgroup\u003e \u003c/table\u003e\u003c/div\u003e \u003c/p\u003e \u003cp\u003e \u003cdiv class=\"gridtable\"\u003e\u003ctable float=\"Yes\" id=\"Tab6\" border=\"1\"\u003e \u003ccaption language=\"En\"\u003e \u003cdiv class=\"CaptionNumber\"\u003eTable 6\u003c/div\u003e \u003cdiv class=\"CaptionContent\"\u003e \u003cp\u003eVAS and MMO preoperatively and at follow-up according to arthroscopy level.\u003c/p\u003e \u003c/div\u003e \u003c/caption\u003e \u003ccolgroup cols=\"5\"\u003e \u003cdiv align=\"left\" class=\"colspec\" colname=\"c1\" colnum=\"1\"\u003e\u003c/div\u003e \u003cdiv align=\"left\" class=\"colspec\" colname=\"c2\" colnum=\"2\"\u003e\u003c/div\u003e \u003cdiv align=\"left\" class=\"colspec\" colname=\"c3\" colnum=\"3\"\u003e\u003c/div\u003e \u003cdiv align=\"left\" class=\"colspec\" colname=\"c4\" colnum=\"4\"\u003e\u003c/div\u003e \u003cdiv align=\"left\" class=\"colspec\" colname=\"c5\" colnum=\"5\"\u003e\u003c/div\u003e \u003cthead\u003e \u003ctr\u003e \u003cth align=\"left\" colname=\"c1\"\u003e \u003cp\u003eSurgery Level\u003c/p\u003e \u003c/th\u003e \u003cth align=\"left\" colname=\"c2\"\u003e\u0026nbsp;\u003c/th\u003e \u003cth align=\"left\" colname=\"c3\"\u003e \u003cp\u003ePreoperative\u003c/p\u003e \u003c/th\u003e \u003cth align=\"left\" colname=\"c4\"\u003e \u003cp\u003ePostoperative\u003c/p\u003e \u003c/th\u003e \u003cth align=\"left\" colname=\"c5\"\u003e \u003cp\u003e\u003cem\u003ep-value\u003c/em\u003e\u003c/p\u003e \u003cp\u003epreoperative vs. postoperative\u003c/p\u003e \u003c/th\u003e \u003c/tr\u003e \u003c/thead\u003e \u003ctbody\u003e \u003ctr\u003e \u003ctd align=\"left\" colname=\"c1\" morerows=\"1\" rowspan=\"2\"\u003e \u003cp\u003eI\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c2\"\u003e \u003cp\u003eVAS\u003c/p\u003e \u003cp\u003e(Mean\u0026thinsp;\u0026plusmn;\u0026thinsp;SD)\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c3\"\u003e \u003cp\u003e4.52\u0026thinsp;\u0026plusmn;\u0026thinsp;2.95\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c4\"\u003e \u003cp\u003e0.78\u0026thinsp;\u0026plusmn;\u0026thinsp;1.69\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c5\"\u003e \u003cp\u003e\u003cb\u003e\u0026lt;\u0026thinsp;0.001****\u003c/b\u003e\u003c/p\u003e \u003c/td\u003e \u003c/tr\u003e \u003ctr\u003e \u003ctd align=\"left\" colname=\"c2\"\u003e \u003cp\u003eMMO\u003c/p\u003e \u003cp\u003e(Mean\u0026thinsp;\u0026plusmn;\u0026thinsp;SD)\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c3\"\u003e \u003cp\u003e33.00\u0026thinsp;\u0026plusmn;\u0026thinsp;7.33\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c4\"\u003e \u003cp\u003e39.76\u0026thinsp;\u0026plusmn;\u0026thinsp;4.83\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c5\"\u003e \u003cp\u003e\u003cb\u003e0.017****\u003c/b\u003e\u003c/p\u003e \u003c/td\u003e \u003c/tr\u003e \u003ctr\u003e \u003ctd align=\"left\" colname=\"c1\" morerows=\"1\" rowspan=\"2\"\u003e \u003cp\u003eII\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c2\"\u003e \u003cp\u003eVAS\u003c/p\u003e \u003cp\u003e(Mean\u0026thinsp;\u0026plusmn;\u0026thinsp;SD)\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c3\"\u003e \u003cp\u003e4.98\u0026thinsp;\u0026plusmn;\u0026thinsp;2.61\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c4\"\u003e \u003cp\u003e0.76\u0026thinsp;\u0026plusmn;\u0026thinsp;1.68\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c5\"\u003e \u003cp\u003e\u003cb\u003e\u0026lt;\u0026thinsp;0.001****\u003c/b\u003e\u003c/p\u003e \u003c/td\u003e \u003c/tr\u003e \u003ctr\u003e \u003ctd align=\"left\" colname=\"c2\"\u003e \u003cp\u003eMMO\u003c/p\u003e \u003cp\u003e(Mean\u0026thinsp;\u0026plusmn;\u0026thinsp;SD)\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c3\"\u003e \u003cp\u003e34.43\u0026thinsp;\u0026plusmn;\u0026thinsp;7.02\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c4\"\u003e \u003cp\u003e39.04\u0026thinsp;\u0026plusmn;\u0026thinsp;5.00\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c5\"\u003e \u003cp\u003e\u003cb\u003e\u0026lt;\u0026thinsp;0.001****\u003c/b\u003e\u003c/p\u003e \u003c/td\u003e \u003c/tr\u003e \u003ctr\u003e \u003ctd align=\"left\" colname=\"c1\" morerows=\"1\" rowspan=\"2\"\u003e \u003cp\u003eIII\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c2\"\u003e \u003cp\u003eVAS\u003c/p\u003e \u003cp\u003e(Mean\u0026thinsp;\u0026plusmn;\u0026thinsp;SD)\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c3\"\u003e \u003cp\u003e4.89\u0026thinsp;\u0026plusmn;\u0026thinsp;2.50\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c4\"\u003e \u003cp\u003e0.98\u0026thinsp;\u0026plusmn;\u0026thinsp;1.49\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c5\"\u003e \u003cp\u003e\u003cb\u003e\u0026lt;\u0026thinsp;0.001****\u003c/b\u003e\u003c/p\u003e \u003c/td\u003e \u003c/tr\u003e \u003ctr\u003e \u003ctd align=\"left\" colname=\"c2\"\u003e \u003cp\u003eMMO\u003c/p\u003e \u003cp\u003e(Mean\u0026thinsp;\u0026plusmn;\u0026thinsp;SD)\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c3\"\u003e \u003cp\u003e35.14\u0026thinsp;\u0026plusmn;\u0026thinsp;5.27\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c4\"\u003e \u003cp\u003e39.34\u0026thinsp;\u0026plusmn;\u0026thinsp;4.28\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c5\"\u003e \u003cp\u003e\u003cb\u003e\u0026lt;\u0026thinsp;0.001****\u003c/b\u003e\u003c/p\u003e \u003c/td\u003e \u003c/tr\u003e \u003ctr\u003e \u003ctd align=\"left\" colspan=\"2\" nameend=\"c2\" namest=\"c1\"\u003e \u003cp\u003e\u003cem\u003ep-value\u003c/em\u003e\u003c/p\u003e \u003cp\u003eArthroscopy Level vs. VAS\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c3\"\u003e \u003cp\u003e0.320\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c4\"\u003e \u003cp\u003e\u003cb\u003e0.018*\u003c/b\u003e\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c5\" morerows=\"1\" rowspan=\"2\"\u003e\u0026nbsp;\u003c/td\u003e \u003c/tr\u003e \u003ctr\u003e \u003ctd align=\"left\" colspan=\"2\" nameend=\"c2\" namest=\"c1\"\u003e \u003cp\u003e\u003cem\u003ep-value\u003c/em\u003e\u003c/p\u003e \u003cp\u003eArthroscopy Level vs. MMO\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c3\"\u003e \u003cp\u003e0.459\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c4\"\u003e \u003cp\u003e0.788\u003c/p\u003e \u003c/td\u003e \u003c/tr\u003e \u003c/tbody\u003e \u003c/colgroup\u003e \u003c/table\u003e\u003c/div\u003e \u003c/p\u003e \u003cp\u003e \u003cdiv class=\"gridtable\"\u003e\u003ctable float=\"Yes\" id=\"Tab7\" border=\"1\"\u003e \u003ccaption language=\"En\"\u003e \u003cdiv class=\"CaptionNumber\"\u003eTable 7\u003c/div\u003e \u003cdiv class=\"CaptionContent\"\u003e \u003cp\u003eSuccess rate of TMJ arthroscopy according to arthroscopy level.\u003c/p\u003e \u003c/div\u003e \u003c/caption\u003e \u003ccolgroup cols=\"10\"\u003e \u003cdiv align=\"left\" class=\"colspec\" colname=\"c1\" colnum=\"1\"\u003e\u003c/div\u003e \u003cdiv align=\"left\" class=\"colspec\" colname=\"c2\" colnum=\"2\"\u003e\u003c/div\u003e \u003cdiv align=\"left\" class=\"colspec\" colname=\"c3\" colnum=\"3\"\u003e\u003c/div\u003e \u003cdiv align=\"left\" class=\"colspec\" colname=\"c4\" colnum=\"4\"\u003e\u003c/div\u003e \u003cdiv align=\"left\" class=\"colspec\" colname=\"c5\" colnum=\"5\"\u003e\u003c/div\u003e \u003cdiv align=\"left\" class=\"colspec\" colname=\"c6\" colnum=\"6\"\u003e\u003c/div\u003e \u003cdiv align=\"left\" class=\"colspec\" colname=\"c7\" colnum=\"7\"\u003e\u003c/div\u003e \u003cdiv align=\"left\" class=\"colspec\" colname=\"c8\" colnum=\"8\"\u003e\u003c/div\u003e \u003cdiv align=\"left\" class=\"colspec\" colname=\"c9\" colnum=\"9\"\u003e\u003c/div\u003e \u003cdiv align=\"left\" class=\"colspec\" colname=\"c10\" colnum=\"10\"\u003e\u003c/div\u003e \u003cthead\u003e \u003ctr\u003e \u003cth align=\"left\" colspan=\"3\" nameend=\"c3\" namest=\"c1\"\u003e\u0026nbsp;\u003c/th\u003e \u003cth align=\"left\" colspan=\"2\" nameend=\"c5\" namest=\"c4\"\u003e\u0026nbsp;\u003c/th\u003e \u003cth align=\"left\" colspan=\"4\" nameend=\"c9\" namest=\"c6\"\u003e \u003cp\u003eSuccess rate\u003c/p\u003e \u003c/th\u003e \u003cth align=\"left\" colname=\"c10\"\u003e\u0026nbsp;\u003c/th\u003e \u003c/tr\u003e \u003c/thead\u003e \u003ctbody\u003e \u003ctr\u003e \u003ctd align=\"left\" colspan=\"2\" nameend=\"c2\" namest=\"c1\"\u003e \u003cp\u003eSurgery Level (joints)\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colspan=\"2\" nameend=\"c4\" namest=\"c3\"\u003e \u003cp\u003eI\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colspan=\"2\" nameend=\"c6\" namest=\"c5\"\u003e \u003cp\u003eI/II\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c7\"\u003e \u003cp\u003eII\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c8\"\u003e \u003cp\u003eII/III\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c9\"\u003e \u003cp\u003eIII\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c10\"\u003e \u003cp\u003ep-value\u003c/p\u003e \u003c/td\u003e \u003c/tr\u003e \u003ctr\u003e \u003ctd align=\"left\" colname=\"c1\"\u003e \u003cp\u003eGood-Acceptable\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c2\"\u003e\u0026nbsp;\u003c/td\u003e \u003ctd align=\"left\" colspan=\"2\" nameend=\"c4\" namest=\"c3\"\u003e \u003cp\u003e11 (78.6%)\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colspan=\"2\" nameend=\"c6\" namest=\"c5\"\u003e \u003cp\u003e18 (69.2%)\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c7\"\u003e \u003cp\u003e110 (80.9%)\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c8\"\u003e \u003cp\u003e20 (87.0%)\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c9\"\u003e \u003cp\u003e53 (84.1%)\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c10\" morerows=\"1\" rowspan=\"2\"\u003e \u003cp\u003e0.515\u003c/p\u003e \u003c/td\u003e \u003c/tr\u003e \u003ctr\u003e \u003ctd align=\"left\" colname=\"c1\"\u003e \u003cp\u003eFailure\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c2\"\u003e\u0026nbsp;\u003c/td\u003e \u003ctd align=\"left\" colspan=\"2\" nameend=\"c4\" namest=\"c3\"\u003e \u003cp\u003e3 (21.4%)\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colspan=\"2\" nameend=\"c6\" namest=\"c5\"\u003e \u003cp\u003e8 (30.8%)\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c7\"\u003e \u003cp\u003e26 (19.1%)\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c8\"\u003e \u003cp\u003e3 (13.0%)\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c9\"\u003e \u003cp\u003e10 (15.9%)\u003c/p\u003e \u003c/td\u003e \u003c/tr\u003e \u003c/tbody\u003e \u003c/colgroup\u003e \u003c/table\u003e\u003c/div\u003e \u003c/p\u003e \u003cp\u003e \u003c/p\u003e \u003c/div\u003e"},{"header":"Discussion","content":"\u003cp\u003eThis prospective multicenter study showed that implementing a strict protocol for TMJ arthroscopy enables satisfactory results to be obtained by different surgeons and in different populations. Bilateral TMJ arthroscopy was an effective procedure in different stages of TMD, resulting in a significant reduction of pain and improvement in MMO in all severity categories. Although better results were observed in pain reduction in Wilkes II and III patients, no differences in success rates were noticed. As expected, preoperative joint pain value distribution increased as Wilkes stage increased. This trend was observed in the postoperative stage in an opposite manner: the lowest level of arthralgia was recorded in stage II, then stage III, and finally stage IV. This can be interpreted as high levels of baseline pain are associated with higher levels of pain in the postoperative phase. In fact, level 3 arthroscopy procedures presented post-operative higher rates of post-operative pain, compatible with a greater surgical manipulation. Moreover, this difference in postoperative pain is more likely to be observed in the early post-operative weeks. This is consistent with the literature [24]: level 3 arthroscopy showed a longer period of post-operative pain than level 2 arthroscopy. Gaete C et al. [25] found a restricted number of patients undergoing level 3 arthroscopy were associated with Wilkes II but had disc perforation. In our population, we found too elongated or damaged discs, and not only in advanced Wilkes degrees, making any kind of arthroscopic discopexy unfeasible. This phenomenon is quite common in the literature due to the reduced diagnostic specificity of preoperative imaging in patients undergoing arthroscopy. Vervaeke K et al. [26] conducted a retrospective cohort study to establish the correlation between MRI and arthroscopic findings with clinical outcomes. Their study demonstrated that MRI findings can be used to predict the outcomes of TMJ arthroscopy. Disc shape and a crumpled disc's absolute/probable absence might be used as a predictive variable, a positive sign of an early damaged joint. The absence of eminence deformation on MRI also predicted good outcomes. Perioperative findings such as degenerative joint disease or absolute or probable absence of disc reduction can predict lower outcomes [27].\u003c/p\u003e \u003cp\u003ePredictive factors for TMJ arthroscopy are still a topic of discussion in the literature. In a study from the group of Ulmner M et al. [11] bilateral masticatory muscle tenderness on palpation was the only preoperative factor found to have a significant impact on the outcome of TMJ arthroscopy. This evidence was supported by \u0026Acirc;ngelo DF et al. [28] in their study about inco-botulin neurotoxin A (inco-BoNT/A) used as preoperative medication in patients undergoing TMJ arthroscopy. BONT/A improved the outcomes as an adjunctive treatment in patients who were candidates for TMJ arthroscopy, reducing arthralgia and myalgia in the long term. The inco-BoNT/A group also experienced a reduced incidence of persistent symptoms after post-treatment and the subsequent necessity of further treatments [28].