Design, Optimization, and Evaluation of a Functionalized Mesoporous Nanoparticle System Loaded with Curcumin for Oral Cancer Therapy

Design, Optimization, and Evaluation of a Functionalized Mesoporous Nanoparticle System Loaded with Curcumin for Oral Cancer Therapy | Research Square window.SnipcartSettings = { analytics: { enabled: false } }; (function() { var accessVector = localStorage.getItem('access_vector') || ''; window.dataLayer = window.dataLayer || []; if (accessVector) { window.dataLayer.push({ user: { profile: { profileInfo: { snid: accessVector } } } }); } })(); (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-K279D39R'); Browse Preprints In Review Journals COVID-19 Preprints AJE Video Bytes Research Tools Research Promotion AJE Professional Editing AJE Rubriq About Preprint Platform In Review Editorial Policies Our Team Advisory Board Help Center Sign In Submit a Preprint Cite Share Download PDF Research Article Design, Optimization, and Evaluation of a Functionalized Mesoporous Nanoparticle System Loaded with Curcumin for Oral Cancer Therapy Priya Patel, Anand Gondhiya, Nasir Vadia, Devesh U Kapoor, Bhupendra G. Prajapati This is a preprint; it has not been peer reviewed by a journal. https://doi.org/ 10.21203/rs.3.rs-6486052/v1 This work is licensed under a CC BY 4.0 License Status: Posted Version 1 posted You are reading this latest preprint version Abstract A mesoporous silica-based nanoparticulate drug delivery system encapsulating curcumin was designed to enhance the targeted delivery of the therapeutic agent to tumor tissues in oral cancer. The drug was entrapped within functionalized mesoporous material, MCM 41, by solvent evaporation technique, and folic acid was used as a targeting agent. The optimization of the prepared formulation was done employing a statistical approach, i.e., Box Behnken Design. The physicochemical properties of the prepared nanoparticulate, including the drug, mesoporous material, and other excipients, were thoroughly evaluated employing a range of analytical methods. The influence of functionalized mesoporous MCM 41 nanoparticles on curcumin bioavailability was checked by an In-vivo study performed using an animal model. The drug entrapment capacity was found to be 85%, with a considerable enhancement of bioavailability. The functionalization of MCM 41 mesoporous material led to the sustained release of the medicament in all tested conditions. Curcumin-loaded mesoporous silica nanoparticles with active targeting agent folic acid were found to be adequate for active targeting of drugs to tumor tissues of oral cancer. Oral cancer Curcumin Mesoporous MCM 41 nanoparticles in vivo study Box Behnken design Full Text Additional Declarations No competing interests reported. Cite Share Download PDF Status: Posted Version 1 posted You are reading this latest preprint version Research Square lets you share your work early, gain feedback from the community, and start making changes to your manuscript prior to peer review in a journal. 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Also discoverable on Platform About Our Team In Review Editorial Policies Advisory Board Help Center Resources Author Services Accessibility API Access RSS feed Manage Cookie Preferences © Research Square 2026 | ISSN 2693-5015 (online) Privacy Policy Terms of Service Do Not Sell My Personal Information {"props":{"pageProps":{"initialData":{"identity":"rs-6486052","acceptedTermsAndConditions":true,"allowDirectSubmit":true,"archivedVersions":[],"articleType":"Research Article","associatedPublications":[],"authors":[{"id":451687937,"identity":"8ab9e317-35f9-4410-8f17-7e3302d482d3","order_by":0,"name":"Priya Patel","email":"","orcid":"","institution":"Saurashtra University","correspondingAuthor":false,"prefix":"","firstName":"Priya","middleName":"","lastName":"Patel","suffix":""},{"id":451687941,"identity":"c427f5d7-e361-495f-b4cf-066a465415aa","order_by":1,"name":"Anand Gondhiya","email":"","orcid":"","institution":"Saurashtra University","correspondingAuthor":false,"prefix":"","firstName":"Anand","middleName":"","lastName":"Gondhiya","suffix":""},{"id":451687942,"identity":"5de15118-c546-45db-9c22-85a560498a10","order_by":2,"name":"Nasir Vadia","email":"","orcid":"","institution":"Marwadi University","correspondingAuthor":false,"prefix":"","firstName":"Nasir","middleName":"","lastName":"Vadia","suffix":""},{"id":451687943,"identity":"6bf115ed-c2e9-433d-93d7-4718a92bc8a3","order_by":3,"name":"Devesh U Kapoor","email":"","orcid":"","institution":"Dr. Dayaram Patel Pharmacy College","correspondingAuthor":false,"prefix":"","firstName":"Devesh","middleName":"U","lastName":"Kapoor","suffix":""},{"id":451687944,"identity":"020096b3-9292-4bdb-bc8e-265b7aec0014","order_by":4,"name":"Bhupendra G. 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