Histopathological features of endometritis eosinophilica in mares.

Grimm AL, Schoon HA, Schöniger S
Histology and histopathology · 2017 · doi:10.14670/hh-11-872 · PMID:28105630
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This study characterized the histological features of equine endometritis eosinophilica (EE) by analyzing endometrial biopsies from 55 mares diagnosed with the condition, alongside control groups. The researchers established diagnostic criteria based on physiological eosinophil counts and found that EE was frequently associated with irregular glandular differentiation and high-grade endometriosis in a significant portion of the affected animals. Additionally, the results indicated an association between eosinophilic infiltration and the presence of neutrophils, suggesting that EE acts as a primary fertility-reducing disease in mares. The paper does not explicitly discuss endometriosis or adenomyosis; it was included in the corpus via a keyword match in the upstream search index.

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Abstract

Equine endometritis eosinophilica (EE) is rarely described and its diagnostic criteria are not defined. The aim of this study was to characterize histological features of EE. A data base (1995-2013) was searched for biopsies with increased eosinophils. This study included all biopsies with this diagnosis and representative biopsies without this record. The definition of equine EE was based on criteria for EE in women and the results of the determination of physiological numbers of eosinophils within the equine endometrium. EE was diagnosed in 55 mares. Biopsies of 10 mares contained eosinophils exceeding the physiological range, but no EE; the diagnosis of eosinophilic infiltrates (EI) was applied. Those of the remaining mares (n = 126) displayed eosinophils within the physiological range (EWPR). An irregular glandular differentiation during the breeding season was detected in 25% of mares with EE, 33% of mares with EI and 24% of the mares with EWPR. Most mares with EE (93%), EI (90%) and EWPR (72%) showed endometrosis; it was high grade in 11% with EE and 7% with EWPR. Endometritis was diagnosed within 56% of mares with EE, 40% of mares with EI and 37% of those with EWPR. In mares with EE suppurative endometritis dominated (58%) and in those with EWPR non-suppurative endometritis (58%). This study indicates EE as a primary fertility reducing disease. Results suggest an association between eosinophilic infiltration and the presence of neutrophils. Further, they provide the basis for future studies into the pathogenesis, prognosis and therapy of EE.
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Histopathological features of endometritis eosinophilica in mares Anna Lena Grimm, Heinz-Adolf Schoon and Sandra Sch�niger Institute of Pathology, Faculty of Veterinary Medicine, University of Leipzig, Leipzig, Germany Offprint requests to: Sandra Sch�niger, Institute of Pathology, Faculty of Veterinary Medicine, University Leipzig, An den Tierkliniken 33, 04103 Leipzig, Germany. e-mail: [email protected] Summary. Equine endometritis eosinophilica (EE) is rarely described and its diagnostic criteria are not defined. The aim of this study was to characterize histological features of EE. A data base (1995-2013) was searched for biopsies with increased eosinophils. This study included all biopsies with this diagnosis and representative biopsies without this record. The definition of equine EE was based on criteria for EE in women and the results of the determination of physiological numbers of eosinophils within the equine endometrium. EE was diagnosed in 55 mares. Biopsies of 10 mares contained eosinophils exceeding the physiological range, but no EE; the diagnosis of eosinophilic infiltrates (EI) was applied. Those of the remaining mares (n=126) displayed eosinophils within the physiological range (EWPR). An irregular glandular differentiation during the breeding season was detected in 25% of mares with EE, 33% of mares with EI and 24% of the mares with EWPR. Most mares with EE (93%), EI (90%) and EWPR (72%) showed endo-metrosis; it was high grade in 11% with EE and 7% with EWPR. Endometritis was diagnosed within 56% of mares with EE, 40% of mares with EI and 37% of those with EWPR. In mares with EE suppurative endometritis dominated (58%) and in those with EWPR non-suppurative endometritis (58%). This study indicates EE as a primary fertility reducing disease. Results suggest an association between eosinophilic infiltration and the presence of neutrophils. Further, they provide the basis for future studies into the pathogenesis, prognosis and therapy of EE. Histol Histopathol 32, 1161-1173 (2017) Key words: Histology, Endmetrium. Endometritis eosinopilica, Equine, Mare DOI: 10.14670/HH-11-872

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