\u003c/p\u003e \u003cp\u003eTMJ arthroscopy procedure has been advanced through various surgical techniques and modifications. The current described surgical steps are portal triangulation, coblation of zones of synovitis and chondromalacia, resection of adhesions, biopsies of fibrocartilage, myotomy, and disc repositioning by capsular scarring, discopexy, subsynovial or intra-articular infiltrations with various substances such as corticosteroids, hyaluronic acid, with and without PRP. \u0026Acirc;ngelo DF [29] proposed the inverted portal technique for TMJ arthroscopy to enhance retrodiscal coblation. This technique aimed to improve the effectiveness of retrodiscal coblation in treating TMJ disorders, increasing the area to treat, particularly the posterolateral one [29]. In some specific cases, arthroscopic disc repositioning and different suturing techniques are employed. The intra-procedural variety, given the many techniques that can be performed, opens interpersonal preferences among surgeons. In this study although the populations of the two centers examined were extremely similar, differences were recorded in the choice of arthroscopic discopexy type, with a peak of level III arthroscopies in the Brazilian population. Despite this difference, postoperatively, across all Wilkes stages and varying levels of arthroscopy surgery, a comparable reduction in VAS pain scores is observed. No differences were found in the success rate when comparing the arthroscopy levels. Plus, there were no variations in the success rate when different levels of arthroscopy were compared. Santos TS et al. [24] conducted a systematic review and meta-analysis comparing open surgery versus arthroscopic techniques for disc repositioning and suturing. Their conclusions indicated that both techniques effectively achieved successful outcomes, with no significant difference in their effectiveness. This suggests that TMJ arthroscopy can provide comparable results to traditional open surgery intra-articular procedures, while offering the benefits of minimally invasive surgery [24].\u003c/p\u003e \u003cp\u003eAnother advantage of TMJ arthroscopy is its possibility of being performed under either local or general anesthesia [22]. This procedural flexibility allows for personalized patient care and can accommodate individual preferences or medical considerations. Sah MK et al. [30] compared the modalities of TMJ arthroscopy performed under local anesthesia (LA) versus general anesthesia (GA). No significant post-operative difference was found in pain reduction outcome and mouth opening improvement. The LA group's median operative time and hospital stay duration were significantly less than the GA group. TMJ arthroscopy for LA group was performed in a minor procedure setup, reducing the surgery costs. The post-operative disc position was excellent and good, with an overall success rate of 95%. The choice of anesthesia did not significantly affect the outcomes of the procedure, indicating that both options can be equally effective, and local anesthesia arthroscopy furnished even additional benefits related to hospital costs and median operative time [22]. In this study, all procedures were performed under general anesthesia. The approach is based on two main fundaments: patients\u0026rsquo; comfort and use of curare drugs to mobilize the joint during the procedures. We believe that these points increase the procedure's success rate granting a smooth performance.\u003c/p\u003e \u003cp\u003eA relevant success in outcomes like MMO and VAS pain level should be attributed to TMJ arthroscopy as part of a well-defined preoperative, intraoperative and postoperative protocol. In this multicentric shared protocol we included intraoperative intra-articular injections of therapeutic substances such as hyaluronic acid. Nowadays, the injection of intra-articular substances during arthroscopic procedures is a well-established additional procedure. Guti\u0026eacute;rrez IQ et al. [31] conducted a systematic review to evaluate the effectiveness of intra-articular injections of platelet-rich plasma (PRP) and plasma rich in growth factors (PRGF) with arthrocentesis or arthroscopy in treating TMJ disorders. The PRP and PRGF intra-articular injections demonstrated significant differences in pain reduction in three studies and improved mandibular function in two. The treatment with PRP or PRGF intra-articular injections demonstrated better clinical results than the control group. Leketas M et al. [32] conducted a randomized clinical trial to evaluate the effect of different intra-articular injection substances on the early postoperative period following TMJ arthroscopy. The study demonstrated that the choice of injection substance can influence the postoperative outcomes: hyaluronic acid injection following temporomandibular joint arthroscopy can decrease pain better than saline and platelet-rich plasma during the first postoperative week [32].