Study on the correlation between ER,PR,Ki-67,CA_(125) and adenomyosis

Objective: To detect the expressions of estrogen receptor( ER),progesterone receptor( PR),and Ki-67 in eutopic endometrium and focal area,plasma CA125level of patients with adenomyosis,explore the relationship between ER,PR,Ki-67,CA125and adenomyosis. Methods: EnVision two-step method was used to detect the expressions of ER,PR,and Ki-67 in eutopic endometrium and focal area of 68 patients with adenomyosis and 15 cases in control group; VAS numeric rating scale was used to evaluate the degree of pain in patients with adenomyosis; photochemical luminescence method was used to detect plasma CA125level; transvaginal ultrasound was used to measure uterine radial lines and calculate uterine volume,AFS grading method was used to assess pelvic adhesion situation and compare the relationship between them. Results: The expression levels of ER and PR in focal area of adenomyosis group was statistically significantly lower than those in eutopic endometrium of adenomyosis group and control group( P 0. 05),the expression level of Ki-67 in focal area of adenomyosis group was statistically significantly higher than those in eutopic endometrium of adenomyosis group and control group( P 0. 05),there was no statistically significant difference in the expression levels of ER,PR,and Ki-67 between eutopic endometrium of adenomyosis group and control group( P 0. 05); there was a correlation between ER,PR and Ki-67 in adenomyosis group( P 0. 05); CA125was moderately correlated with painful degree,uterine volume,and AFS score( P 0. 05). Conclusion: There is a correlation between ER,PR and Ki-67 in adenomyosis in focal area of patients with adenomyosis,but there isn't periodical change,which indicates that proliferation of endometrial cells in focal area of patients with adenomyosis can't be regulated by ovarian hormones to a certain degree,there are a certain differences in growing environment,proliferation and differentiation mechanism between ectopic endometrium and eutopic endometrium probably; CA125is correlated with painful degree,uterine volume,and AFS score,detecting CA125has important clinical significance in auxiliary diagnosis of adenomyosis and observing progress of the disease.