Эндометриоз: время сделать больше. Краткий обзор исследования «ОРХИДЕЯ»

Л. В. Гутикова, А. М. Дощанова, Н. Ф. Захаренко, Ю. В. Кухарчик, Н. Н. Педаченко, Т. Н. Тутченко, Т. Ф Татарчук, Э. А. Тойлыева, А. С. Тулетова, Т. М. Укыбасова, О. А. Якубова
In: REPRODUCTIVE ENDOCRINOLOGY · 2020 · pp. 118–122 · doi:10.18370/2309-4117.2020.54.118-122 · W3101196444
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The ORCHIDEA study investigated the burden and unmet needs of endometriosis patients, highlighting the significant impact of the disease on women's lives and the need for improved management strategies.

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This paper provides a brief overview of the ORCHIDEA study, which is an open-label, multicenter observational investigation evaluating the real-world clinical practice of treating confirmed endometriosis with oral dydrogesterone. The authors discuss the rationale for using this progestin based on existing guidelines and prior research, highlighting its role in managing symptoms associated with the condition. The text serves as a summary of the study's design and objectives rather than presenting new primary data or detailed statistical outcomes. This paper is centrally about endometriosis — specifically, it reviews the methodology and context of a clinical trial assessing the efficacy of oral dydrogesterone for treatment.

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Abstract

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Эндометриоз: время сделать больше. Краткий обзор исследования «ОРХИДЕЯ» DOI: https://doi.org/10.18370/2309-4117.2020.54.118-122Abstract - References - Liang, B., Wu, L., et al. “Efficacy, safety and recurrence of new progestins and selective progesterone receptor modulator for the treatment of endometriosis: a comparison study in mice.” Reproductive Biology and Endocrinology (2018). DOI: 10.1186/s12958-018-0347-9 - Study of Real Clinical Practice to Evaluate the Effects of Oral Dydrogesterone for Treatment of Confirmed Endometriosis. Available from: [https://www.clinicaltrials.gov/ct2/show/study/NCT03690765?term=ORCHIDEA&cond=Endometriosis&draw=2&rank=1], last accessed Aug 14, 2020. - Dunselman, G.A., et al. “ESHRE guideline: management of women with endometriosis.” Hum Reprod 29.3 (2014): 400–12. - The National Institute for Health and Care Excellence. Endometriosis: diagnosis and management. Guideline (2017). Available from: [https://www.nice.org.uk/guidance/ng73/resources/endometriosis-diagnosis-and-management-pdf-1837632548293], last accessed Aug 14, 2020. - Lee, H.J., Park, T.C., Kim, J.H., et al. “The Influence of Oral Dydrogesterone and Vaginal Progesterone on Threatened Abortion: A Systematic Review and Meta-Analysis.” Biomed Res Int 2017 (2017): 3616875. DOI: 10.1155/2017/3616875 - Santulli, P., et al. “Oligo-anovulation is not a rarer feature in women with documented endometriosis.” Fertil Steril 110.5 (2018): 941–8. - Trivedi, P., et al. “Effective post-laparoscopic treatment of endometriosis with dydrogesterone.” Gynecol Endocrinol 23 Suppl. 1 (2007): S73–S76. - Order of the Ministry of Health of Ukraine from 06.04.2016 No. 319. Standardization of the Clinical Protocol for the first, second (special) and third (highly specialized) medical assistance. - Clinical Protocol for diagnosis and treatment: genital endometriosis. Approved by the Joint Commission for the Quality of Medical Services of the Ministry of Health of Republic of Kazakhstan, March 1, 2019, protocol No. 56. - Sukhikh, G.T., Adamyan, L.V., Serov, V.N., et al. “Resolution of the Expert Meeting on the topic ‘Possibilities of personalization of endometriosis hormone therapy with dydrogesterone. Approval of the protocol of a multicenter open observational study of dydrogesterone for treatment of endometriosis in Russia (the ORCHIDEA study)’“. Reproduction problems 5 (2018): 41–4. DOI: 10.17116/repro20182405141 - Resolution of the Ministry of Health of Belarus Republic, February 19, 2018, No. 17. Clinical Protocol “Medical observation and medical care for women in obstetrics and gynecology”. - Orazov, M.R., Radzinsky, V.E., Khamoshina, M.B., et al. “Infertility associated with endometriosis: from legend to harsh reality.” Difficult patient 1–2 (2019). - Dubrovina, S.O., Berlim, Y.D. “Medical treatment of pain associated with endometriosis.” Obstetrics and Gynecology 2 (2019): 34–40. - Kozachenko, A.V. Speech at the XIV International Congress on Reproductive Medicine 01.21.2020 (Moscow). Available from: [https://www.mediexpo.ru/fileadmin/user_upload/content/pdf/thesis/rzs2020-abstracts.pdf], last accessed Aug 14, 2020. - Yakovleva, E. “Reproductive medicine: new horizons of well-known methods of treatment.” Mother and Child 1.19 (2020). Available from: [https://aig-journal.ru/articles/Reproduktivnaya-medicina-novye-gorizonty-horosho-izvestnyh-metodov-lecheniya.html], last accessed Aug 14, 2020. Downloads Published How to Cite Issue Section License Copyright (c) 2020 Л. В. Гутикова, А. М. Дощанова, Н. Ф. Захаренко, Ю. В. Кухарчик, Н. Н. Педаченко, Т. Н. Тутченко, Т. Ф. Татарчук, Э. А. Тойлыева, А. С. Тулетова, Т. М. Укыбасова, Т. М. Укыбасова, О. А. Якубова This work is licensed under a Creative Commons Attribution 4.0 International License. Authors who publish with this journal agree to the following terms: - Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal. - Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.

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