Misleading hepatitis B testing in the setting of intravenous immunoglobulin

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Abstract

Intravenous immunoglobulin (IVIG) is commonly used for a wide range of diagnoses, by multiple pediatric subspecialists. We report two cases of hepatitis B screening results post IVIG infusion, where positive anti-Hepatitis B core antigen serology tests indicated possible occult hepatitis infection, leading to a delay in care. However, serial antibody testing showed results consistent with the passive transfer of antibodies.

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europepmc
last seen: 2026-05-19T01:45:01.086888+00:00