\u003c/p\u003e \u003cp\u003eConsidering the reduced invasiveness of the procedure, the complications related to the arthroscopic technique are not numerous. They are mainly represented by extravasation of the fluids used for irrigation with the possibility of pharyngeal edema, intra-articular bleeding during myotomy in the anterior recess, iatrogenic joint damage (disc perforations, fragmentation of the articular eminence, excessive synovial fibrillation), and damage to the external auditory canal or middle ear [8, 33]. From a technical point of view, double portal procedures have a higher incidence of intra-operative complications if compare with single portal ones, especially for articular bleeding and preauricular area edema [34]. In cases where the outcome is unsatisfactory, the further step could be open surgery, but some authors suggest repeating the arthroscopic procedure. Re-arthroscopy should be offered to patients where it is still possible to perform further operative and more advanced techniques, especially when the previous stage is not advanced (Wilkes stage IV or V) [12].\u003c/p\u003e \u003cp\u003eOne of the possible limitations of our study is the differences between the two populations; although similar, they are not totally equal. Similarly, concerns interpersonal surgical preferences: although the end result is still disc repositioning, discopexy in level 2 and level 3 have different disability criteria.\u003c/p\u003e"},{"header":"Conclusion","content":"\u003cp\u003eIn this prospective multicentric study, the implementation of a unified protocol by different surgeons shows that bilateral TMJ arthroscopy is a safe technique with a high degree of efficacy in reducing pain and increasing maximum mouth opening, regardless of the degree of severity and complexity of the technique. The results were stable throughout the follow-up period.\u003c/p\u003e \u003cp\u003eThrough advancements in surgical techniques and research, TMJ arthroscopy continues to evolve and improve, providing better outcomes for patients with TMJ disorders. Healthcare professionals dealing with temporomandibular joint surgery need to stay updated with the latest research and advancements in TMJ arthroscopy to ensure the delivery of optimal care to patients. We encourage more multicenter studies to be conducted, involving more centers and a larger population.\u003c/p\u003e"},{"header":"Declarations","content":"\u003ch2\u003eFunding\u003c/h2\u003e\n\u003cp\u003eThe authors declare that no funds, grants, or other support were received during the preparation of this manuscript.\u003c/p\u003e\n\u003ch2\u003eCompeting interests\u003c/h2\u003e\n\u003cp\u003eThe authors have no relevant financial or non-financial interests to disclose.\u003c/p\u003e\n\u003ch2\u003eEthics approval\u003c/h2\u003e\n\u003cp\u003eThis study was approved by the ethics committee of the organizing center (Instituto Portugu\u0026ecirc;s da Face - PT/IPFace/RCT/1901/02).\u003c/p\u003e\n\u003ch2\u003eConsent to participate and to publish\u003c/h2\u003e\n\u003cp\u003eInformed consent was obtained from all individual participants included in the study.\u003c/p\u003e\n\u003ch2\u003eAvailability of data and materials\u003c/h2\u003e\n\u003cp\u003eNot applicable.\u003c/p\u003e"},{"header":"References","content":"\u003col\u003e\n\u003cli\u003eMurakami K, Segami N, Okamoto M, Yamamura I, Takahashi K, Tsuboi Y (2000) Outcome of arthroscopic surgery for internal derangement of the temporomandibular joint: long-term results covering 10 years. J Craniomaxillofac Surg 28(5):264-71. https://doi.org/10.1054/jcms.2000.0162\u003c/li\u003e\n\u003cli\u003e\u0026Acirc;ngelo DF, Ara\u0026uacute;jo RAD, Sanz D (2021) Surgical complications related to temporomandibular joint arthroscopy: a prospective analysis of 39 single-portal versus 43 double-portal procedures. Int J Oral Maxillofac Surg 50(8):1089-94. https://doi.org/10.1016/j.ijom.2020.07.020\u003c/li\u003e\n\u003cli\u003eOnishi M (1975) [Arthroscopy of the temporomandibular joint (author\u0026apos;s transl)]. Kokubyo Gakkai Zasshi 42(2):207-13.\u003c/li\u003e\n\u003cli\u003eHolmlund A, Gynther G, Axelsson S (1994) Efficacy of arthroscopic lysis and lavage in patients with chronic locking of the temporomandibular joint. Int J Oral Maxillofac Surg 23(5):262-5. https://doi.org/10.1016/s0901-5027(05)80104-3\u003c/li\u003e\n\u003cli\u003eMcCain JP, Sanders B, Koslin MG, Quinn JH, Peters PB, Indresano AT (1992) Temporomandibular joint arthroscopy: a 6-year multicenter retrospective study of 4,831 joints. J Oral Maxillofac Surg 50(9):926-30. https://doi.org/10.1016/0278-2391(92)90047-4\u003c/li\u003e\n\u003cli\u003eKondoh T, Dolwick MF, Hamada Y, Seto K (2003) Visually guided irrigation for patients with symptomatic internal derangement of the temporomandibular joint: a preliminary report. