UJI TOKSISITAS VAKSIN ROTAVIRUS TERHADAP \nGAMBARAN HISTOPATOLOGI UTERUS PADA \nKELINCI BETINA (Oryctolagus cuniculus)

This research aimed to evaluate the influence of administered orally \nrotavirus vaccine on histopathological changes of uterine in rabbit (Oryctolagus \ncuniculus). Six female rabbits five-week old were divided randomly into two \ngroups with different treatments for 56 days. The treatments consist of \nadministered orally with 1 ml of sucrose (P0) and 1 ml of rotavirus vaccine from \nPT. Biofarma (P1). Rabbits adapted in BSL-3 for 7 days with ad libitum food and \nwater everyday. Sucrose and rotavirus vaccine was administered orally on day 0, \nday 11, and day 22. All rabbits euthanized on day 56 to collect the uterine sample. \nThe histopathological feature of uterine were examined by using International \nHarmonization of Toxicologic Pathology Nomenclature scoring method. Data was \nanalyzed using Mann Whitney U Test. The results showed that rotavirus vaccine \nprovides no significant changes in inflammation cell infiltration, hyperplasia of \nendometrium epithelium, hyperplasia of uterine gland epithelium, fibrosis, \nhemorrhage, and edema in uterine histopathology (p>0.05).