Impact of Delayed Umbilical Cord Clamping on Days of Phototherapy in Preterm Neonates 23–35 Weeks’ Gestation - A Retrospective, Single-Center Cohort Study

Impact of Delayed Umbilical Cord Clamping on Days of Phototherapy in Preterm Neonates 23–35 Weeks’ Gestation - A Retrospective, Single-Center Cohort Study | Research Square window.SnipcartSettings = { analytics: { enabled: false } }; (function() { var accessVector = localStorage.getItem('access_vector') || ''; window.dataLayer = window.dataLayer || []; if (accessVector) { window.dataLayer.push({ user: { profile: { profileInfo: { snid: accessVector } } } }); } })(); (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-K279D39R'); Browse Preprints In Review Journals COVID-19 Preprints AJE Video Bytes Research Tools Research Promotion AJE Professional Editing AJE Rubriq About Preprint Platform In Review Editorial Policies Our Team Advisory Board Help Center Sign In Submit a Preprint Cite Share Download PDF Article Impact of Delayed Umbilical Cord Clamping on Days of Phototherapy in Preterm Neonates 23–35 Weeks’ Gestation - A Retrospective, Single-Center Cohort Study Toby Yanowitz, Avni Patel This is a preprint; it has not been peer reviewed by a journal. https://doi.org/ 10.21203/rs.3.rs-8158705/v1 This work is licensed under a CC BY 4.0 License Status: Under Revision Version 1 posted 8 You are reading this latest preprint version Abstract OBJECTIVE: To evaluate whether delayed cord clamping (DCC) duration predicts hyperbilirubinemia and phototherapy days among preterm infants of different gestational ages. STUDY DESIGN: In this retrospective cohort study, 2,421 preterm infants inborn at Magee-Womens Hospital 2018-22 were stratified into 3 cohorts: 65sec). Univariable analysis and multivariable regression assessed predictors of phototherapy days. RESULTS: DCC occurred in 30%, 44%, and 63% of the cohorts, respectively. In univariable analysis, DCC was associated with higher hemoglobin, peak bilirubin, and phototherapy days for the 31-34 6/7wk cohort only. DCC duration did not predict phototherapy days in adjusted multivariable analysis. CONCLUSION: Longer durations of DCC are not associated with increased phototherapy days in preterm neonates, supporting DCC safety and emphasizing the need to address barriers to consistent implementation. Biological sciences/Physiology Health sciences/Medical research/Outcomes research Full Text Additional Declarations There is NO conflict of interest to disclose. Tables 1 and 2 are available in the Supplementary Files section. Supplementary Files DCCSupplementalTable1.pdf Supplemental Table 1 DCCSupplFig1.pdf Supplemental Figure 1 DCCTable1.pdf Table 1 DCCTable2.pdf Table 2 Cite Share Download PDF Status: Under Revision Version 1 posted Editorial decision: revise 19 Jan, 2026 Review # 1 received at journal 15 Dec, 2025 Reviewer # 1 agreed at journal 01 Dec, 2025 Reviewers invited by journal 24 Nov, 2025 Submission checks completed at journal 21 Nov, 2025 First submitted to journal 20 Nov, 2025 Unknown event 20 Nov, 2025 Editor assigned by journal 19 Nov, 2025 You are reading this latest preprint version Research Square lets you share your work early, gain feedback from the community, and start making changes to your manuscript prior to peer review in a journal. As a division of Research Square Company, we’re committed to making research communication faster, fairer, and more useful. We do this by developing innovative software and high quality services for the global research community. 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Also discoverable on Platform About Our Team In Review Editorial Policies Advisory Board Help Center Resources Author Services Accessibility API Access RSS feed Manage Cookie Preferences © Research Square 2026 | ISSN 2693-5015 (online) Privacy Policy Terms of Service Do Not Sell My Personal Information {"props":{"pageProps":{"initialData":{"identity":"rs-8158705","acceptedTermsAndConditions":true,"allowDirectSubmit":false,"archivedVersions":[],"articleType":"Article","associatedPublications":[],"authors":[{"id":550234655,"identity":"7e121677-81a0-4f98-b5c7-aefaf51d1459","order_by":0,"name":"Toby 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Umbilical Cord Clamping on Days of Phototherapy in Preterm Neonates 23–35 Weeks’ Gestation - A Retrospective, Single-Center Cohort Study","fulltext":[],"fulltextSource":"","fullText":"","funders":[],"hasAdminPriorityOnWorkflow":false,"hasManuscriptDocX":false,"hasOptedInToPreprint":true,"hasPassedJournalQc":"","hasAnyPriority":false,"hideJournal":false,"highlight":"","institution":"","isAcceptedByJournal":false,"isAuthorSuppliedPdf":true,"isDeskRejected":"","isHiddenFromSearch":false,"isInQc":false,"isInWorkflow":false,"isPdf":true,"isPdfUpToDate":true,"isWithdrawnOrRetracted":false,"journal":{"display":true,"email":"[email