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 95(5):544-51. https://doi.org/10.1067/moe.2003.160\u003c/li\u003e\n\u003cli\u003eMiloro M, Ghali GE, Larsen P, Waite P (2004) Peterson\u0026apos;s Principles of Oral and Maxillofacial Surgery: BC Decker.\u003c/li\u003e\n\u003cli\u003eGonz\u0026aacute;lez LV, L\u0026oacute;pez JP, D\u0026iacute;az-B\u0026aacute;ez D, Martin-Granizo L\u0026oacute;pez R (2022) Intraoperative complications in temporomandibular joint arthroscopy: A retrospective observational analysis of 899 arthroscopies. J Craniomaxillofac Surg 50(8):651-6. https://doi.org/10.1016/j.jcms.2022.06.011\u003c/li\u003e\n\u003cli\u003e\u0026Acirc;ngelo DF, Sanz D, Cardoso HJ (2023) Bilateral arthroscopy of the temporomandibular joint: clinical outcomes and the role of a second intervention-a prospective study. Clin Oral Investig 27(10):6167-76. https://doi.org/10.1007/s00784-023-05233-6\u003c/li\u003e\n\u003cli\u003eSilva PA, Lopes MT, Freire FS (2015) A prospective study of 138 arthroscopies of the temporomandibular joint. Braz J Otorhinolaryngol 81(4):352-7. https://doi.org/10.1016/j.bjorl.2014.08.021\u003c/li\u003e\n\u003cli\u003eUlmner M, Weiner CK, Lund B (2020) Predictive factors in temporomandibular joint arthroscopy: a prospective cohort short-term outcome study. Int J Oral Maxillofac Surg 49(5):614-20. https://doi.org/10.1016/j.ijom.2019.09.002\u003c/li\u003e\n\u003cli\u003eMartin Granizo R, Correa Mu\u0026ntilde;oz DC, Varela Reyes E (2018) Rearthroscopy of the temporomandibular joint: A retrospective study of 600 arthroscopies. Journal of Cranio-Maxillofacial Surgery 46(9):1555-60. https://doi.org/10.1016/j.jcms.2017.12.007\u003c/li\u003e\n\u003cli\u003e\u0026Acirc;ngelo DF, Moreira A, Sanz D, S\u0026atilde;o Jo\u0026atilde;o R (2021) Hearing changes after temporomandibular joint arthroscopy: a prospective study. Int J Oral Maxillofac Surg. https://doi.org/10.1016/j.ijom.2021.02.013\u003c/li\u003e\n\u003cli\u003eIndresano AT (1989) Arthroscopic surgery of the temporomandibular joint: report of 64 patients with long-term follow-up. J Oral Maxillofac Surg 47(5):439-41. https://doi.org/10.1016/0278-2391(89)90274-7\u003c/li\u003e\n\u003cli\u003eDimitroulis G (2002) A review of 56 cases of chronic closed lock treated with temporomandibular joint arthroscopy. J Oral Maxillofac Surg 60(5):519-24; discussion 25. https://doi.org/10.1053/joms.2002.31848\u003c/li\u003e\n\u003cli\u003eHolmlund A, Gynther G, Axelsson S (1994) Efficacy of arthroscopic lysis and lavage in patients with chronic locking of the temporomandibular joint. International Journal of Oral and Maxillofacial Surgery 23(5):262-5. https://doi.org/10.1016/S0901-5027(05)80104-3\u003c/li\u003e\n\u003cli\u003eMachoň V, Levorov\u0026aacute; J, Hirjak D, Beňo M, Draho\u0026scaron; M, Folt\u0026aacute;n R (2021) Does arthroscopic lysis and lavage in subjects with Wilkes III internal derangement reduce pain? Oral Maxillofac Surg. https://doi.org/10.1007/s10006-020-00935-7\u003c/li\u003e\n\u003cli\u003ePerrott DH, Alborzi A, Kaban LB, Helms CA (1990) A prospective evaluation of the effectiveness of temporomandibular joint arthroscopy. Journal of Oral and Maxillofacial Surgery 48(10):1029-32. https://doi.org/10.1016/0278-2391(90)90283-8\u003c/li\u003e\n\u003cli\u003eSorel B, Piecuch JF (2000) Long-term evaluation following temporomandibular joint arthroscopy with lysis and lavage. Int J Oral Maxillofac Surg 29(4):259-63.\u003c/li\u003e\n\u003cli\u003eKurita K, Goss AN, Ogi N, Toyama M (1998) Correlation between preoperative mouth opening and surgical outcome after arthroscopic lysis and lavage in patients with disc displacement without reduction. Journal of Oral and Maxillofacial Surgery 56(12):1394-7. https://doi.org/10.1016/S0278-2391(98)90401-3\u003c/li\u003e\n\u003cli\u003eKondoh T, Dolwick MF, Hamada Y, Seto K (2003) Visually guided irrigation for patients with symptomatic internal derangement of the temporomandibular joint: A preliminary report. Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontology 95(5):544-51. https://doi.org/10.1067/moe.2003.160\u003c/li\u003e\n\u003cli\u003eIndresano AT (2001) Surgical arthroscopy as the preferred treatment for internal derangements of the temporomandibular joint. J Oral Maxillofac Surg 59(3):308-12. https://doi.org/10.1053/joms.2001.21001\u003c/li\u003e\n\u003cli\u003eSchiffman E, Ohrbach R, Truelove E, Look J, Anderson G, Goulet JP, et al. (2014) Diagnostic Criteria for Temporomandibular Disorders (DC/TMD) for Clinical and Research Applications. J Oral Facial Pain Headache 28(1):6-27. https://doi.org/10.11607/jop.1151\u003c/li\u003e\n\u003cli\u003eSantos TS, Pagotto LEC, Santos Nascimento E, Rezende