ENOX1, CCDC122ANDLACC1ROLE IN PROGRESSION OF PROSTATE CANCER

Prostate cancer (PCa) continues to trend among top 3 cancers that kill men over 20 years in the United Kingdom and worldwide despite extensive research and resources directed towards its treatment and prevention. In the application of a hallmark of survival mechanisms by the cancer, our study used mRNA seq data to identify genes that are increasingly mutated with progressing PCa from a cohort of 491 PCa patients. We found that ENOX1, CCDC122 and LACC1 deep deletion was positively associated with increasing age of diagnosis. Pathway analysis of enriched genes, following their deep deletion identified estrogen biosynthesis, KSRP signalling, omega 3 and 6 fatty acid biosynthesis and, Rap1 signalling as the top 5 enriched pathways. Previous individual and combined role of these genes in PCa progression was not fully established but thanks to this study, these pathways could be druggable targets in PCa patients with these gene deep deletions.