Relationship between oxidative stress and endometrial polyps in pre-and postmenopausal women

Emre Erdem Taş, Eyyüp ÖZGEN, Gamze Yılmaz, Almila Şenat
In: Pakistan Journal of Medical Sciences · 2024 · vol. 41(1) , pp. 130–135 · doi:10.12669/pjms.41.1.10170 · PMID:39867798 · W4405744998
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Abstract

Objective: This study aimed to investigate the relationship between oxidative stress (OS) and endometrial polyps (EP) in pre- versus postmenopausal women with abnormal uterine bleeding. Methods: This prospective case control study was conducted in the Gynecology Department of Ankara Bilkent City Hospital between January and December 2019. In this study, the EP and control groups included 45 participants each (30 pre- and 15 postmenopausal women). Demographics (age, gravidity, parity, and body mass index), serum complete blood count parameters, serum total antioxidant status, total oxidant status (TOS), oxidative stress index (OSI), and thiol/disulfide balance were compared between groups. Subsequently, all women were stratified based on menopausal status, and the investigated parameters were investigated separately in the pre- and postmenopausal participants between groups. Results: Equiv/L and 0.8 vs. 0.6 AU; P=0.01). Conclusions: Serum OS may play a role in the development of EP, particularly among postmenopausal women. Further investigations are required in this area.
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Objective

This study aimed to investigate the relationship between oxidative stress (OS) and endometrial polyps (EP) in pre- versus postmenopausal women with abnormal uterine bleeding.

Methods

This prospective case control study was conducted in the Gynecology Department of Ankara Bilkent City Hospital between January and December 2019. In this study, the EP and control groups included 45 participants each (30 pre- and 15 postmenopausal women). Demographics (age, gravidity, parity, and body mass index), serum complete blood count parameters, serum total antioxidant status, total oxidant status (TOS), oxidative stress index (OSI), and thiol/disulfide balance were compared between groups. Subsequently, all women were stratified based on menopausal status, and the investigated parameters were investigated separately in the pre- and postmenopausal participants between groups.

Results

There were no significant intergroup differences in the investigated parameters among all participants (P>0.05). However, unlike in the control group, the age distribution in the EP group was bimodal, peaking in the early 40s and late 50s. Stratification based on menopausal status revealed no significant intergroup differences in the investigated parameters among the premenopausal participants. However, among the postmenopausal participants, serum TOS and OSI levels were significantly higher in the EP versus control group (9.0 vs. 7.2 μmol H2O2 Equiv/L and 0.8 vs. 0.6 AU; P=0.01).

Conclusions

Serum OS may play a role in the development of EP, particularly among postmenopausal women. Further investigations are required in this area. doi: https://doi.org/10.12669/pjms.41.1.10170 How to cite this: Tas EE, Ozgen E, Yilmaz G, Senat A. Relationship between oxidative stress and endometrial polyps in pre-and postmenopausal women. Pak J Med Sci. 2025;41(1):130-135. doi: https://doi.org/10.12669/pjms.41.1.10170 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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