da Cunha L, Serra Cassano D, Gon\u0026ccedil;alves JR (2021) Effectiveness of disk repositioning and suturing comparing open-joint versus arthroscopic techniques: a systematic review and meta-analysis. Oral Surg Oral Med Oral Pathol Oral Radiol 132(5):506-13. https://doi.org/10.1016/j.oooo.2021.02.015\u003c/li\u003e\n\u003cli\u003eGaete C, Droguett C, S\u0026aacute;ez F, Astorga P (2024) Clinical and demographic factors associated with the effectiveness of temporomandibular joint arthroscopy. Oral Maxillofac Surg 28(1):405-11. https://doi.org/10.1007/s10006-023-01158-2\u003c/li\u003e\n\u003cli\u003eVervaeke K, Verhelst PJ, Orhan K, Lund B, Benchimol D, Van der Cruyssen F, et al. (2022) Correlation of MRI and arthroscopic findings with clinical outcome in temporomandibular joint disorders: a retrospective cohort study. Head Face Med 18(1):2. https://doi.org/10.1186/s13005-021-00305-y\u003c/li\u003e\n\u003cli\u003eTzanidakis K, Sidebottom AJ (2013) How accurate is arthroscopy of the temporomandibular joint? A comparison of findings in patients who had open operations after arthroscopic management failed. Br J Oral Maxillofac Surg 51(8):968-70. https://doi.org/10.1016/j.bjoms.2013.05.149\u003c/li\u003e\n\u003cli\u003e\u0026Acirc;ngelo DF, Sanz D, Maffia F, Cardoso HJ (2023) Outcomes of IncobotulinumtoxinA Injection on Myalgia and Arthralgia in Patients Undergoing Temporomandibular Joint Arthroscopy: A Randomized Controlled Trial. Toxins (Basel) 15(6). https://doi.org/10.3390/toxins15060376\u003c/li\u003e\n\u003cli\u003e\u0026Acirc;ngelo DF (2022) Temporomandibular joint arthroscopy: inverted portal technique for more effective retrodiscal coblation. Int J Oral Maxillofac Surg 51(8):1074-7. https://doi.org/10.1016/j.ijom.2022.01.013\u003c/li\u003e\n\u003cli\u003eSah MK, Abdelrehem A, Nie X, Yang C (2024) The hue of temporomandibular joint arthroscopy under local versus general anaesthesia. J Oral Rehabil 51(3):510-6. https://doi.org/10.1111/joor.13611\u003c/li\u003e\n\u003cli\u003eGuti\u0026eacute;rrez IQ, S\u0026aacute;bado-Bund\u0026oacute; H, Gay-Escoda C (2022) Intraarticular injections of platelet rich plasma and plasma rich in growth factors with arthrocenthesis or arthroscopy in the treatment of temporomandibular joint disorders: A systematic review. J Stomatol Oral Maxillofac Surg 123(5):e327-e35. https://doi.org/10.1016/j.jormas.2021.12.006\u003c/li\u003e\n\u003cli\u003eLeketas M, Dvylys D, Sakalys D, Simuntis R (2022) Different intra-articular injection substances following temporomandibular joint arthroscopy and their effect on early postoperative period: A randomized clinical trial. Cranio:1-6. https://doi.org/10.1080/08869634.2022.2081445\u003c/li\u003e\n\u003cli\u003eNogueira EFC, Lemos CAA, Vasconcellos RJH, Moraes SLD, Vasconcelos BCE, Pellizzer EP (2021) Does arthroscopy cause more complications than arthrocentesis in patients with internal temporomandibular joint disorders? Systematic review and meta-analysis. Br J Oral Maxillofac Surg 59(10):1166-73. https://doi.org/10.1016/j.bjoms.2021.05.007\u003c/li\u003e\n\u003cli\u003e\u0026Acirc;ngelo DF, Moreira A, Sanz D, S\u0026atilde;o Jo\u0026atilde;o R (2021) Hearing changes after temporomandibular joint arthroscopy: a prospective study. Int J Oral Maxillofac Surg 50(11):1491-5. https://doi.org/10.1016/j.ijom.2021.02.013\u003cstrong\u003e\u003c/strong\u003e\u003c/li\u003e\n\u003c/ol\u003e"}],"fulltextSource":"","fullText":"","funders":[],"hasAdminPriorityOnWorkflow":false,"hasManuscriptDocX":true,"hasOptedInToPreprint":true,"hasPassedJournalQc":"","hasAnyPriority":false,"hideJournal":false,"highlight":"","institution":"","isAcceptedByJournal":true,"isAuthorSuppliedPdf":false,"isDeskRejected":"","isHiddenFromSearch":false,"isInQc":false,"isInWorkflow":false,"isPdf":false,"isPdfUpToDate":true,"isWithdrawnOrRetracted":false,"journal":{"display":true,"email":"[email protected]","identity":"oral-and-maxillofacial-surgery","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":false,"externalIdentity":"omfs","sideBox":"Learn more about [Oral and Maxillofacial Surgery](http://link.springer.com/journal/10006)","snPcode":"10006","submissionUrl":"https://submission.nature.com/new-submission/10006/3","title":"Oral and Maxillofacial Surgery","twitterHandle":"","acdcEnabled":true,"dfaEnabled":true,"editorialSystem":"em","reportingPortfolio":"Springer Hybrid","inReviewEnabled":true,"inReviewRevisionsEnabled":false},"keywords":"temporomandibular joint, temporomandibular disorders, TMJ arthroscopy, minimally invasive surgery, multicentric study","lastPublishedDoi":"10.21203/rs.3.rs-4705984/v1","lastPublishedDoiUrl":"https://doi.org/10.21203/rs.3.rs-4705984/v1","license":{"name":"CC BY 4.0","url":"https://creativecommons.org/licenses/by/4.0/"},"manuscriptAbstract":"\u003cp\u003e\u003cstrong\u003ePurpose\u003c/strong\u003e: This study aimed to evaluate the efficacy of bilateral TMJ arthroscopy in patients with different Wilkes stages, comparing the results obtained in different arthroscopic levels on a larger scale, unifying similar populations.