protected]","identity":"journal-of-perinatology","isNatureJournal":false,"hasQc":false,"allowDirectSubmit":false,"externalIdentity":"jp","sideBox":"Learn more about [Journal of Perinatology](http://www.nature.com/jp/)","snPcode":"41372","submissionUrl":"https://mts-jper.nature.com/cgi-bin/main.plex","title":"Journal of Perinatology","twitterHandle":"@jperinatology","acdcEnabled":true,"dfaEnabled":true,"editorialSystem":"ejp","reportingPortfolio":"Nature AJ","inReviewEnabled":true,"inReviewRevisionsEnabled":false},"keywords":"","lastPublishedDoi":"10.21203/rs.3.rs-8158705/v1","lastPublishedDoiUrl":"https://doi.org/10.21203/rs.3.rs-8158705/v1","license":{"name":"CC BY 4.0","url":"https://creativecommons.org/licenses/by/4.0/"},"manuscriptAbstract":"\u003cp\u003e\u003cstrong\u003eOBJECTIVE:\u003c/strong\u003e To evaluate whether delayed cord clamping (DCC) duration predicts hyperbilirubinemia and phototherapy days among preterm infants of different gestational ages.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eSTUDY DESIGN:\u003c/strong\u003e In this retrospective cohort study, 2,421 preterm infants inborn at Magee-Womens Hospital 2018-22 were stratified into 3 cohorts: \u0026lt;27wks (n=206), 27-30 6/7wks (n=464), and 31-34 6/7wks (n=1751). DCC duration was assessed in 15 second intervals (0, 15, 30, 45, 60, \u0026gt;65sec). Univariable analysis and multivariable regression assessed predictors of phototherapy days.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eRESULTS:\u003c/strong\u003e DCC occurred in 30%, 44%, and 63% of the cohorts, respectively. In univariable analysis, DCC was associated with higher hemoglobin, peak bilirubin, and phototherapy days for the 31-34 6/7wk cohort only. DCC duration did not predict phototherapy days in adjusted multivariable analysis.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eCONCLUSION:\u003c/strong\u003e Longer durations of DCC are not associated with increased phototherapy days in preterm neonates, supporting DCC safety and emphasizing the need to address barriers to consistent implementation.\u003c/p\u003e","manuscriptTitle":"Impact of Delayed Umbilical Cord Clamping on Days of Phototherapy in Preterm Neonates 23–35 Weeks’ Gestation - A Retrospective, Single-Center Cohort Study","msid":"","msnumber":"","nonDraftVersions":[{"code":1,"date":"2025-11-28 05:18:51","doi":"10.21203/rs.3.rs-8158705/v1","editorialEvents":[{"type":"communityComments","content":0},{"type":"decision","content":"revise","date":"2026-01-19T10:48:18+00:00","index":"","fulltext":""},{"type":"editorInvitedReview","content":"This content is not available.","date":"2025-12-15T23:27:16+00:00","index":1,"fulltext":"This content is not available."},{"type":"reviewerAgreed","content":"This content is not available.","date":"2025-12-01T12:45:21+00:00","index":1,"fulltext":"This content is not available."},{"type":"reviewersInvited","content":"","date":"2025-11-25T01:18:51+00:00","index":"","fulltext":""},{"type":"checksComplete","content":"","date":"2025-11-21T11:27:45+00:00","index":"","fulltext":""},{"type":"submitted","content":"Journal of Perinatology","date":"2025-11-20T16:39:46+00:00","index":"","fulltext":""},{"type":"checksFailed","content":"","date":"2025-11-20T12:54:49+00:00","index":"","fulltext":""},{"type":"editorAssigned","content":"","date":"2025-11-19T21:24:34+00:00","index":"","fulltext":""}],"status":"published","journal":{"display":true,"email":"[email protected]","identity":"journal-of-perinatology","isNatureJournal":false,"hasQc":false,"allowDirectSubmit":false,"externalIdentity":"jp","sideBox":"Learn more about [Journal of Perinatology](http://www.nature.com/jp/)","snPcode":"41372","submissionUrl":"https://mts-jper.nature.com/cgi-bin/main.plex","title":"Journal of Perinatology","twitterHandle":"@jperinatology","acdcEnabled":true,"dfaEnabled":true,"editorialSystem":"ejp","reportingPortfolio":"Nature AJ","inReviewEnabled":true,"inReviewRevisionsEnabled":false}}],"origin":"","ownerIdentity":"f11bf060-068d-4d61-8814-4b3928a6c65c","owner":[],"postedDate":"November 28th, 2025","published":true,"recentEditorialEvents":[],"rejectedJournal":[],"revision":"","amendment":"","status":"in-revision","subjectAreas":[{"id":58543549,"name":"Biological sciences/Physiology"},{"id":58543550,"name":"Health sciences/Medical research/Outcomes research"}],"tags":[],"updatedAt":"2026-01-19T11:03:55+00:00","versionOfRecord":[],"versionCreatedAt":"2025-11-28 05:18:51","video":"","vorDoi":"","vorDoiUrl":"","workflowStages":[]},"version":"v1","identity":"rs-8158705","journalConfig":"researchsquare"},"__N_SSP":true},"page":"/article/[identity]/[[...version]]","query":{"redirect":"/article/rs-8158705","identity":"rs-8158705","version":["v1"]},"buildId":"8U1c8b4HqxoKbykW_rLl7","isFallback":false,"isExperimentalCompile":false,"dynamicIds":[84888],"gssp":true,"scriptLoader":[]}