\u0026nbsp;\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eMethods\u003c/strong\u003e: A multicentric prospective clinical study was conducted in three TMJ departments performing temporomandibular joint surgery in Portugal and Brazil, with an enrolling window active from January 1, 2019, to December 1, 2022. The primary clinical outcome was TMJ pain evaluated through a visual analog scale. The secondary clinical outcome was the maximum mouth opening (MMO). TMJ arthroscopy was performed with a 1.9-mm arthroscope, including a video system with a 2.8-mm outer protective cannula.\u0026nbsp;\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eResults\u003c/strong\u003e: 262 patients, representing a total of 524 operated joints were enrolled. The mean age was 35.3 years. A significant decrease postoperatively in VAS pain was observed for all Wilkes stages. The lowest value of VAS pain was observed in Wilkes II compared to Wilkes III and IV. In the secondary outcome, MMO was observed to have a significant improvement in all Wilkes Stages.\u0026nbsp;\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eConclusion\u003c/strong\u003e: in this multicentric study, bilateral TMJ arthroscopy was shown to be an effective procedure to reduce pain and increase maximum mouth opening in patients with different Wilkes stages, representing a valid minimally invasive solution.\u003c/p\u003e","manuscriptTitle":"Outcomes of bilateral temporomandibular joint arthroscopy: an international multicentric prospective study including 524 joints","msid":"","msnumber":"","nonDraftVersions":[{"code":1,"date":"2024-08-10 11:49:16","doi":"10.21203/rs.3.rs-4705984/v1","editorialEvents":[{"type":"communityComments","content":0},{"type":"decision","content":"Revision requested","date":"2024-09-20T09:14:04+00:00","index":"","fulltext":""},{"type":"editorInvitedReview","content":"","date":"2024-07-31T20:51:39+00:00","index":"hide","fulltext":""},{"type":"reviewerAgreed","content":"280626938746039322020176423924317055165","date":"2024-07-29T11:47:10+00:00","index":"hide","fulltext":""},{"type":"reviewerAgreed","content":"11002466659745581031229859520122082937","date":"2024-07-28T21:49:26+00:00","index":"hide","fulltext":""},{"type":"reviewersInvited","content":"","date":"2024-07-28T16:22:25+00:00","index":"","fulltext":""},{"type":"editorAssigned","content":"","date":"2024-07-11T07:26:39+00:00","index":"","fulltext":""},{"type":"checksComplete","content":"","date":"2024-07-11T07:25:16+00:00","index":"","fulltext":""},{"type":"submitted","content":"Oral and Maxillofacial Surgery","date":"2024-07-08T13:39:54+00:00","index":"","fulltext":""}],"status":"published","journal":{"display":true,"email":"[email protected]","identity":"oral-and-maxillofacial-surgery","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":false,"externalIdentity":"omfs","sideBox":"Learn more about [Oral and Maxillofacial Surgery](http://link.springer.com/journal/10006)","snPcode":"10006","submissionUrl":"https://submission.nature.com/new-submission/10006/3","title":"Oral and Maxillofacial Surgery","twitterHandle":"","acdcEnabled":true,"dfaEnabled":true,"editorialSystem":"em","reportingPortfolio":"Springer Hybrid","inReviewEnabled":true,"inReviewRevisionsEnabled":false}}],"origin":"","ownerIdentity":"ca77eb0a-c5ec-45ed-932d-00eeb2ae4ef9","owner":[],"postedDate":"August 10th, 2024","published":true,"recentEditorialEvents":[],"rejectedJournal":[],"revision":"","amendment":"","status":"published-in-journal","subjectAreas":[],"tags":[],"updatedAt":"2024-11-04T16:27:55+00:00","versionOfRecord":{"articleIdentity":"rs-4705984","link":"https://doi.org/10.1007/s10006-024-01299-y","journal":{"identity":"oral-and-maxillofacial-surgery","isVorOnly":false,"title":"Oral and Maxillofacial Surgery"},"publishedOn":"2024-10-28 16:20:23","publishedOnDateReadable":"October 28th, 2024"},"versionCreatedAt":"2024-08-10 11:49:16","video":"","vorDoi":"10.1007/s10006-024-01299-y","vorDoiUrl":"https://doi.org/10.1007/s10006-024-01299-y","workflowStages":[]},"version":"v1","identity":"rs-4705984","journalConfig":"researchsquare"},"__N_SSP":true},"page":"/article/[identity]/[[...version]]","query":{"redirect":"/article/rs-4705984","identity":"rs-4705984","version":["v1"]},"buildId":"qtupq5eGEP_6zYnWcrvyt","isFallback":false,"isExperimentalCompile":false,"dynamicIds":[84888],"gssp":true,"scriptLoader":[]}